Merkel cell (neuroendocrine) carcinoma of the vulva. A case report with immunohistochemical and ultrastructural findings and review of the literature

Pathology Research and Practice

Volumn 196, Issue 7, 2000, Pages 503-509

  Hierro, Isabel ^a   Blanes, Alfredo ^a   Matilla, Alfredo ^a   Muñoz, Santiago ^a   Vicioso, Luis ^a   Nogales, Francisco F ^a  

^a UNIVERSIDAD DE MÁLAGA   (Spain)

Author keywords

Cytokeratin 20; Intermediate filaments; Merkel cell carcinoma; Neuroendocrine carcinoma of the vulva; Small cell tumor

Indexed keywords

CHROMOGRANIN A; CYTOKERATIN; EPITHELIAL MEMBRANE ANTIGEN; NEURON SPECIFIC ENOLASE;

AGED; ARTICLE; CASE REPORT; CELL ULTRASTRUCTURE; CLINICAL FEATURE; ELECTRON MICROSCOPY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MERKEL CELL TUMOR; MITOSIS INDEX; NEUROENDOCRINE TUMOR; NEUROFILAMENT; TUMOR RECURRENCE; VULVA CARCINOMA;

EID: 0033941973     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(00)80052-7     Document Type: Article

References (27)

1. Battifora H, Silva EG (1986) The use of antikeratin antibodies in the immunohistochemical distinction between neuroendocrine (Merkel cell) carcinoma of the skin, lymphoma, and oat cell carcinoma. Cancer 58: 1040-1046
2. Bottles K, Lacey CG, Goldberg J, Lanner-Cusin K, Horn, J, Miller TR (1984) Merkel cell carcinoma of the vulva. Obstet Gynecol 63: 61-65
3. Cliby W, Soisson AP, Berschuck A, Clarke-Pearson DL (1991) Stage I small cell carcinoma of the vulva treated with vulvectomy, lymphadenectomy, and adjuvant chemotherapy. Cancer 67: 2415-2417
4. Copeland LJ, Cleary K,. Sneige N, Edwards CL (1985) Neuroendocrine (Merkel Cell) carcinoma of the vulva: A case report and review of the literature. Gynecol Oncol 22: 367-378
5. Chandeying V, Sutthijumroon S, Tungphaisal S (1989) Merkel cell carcinoma of the vulva: A case report. Asia-Oceania J Obstet Gynecol 15: 261-269
6. Chen KTK (1994) Merkel's cell (neuroendocrine) carcinoma of the vulva. Cancer 73: 2186-2191
7. Feun LG, Savaraj N, Legha S, Silva EG, Benjamin RS, Burguess MA (1988) Chemotherapy for metastatic Merkel cell carcinoma. Review of the M.D. Anderson Experience. Cancer 62: 683-685
8. Gil-Moreno A. García-Jimenez A, González-Bosquet J, Esteller M, Castellvi-Vives J, Martinez Palones JM, Xercavins J (1997) Merkel cell carcinoma of the vulva. Gynecol Oncol 64: 526-532
9. Could VE, Moll R, Moll I, Lee I, Franke WW (1985) Biology of disease. Neuroendocrine (Merkel) cells of the skin: hyperplasias, dysplasias, and neoplasms. Lab Invest 52: 334-352
10. Haneke E (1985) Electron microscopy of Merkel cell carcinoma from formalin-fixed tissue. J Am Acad Dermatol 12: 487-492
11. Heenan PJ, Cole JM, Spagnolo DV (1990) Primary cutaneous neuroendocrine carcinoma (Merkel cell tumor). An adnexal epithelial neoplasm. Am J Dermatopathol 12: 7-16
12. Husseinzadeh N, Wesseler T, Newman N, et al (1988) Neuroendocrine (Merkel cell) carconoma of the vulva. Gynecol Oncol 29: 105-112
13. Loret de Mola JR, Hudcock PA, Steietz C, Jacobs G, Macfee M, Abdul-Karim FW (1993) Merkel cell carcinoma of the vulva. Gynecol Oncol 51. 272-276
14. Moll R, Lowe A, Laufer J, Franke WW (1992) Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol 140: 427-447
15. Raaf JH, Urmacher C, Knapper WK, Shu MH, Cheng WVK (1986) Trabecular (Merkel cell) carcinoma of the skin. Treatment of primary, recurrent and metastatic disease. Cancer 57: 178-182
16. Ratner D, Nelson BR, Brown MD, Johnson TM (1993) Merkel cell carcinoma. J Am Acad Dermatol 29: 143-156
17. Rosai J (1982) On the nature and nomenclature of a primary small cell carcinoma of the skin exhibiting endocrine (Merkel cell?) differentiation. Am J Dermatopathol 4: 501-505
18. Rubsamen PE, Tanenbaum M, Grove AS, Gould E (1990) Merkel cell carcinoma of the eyelid and periocular tissues. Am J Ophth 113: 674-680
19. Scurry J, Brand A. Planner R, Dowling J, Rode J (1996) Vulvar Merkel cell tumor with glandular and squamous differentiation. Gynecol Oncol 62: 292-297
20. Sibley RK, Dehner LR Rosai J (1985) Primary neuroendocrine (Merkel cell?) carcinoma of the skin: clinicopathologic and ultrastructural study of 43 cases. Am J Surg Pathol 9: 95-108
21. Stern JB (1982) "Murky cell" carcinoma (formerly trabecular carcinoma). Am J Dermatopathol 4: 517-519
22. Tang C, Toker C (1978) Trabecular carcinoma of the skin: an ultrastructural study. Cancer 42. 2311-2322
23. Tang C-K, Nedwich A, Toker C, Zaman ANF (1982) Unusual cutaneous carcinoma with features of small cell (oat cell-like) and squamous carcinomas. A variant of malignant Merkel cell neoplasm. Am J Dermatopathol 4: 537-548
24. Toker C (1972) Trabecular carcinoma of the skin. Arch Dermatol 105: 107-110
25. Vigneswaran N, Müller S, Lense E, et al (1992) Merkel cell carcinoma of the labial mucosa. An immunohistochemical and ultrastructural study with a review of the literature on oral Merkel cell carcinomas. Oral Surg Oral Med Oral Pathol 74: 193-200
26. Waibel M, Richter K, Von Lengerken W, Niedobitek F (1991) Merkel cell tumor (neuroendocrine carcinoma of the skin) in an unusual location. Immunohistochemical and lectin histochemical findings. Zentralbl Pathol 137(2): 140-150
27. Warner T, Uno H, Hafez R, et al (1983) Merkel cell and Merkel cell tumors: Ultrastructure, immunocytochemistry and review of the literature. Cancer 52: 238-245