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Volumn 73, Issue 3, 2007, Pages 173-179

Novel drug delivery systems in pain therapy

Author keywords

Biodegradable materials; Controlled drug delivery systems; Pain; Polymers

Indexed keywords

BUPIVACAINE; CHITOSAN; COLLAGEN; DENDRIMER; DEXAMETHASONE; DEXTRAN; GELATIN; HYALURONIC ACID; LECTIN; LOCAL ANESTHETIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; POLY(ORTHO ESTER); POLYAMINOACID; POLYESTER; POLYETHYLENE; POLYETHYLENE TEREPHTHALATE; POLYGLACTIN; POLYHYDROXYALKANOIC ACID; POLYLACTIC ACID; POLYMER; POLYPROPYLENE; POLYSILOXANE; POLYVINYLCHLORIDE; RUBBER; SILICONE; STEROID;

EID: 34249092645     PISSN: 03759393     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (58)
  • 1
    • 24044443450 scopus 로고    scopus 로고
    • IASP International Association for the Study of Pain, November 9
    • IASP International Association for the Study of Pain. IASP Pain Terminology [IASP web site]. November 9, 2004. http://www.iasp-pain.org/ terms-p.html
    • (2004) IASP Pain Terminology [IASP web site]
  • 3
    • 0032496903 scopus 로고    scopus 로고
    • Persistent pain and well-being: A World Health Organization Study in Primary Care
    • Gureje O, Von Korff M, Simon GE, Gater R. Persistent pain and well-being: a World Health Organization Study in Primary Care. JAMA 1998;280:147-51.
    • (1998) JAMA , vol.280 , pp. 147-151
    • Gureje, O.1    Von Korff, M.2    Simon, G.E.3    Gater, R.4
  • 4
    • 0026353744 scopus 로고
    • Prevalence of chronic pain in the British population: A telephone survey of 1037 households
    • Bowsher D, Rigges M, Sopp L. Prevalence of chronic pain in the British population: a telephone survey of 1037 households. Pain Clin 1991;4:223-30.
    • (1991) Pain Clin , vol.4 , pp. 223-230
    • Bowsher, D.1    Rigges, M.2    Sopp, L.3
  • 5
    • 0027302981 scopus 로고
    • Chronic pain in a geographically defined population: Studies of differences in age, gender, social class, and pain localization
    • Andersson HI, Ejlertsson G, Leden I, Rosenberg C. Chronic pain in a geographically defined population: studies of differences in age, gender, social class, and pain localization. Clin J Pain 1993;9:174-82.
    • (1993) Clin J Pain , vol.9 , pp. 174-182
    • Andersson, H.I.1    Ejlertsson, G.2    Leden, I.3    Rosenberg, C.4
  • 6
    • 0343085682 scopus 로고    scopus 로고
    • World Health Organization, Geneve, Switzerland: World Health Organization;
    • World Health Organization. WHO Guidelines: Cancer Pain Relief (2nd). Geneve, Switzerland: World Health Organization; 1996.
    • (1996) WHO Guidelines: Cancer Pain Relief (2nd)
  • 7
    • 34249049360 scopus 로고    scopus 로고
    • Breaking pain barriers. The white paper on opiods and pain: A pan-european challenge. A Report compiled by OPEN Minds (Opioids and Pain European Network of Minds) June 2005. www.eurpeanpainnetwork.com/ files/White_Paper.pdf.
    • Breaking pain barriers. The white paper on opiods and pain: A pan-european challenge. A Report compiled by OPEN Minds (Opioids and Pain European Network of Minds) June 2005. www.eurpeanpainnetwork.com/ files/White_Paper.pdf.
  • 8
    • 0000910463 scopus 로고
    • The prevalence of persistent pain in a Danish population
    • Andersen S, Worm-Pedersen J. The prevalence of persistent pain in a Danish population. Pain 1987;S4:S332.
    • (1987) Pain , vol.S4
    • Andersen, S.1    Worm-Pedersen, J.2
  • 10
    • 0008200814 scopus 로고    scopus 로고
    • Innovations in assessment: Epidemiology and assessment of pain in advanced cancer
    • Jensen TS, Turner JA, Wiesenfeld-Hallin Z editors, Seattle: IASP Press;
    • Higginson IJ. Innovations in assessment: epidemiology and assessment of pain in advanced cancer. In: Jensen TS, Turner JA, Wiesenfeld-Hallin Z editors. Proceedings of the 8th World Congress on pain, Progress in Pain Research and Management. Seattle: IASP Press; 1997;8:707-11.
