Silencing the PTEN gene is protective against neuronal death induced by human immunodefienciency virus type 1 Tat

Journal of NeuroVirology

Volumn 13, Issue 2, 2007, Pages 97-106

  Zhao, Tianyong ^a   Adams, Mary H ^a   Zou, Shi Ping ^a   El Hage, Nazira ^a   Hauser, Kurt F ^a   Knapp, Pamela E ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Akt; Apoptosis; Cell death; Endonuclease G; Glial cells; HIVE; NeuroAIDS; Neuroprotection; Phosphoinositide 3 kinase; SiRNA

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAD; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFICACY; DRUG TARGETING; EMBRYO; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; GENE SILENCING; GENETIC TRANSFECTION; HUMAN IMMUNODEFICIENCY VIRUS 1; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS ENCEPHALITIS;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CORPUS STRIATUM; FEMALE; GENE PRODUCTS, TAT; GENE SILENCING; HIV INFECTIONS; HIV-1; HUMANS; MICE; NEURONS; PTEN PHOSPHOHYDROLASE; TRANSFECTION; VIRULENCE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 34249104307     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280701236841     Document Type: Article

References (57)

1. Acquas, E., Bachis, A., Nosheny, R. L., Cernak, I. and Mocchetti, I. (2004) Human immunodeficiency virus type 1 protein gp120 causes neuronal cell death in the rat brain by activating caspases. Neurotox Res, 5, pp. 605-615.
2. Aksenov, M. Y., Hasselrot, U., Nath, A., Anderson, C., Mactutus, C. F. and Booze, R. M. (2003) Temporal relationships between HIV-1 Tat-induced neuronal degeneration, OX-42 immunoreactivity, reactive astrocytosis, and protein oxidation in the rat striatum. Brain Res, 987, pp. 1-9.
3. Altomare, D. A. and Testa, J. R. (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene, 24, pp. 7455-7464.
4. Bonavia, R., Bajetto, A., Barbero, S., Albini, A., Noonan, D. M. and Schettini, G. (2001) HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons. Biochem Biophys Res Commun, 288, pp. 301-308.
5. Bonneau, D. and Longy, M. (2000) Mutations of the human PTEN gene. Human Mutat, 16, pp. 109-122.
6. Bruce-Keller, A. J., Chauhan, A., Dimayuga, F. O., Gee, J., Keller, J. N. and Nath, A. (2003) Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain. J Neurosci, 23, pp. 8417-8422.
7. Cantley, L. C. and Neel, B. G. (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA, 96, pp. 4240-4245.
8. Costantini, C., Scrable, H. and Puglielli, L. (2006) An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generation. EMBO J, 25, pp. 1997-2006.
9. Cully, M., You, H., Levine, A. J. and Mak, T. W. (2006) Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer, 6, pp. 184-192.
10. Dou, H., Ellison, B., Bradley, J., Kasiyanov, A., Poluektova, L. Y., Xiong, H., Maggirwar, S., Dewhurst, S., Gelbard, H. A. and Gendelman, H. E. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. J Neurosci, 25, pp. 8375-8385.
11. Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R. and Greenberg, M. E. (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science, 275, pp. 661-665.
12. Eng, C. (2003) PTEN: One gene, many syndromes. Human Mutat, 22, pp. 183-198.
13. Falk, T., Zhang, S., Erbe, E. L. and Sherman, S. J. (2006) Neurochemical and electrophysiological characteristics of rat striatal neurons in primary culture. J Comp Neurol, 494, pp. 275-289.
14. Fischer-Smith, T. and Rappaport, J. (2005) Evolving paradigms in the pathogenesis of HIV-1-associated dementia. Expert Rev Mol Med, 7, pp. 1-26.
15. Freeman, D. J., Li, A. G., Wei, G., Li, H. H., Kertesz, N., Lesche, R., Whale, A. D., Martinez-Diaz, H., Rozengurt, N., Cardiff, R. D. and Liu, X. (2003) PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell, 3, pp. 117-130.
16. Garden, G. A., Budd, S. L., Tsai, E., Hanson, L., Kaul, M., D'Emilia, D. M., Friedlander, R. M., Yuan, J., Masliah, E. and Lipton, S. A. (2002) Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J Neurosci, 22, pp. 4015-4024.
