AT1 receptor antisense therapy transiently lowers blood pressure in Ren-2 transgenic rats

Vascular Pharmacology

Volumn 47, Issue 1, 2007, Pages 63-67

  Vaněčková, Ivana ^a,b   Kopkan, Libor ^a,b   Husková, Zuzana ^a,b   Vaňourková, Zdenka ^a,b   Schejbalová, Stanislava ^a,b   Červenka, Luděk ^a,b,c   Kramer, Herbert J ^d  

^a INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^b Ctr for Exp Cardiovasc Research   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

^d UNIVERSITY OF BONN   (Germany)

Author keywords

Antisense therapy; AT1 receptor; Blood pressure; Phosphorothioated oligodeoxynucleotides

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PLACEBO; RENIN; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTISENSE OLIGODEOXYNUCLEOTIDE; NUCLEOSIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ANTISENSE THERAPY; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; BOLUS INJECTION; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; GENE TARGETING; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAT; SINGLE DRUG DOSE; SYSTOLIC BLOOD PRESSURE; TRANSGENIC RAT; ANIMAL; DISEASE MODEL; DRUG EFFECT; GENETICS; HEART LEFT VENTRICLE HYPERTROPHY; SPRAGUE DAWLEY RAT; SYSTOLE; TRANSGENIC ANIMAL;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; MALE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PROTEINURIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN; SYSTOLE; THIONUCLEOSIDES;

EID: 34249324447     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2007.04.005     Document Type: Article

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