    • (1997) Proceedings of the 8th World Congress on pain, Progress in Pain Research and Management , vol.8 , pp. 707-711
    • Higginson, I.J.1
  • 11
    • 3142733433 scopus 로고    scopus 로고
    • Chronic pain. Epidemiology and management in Germany
    • Zimmermann M. Chronic pain. Epidemiology and management in Germany. Orthopade 2004;33:508-14.
    • (2004) Orthopade , vol.33 , pp. 508-514
    • Zimmermann, M.1
  • 12
    • 1642521216 scopus 로고    scopus 로고
    • Pain management in primary-care medical practice
    • Tollison CD, Satterthwaithe JR, Tollison JW, editors, 3rd ed. Philadelphia, PA: Lippincott Williams and Wilkins;
    • Parrott T. Pain management in primary-care medical practice. In: Tollison CD, Satterthwaithe JR, Tollison JW, editors. Practical Pain Management. 3rd ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2002.p.729-59.
    • (2002) Practical Pain Management , pp. 729-759
    • Parrott, T.1
  • 15
    • 0020573952 scopus 로고
    • Implantable controlled release systems
    • Langer R. Implantable controlled release systems. Pharmacol Ther 1983;21:35-51.
    • (1983) Pharmacol Ther , vol.21 , pp. 35-51
    • Langer, R.1
  • 16
    • 0025880429 scopus 로고
    • Implantable controlled release drug delivery systems: A review
    • Danckwerts M, Fassihi A. Implantable controlled release drug delivery systems: a review. Drug Dev Ind Pharm 1991;17:1465-502.
    • (1991) Drug Dev Ind Pharm , vol.17 , pp. 1465-1502
    • Danckwerts, M.1    Fassihi, A.2
  • 17
    • 0032408601 scopus 로고    scopus 로고
    • Dash AK, Cudworth GC 2nd. Therapeutic applications of implantable drug delivery systems. J Pharmacol Toxicol Methods 1998;40:1-12.
    • Dash AK, Cudworth GC 2nd. Therapeutic applications of implantable drug delivery systems. J Pharmacol Toxicol Methods 1998;40:1-12.
  • 18
    • 0025015676 scopus 로고
    • Drug delivery systems. 4. Implants in drug delivery
    • Ranade V. Drug delivery systems. 4. Implants in drug delivery. J Clin Pharmacol 1990;30:871-89.
    • (1990) J Clin Pharmacol , vol.30 , pp. 871-889
    • Ranade, V.1
  • 21
    • 0037619257 scopus 로고    scopus 로고
    • Biocompatibility of implantable synthetic polymeric drug carriers: Focus on brain biocompatibility
    • Fournier E, Passirani C, Montero-Menei CN, Benoit JP. Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility. Biomaterials 2003;24:3311-31.
    • (2003) Biomaterials , vol.24 , pp. 3311-3331
    • Fournier, E.1    Passirani, C.2    Montero-Menei, C.N.3    Benoit, J.P.4
  • 22
    • 35948986208 scopus 로고    scopus 로고
    • Biodegradable synthetic polymers for tissue engineering
    • Gunatillake PA, Adhikari R. Biodegradable synthetic polymers for tissue engineering. Eur Cell Mater 2003;5:1-16.
    • (2003) Eur Cell Mater , vol.5 , pp. 1-16
    • Gunatillake, P.A.1    Adhikari, R.2
  • 23
    • 0037120665 scopus 로고    scopus 로고
    • Polyanhydride degradation and erosion
    • Gopferich A, Tessmar J. Polyanhydride degradation and erosion. Adv Drug Deliv Rev 2002;54:911-31.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 911-931
    • Gopferich, A.1    Tessmar, J.2
  • 24
    • 2942541913 scopus 로고    scopus 로고
    • Biodegradable polymers and their potential use in parenteral veterinary drug delivery systems
    • Winzenburg G, Schmidt C, Fuchs S, Kissel T. Biodegradable polymers and their potential use in parenteral veterinary drug delivery systems. Adv Drug Deliv Rev 2004;56:1453-66.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1453-1466
    • Winzenburg, G.1    Schmidt, C.2    Fuchs, S.3    Kissel, T.4
  • 25
    • 16344380049 scopus 로고    scopus 로고
    • Aliphatic polyesters: Great degradable polymers that cannot do everything
    • Vert M. Aliphatic polyesters: great degradable polymers that cannot do everything. Biomacromolecules 2005;6:538-46.