17. Gelbard, H. A., James, H. J., Sharer, L. R., Perry, S. W., Saito, Y., Kazee, A. M., Blumberg, B. M. and Epstein, L. G. (1995) Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol Appl Neurobiol, 21, pp. 208-217.
18. Ghafouri, M., Amini, S., Khalili, K. and Sawaya, B. E. (2006) HIV-1 associated dementia: Symptoms and causes. Retrovirology, 3, p. 28.
19. Goody, R. J., Martin, K. M., Goebel, S. M. and Hauser, K. F. (2003) Dynorphin A toxicity in striatal neurons via an a-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor mechanism. Neuroscience, 116, pp. 807-816.
20. Haberstock-Debic, H., Kim, K. A., Yu, Y. J. and von Zastrow, M. (2005) Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons. J Neurosci, 25, pp. 7847-7857.
21. Haughey, N. J. and Mattson, M. P. (2002) Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120. J Acquir Immune Defic Syndr, 31, pp. S55-S61.
22. Hostettler, M. E., Knapp, P. E. and Carlson, S. L. (2002) Platelet activating factor induces caspase-3 dependent apoptosis in astrocytes and oligodendrocytes in vitro. Glia, 38, pp. 228-239.
23. Jana, A. and Pahan, K. (2004) Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase. J Neurosci, 27, pp. 9531-9540.
24. Kandel, E. S. and Hay, N. (1999) The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res, 253, pp. 210-229.
25. Kennedy, S. G., Wagner, A. J., Conzen, S. D., Jordan, J., Bellacosa, A., Tsichlis, P. N. and Hay, N. (1997) The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev, 11, pp. 701-713.
26. Kim, B. O., Liu, Y., Ruan, Y., Xu, Z. C., Schantz, L. and He, J. J. (2003) Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycycline. Am J Pathol, 162, pp. 1693-1707.
27. Kruman, I. I., Nath, A. and Mattson, M. P. (1998) HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp Neurol, 154, pp. 276-288.
28. Kwon, C. H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Baker, S. J. and Parada, L. F. (2006) PTEN regulates neuronal arborization and social interaction in mice. Neuron, 50, pp. 377-388.
29. Luo, X. and Wang, X. (2001) Endonuclease G is an apoptotic DNase when released from mitochondria. Nature, 412, pp. 95-99.
30. Lipton, S. A. (1997) Neuropathogenesis of acquired immunodeficiency syndrome dementia. Curr Opin Neurol, 10, pp. 247-253.
31. Lipton, S. A. and Gendelman, H. E. (1995) Dementia associated with the acquired immunodeficiency syndrome. Seminars in medicine of the Beth Israel Hospital, Boston. N Engl J Med, 332, pp. 934-940.
32. Maggirwar, S. B., Tong, N., Ramirez, S., Gelbard, H. A. and Dewhurst, S. (1999) HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity. J Neurochem, 73, pp. 578-586.
33. Mao, L. and Wang, J. Q. (2001) Upregulation of preprodynorphin and preproenkephalin mRNA expression by selective activation of group I metabotropic glutamate receptors in characterized primary cultures of rat striatal neurons. Mol Brain Res, 86, pp. 125-137.
34. Markus, A., Zhong, J. and Snider, W. D. (2002) Raf and akt mediate distinct aspects of sensory axon growth. Neuron, 35, pp. 65-76.
35. Masliah, E. and Mucke, L. (1996) Pathogenesis of HIV-1 associated neurodegeneration. Crit Rev Neurobiol, 10, pp. 57-67.
36. McArthur, J. C., Haughey, N., Gartner, S., Conant, K., Pardo, C., Nath, A. and Sacktor, N. (2003) Human immunodeficiency virus-associated dementia: An evolving disease. J NeuroVirol, 9, pp. 205-221.
37. McArthur, J. C., Hoover, D. R., Bacellar, H., Miller, E. N., Cohen, B. A., Becker, J. T., Graham, N. M., McArthur, J. H., Selnes, O. A. and Jacobson, L. P. (1993) Dementia in AIDS patients: Incidence and risk factors. Multicenter AIDS Cohort Study. Neurology, 43, pp. 2245-2252.
38. Mordelet, E., Kissa, K., Cressant, A., Gray, F., Ozden, S., Vidal, C., Charneau, P. and Granon, S. (2004) Histopathological and cognitive defects induced by Nef in the brain. FASEB J, 18, pp. 1851-1861.
