Merkel Cell Carcinomas

Hematology/Oncology Clinics of North America

Volumn 21, Issue 3, 2007, Pages 527-544

  Dinh, Vy ^a   Feun, Lynn ^a   Elgart, George ^a   Savaraj, Niramol ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CARBOPLATIN; CHLORAMBUCIL; CISPLATIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; FLUOROURACIL; IMATINIB; IMIDAZOLECARBOXAMIDE; METHOTREXATE; PREDNISONE; PROTEIN P73; STREPTOZOCIN; VINCRISTINE;

ANAPLASTIC CARCINOMA; ANTINEOPLASTIC ACTIVITY; CANCER RISK; CANCER STAGING; CHROMOSOME ABERRATION; CLINICAL FEATURE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; DRUG MECHANISM; DRUG RESPONSE; ENZYME INHIBITION; EPIDERMIS; ETHNIC DIFFERENCE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; KERATINOCYTE; MECHANORECEPTOR; MERKEL CELL TUMOR; MONOTHERAPY; NEUROSECRETORY CELL; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SEX DIFFERENCE; SKIN CANCER; SMALL CELL CARCINOMA;

CARCINOMA, MERKEL CELL; DIAGNOSIS, DIFFERENTIAL; HUMANS; NEOPLASM STAGING; PROGNOSIS; SKIN NEOPLASMS;

EID: 34249790866     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hoc.2007.04.008     Document Type: Review

References (124)

1. Moll I., Roessler M., Brandner J.M., et al. Human Merkel cells-aspects of cell biology, distribution and functions. Eur J Cell Biol 84 2-3 (2005) 259-271
2. Toker C. Trabecular carcinoma of the skin. Arch Dermatol 105 1 (1972) 107-110
3. De Wolff Peeters C., Marien K., Mebis J., et al. A cutaneous APUDoma or Merkel cell tumor? A morphologically recognizable tumor with a biological and histological malignant aspect in contrast with its clinical behavior. Cancer 46 8 (1980) 1810-1816
4. Winkelmann R.K., and Breathnach A.S. The Merkel cell. J Invest Dermatol 60 (1973) 2-15
5. Pinkus F. Uber einen bisher unbekannten Nebenapparat am Haarsystem des Menschen: Haarscheiben. Dermatologische Zeitschrift 9 (1902) 465-469
6. Moll I., Zieger W., and Schmelz M. Proliferative Merkel cells were not detected on human skin. Arch Dermatol Res 288 (1996) 184-187
7. Goessling W., McKee P., and Mayer R. Merkel cell carcinoma. J Clin Oncol 20 2 (2002) 588-598
8. Hodgson N. Merkel cell carcinoma: changing incidence trends. J Surg Oncol 89 1 (2004) 1-4
9. Agelli M., and Clegg L. Epidemiology of primary Merkel cell carcinoma in the United States. J Am Acad Dermatol 49 5 (2003) 832-841
10. Penn I., and First M.R. Merkel's cell carcinoma in organ recipients: report of 41 cases. Transplantation 68 11 (1999) 1717-1721
11. Calza L., Beltrami C., Manfredi R., et al. Merkel cell carcinoma in a human immunodeficiency virus-infected patient. Br J Dermatol 146 5 (2002) 895-898
12. Matichard E., Descamps V., Grossin M., et al. Merkel cell carcinoma in a black human immunodeficiency virus-infected patient. Br J Dermatol 146 4 (2002) 671-673
13. An K.P., and Ratner D. Merkel cell carcinoma in the setting of HIV infection. J Am Acad Dermatol 45 2 (2001) 309-312
14. Engels E.A., Frisch M., Goedert J.J., et al. Merkel cell carcinoma and HIV infection. Lancet 359 9305 (2002) 497-498
15. Burack J., and Altschuler E.L. Sustained remission of metastatic Merkel cell carcinoma with treatment of HIV infection. J R Soc Med 96 5 (2003) 238-239
16. Colebunders R., Bottieau E., Van den Brande J., et al. Merkel cell carcinoma and multiple basal cell carcinoma in an African albino woman with HIV infection. HIV Med 5 6 (2004) 452-454
17. Solomon R.K., Lundeen S.J., Hamlar D.D., et al. Fine-needle aspiration diagnosis of unusual cutaneous neoplasms of the scalp in HIV-infected patients: a report of two cases and review of the literature. Diagn Cytopathol 24 3 (2001) 186-192