    • (2005) Biomacromolecules , vol.6 , pp. 538-546
    • Vert, M.1
  • 26
    • 5044235051 scopus 로고    scopus 로고
    • Poly(ortho esters) - from concept to reality
    • Heller J, Barr J. Poly(ortho esters) - from concept to reality. Biomacromolecules 2004;5:1625-32.
    • (2004) Biomacromolecules , vol.5 , pp. 1625-1632
    • Heller, J.1    Barr, J.2
  • 27
    • 0019803409 scopus 로고
    • Preparation and evaluation in vitro of polylactic acid microspheres containing local anesthetics
    • Wakiyama N, Juni K, Nakano M. Preparation and evaluation in vitro of polylactic acid microspheres containing local anesthetics. Chem Pharm Bull (Tokyo) 1981;29:3363-8.
    • (1981) Chem Pharm Bull (Tokyo) , vol.29 , pp. 3363-3368
    • Wakiyama, N.1    Juni, K.2    Nakano, M.3
  • 28
    • 0029020140 scopus 로고
    • Prolongation of spinal anesthesia with bupivacaine-loaded (DL-lactide) microspheres
    • Estebe JP, Le Corre P, Malledant Y, Chevanne F, Leverge R. Prolongation of spinal anesthesia with bupivacaine-loaded (DL-lactide) microspheres. Anesth Analg 1995;81:99-103.
    • (1995) Anesth Analg , vol.81 , pp. 99-103
    • Estebe, J.P.1    Le Corre, P.2    Malledant, Y.3    Chevanne, F.4    Leverge, R.5
  • 29
    • 0347298768 scopus 로고    scopus 로고
    • Effect of dexamethasone on motor brachial plexus block with bupivacaine and with bupivacaine-loaded microspheres in a sheep model
    • Estebe JP, Le Corre P, Clement R, Du Plessis L, Chevanne F, Le Verge R et al. Effect of dexamethasone on motor brachial plexus block with bupivacaine and with bupivacaine-loaded microspheres in a sheep model. Eur J Anaesthesiol 2003;20:305-10.
    • (2003) Eur J Anaesthesiol , vol.20 , pp. 305-310
    • Estebe, J.P.1    Le Corre, P.2    Clement, R.3    Du Plessis, L.4    Chevanne, F.5    Le Verge, R.6
  • 30
    • 8944222570 scopus 로고    scopus 로고
    • Prolonged regional nerve blockade. Injectable biodegradable bupivacaine/ polyester microspheres
    • Curley J, Castillo J, Hotz J, Uezono M, Hernandez S, Lim JO et al. Prolonged regional nerve blockade. Injectable biodegradable bupivacaine/ polyester microspheres. Anesthesiology 996;84:1401-10.
    • Anesthesiology , vol.996 , Issue.84 , pp. 1401-1410
    • Curley, J.1    Castillo, J.2    Hotz, J.3    Uezono, M.4    Hernandez, S.5    Lim, J.O.6
  • 31
    • 0342546477 scopus 로고    scopus 로고
    • Diclofenac sodium incorporated PLGA (50:50) microspheres: Formulation considerations and in vitro/in vivo evaluation
    • Tunçay M, Calis S, Kas HS. Diclofenac sodium incorporated PLGA (50:50) microspheres: formulation considerations and in vitro/in vivo evaluation. Int J Pharm 2000;195:179-88.
    • (2000) Int J Pharm , vol.195 , pp. 179-188
    • Tunçay, M.1    Calis, S.2    Kas, H.S.3
  • 32
    • 0344851844 scopus 로고    scopus 로고
    • Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block
    • Suter MR, Papaloizos M, Berde CB. Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block. Anesthesiology 2003;99:1402-8.
    • (2003) Anesthesiology , vol.99 , pp. 1402-1408
    • Suter, M.R.1    Papaloizos, M.2    Berde, C.B.3
  • 33
    • 0041430634 scopus 로고    scopus 로고
    • Tramadol encapsulated into polyhydroxybutyrate microspheres: In vitro release and epidural analgesic effect in rats
    • Salman MA, Sahin A, Onur MA. Tramadol encapsulated into polyhydroxybutyrate microspheres: in vitro release and epidural analgesic effect in rats. Acta Anaesthesiol Scand 2003;47:1006-12.
