Inhibition of protein phosphatase 2A by cantharidin analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 9, 1996, Pages 1025-1028

  McCluskey, Adam ^a   Taylor, Cherie ^a   Quinn, Ronald J ^a   Suganuma, Masami ^b   Fujiki, Hirota ^b  

^a GRIFFITH UNIVERSITY   (Australia)

^b SAITAMA CANCER CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CANTHARIDIN; CANTHARIDIN DERIVATIVE; ENZYME INHIBITOR; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 0029955279     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00166-7     Document Type: Article

References (24)

1. Wang, G.-S; J. Ethnoparmacol., 1989, 26, 147.
2. a. Cavill, G.W.K.; Clark, D.V.; Naturally Occuring Insecticides (M.Jacobson and D.G. Crosby, Eds), Marcel Dekker, New York, 1971, 271.
3. b. Oaks, W.W.; DiTunno, J.F.; Magnani, T.; Levey, H.A.; Mills, L.C.; A.M.A. Arch. Int. Med. 1960, 105, 106.
4. Goldfarb, M.T.; Gupta, A.K.; Sawchuk, W.S.; Dermatologic Clinics, 1991, 9, 287.
5. a. Matsuzawa, M.; Graziano, M.J.; Casida, J.E.; J. Agric. Food Chem. 1987, 35, 823-829.
6. b. Bagatell, F.K.; Dugan, K.; Wilgram, G.F.; Toxicol. Appl. Pharmacol. 1969, 15, 249.
7. Nickolls, L.C.; Tear, D.; Br. Med. J., 1954, 2, 1384.
8. Schmitz, D.G.; J. Vet. Intern. Med. 1989, 3, 208.
9. Polettini, A.; Crippa, U.; Ravagii, A.; Saragoni, A.; Forensic. Sci. Int. 1992, 56(1), 37.
10. Li, Y-M.; Casida, J.E.; Proc. Natl. Acad. Sci. USA, 1992, 89, 11867.
11. Honkanen, R.E.; FEBS, 1993, 330(3), 283.
12. Fujiki, H.; Suganuma, M.; Adv. Cancer Res. 1993, 61, 143.
13. Tachibana, K.; Scheuer, P.J.; Tsukitani, Y.; Kikuchi, H.; Van Engen, D.; Clardy, J.; Gopichand, Y.; Schmitz, F.J.; J. Am. Chem. Soc. 1981, 103, 2469.
14. Kato, Y.; Fusetani, N.; Matsunaga, S.; Hashimoto, K.; Fujita, S.; Furuya, T.J.; J. Am. Chem. Soc. 1986, 108, 2780.
15. a. Botes, D.P.; Tuinman, A.A.; Wessels, P.L.; Viljoen, C.C.; Kruger, H.; Williams, D.H.; Santikarn, S.; Smith, K.J.; Hammond, S.J.; J. Chem. Soc. Perkin Trans 1 1984, 2311.
16. b. Harada, K-I.; Matsuura, K.; Suzuki, M.; Oka, H.; Watanabe, M.F.; Oishi, S.; Dahlem, A.M.; Beasley, V.R.; Carmichael, W.W.; J. Chromatog., 1988, 448, 275.
17. Rinehart, K. L.; Harada, K.-I.; Namikoshi, M.; Chen, C.; Harvis, C. A.; J. Am. Chem. Soc. 1988, 110, 8557.
18. Cheng, X.-C.; Kihara, T.; Kusakabe, H.; Magae, J.; Kobayashi, Y.; Fang, R.-P.; Ni, Z.-F.; Shen, Y.-C.; Ko, K.; Yamaguchi, I.; Isono, K.; J. Antibiot. 1987, 40, 907.
19. a. Ver Nooy, C. D.; Rondestvendt Jr, C. S.; J. Am. Chem. Soc. 1955, 77, 3583.
20. b. Adams, L. D.; Vaughan, W. R.; J. Org. Chem. 1972, 37, 3906.
21. Sample Jr, T. E.; Hatch, L. F.; J. Chem. Ed., 1968, 45, 55.
22. Woodward, R. B.; Baer, H.; J. Am. Chem. Soc. 1948, 70, 1161.
23. e. Canonne, P.; Belanger, D; Lemay, G.; J. Org. Chem. 1982, 47, 3953.
24. 32P]phosphorylase a (5 μg), protein phosphatase 2A (11.8 μg) and various concentrations of cantharidin or cantharidin derivatives for 10 min at 30°C in 100 μL volume in duplicate. The reaction was terminated by addition of 100 μL of ice cold 50% trichloroacetic acid. After centrifugation an aliquot (150 μL) of supernatant was counted in Amersham Aquasol scintillant. Data expressed as percent inhibition with respect to a control (absence of competing compound) incubation.