18. Samarendra P., Berkowitz L., Kumari S., et al. Primary nodal neuroendocrine (Merkel cell) tumor in a patient with HIV infection. South Med J 93 9 (2000) 920-922
19. Ziprin P., Smith S., Salerno G., et al. Two cases of Merkel cell tumour arising in patient with chronic lymphocytic leukemia. Br J Dermatol 142 3 (2000) 525-528
20. Yiengpruksawan A., Coit D.G., Thaler H.T., et al. Merkel cell carcinoma: prognosis and management. Arch Surg 126 (1991) 1514-1519
21. Hitchcock C.L., Bland K.I., Laney III R.G., et al. Neuroendocrine (Merkel cell) carcinoma of the skin: its natural history, diagnosis, and treatment. Ann Surg 207 (1988) 201-207
22. Huang G.S., Chang W.C., Lee H.S., et al. Merkel cell carcinoma arising from the subcutaneous fat of the arm with intact skin. Dermatol Surg 31 6 (2005) 717-719
23. Meyer-Pannwitt U., Kummerfeldt K., Boubaris P., et al. Merkel cell tumor or neuroendocrine skin carcinoma. Langenbecks Arch Chir 382 6 (1997) 349-358
24. Allen P.J., Zhang Z.F., and Coit D.G. Surgical management of Merkel cell carcinoma. Ann Surg 229 1 (1999) 97-105
25. Raaf J.H., Urmacher C., Knapper W.K., et al. Trabecular (Merkel cell) carcinoma of the skin: treatment of primary, recurrent, and metastatic disease. Cancer 57 1 (1986) 178-182
26. Savage P., Constenla D., Fisher C., et al. The natural history and management of Merkel cell carcinoma of the skin: a review of 22 patients treated at the Royal Marsden Hospital. Clin Oncol (R Coll Radiol) 9 3 (1997) 164-167
27. Chen K.T. Merkel's cell (neuroendocrine) carcinoma of the vulva. Cancer 73 (1994) 2186-2191
28. Gil-Moreno A., Garcia-Jimenez A., Gonzalez-Bosquet J., et al. Merkel cell carcinoma of the vulva. Gynecol Oncol 64 3 (1997) 526-532
29. Hierro I., Blanes A., Matilla A., et al. Merkel cell (neuroendocrine) carcinoma of the vulva: a case report with immunohistochemical and ultrastructural findings and review of the literature. Pathol Res Pract 196 7 (2000) 503-509
30. Tomic S., Warner T.F., Messing E., et al. Penile Merkel cell carcinoma. Urology 45 6 (1995) 1062-1065
31. Azevedo Cavalcanti Reis F., Quirino R., Monnerat Lott F., et al. Merkel cell carcinoma of penis. Progres en Urologie 14 4 (2004) 558-560
32. Mir R., Sciubba J.J., Bhuiya T.A., et al. Merkel cell carcinoma arising in the oral mucosa. Oral Surg Oral Med Oral Pathol 65 1 (1988) 71-75
33. Hauschild A., Rademacher D., Rowert J., et al. Merkel cell carcinoma: follow-up of 10 patients. Current diagnosis and therapy. Langenbecks Arch Chir 382 4 (1997) 185-191
34. Longo F., Califano L., Mangone G.M., et al. Neuroendocrine (Merkel cell) carcinoma of the oral mucosa: report of a case with immunohistochemical study and review of literature. J Oral Pathol Med 28 2 (1999) 88-91
35. Medina-Franco H., Urist M., Fiveash J., et al. Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases. Ann Surg Oncol 8 3 (2001) 204-208
36. Voog E., Biron P., Marting J.P., et al. Chemotherapy for patients with locally advanced or metastatic Merkel cell carcinoma. Cancer 85 (1999) 2589-2595
37. Chang D.T., Mancuso A.A., Riggs Jr. C.E., et al. Merkel cell carcinoma of the skin with leptomeningeal metastases. Am J Otolaryngol 26 3 (2005) 210-213
38. Routh A., Hickman B.T., and Johnson W.W. Superior vena cava obstruction from Merkel cell carcinoma. Arch Dermatol 123 (1987) 714-716
39. Walsh M.Y. Superior vena cava obstruction from Merkel cell carcinoma. Arch Dermatol 124 1 (1988) 21