    • (2003) Acta Anaesthesiol Scand , vol.47 , pp. 1006-1012
    • Salman, M.A.1    Sahin, A.2    Onur, M.A.3
  • 34
    • 0028920468 scopus 로고
    • Prolongation of lidocaine-induced epidural anesthesia by medium molecular weight hyaluronic acid formulations: Pharmacodynamic and pharmacokinetic studies in the rabbit
    • Doherty MM, Hughes PJ, Korszniak NV. Prolongation of lidocaine-induced epidural anesthesia by medium molecular weight hyaluronic acid formulations: pharmacodynamic and pharmacokinetic studies in the rabbit. Anesth Analg 1995;80:740-6.
    • (1995) Anesth Analg , vol.80 , pp. 740-746
    • Doherty, M.M.1    Hughes, P.J.2    Korszniak, N.V.3
  • 35
    • 0029626640 scopus 로고
    • Controlled release of lidocaine from injectable gels and efficacy in rat sciatic nerve block
    • Paavola A, Yliruusi J, Kajimoto Y. Controlled release of lidocaine from injectable gels and efficacy in rat sciatic nerve block. Pharm Res 1995;12:1997-2002.
    • (1995) Pharm Res , vol.12 , pp. 1997-2002
    • Paavola, A.1    Yliruusi, J.2    Kajimoto, Y.3
  • 36
    • 3042844192 scopus 로고    scopus 로고
    • Controlled release of biomolecules from pH-sensitive network polymers prepared by radiation polymerization
    • Mahkam M, Allahverdipoor M. Controlled release of biomolecules from pH-sensitive network polymers prepared by radiation polymerization. J Drug Target 2004;12:151-6.
    • (2004) J Drug Target , vol.12 , pp. 151-156
    • Mahkam, M.1    Allahverdipoor, M.2
  • 37
    • 0038042316 scopus 로고    scopus 로고
    • In vivo pain relief effectiveness of an analgesic-anesthetic carrying biodegradable controlled release rod systems
    • Sendil-Keskin D, Altunay H, Wise DL. In vivo pain relief effectiveness of an analgesic-anesthetic carrying biodegradable controlled release rod systems. J Biomater Sci Polym Ed 2003;14:497-514.
    • (2003) J Biomater Sci Polym Ed , vol.14 , pp. 497-514
    • Sendil-Keskin, D.1    Altunay, H.2    Wise, D.L.3
  • 38
    • 0142157531 scopus 로고    scopus 로고
    • Antihyperalgesic effect of simultaneously released hydromorphone and bupivacaine from polymer fibers in the rat chronic constriction injury model
    • Hasirci V, Bonney I, Goudas LC. Antihyperalgesic effect of simultaneously released hydromorphone and bupivacaine from polymer fibers in the rat chronic constriction injury model. Life Sci 2003;73:3323-37.
    • (2003) Life Sci , vol.73 , pp. 3323-3337
    • Hasirci, V.1    Bonney, I.2    Goudas, L.C.3
  • 39
    • 34249030445 scopus 로고    scopus 로고
    • Masters DB1, Berde CB, Ward JM. Biochemical and histologic effects of prolonged sciatic nerve blockade with bupivacaine using a biodegradable polymer matrix. Anesthesiology 1991;75(3A):A680.
    • Masters DB1, Berde CB, Ward JM. Biochemical and histologic effects of prolonged sciatic nerve blockade with bupivacaine using a biodegradable polymer matrix. Anesthesiology 1991;75(3A):A680.
  • 40
    • 0033061523 scopus 로고    scopus 로고
    • Evaluation of the efficacy of a bioerodible bupivacaine polymer system on antinociception and inflammatory mediator release
    • Garry MG, Jackson DL, Geier HE. Evaluation of the efficacy of a bioerodible bupivacaine polymer system on antinociception and inflammatory mediator release. Pain 1999;82: 49-55.
    • (1999) Pain , vol.82 , pp. 49-55
    • Garry, M.G.1    Jackson, D.L.2    Geier, H.E.3
  • 41
    • 0029789140 scopus 로고    scopus 로고
    • Biodegradable injectable implant systems for long term drug delivery using poly (lactic-co-glycolic) acid copolymers
    • Chandrashekar G, Udupa N. Biodegradable injectable implant systems for long term drug delivery using poly (lactic-co-glycolic) acid copolymers. J Pharm Pharmacol 1996;48: 669-74.
