The role of intrarenal angiotensin II in the development of hypertension in Ren-2 transgenic rats

Journal of Hypertension

Volumn 23, Issue 8, 2005, Pages 1531-1539

  Kopkan, Libor ^a   Kramer, Herbert J ^b   Husková, Zuzana ^a   Vaňourková, Zdeňka ^a   Škaroupková, Petra ^a   Thurmová, Monika ^a   Červenka, Luděk ^a  

^a INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Arginine vasopressin; Bradykinin; Hypertension; Norepinephrine; Plasma and kidney angiotensin II levels; Renal angiotensin receptor subtype 1; Renal haemodynamics; Sodium excretion; Transgenic rats

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN RECEPTOR; CANDESARTAN;

ANGIOTENSIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; HYPERTENSION; IMMUNOBLOTTING; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; KIDNEY TUBULE EXCRETION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; SODIUM URINE LEVEL; TRANSGENIC MOUSE;

EID: 23344452101     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.hjh.0000174972.46663.5e     Document Type: Article

References (29)

1. Mullins JJ, Peters J, Ganten D. Fulminant hypertension in transgenic rats harboring the mouse Ren-2 gene. Nature 1990; 344:541-544.
2. Kopkan L, Kramer HJ, Husková Z, Vaňourková Z, Bäcker A, Bader M, et al. Plasma and kidney angiotensin II levels and renal functional responses to AT, receptor blockade in hypertensive Ren-2 transgenic rats. J Hypertens 2004; 22:819-825.
3. Mitchell KD, Jacinto SM, Mullins JJ. Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats. Am J Physiol 1997; 273:F246-F253.
4. Peters J, Hilgers KF, Maser-Gluth C, Kreutz R. Role of the circulating renin-angiotensin system in the pathogenesis of hypertension in transgenic rats TGR(mRen2)27. Clin Exp Hypertens 1996; 18:933-948.
5. Jacinto SM, Mullins JJ, Mitchell KD. Enhanced renal vascular responsiveness to angiotensin II in hypertensive ren-2 transgenic rats. Am J Physiol 1999; 276:F315-F322.
6. Böhm M, Lee MA, Kreutz R, Kim S, Schinke M, Djavidani B, et al. Angiotensin II receptor blockade in TGR(mRen2)27: effects of renin-angiotensin-system gene expression and cardiovascular functions. J Hypertens 1995; 13:891-899.
7. Gross V, Lippoldt A, Schneider W, Luft FC. Effect of captopril and angiotensin II receptor blockade on pressure natriuresis in transgenic TGR(mRen2)27 rats. Hypertension 1995; 26:471-479.
8. Mitchell KD, Mullins JJ. ANG II dependence of tubuloglomerular feedback responsiveness in hypertensive ren-2 transgenic rats. Am J Physiol 1995; 268:F821-F828.
9. Vyas SJ, Jackson EK. Angiotensin II: enhanced renal responsiveness in young genetically hypertensive rats. J Pharmacol Exp Ther 1995; 273:768-777.
10. Chatziantoniou C, Daniels FH, Arendshorst WJ. Exaggerated renal vascular reactivity to angiotensin and thromboxane in young genetically hypertensive rats. Am J Physiol 1990; 259:F372-F382.
11. Imig JD. Afferent arteriolar reactivity to angiotensin II is enhanced during the early phase of angiotensin II hypertension. Am J Hypertens 2000; 13:810-818.
12. Navar LG. The intrarenal renin-angiotensin system in hypertension. Kidney Int 2004; 65:1522-1532.
13. Vatner SF. Effects of anesthesia on cardiovascular control mechanisms. Environ Health Perspect 1978; 26:193-206.
14. 1 receptor blockade in nonclipped kidneys of Goldblatt hypertensive rats. Hypertension 1999; 33:102-107.
15. Fox J, Guan S, Hymel AA, Navar LG. Dietary Na and ACE inhibition effects on renal tissue angiotensin I and II and ACE activity in rats. Am J Physiol 1992; 262:F902-F909.
16. Wang CT, Navar LG, Mitchell KD. Proximal tubular fluid angiotensin II levels in angiotensin II-induced hypertensive rats. J Hypertens 2003; 21:353-360.
17. 7 Ruan X, Purdy KE, Oliverio MI, Coffman TM, Arendshorst WJ. Effects of candesartan on angiotensin II-induced renal vasoconstriction in rats and mice. J Am Soc Nephrol 1999; 10(Suppl. 11):S202-S207.
18. Morsing P. Candesartan: a new-generation angiotensin II AT1 receptor blocker: pharmacology, antihypertensive efficacy, renal function, and renoprotection. J Am Soc Nephrol 1999; 10(Suppl. 11):S248-S254.
19. Harrison-Bernard LM, Zhuo J, Kobori H, Ohishi M, Navar LG. Intrarenal AT, receptor and ACE binding in ANG II-induced hypertensive rats. Am J Physiol 2002; 281:F19-F25.
20. Kurtz TW, Griffin KA, Bidani AK, Davisson RL, Hall JE. Recommendations for blood pressure measurements in humans and experimental animals. Part 2: Blood pressure measurements in experimental animals. Hypertension 2005; e-pub ahead of print.
21. Heller J, Hellerova S. Long-term effect on blood pressure of early brief treatment by different antihypertensive agents: a study in the Prague hypertensive rat. Kidney Blood Press Res 1998; 21:445-451.
22. Dvořák P, Kramer HJ, Bäcker A, Malý J, Kopkan L, Vaněčková I, et al. Blockade of endothelin receptors attenuates end-organ damage in homozygous hypertensive Ren-2 transgenic rats. Kidney Blood Press Res 2004; 27:248-258.
23. Arribas S, Sanchez-Ferrer CF, Peiro C, Ponte A, Salaices M, Marin J. Functional vascular renin-angiotensin system in hypertensive transgenic rats for the mouse renin gene Ren-2. Gen Pharmacol 1994; 25:1163-1170.
24. DiBona GF, Kopp UC. Neural control of renal function. Physiol Rev 1997; 77:75-197.
25. Cervenka L, Kramer HJ, Malý J, Vaněčková I, Bäcker A, Bokemeyer D, et al. Role of nNOS in regulation of renal function in hypertensive Ren-2 transgenic rats. Physiol Res 2002; 52:571-580.
26. Zou LX, Imig JD, Von Thun AM, Hymel A, Ono H, Navar LG. Receptor-mediated intrarenal angiotensin II-infused hypertensive rats. Hypertension 1996; 28:669-677.
27. 1A receptors. Am J Physiol 1999; 277:F303-F311.
28. Navar LG, Nishiyama A. Why are angiotensin concentrations so high in the kidney? Curr Opin Nephrol Hypertens 2004; 13:107-115.
29. Lee MA, Böhm M, Kim S, Bachmann S, Bachmann J, Bader M, et al. Differential gene expression of renin and angiotensinogen in the TGR(mRen-2)27 transgenic rat. Hypertension 1995; 25:570-580.