메뉴 건너뛰기




Volumn 30, Issue 11, 1999, Pages 1367-1372

Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: Can they predict treatment response and clinical outcome?

Author keywords

Apoptosis; Merkel cell carcinoma; Proapoptotic and antiapoptotic genes; Treatment

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

EID: 0032745541     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(99)90070-9     Document Type: Article
Times cited : (72)

References (35)
  • 1
    • 0028839018 scopus 로고
    • Further insights into the natural history and management of primary cutaneous neuroendocrine (Merkel cell) carcinoma
    • Boyle F, Pendlebury S, Bell D: Further insights into the natural history and management of primary cutaneous neuroendocrine (Merkel cell) carcinoma. Int J Radiat Oncol Biol Phys 31:315-323, 1995
    • (1995) Int J Radiat Oncol Biol Phys , vol.31 , pp. 315-323
    • Boyle, F.1    Pendlebury, S.2    Bell, D.3
  • 4
    • 0023836680 scopus 로고
    • Neuroendocrine (Merkel cell) carcinoma of the skin
    • Hitchcock CL, Bland KI, Laney RG: Neuroendocrine (Merkel cell) carcinoma of the skin: Ann Surg 207:201-207, 1988
    • (1988) Ann Surg , vol.207 , pp. 201-207
    • Hitchcock, C.L.1    Bland, K.I.2    Laney, R.G.3
  • 5
    • 0021712369 scopus 로고
    • Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck
    • Goepfert H, Remmler De Silva E, et al: Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck. Arch Otolaryngol 110:707-712, 1984
    • (1984) Arch Otolaryngol , vol.110 , pp. 707-712
    • Goepfert, H.1    Remmler De Silva, E.2
  • 6
  • 7
    • 0028832033 scopus 로고
    • The importance of postoperative radiation therapy in the treatment of Merkel cell carcinoma
    • Meeuwissen JA, Bourne RG, Kearsley JH: The importance of postoperative radiation therapy in the treatment of Merkel cell carcinoma. Int J Radiation Oncol Biol Phys 31:325-331, 1995
    • (1995) Int J Radiation Oncol Biol Phys , vol.31 , pp. 325-331
    • Meeuwissen, J.A.1    Bourne, R.G.2    Kearsley, J.H.3
  • 8
    • 0027404381 scopus 로고
    • The use of cycloheximide, methotrexate, and 5-fluorouracil in the treatment of Merkel cell carcinoma
    • Fenig E, Lurie H, Sulkes A: The use of cycloheximide, methotrexate, and 5-fluorouracil in the treatment of Merkel cell carcinoma. Am J Clin Oncol 16:54-57, 1993
    • (1993) Am J Clin Oncol , vol.16 , pp. 54-57
    • Fenig, E.1    Lurie, H.2    Sulkes, A.3
  • 9
    • 0028329172 scopus 로고
    • Apoptosis: Its significance in cancer and cancer therapy
    • Kerr JFR, Winterford CM, Harmon BV: Apoptosis: Its significance in cancer and cancer therapy. Cancer 73:2013-2026, 1994
    • (1994) Cancer , vol.73 , pp. 2013-2026
    • Kerr, J.F.R.1    Winterford, C.M.2    Harmon, B.V.3
  • 11
    • 0031033362 scopus 로고    scopus 로고
    • Enhanced induction of apoptosis of human gastric carcinoma cells after preoperative treatment with 5-fluorouracil
    • Sugamura K, Makino M, Shirai H, et al: Enhanced induction of apoptosis of human gastric carcinoma cells after preoperative treatment with 5-fluorouracil. Cancer 79:12-17, 1997
    • (1997) Cancer , vol.79 , pp. 12-17
    • Sugamura, K.1    Makino, M.2    Shirai, H.3
  • 12
    • 0030952902 scopus 로고    scopus 로고
    • Expression and regulation of Bcl-2, Bcl-xl and bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia
    • Findley HW, Lubing G, Yeager AM, et al: Expression and regulation of Bcl-2, Bcl-xl and bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia. Blood 89:2986-2993, 1997
    • (1997) Blood , vol.89 , pp. 2986-2993
    • Findley, H.W.1    Lubing, G.2    Yeager, A.M.3
  • 13
    • 0029045784 scopus 로고
    • Reduced expression of proapoptotic gene bax is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