    • (1996) J Pharm Pharmacol , vol.48 , pp. 669-674
    • Chandrashekar, G.1    Udupa, N.2
  • 42
    • 0028832994 scopus 로고
    • Prolongation of epidural anesthesia in the rabbit with the use of a biodegradable copolymer paste containing lidocaine
    • Sato S, Baba Y, Tajima K. Prolongation of epidural anesthesia in the rabbit with the use of a biodegradable copolymer paste containing lidocaine. Anesth Analg 1995;80:97-101.
    • (1995) Anesth Analg , vol.80 , pp. 97-101
    • Sato, S.1    Baba, Y.2    Tajima, K.3
  • 43
    • 0033801571 scopus 로고    scopus 로고
    • In vitro iontophoretic release of lithium chloride and lidocaine hydrochloride from polymer electrolytes
    • Sahota TS, Latham RJ, Linford RG. In vitro iontophoretic release of lithium chloride and lidocaine hydrochloride from polymer electrolytes. Drug Dev Ind Pharm 2000;26:1039-44.
    • (2000) Drug Dev Ind Pharm , vol.26 , pp. 1039-1044
    • Sahota, T.S.1    Latham, R.J.2    Linford, R.G.3
  • 44
    • 0029892505 scopus 로고    scopus 로고
    • Anti-inflammatory activity of polyphosphazene-based naproxen slow-release systems
    • Conforti A, Bertani S, Lussignoli S. Anti-inflammatory activity of polyphosphazene-based naproxen slow-release systems. J Pharm Pharmacol 1996;48:468-73.
    • (1996) J Pharm Pharmacol , vol.48 , pp. 468-473
    • Conforti, A.1    Bertani, S.2    Lussignoli, S.3
  • 45
    • 0037018969 scopus 로고    scopus 로고
    • A local delivery system for fentanyl based on biodegradable poly(L-lactide-co-glycolide) oligomer
    • Seo SA, Choi HS, Khang G. A local delivery system for fentanyl based on biodegradable poly(L-lactide-co-glycolide) oligomer. Int J Pharm 2002;239:93-101.
    • (2002) Int J Pharm , vol.239 , pp. 93-101
    • Seo, S.A.1    Choi, H.S.2    Khang, G.3
  • 46
    • 16544393702 scopus 로고    scopus 로고
    • Solid-state NMR studies of pharmaceutical solids in polymer matrices
    • Lubach JW, Padden BE, Winslow SL. Solid-state NMR studies of pharmaceutical solids in polymer matrices. Anal Bioanal Chem 2004;378:1504-10.
    • (2004) Anal Bioanal Chem , vol.378 , pp. 1504-1510
    • Lubach, J.W.1    Padden, B.E.2    Winslow, S.L.3
  • 47
    • 21344454781 scopus 로고    scopus 로고
    • Pain control via opioid analgesic - local anesthetic loaded IPNs
    • Sendil KD, Wise DL, Hasirci V. Pain control via opioid analgesic - local anesthetic loaded IPNs. Curr Drug Delivery 2004;1:57-64.
    • (2004) Curr Drug Delivery , vol.1 , pp. 57-64
    • Sendil, K.D.1    Wise, D.L.2    Hasirci, V.3
  • 48
    • 0037006611 scopus 로고    scopus 로고
    • Preparation and characterization of fentanyl-loaded PLGA microspheres: In vitro release profiles
    • Choi HS, Seo SA, Khang G. Preparation and characterization of fentanyl-loaded PLGA microspheres: in vitro release profiles. Int J Pharm 2002;234:195-203.
    • (2002) Int J Pharm , vol.234 , pp. 195-203
    • Choi, H.S.1    Seo, S.A.2    Khang, G.3
  • 49
    • 0036552284 scopus 로고    scopus 로고
    • Bupivacaine pharmacokinetics and motor blockade following epidural administration of the bupivacaine-sulphobutylether 7-beta-cyclodextrin complex in sheep
    • Estebe JP, Ecoffey C, Dollo G. Bupivacaine pharmacokinetics and motor blockade following epidural administration of the bupivacaine-sulphobutylether 7-beta-cyclodextrin complex in sheep. Eur J Anaesthesiol 2002;19:308-10.
    • (2002) Eur J Anaesthesiol , vol.19 , pp. 308-310
    • Estebe, J.P.1    Ecoffey, C.2    Dollo, G.3
  • 50
    • 0031707473 scopus 로고    scopus 로고
    • Prolonged intercostal nerve blockade in sheep using controlled-release of bupivacaine and dexamethasone from polymer microspheres
    • Drager C, Benziger D, Gao F. Prolonged intercostal nerve blockade in sheep using controlled-release of bupivacaine and dexamethasone from polymer microspheres. Anesthesiology 1998;89:969-79.
