Prolonged regional nerve blockade: Injectable biodegradable bupivacaine/polyester microspheres

Anesthesiology

Volumn 84, Issue 6, 1996, Pages 1401-1410

  Curley, Joanne ^a   Castillo, Jenny ^b   Hotz, Joyce ^c   Uezono, Megumi ^b   Hernandez, Sonia ^b   Lim, Jeong Ok ^b   Tigner, Joseph ^d   Chasin, Mark ^d   Langer, Robert ^a   Berde, Charles ^e,f  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Children's Hospital   (United States)

^c Medisorb Technologies

^d PURDUE PHARMA L P   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Anesthesia: regional; Anesthetics, local: bupivacaine; dexamethasone; Drug delivery: sustained release; Microspheres: biodegradable polyester; Nerves, sciatic: blockade

Indexed keywords

BUPIVACAINE; DEXAMETHASONE; LOCAL ANESTHETIC AGENT; MICROSPHERE; POLYESTER;

ANIMAL EXPERIMENT; ARTICLE; BIODEGRADATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; MALE; NERVE BLOCK; NONHUMAN; PRIORITY JOURNAL; RAT; REGIONAL PERFUSION; SCIATIC NERVE; SUSTAINED RELEASE PREPARATION;

ANESTHETICS, LOCAL; ANIMALS; BIODEGRADATION, ENVIRONMENTAL; BUPIVACAINE; DEXAMETHASONE; INJECTIONS; LACTIC ACID; MALE; MICROSPHERES; NERVE BLOCK; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; TIME FACTORS;

EID: 8944222570     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199606000-00017     Document Type: Article

References (27)

1. Strichartz GR, Berde CB: Local anesthetics, Anesthesia. Edited by Miller RD. New York, Churchill Livingstone, 1993, pp 489-522
2. Masters DB, Berde CB, Dutta SK, Griggs CT, Hu D, Kupsky W, Langer R: Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix. ANESTHESIOLOGY 1993; 79:340-6
3. Masters DB, Berde CB, Dutta S, Turek T, Langer R: Sustained local anesthetic release from bioerodable polymer matrices: A potential method for prolonged regional anesthesia. Pharm Res 1993; 10:1527-32
4. Lim J-O, Curley J, Castillo JM, Langer R, Berde C: Prolonged rat sciatic nerve blockade II: Local anesthetic polymer microspheres. ANESTHESIOLOGY 1995; 83:810
5. Mathiowitz E, Saltzman WM, Domb A, Dor P, Langer R: Polyanhydride microspheres as drug carriers, II. Microencapsulation by solvent removal. J Biomed Mater Res 1988; 35:755-74
6. Mathiowitz E, Langer R: Polyanhydride microspheres as drug carriers I. Hot-Melt microencapsulation. J Biomed Mater Res 1987; 5:13-22
7. Mayberg MR, Gross AS, Mathiowitz E, Langer R: Sustained release of acetylcholine in rat hippocampus using a polyanhydride drug-delivery systems. J Biomed Mat Res 1992; 33:331-5
8. Okada H, Doken Y, Ogawa Y, Toguchi H: Preparation of three-month depot injectable microspheres of leuprorelin acetate using biodegradable polymers. Pharm Res 1994; 118:1143-7
9. Lewis DH: Controlled Release of bioactive agents from lactide/ glycolide polymers, Biodegradable Polymers as Drug Delivery Systems. Edited by Chasin M, Langer R, New York, Marcel Dekker, 1990, pp 1-41
10. Yamaguchi K, Anderson JM: In vivo biocompatibility studies of medisorb® 65/35 D,L lactide, glycolid copolymer microspheres. J Cont Rel 1993; 24:81-93
11. Le Corre P, Le Guevello P, Gajan V, Chevanne F, Le Verge R: Preparation and characterization of bupivacaine loaded polylactide and polylactide-co-glycolide microspheres. J Biomed Mater Res 1994; 107:41-49
12. Malinovsky J-M, Bernanrd J-M, Le Corre P, Dumand J-B, Lepage J-Y, Le Verge R, Souron R: Motor and blood pressure effects of epidural sustained-release bupivacaine from polymer microspheres. A dose-response study in rabbits. Anesth Analg 1995; 81:519-24
13. Kulkarni RW, Moore EG, Hegyelli AF, Leonard F: Biodegradable polylactic acid polymers. J Biomed Mater Res 1971; 5:169-175
14. Dittrich VW, Schultz RC: Kinetics and mechanisms of the ring opening polymerization of L-lactide. J Biomed Mater Res 1971; 15: 109
15. Watts PJ, Davies MC, Melia CD: Microencapsulation using emulsification/solvent evaporation: An overview of techniques and applications. J Crit Rev Ther Drug Carr Sys 1990; 7:237-59
16. Thalhammer JG, Vladimirova M, Bershadsky B, Strichartz GR: Neurological evaluation of the rat during sciatic nerve block with lidocaine. ANESTHESIOLOGY 1995; 82:1013-25
17. Lee KC, Wilder RT, Smith RL, Berde CB: Thermal hyperalgesia accelerates and MK-801 prevents the development of tachyphylaxis to rat sciatic nerve blockade. ANESTHESIOLOGY 1994; 81:1284-93
18. Dubner R: Methods of assessing pain in animals. Textbook of Pain. Edited by Wall PD, Melzack R. Edinburgh, Churchill Livingstone, 1984, pp 293-302
19. Boogaerts J, Lafont N, Donnay M, Luo H, Legros FJ: Motor blockade and absence of local nerve toxicity induced by liposomal bupivacaine injected into the brachial plexus of rabbits. Acta Anaesthesiol Belgica 1995; 46:19-24
20. Grant GJ, Vermeulen K, Langerman L, Zakowski M, Turndorf H: Prolonged analgesia with liposomal bupivacaine in a mouse model. Reg Anesth 1994; 19:264-9
21. Boogaerts JG, Lafont ND, Declercq AG, Luo HC, Gravel ET, Bianchi JA, Legros FJ: Epidural administration of liposome-associated bupivacaine for the management of postsurgical pain: a first study. J Clin Anesth 1994; 6:315-20
22. Boedeker BH, Lojeski EW, Kline MD, Haynes DH: Ultra-long-duration local anesthesia produced by injection of lecithin-coated tetracaine microcrystals. J Clin Pharmacol 1994; 34:699-702
23. Physicians' Desk Reference. Oradell J., Medical Economics Company, 1995; 2598-602, 2422-4
24. Denson DD, Raj PP: Perineural infusions of bupivacaine for prolonged analgesia: Pharmacokinetic considerations. Int J Clin Pharmacol Ther Toxicol 1983; 21:591-7
25. Raj PP: Prognostic and therapeutic local anesthetic blockade. Neural Blockade in Clinical Anesthesia and Management of Pain. Edited by Cousins MJ, Bridenbaugh PO. Philadelphia, JB Lippincott, 1980, pp 899-933.
26. Shah JC, Maniar M: pH-Dependent solubility and dissolution of bupivacaine and its relevance to the formulation of a controlled release system. J Biomed Mater Res 1993; 23:261-70.
27. Devor MD, Gorvin-Lippmann R, Raber P: Corticosteroids suppress ectopic neural discharge originating in experimental neuromas. Pain 1985; 22:127-37