40. Eggers S.D., Salomao D.R., Dinapoli R.P., et al. Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma. Mayo Clin Proc 76 (2001) 327-330
41. Lopez M.C., Pericay C., Agusti M., et al. Merkel cell carcinoma associated with a paraneoplastic neurological syndrome. Histopathology 44 6 (2004) 628-629
42. Pitale M., Sessions R.B., and Husain S. An analysis of prognostic factors in cutaneous neuroendocrine carcinoma. Laryngoscope 102 3 (1992) 244-249
43. Miller R.W., and Rabkin C.S. Merkel cell carcinoma and melanoma: etiological similarities and differences. Cancer Epidemiol Biomarkers Prev 8 2 (1999) 153-158
44. Van Gele M., Kaghad M., Leonard J.H., et al. Mutation analysis of p73 and tp53 in Merkel cell carcinoma. Br J Cancer 82 (2000) 823-826
45. Lunder E.J., and Stern R.S. Merkel cell carcinomas in patients treated with methoxsalen and ultraviolet A radiation. N Engl J Med 339 (1998) 1247-1248
46. Tsuruta D., Hamada T., Mochida K., et al. Merkel cell carcinoma: Bowen's disease and chronic occupational arsenic poisoning. Br J Dermatol 139 2 (1998) 291-294
47. Ho S.Y., Tsai Y.C., Lee M.C., et al. Merkel cell carcinoma in patients with long-term ingestion of arsenic. J Occup Health 47 2 (2005) 188-192
48. Gooptu C., Woollons A., Ross J., et al. Merkel cell carcinoma arising after therapeutic immunosuppression. Br J Dermatol 137 (1997) 637-641
49. Lillis J., Ceilley R.I., and Nelson P. Merkel cell carcinoma in a patient with autoimmune hepatitis. J Drugs Dermatol 4 3 (2005) 357-359
50. Miller J., Huhn K., Goldman G., et al. Merkel cell carcinoma in a stem cell transplant patient. Dermatol Surg 24 8 (1998) 913-914
51. Quaglino D., Di Leonardo G., Lalli G., et al. Association between chronic lymphocytic leukemia and secondary tumors: unusual occurrence of a neuroendocrine (Merkel cell) carcinoma. Eur Rev Med Pharmacol Sci 1 (1997) 11-16
52. Van Gele M., Van Roy N., Ronan S.G., et al. Molecular analysis of 1p36 breakpoints in two Merkel cell carcinomas. Genes Chromosomes Cancer 23 (1998) 67-71
53. Harnett P.R., Kearsley J.H., Hayward N.K., et al. Loss of allelic heterozygosity on distal chromosome 1p in Merkel cell carcinoma: a marker of neural crest origins?. Cancer Genet Cytogenet 54 (1991) 109-113
54. Carson H.J., Lueck N.E., and Horten B.C. Comparison of mutant and wild-type p53 proteins in Merkel cell carcinoma. Clin Diagn Lab Immunol 7 (2000) 326
55. Leonard J.H., Williams G., Walters M.K., et al. Deletion mapping of the short arm of chromosome 3 in Merkel cell carcinoma. Genes Chromosomes Cancer 15 (1996) 102-107
56. Dammann R., Li C., Yoon J.H., et al. Epigenetic inactivation of RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet 35 (2000) 315-319
57. Burbee D.G., Forgacs E., Zochbauer-Muller S., et al. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst 93 (2001) 691-699
58. Sibley R.K., Rosai J., Foucar E., et al. Neuroendocrine (Merkel cell) carcinoma of the skin: a histologic and ultrastructural study of two cases. Am J Surg Pathol 4 3 (1980) 211-221
59. Rocamora A., Badia N., Vives R., et al. Epidermotropic primary neuroendocrine (Merkel cell) carcinoma of the skin with Pautrier-like microabscesses: report of three cases and review of the literature. J Am Acad Dermatol 16 6 (1987) 1163-1168
60. Boutilier R., Desormeau L., Cragg F., et al. Merkel cell carcinoma: squamous and atypical fibroxanthoma-like differentiation in successive local tumor recurrences. Am J Dermatopathol 23 1 (2001) 46-49
61. Gu J., Polak J.M., Van Noorden S., et al. Immunostaining of neuron-specific enolase as a diagnostic tool for Merkel cell tumors. Cancer 52 6 (1983) 1039-1043