39. Nath, A., Psooy, K., Martin, C., Knudsen, B., Magnuson, D. S., Haughey, N. and Geiger, J. D. (1996) Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol, 70, pp. 1475-1480.
40. Ogata, T., Iijima, S., Hoshikawa, S., Miura, T., Yamamoto, S., Oda, H., Nakamura, K. and Tanaka, S. (2004) Opposing extracellular signal-regulated kinase and Akt pathways control Schwann cell myelination. J Neurosci, 24, pp. 6724-6732.
41. Patel, C. A., Mukhtar, M., Harley, S., Kulkosky, J. and Pomerantz, R. J. (2002) Lentiviral expression of HIV-1 Vpr induces apoptosis in human neurons. J NeuroVirol, 8, pp. 86-99.
42. Rao, R. D. and James, C. D. (2004) Altered molecular pathways in gliomas: An overview of clinically relevant issues. Semin Oncol, 31, pp. 595-604.
43. Sa, M. J., Madeira, M. D., Ruela, C., Volk, B., Mota-Miranda, A. and Paula-Barbosa, M. M. (2004) Dendritic changes in the hippocampal formation of AIDS patients: A quantitative Golgi study. Acta Neuropathol (Berl), 107, pp. 97-110.
44. Sabbah, E. N. and Roques, B. P. (2005) Critical implication of the (70-96) domain of human immunodeficiency virus type 1 Vpr protein in apoptosis of primary rat cortical and striatal neurons. J NeuroVirol, 11, pp. 489-502.
45. Simpson, L. and Parsons, R. (2001) PTEN: Life as a tumor suppressor. Exp Cell Res, 264, pp. 29-41.
46. Singh, I. N., El-Hage, N., Campbell, M. E., Lutz, S. E., Knapp, P. E., Nath, A. and Hauser, K. F. (2005) Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons. Neuroscience, 135, pp. 781-790.
47. Singh, I. N., Goody, R. J., Dean, C., Ahmad, N. M., Lutz, S. E., Knapp, P. E., Nath, A. and Hauser, K. F. (2004) Apoptotic death of striatal neurons induced by HIV-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G. J NeuroVirol, 10, pp. 141-151.
48. Stambolic, V., MacPherson, D., Sas, D., Lin, Y., Snow, B., Jang, Y., Benchimol, S. and Mak, T. W. (2001) Regulation of PTEN transcription by p53. Mol Cell, 8, pp. 317-325.
49. Stiles, B., Groszer, M., Wang, S. and Jiao, J. (2004) PTENless means more. Dev Biol, 273, pp. 175-184.
50. Sun, H., Lesche, R., Li, D. M., Liliental, J., Zhang, H., Gao, J., Gavrilova, N., Mueller, B. and Liu, X. (1999) PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5, -trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA, 96, pp. 6199-6204.
51. Suzuki, A., de la Pompa, J. L., Stambolic, V., Elia, A. J., Sasaki, T., Barrantes, I del Barco, Wakeham, A., Itie, A., Khoo, W., Fukumoto, M. and Mak, T. W. (1998) High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol, 8, pp. 1169-1178.
52. van Loo, G., Schotte, P., van Gurp, M., Demol, H., Hoorelbeke, B., Gevaert, K., Rodriguez, I., Ruiz-Carrillo, A., Vandekerckhove, J., Declercq, W., Beyaert, R. and Vandenabeele, P. (2001) Endonuclease G: A mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ, 8, pp. 1136-1142.
53. van Marle, G., Henry, S., Todoruk, T., Sullivan, A., Silva, C., Rourke, S. B., Holden, J., McArthur, J. C., Gill, M. J. and Power, C. (2004) Human immunodeficiency virus type 1 Nef protein mediates neural cell death: A neurotoxic role for IP-10. Virology, 329, pp. 302-318.
54. Wee, K. B. and Aguda, B. D. (2006) Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death. Biophys J, 91:3, pp. 857-865.
55. Yoshimura, T., Arimura, N., Kawano, Y., Kawabata, S., Wang, S. and Kaibuchi, K. (2006) Ras regulates neuronal polarity via the PI3-kinase/ Akt/GSK-3beta/CRMP-2 pathway. Biochem Biophys Res Commun, 340, pp. 62-68.
56. Zhao, T-Y, Zou, S-P, Alimova, Y. V., Wang, G., Hauser, K. F., Ghandour, M. S. and Knapp, P. E. (2006) Short-interfering RNA Induced gene silencing is transmitted between cells from the mammalian central nervous system. J Neurochem, 98, pp. 1541-1550.
57. Zhou, X. P., Waite, K. A., Pilarski, R., Hampel, H., Fernandez, M. J., Bos, C., Dasouki, M., Feldman, G. L., Greenberg, L. A., Ivanovich, J., Matloff, E., Patterson, A., Pierpont, M. E., Russo, D., Nassif, N. T. and Eng, C. (2003) Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway. Am J Human Genet, 73, pp. 404-411.