Dose-dependence and repeated-dose studies for receptor/gene-mediated pharmacodynamics of methylprednisolone on glucocorticoid receptor down- regulation and tyrosine aminotransferase induction in rat liver

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 26, Issue 6, 1998, Pages 619-648

  Sun, Yu Nien ^a,b   DuBois, Debra C ^a   Almon, Richard R ^a   Pyszczynski, Nancy A ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b GENENTECH INC   (United States)

Author keywords

Dose dependence; Down regulation; Glucocorticoid receptor; Indirect pharmacodynamic response models; Methylprednisolone; mRNA; Northern hybridization; Pharmacodynamics; Pharmacokinetics; Tolerance; Tyrosine aminotransferase

Indexed keywords

GLUCOCORTICOID RECEPTOR; MESSENGER RNA; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; TYROSINE AMINOTRANSFERASE;

AREA UNDER THE CURVE; ARTICLE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG TOLERANCE; ENZYME ACTIVITY; ENZYME INDUCTION; INTRAVENOUS DRUG ADMINISTRATION; LIVER; MALE; MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION;

ANIMALS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; LIVER; MALE; METHYLPREDNISOLONE; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; TYROSINE TRANSAMINASE;

EID: 0032449041     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020746822634     Document Type: Article

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