62. Miettinen M. Keratin 20: immunohistochemical marker for gastrointestinal, urothelial, and Merkel cell carcinomas. Mod Pathol 8 4 (1995) 384-388
63. Chan J.K., Suster S., Wenig B.M., et al. Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol 21 2 (1997) 226-234
64. Mott R.T., Smoller B.R., and Morgan M.B. Merkel cell carcinoma: a clinicopathologic study with prognostic implications. J Cutan Pathol 31 3 (2004) 217-223
65. Scott M.P., and Helm K.F. Cytokeratin 20: a marker for diagnosing Merkel cell carcinoma. Am J Dermatopathol 21 1 (1999) 16-20
66. Kuhajda F.P., Olson J.L., and Mann R.B. Merkel cell (small cell) carcinoma of the skin: immunohistochemical and ultrastructural demonstration of distinctive perinuclear cytokeratin aggregates and a possible association with B cell neoplasms. Histochem J 18 5 (1986) 239-244
67. Moll R., Lowe A., Laufer J., et al. Cytokeratin 20 in human carcinomas: a new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol 140 2 (1992) 427-447
68. Hanly A.J., Elgart G.W., Jorda M., et al. Analysis of thyroid transcription factor-1 and cytokeratin 20 separates Merkel cell carcinoma from small cell carcinoma of lung. J Cutan Pathol 27 3 (2000) 118-120
69. Morton D.L., Wen D.R., Wong J.H., et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 127 (1992) 392-399
70. Gipponi M. Clinical applications of sentinel lymph node biopsy for staging and treatment of solid neoplasms. Minerva Chir 60 5 (2005) 217-233
71. Schmalbach C., Lowe L., Teknos T., et al. Reliability of sentinel lymph node biopsy for regional staging of head and neck Merkel cell carcinoma. Arch Otolaryngol Head Neck Surg 131 (2005) 610-614
72. Zeitouni N.C., Cheney R.T., and Delacure M.D. Lymphoscintigraphy, sentinel lymph node biopsy, and Mohs micrographic surgery in the treatment of Merkel cell carcinoma. Dermatol Surg 26 1 (2000) 12-18
73. Gollub M.J., Gruen D.R., and Dershaw D.D. Merkel cell carcinoma: CT finding in 12 patients. Am J Roentgenol 167 (1996) 617-620
74. Lampreave J.L., Benard F., Alavi A., et al. PET evaluation of therapeutic limb perfusion in Merkel's cell carcinoma. J Nucl Med 39 (1998) 2087-2090
75. Yao M., Smith R.B., Hoffman H.T., et al. Merkel cell carcinoma: two case reports focusing on the role of fluorodeoxyglucose positron emission tomography imaging in staging and surveillance. Am J Clin Oncol 28 2 (2005) 205-210
76. Lin O., Thomas A., Singh A., et al. Complementary role of positron emission tomography in Merkel cell carcinoma. South Med J 97 11 (2004) 1110-1112
77. Talbot J.N., Kerrou K., Missoum F., et al. 6-[F-18]Fluoro-L: DOPA positron emission tomography in the imaging of Merkel cell carcinoma: preliminary report of three cases with 2-deoxy-2-[F-18]fluoro-D: glucose positron emission tomography or pentetreotide-(111In) SPECT data. Mol Imaging Biol 7 4 (2005) 257-261
78. Cirillo F., Filippini L., Lima G.F., et al. Merkel cell tumor: report of case and treatment with octreotide. Minerva Chir 52 (1997) 1359-1365
79. Kwekkeboom D.J., Hoff A.M., Lamberts S.W., et al. Somatostatin analogue scintigraphy: a simple and sensitive method for the in vivo visualization of Merkel cell tumors and their metastases. Arch Dermatol 128 6 (1992) 818-821
80. Boyle F., Pendlebury S., and Bell D. Further insights into the natural history and management of primary cutaneous neuroendocrine (Merkel cell) carcinoma. Int J Radiat Oncol Biol Phys 31 (1995) 315-323
81. Goepfert H., Remmler D., Silva E., et al. Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck. Arch Otolaryngol 110 11 (1984) 707-712
