Differences of bcl-2 protein expression between Merkel cells and Merkel cell carcinomas

Journal of Cutaneous Pathology

Volumn 23, Issue 2, 1996, Pages 109-117

  Moll, Ingrid ^a,c   Gillardon, Frank ^a   Waltering, Stefan ^a   Schmelz, Monika ^b   Moll, Roland ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN;

ARTICLE; CELL LINE; CONFOCAL LASER MICROSCOPY; DOWN REGULATION; EPIDERMIS; HAIR FOLLICLE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MELANOCYTE; MERKEL CELL; MERKEL CELL TUMOR; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN CARCINOMA; STAINING;

ADULT; CARCINOMA, MERKEL CELL; EMBRYONIC AND FETAL DEVELOPMENT; HUMANS; IMMUNOHISTOCHEMISTRY; MERKEL CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; SKIN NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0030005636     PISSN: 03036987     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0560.1996.tb01283.x     Document Type: Article

References (41)

1. Tsujinioto X Cossman J, Jaffe E, Corce C. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985: 228: 1440.
2. Krajewski, S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC. Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 1993: 53: 4701.
3. Korsmeyer SJ, McDonnell TJ, Nunez G, Hockenbery D, Young R. Bcl-2: B cell life, death and neoplasia. Curr Top Microbiol Immunol 1990: 166: 203.
4. Nunez G, London L, Hockenbery D, Alexander M, McKearn JP, Korsmeyer SJ. Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol 1990: 144: 3602.
5. Evan G, Wyllie AH, Gilbert CS, et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992: 69: 119.
6. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ. Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 1991: 88: 6961.
7. LeBrun DP, Warnke RA, Cleary ML. Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol 1993: 142: 743.
8. Triscott JA, Ritter JH, Swanson RP, Wick MR. Immunoreactivity for bcl-protein in cutaneous lymphomas and lymphoid hyperplasias. J Cutan Pathol 1995: 22: 2.
9. Lu Q-L, Poulsom R, Wong L, Hanby AM. Bcl-2 expression in adult and embryonic non-haematopoietic tissues. J Pathol 1993: 169: 431.
10. Klein-Parker HA, Warshawski L, Tron VA. Melanocytes in human skin express bcl-2 protein. J Cutan Pathol 1994: 21: 297.
11. van den Oord JJ, Vandeghinste N, De Ley M, De Wolf-Peeters C. Bcl-2 expression in human melanocytes and melanocytic tumors. Am J Pathol 1994: 145: 294.
12. Saenz-Santamaría MC, Reed JA, McNutt NS, Shea CR. Immunohistochemical expression of BCL-2 in melanomas and intradermal nevi. J Cutan Pathol 1994: 21: 393.
13. Sleater JP, Beers BB, Stephens CA, Hendricks JB. Keratoacanthoma: A deficient squamous cell carcinoma? Study of bcl-2 expression. J Cutan Pathol 1994: 21: 514.
14. Cerroni L, Kerl H. Aberrant bcl-2 protein expression provides a possible mechanism of neoplastic cell growth in cutaneous basal-cell carcinoma. J Cutan Pathol 1994: 21: 398.
15. Verhaegh MEJM, Sanders CJG, Arends JW, Neumann HAM. Expression of the apoptosis-suppressing protein bcl-2 in non-melanoma skin cancer. Br J Dermatol 1995: 132: 740.
16. Moll R, Moll I, Franke WW. Identification of Merkel cells in human skin by specific cytokeratin antibodies: changes of cell density and distribution in fetal and adult plantar epidermis. Differentiation 1984: 28: 136.
17. Moll I, Moll R, Franke WW. Formation of epidermal and dermal Merkel cells during human fetal skin development. J Invest Dermatol 1986: 87: 779.
18. Hartschuh W, Weihe E, Reinecke M. The Merkel cell. In: Bereiter-Hahn J, Maltoltsy AG, Richards KS (Hrsg.): Biology of the integument, vertebrates (Vol. 2). Berlin: Springer-Verlag, 1986: 605.