    • (1998) Anesthesiology , vol.89 , pp. 969-979
    • Drager, C.1    Benziger, D.2    Gao, F.3
  • 51
    • 0020076623 scopus 로고
    • Duration of the local anesthetic effect of tetracaine hydrochloride solutions and tetracaine in microspheres
    • Wakiyama N, Juni K, Nakano M. Duration of the local anesthetic effect of tetracaine hydrochloride solutions and tetracaine in microspheres. J Pharmacobiodyn 1982;5:13-7.
    • (1982) J Pharmacobiodyn , vol.5 , pp. 13-17
    • Wakiyama, N.1    Juni, K.2    Nakano, M.3
  • 52
    • 0029616209 scopus 로고
    • Spinal controlled delivery of bupivacaine from DL-lactic acid oligomer microspheres
    • Le Corre P, Estebe JP, Chevanne F. Spinal controlled delivery of bupivacaine from DL-lactic acid oligomer microspheres. J Pharm Sci 1995;84:75-8.
    • (1995) J Pharm Sci , vol.84 , pp. 75-78
    • Le Corre, P.1    Estebe, J.P.2    Chevanne, F.3
  • 54
    • 0000174081 scopus 로고    scopus 로고
    • Extended local anesthesia of bupivacaine-loaded microspheres-role of dexamethasone
    • Kopacz DJ, Allen HW, Hopt K. Extended local anesthesia of bupivacaine-loaded microspheres-role of dexamethasone. Anesth Analg 2001;92:S260.
    • (2001) Anesth Analg , vol.92
    • Kopacz, D.J.1    Allen, H.W.2    Hopt, K.3
  • 55
    • 0036267182 scopus 로고    scopus 로고
    • Dexamethasone prolongs local anesthesia after subcutaneous infiltration of bupivacaine microcapsu- les in human volunteers
    • Holte K, Werner MU, Lacouture PG, Kehlet H. Dexamethasone prolongs local anesthesia after subcutaneous infiltration of bupivacaine microcapsu- les in human volunteers. Anesthesiology 2002;96:1331-5.
    • (2002) Anesthesiology , vol.96 , pp. 1331-1335
    • Holte, K.1    Werner, M.U.2    Lacouture, P.G.3    Kehlet, H.4
  • 56
    • 0038650795 scopus 로고    scopus 로고
    • A model to evaluate the pharmacokinetic and pharmacodynamic variables of extended- release products using in vivo tissue microdialysis in humans: Bupivacaine-loaded microcapsules
    • Kopacz DJ, Bernards CM, Allen HW, Landau C, Nandy P, Wu D et al. A model to evaluate the pharmacokinetic and pharmacodynamic variables of extended- release products using in vivo tissue microdialysis in humans: bupivacaine-loaded microcapsules. Anesth Analg 2003;97:124-31.
    • (2003) Anesth Analg , vol.97 , pp. 124-131
    • Kopacz, D.J.1    Bernards, C.M.2    Allen, H.W.3    Landau, C.4    Nandy, P.5    Wu, D.6
  • 57
    • 0037301980 scopus 로고    scopus 로고
    • The dose response and effects of dexamethasone on bupivacaine microcapsules foe intercostal blockade (T9 to T11) in healthy volunteers
    • Kopacz DJ, Lacouture PG, Wu D, Nandy P, Swanton R, Landau C. The dose response and effects of dexamethasone on bupivacaine microcapsules foe intercostal blockade (T9 to T11) in healthy volunteers. Anesth Analg 2003;96:576-82.
    • (2003) Anesth Analg , vol.96 , pp. 576-582
    • Kopacz, D.J.1    Lacouture, P.G.2    Wu, D.3    Nandy, P.4    Swanton, R.5    Landau, C.6
  • 58
    • 4143126747 scopus 로고    scopus 로고
    • Bupivacaine in microcapsules prolong analgesia after subcutaneous infiltration in humans: A dosefinding study
    • Pedersen JL, Lillesø J, Hammer NA, Werner MU, Holte K, Lacouture PG et al. Bupivacaine in microcapsules prolong analgesia after subcutaneous infiltration in humans: a dosefinding study. Anesth Analg 2004;99:912-8.
    • (2004) Anesth Analg , vol.99 , pp. 912-918
    • Pedersen, J.L.1    Lillesø, J.2    Hammer, N.A.3    Werner, M.U.4    Holte, K.5    Lacouture, P.G.6


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