82. Ott M., Tanabe K., Gadd M., et al. Multimodality management of Merkel cell carcinoma. Arch Surg 134 4 (1999) 388-392
83. Shaw J.H., and Rumball E. Merkel cell tumour: clinical behaviour and treatment. Br J Surg 78 (1991) 138-142
84. McAfee W.J., Morris C.G., Mendenhall C.M., et al. Merkel cell carcinoma. Cancer 104 8 (2005) 1761-1764
85. Veness M., Morgan G., et al. Adjuvant locoregional radiotherapy as best practice in patients with Merkel cell carcinoma of the head and neck. Head Neck 27 3 (2005) 208-216
86. Boyer J., Zitelli J., Brodland D., et al. Local control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation. J Am Acad Dermatol 47 6 (2002) 885-892
87. Snow S.N., Larson P.O., Hardy S., et al. Merkel cell carcinoma of the skin and mucosa: report of 12 cutaneous cases with 2 cases arising from the nasal mucosa. Dermatol Surg 27 2 (2001) 165-170
88. Gollard R., Weber R., Kosty M., et al. Merkel cell carcinoma: review of 22 cases with surgical, pathologic, and therapeutic considerations. Cancer 88 8 (2000) 1842-1851
89. O'Connor W.J., Roenigk R.K., and Brodland D.G. Merkel cell carcinoma: comparison of Mohs micrographic surgery and wide excision in eighty-six patients. Dermatol Surg 23 10 (1997) 929-933
90. Smith D.E., Bielamowicz S., Kagan A.R., et al. Cutaneous neuroendocrine (Merkel cell) carcinoma: a report of 35 cases. Am J Clin Oncol 18 (1995) 199-203
91. Meeuwissen J.A., Bourne R.G., and Kearsley J.H. The importance of postoperative radiation therapy in the treatment of Merkel cell carcinoma. Int J Radiat Oncol Biol Phys 31 2 (1995) 325-331
92. Kokoska E.R., Kokoska M.S., Collins B.T., et al. Early aggressive treatment for Merkel cell carcinoma improves outcome. Am J Surg 174 6 (1997) 688-693
93. Cotlar A.M., Gates J.O., and Gibs Jr. F.A. Merkel cell carcinoma: combined surgery and radiation therapy. Am Surg 52 3 (1986) 159-164
94. Wong K.C., Zuletta F., Clarke S.J., et al. Clinical management and treatment outcomes of Merkel cell carcinoma. Aust N Z J Surg 68 5 (1998) 354-358
95. Morrison W.H., Peters L.J., Silva E.G., et al. The essential role of radiation therapy in securing locoregional control of Merkel cell carcinoma. Int J Radiat Oncol Biol Phys 19 (1990) 583-591
96. Wynne C.J., and Kearsley J.H. Merkel cell tumor: a chemosensitive skin cancer. Cancer 62 (1988) 28-31
97. Feun L.G., Savaraj N., Legha S.S., et al. Chemotherapy for metastatic Merkel cell carcinoma: review of the M.D. Anderson Hospital's experience. Cancer 62 (1988) 683-685
98. George T.K., di Sant'agnese P.A., and Bennett J.M. Chemotherapy for metastatic Merkel cell carcinoma. Cancer 56 (1985) 1034-1038
99. Fenig E., Brenner B., Katz A., et al. The role of radiation therapy and chemotherapy in the treatment of Merkel cell carcinoma. Cancer 80 5 (1997) 881-885
100. Pectasides D., Moutzourides G., Dimitriadis M., et al. Chemotherapy for Merkel cell carcinoma with carboplatin and etoposide. Am J Clin Oncol 18 5 (1995) 418-420
101. Crosh W.W., Giannone L., Hande K.R., et al. Disseminated Merkel cell tumor: treatment with systemic chemotherapy. Am J Clin Oncol 10 (1987) 227-230
102. Crown J., Lipzstein R., Cohen S., et al. Chemotherapy of metastatic Merkel cell cancer. Cancer Invest 9 2 (1991) 129-132
103. Bourne R.G., and O'Rourke M.G.E. Management of Merkel cell tumour. Aust NZ J Surg 58 (1988) 971-974
104. Poulsen M., Rischin D., Walpole E., et al. High-risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: a Trans-Tasman Radiation Oncology Group Study-TROG 96:07. J Clin Oncol 21 23 (2003) 4371-4376