19. Merot Y, Chavaz P, Carraux P, Polla L, Saurat J-H. Merkel cells do divide in the epidermis. J Invest Dermatol 1986: 87: 155A.
20. Moll I, Bladt U, Jung EG. Distribution of Merkel cells in acute UVB erythema. Arch Dermatol Res 1992: 284: 271.
21. Moll I, Bladt U, Jung EG. Presence of Merkel cells in sun-exposed and not sun-exposed skin: a quantitative study. Arch Dermatol Res 1990: 282: 213.
22. Ratner D, Nelson BR, Brown MD, Johnson TM. Merkel cell carcinoma. J Am Acad Dermatol 1993: 29: 143.
23. Moll I, Bohnert E, Herbst C, Förster W, Moll R, Franke WW. Establishment and characterization of two Merkel cell tumor cultures. J Invest Dermatol 1994: 102: 346.
24. Franke WW, Schmid E, Osborn M, Weber K. Different intermediate-sized filaments distinguished by immunofluorescence microscopy. Proc Natl Acad Sci USA 1978: 75: 5034.
25. Franke WW, Moll R. Cytoskeletal components of lymphoid organs. I. Synthesis of cytokeratins 8 and 18 and desmin in subpopulations of extrafollicular reticulum cells of human lymph nodes, tonsils, and spleen. Differentiation 1987: 36: 145.
26. Shi S-R, Key ME, Kalra KL. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 1991: 39: 741.
27. Moll I, Kuhn C, Moll R. Cytokeratin 20 is a general marker of cutaneous Merkel cells while cerain neuronal proteins are absent. J Invest Dermatol 1995: 104: 910.
28. Moll R, Zimbelmann R, Goldschmidt MD, et al. The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. Differentiation 1993: 53: 75.
29. Gillardon F, Eschenfelder C, Uhlmann E, Hartschuh W, Zimmermann M. Differential regulation of c-fos, fosB, c-jun, junB, bcl-2 and bax expression in rat skin following single or chronic ultraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion. Oncogene 1994: 9: 112.
30. Reed JC, Meister L, Tanaka S, et al. Differential expression of bcl2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin. Cancer Res 1991: 51: 6529.
31. Moll R, Osborn M, Hartschuh W, Moll I, Mahrle G, Weber K. Variability of expression and arrangement of cytokeratin and neurofilaments in cutaneous neuroendocrine carcinomas (Merkel cell tumors): Immunocytochemical and biochemical analysis of twelve cases. Ultrastruct Path 1986: 10: 473.
32. Baudoin C, Meneguzzi G, Portier MM, et al. Peripherin, a neuronal intermediate protein, is stably expressed by neuroendocrine carcinomas of the skin, their xenograft on nude mice, and the corresponding primary cultures. Cancer Res 1993: 53: 1175.
33. Pezzella F, Turley H. Kuzu I. Bcl-2 protein in non-small-cell lung carcinoma. N Engl J Med 1993: 329: 690.
34. Rosen ST, Gould VE, Salwan HR, et al. Establishment and characterization of neuroendocrine skin carcinoma cell line. Lab Invest 1987: 56: 302.
35. Yin X-M, Oltvai ZN, Veis-Novack DJ, Linette GP, Korsmeyer SJ. Bcl-2 gene family and the regulation of programmed cell death. Cold Spring Harbour Symp 1994: LIX: 387.
36. Pezzela F, Tse AG, Cordell JL, Pulford KAF, Guter KC, Mason RY. Expression of the bcl-2 oncogene protein is not specific for the 14; 18 chromosome translocation. Am J Pathol 1990: 137: 225.
37. Boise LH, González-García M, Postema CE, et al. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993: 74: 597.
38. L and Bcl-2, displaces bax and promotes cell death. Cell 1995: 80: 285.
39. Tachibana T, Nawa T. Merkel cell differentiation in the labial mucous epithelium of the rabbit. J Anat 1980: 131: 145.
40. Moll I, Moll R. Early development of human Merkel cells. Exp Dermatol 1992: 1: 180.
41. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ. Bcl-2 deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993: 75: 229.