    • Krajewski S, Blomqvist C, Franssila K, et al: Reduced expression of proapoptotic gene bax is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res 55:4471-4478, 1995
    • (1995) Cancer Res , vol.55 , pp. 4471-4478
    • Krajewski, S.1    Blomqvist, C.2    Franssila, K.3
  • 14
    • 8944244998 scopus 로고    scopus 로고
    • Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis
    • Sakakura C, Sweeney EA, Shirahama T, et al: Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis. Int J Cancer 67:101-105, 1996
    • (1996) Int J Cancer , vol.67 , pp. 101-105
    • Sakakura, C.1    Sweeney, E.A.2    Shirahama, T.3
  • 15
    • 0027389763 scopus 로고
    • Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
    • Miyashita T, Reed JC: Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 81:151-157, 1993
    • (1993) Blood , vol.81 , pp. 151-157
    • Miyashita, T.1    Reed, J.C.2
  • 16
    • 0026781986 scopus 로고
    • bcl-2 gene transfer increases relative resistance of S49.1 and WEH 17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs
    • Miyashita T, Reed JC: bcl-2 gene transfer increases relative resistance of S49.1 and WEH 17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res 52:5407-5411, 1992
    • (1992) Cancer Res , vol.52 , pp. 5407-5411
    • Miyashita, T.1    Reed, J.C.2
  • 17
    • 0027451668 scopus 로고
    • p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T, et al: p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967, 1993
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3
  • 18
    • 0028944271 scopus 로고
    • Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-α expression in tumor cells correlates with resistance towards apoptosis
    • Bargou RC, Daniel PT, Mapara MY, et al: Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-α expression in tumor cells correlates with resistance towards apoptosis. Int J Cancer 60:854-859, 1995
    • (1995) Int J Cancer , vol.60 , pp. 854-859
    • Bargou, R.C.1    Daniel, P.T.2    Mapara, M.Y.3
  • 19
    • 0030799585 scopus 로고    scopus 로고
    • The role of radiation therapy and chemotherapy in the treatment of Merkel cell carcinoma
    • Fenig E, Brenner B, Katz A, et al: The role of radiation therapy and chemotherapy in the treatment of Merkel cell carcinoma. Cancer 80:881-885, 1997
    • (1997) Cancer , vol.80 , pp. 881-885
    • Fenig, E.1    Brenner, B.2    Katz, A.3
  • 20
    • 0021880983 scopus 로고
    • Biology of disease: Neuroendocrine (Merkel) cells of the skin: Hyperplasias, dysplasias and neoplasms
    • Gould VE, Moll R, Moll I, et al: Biology of disease: Neuroendocrine (Merkel) cells of the skin: Hyperplasias, dysplasias and neoplasms. Lab Invest 52:334-353, 1985
    • (1985) Lab Invest , vol.52 , pp. 334-353
    • Gould, V.E.1    Moll, R.2    Moll, I.3
  • 21
    • 0029919668 scopus 로고    scopus 로고
    • Immunohistochemical analysis of bcl-2, bax, bcl-x and mcl-1 expression in prostate cancers
    • Krajewska M, Krajewski S, Epstein IE, et al: Immunohistochemical analysis of bcl-2, bax, bcl-x and mcl-1 expression in prostate cancers. Am J Pathol 148:1567-1576, 1996
    • (1996) Am J Pathol , vol.148 , pp. 1567-1576
    • Krajewska, M.1    Krajewski, S.2    Epstein, I.E.3
  • 22
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of programmed cell death
    • Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6, 1994
    • (1994) J Cell Biol , vol.124 , pp. 1-6
    • Reed, J.C.1
  • 23
    • 0022546957 scopus 로고
    • Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma
    • Tsujimoto Y, Croce CM: Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci U S A 83:5214-5218, 1986
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 5214-5218
    • Tsujimoto, Y.1    Croce, C.M.2
  • 24
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai ZN, Milliman C, Korsmeyer S: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619, 1993