105. Tai P.T., Yu E., Winquist E., et al. Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 cases. J Clin Oncol 18 12 (2000) 2493-2499
106. Durand J.M., Weiller C., Richard M.A., et al. Treatment of Merkel cell tumor with interferon-alpha-2b. Br J Dermatol 124 5 (1991) 509
107. Zilembo N., Buzzoni R., Bajetta E., et al. Salvage treatment after r-interferon alpha-2a in advanced neuroendocrine tumors. Acta Oncol 32 2 (1993) 245-250
108. Olieman A.F., Lienard D., Eggermont A.M., et al. Hyperthermic isolated limb perfusion with tumor necrosis factor alpha, interferon gamma, and melphalan for local advanced nonmelanoma skin tumors of the extremities: a multicenter study. Arch Surg 134 3 (1999) 303-307
109. Bajetta E., Zilembo N., Di Bartolomeo M., et al. Treatment of metastatic carcinoids and other neuroendocrine tumors with recombinant interferon-alpha-2a: a study by the Italian Trials in Medical Oncology Group. Cancer 72 10 (1993) 3099-3105
110. Ito Y., Kawamura K., Miura T., et al. Merkel cell carcinoma: a successful treatment with tumor necrosis factor. Arch Dermatol 125 8 (1989) 1093-1095
111. Hata Y., Matsuka K., Ito O., et al. Two cases of Merkel cell carcinoma cured by intratumor injection of natural human tumor necrosis factor. Plast Reconstr Surg 99 2 (1997) 547-553
112. Jansen B., Heere-Ress E., Schlagbauer-Wadl H., et al. Farnesylthiosalicyclic acid inhibits the growth of human Merkel cell carcinoma in SCID mice. J Mol Med 77 11 (1999) 792-797
113. Kennedy M.M., Blessing K., King G., et al. Expression of bcl-2 and p53 in Merkel cell carcinoma: an immunohistochemical study. Am J Dermatopathol 18 3 (1996) 273-277
114. Feinmesser M., Halpern M., Fenig E., et al. Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: can they predict treatment response and clinical outcome?. Hum Pathol 30 11 (1999) 1367-1372
115. Moll I., Gillardon F., Waltering S., et al. Differences of bcl-2 protein expression between Merkel cells and Merkel cell carcinomas. J Cutan Pathol 23 2 (1996) 109-117
116. Schlagbauer-Wadl H., Klosner G., Heere-Ress E., et al. Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice. J Invest Dermatol 114 4 (2000) 725-730
117. National Cancer Institute. Phase II study of imatinib mesylate in patients with metastatic or unresectable neuroendocrine carcinoma of the skin (Merkel cell carcinoma). 2005. Available at: http://www.cancer.gov/search/ViewClinicalTrials.aspx?cdrid=328120&;v ersion=patient&protocolsearchid=1858858. Accessed September 30, 2005.
118. Rowinsky E.K. A widening prospect: imatinib and novel applications of targeted therapy. Semin Oncol 31 2 Suppl 6 (2004) 1-3
119. O'Brien S.G., Guilhot F., Larson R.A., et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 348 11 (2003) 994-1004
120. Chalandon Y., and Schwaller J. Targeting mutated protein tyrosine kinases and their signaling pathways in hematologic malignancies. Haematologica 90 7 (2005) 949-968
121. Okuda K., Weisberg E., Gilliland D.G., et al. ARG tyrosine kinase activity is inhibited by ST1571. Blood 97 8 (2001) 2440-2448
122. Buchdunger E., Cioffi C.L., Law N., et al. Abl protein-tyrosine kinase inhibitor ST1571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 295 1 (2000) 139-145
123. Fletcher J. Role of KIT and platelet-derived growth factor receptors as oncoproteins. Semin Oncol 31 2 Suppl 6 (2004) 4-11
124. Feinmesser M., Halpem M., Kaganovsky E., et al. C-kit expression in primary and metastatic Merkel cell carcinoma. Am J Dermatopathol 26 6 (2004) 458-462