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.2    Korsmeyer, S.3
  • 25
    • 0026493580 scopus 로고
    • Bcl-2: An antidote to programmed cell death
    • Korsmeyer SJ: Bcl-2: An antidote to programmed cell death. Cancer Surveys 15:105-118, 1992
    • (1992) Cancer Surveys , vol.15 , pp. 105-118
    • Korsmeyer, S.J.1
  • 26
    • 0028206341 scopus 로고
    • BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with bax
    • Yin XM, Oltvai ZN, Korsmeyer SJ: BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with bax. Nature 369:321-323, 1994
    • (1994) Nature , vol.369 , pp. 321-323
    • Yin, X.M.1    Oltvai, Z.N.2    Korsmeyer, S.J.3
  • 27
    • 0029845760 scopus 로고    scopus 로고
    • Structure and function of the p53 tumor suppressor gene: Clues for rationale cancer therapeutic strategies
    • Harris CC: Structure and function of the p53 tumor suppressor gene: Clues for rationale cancer therapeutic strategies. J Natl Cancer Inst 88:1442-1455, 1996
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1442-1455
    • Harris, C.C.1
  • 28
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human Bax gene
    • Miyashita T, Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human Bax gene. Cell 80:293-299, 1995
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 29
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
    • Miyashita T, Krajewski S, Krajewska M, et al: Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9:1799-1805, 1995
    • (1995) Oncogene , vol.9 , pp. 1799-1805
    • Miyashita, T.1    Krajewski, S.2    Krajewska, M.3
  • 30
    • 0030934769 scopus 로고    scopus 로고
    • p53 abnormalities are rare events in neuroendocrine (Merkel cell) carcinoma of the skin
    • Schmid M, Janben K, Dockhorn-Dworniczak B, et al: p53 abnormalities are rare events in neuroendocrine (Merkel cell) carcinoma of the skin. Virchows Arch 430:233-237, 1997
    • (1997) Virchows Arch , vol.430 , pp. 233-237
    • Schmid, M.1    Janben, K.2    Dockhorn-Dworniczak, B.3
  • 31
    • 0025271203 scopus 로고
    • Association of human papillomavirus types 16 and 18 E6 proteins
    • Werness BA, Levine AJ, Howley PM: Association of human papillomavirus types 16 and 18 E6 proteins. Science 248:76-79, 1990
    • (1990) Science , vol.248 , pp. 76-79
    • Werness, B.A.1    Levine, A.J.2    Howley, P.M.3
  • 32
    • 0027287748 scopus 로고
    • Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation
    • Campbell C, Quinn AG, Angus B, et al: Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation. Cancer Res 53:2697-2699, 1993
    • (1993) Cancer Res , vol.53 , pp. 2697-2699
    • Campbell, C.1    Quinn, A.G.2    Angus, B.3
  • 33
    • 0030005636 scopus 로고    scopus 로고
    • Differences of bcl-2 protein expression between Merkel cells and Merkel cell carcinomas
    • Moll I, Gillardon F, Waltering S, et al: Differences of bcl-2 protein expression between Merkel cells and Merkel cell carcinomas. J Cutan Pathol 23:109-117, 1996
    • (1996) J Cutan Pathol , vol.23 , pp. 109-117
    • Moll, I.1    Gillardon, F.2    Waltering, S.3
  • 34
    • 0028958030 scopus 로고
    • Bcl-2: Prevention of apoptosis as a mechanism of drug resistance
    • Reed JC: Bcl-2: Prevention of apoptosis as a mechanism of drug resistance. Hematol Oncol Clin North Am 9:451-474, 1995
    • (1995) Hematol Oncol Clin North Am , vol.9 , pp. 451-474
    • Reed, J.C.1
  • 35
    • 0029902064 scopus 로고    scopus 로고
    • Expression of bcl-2 and p53 in Merkel cell carcinoma
    • Kennedy MM, Blessing K, King G, et al: Expression of bcl-2 and p53 in Merkel cell carcinoma. Am J Dermatol Pathol 18:273-277, 1996
    • (1996) Am J Dermatol Pathol , vol.18 , pp. 273-277
    • Kennedy, M.M.1    Blessing, K.2    King, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.