Bupivacaine pharmacokinetics and motor blockade following epidural administration of the bupivacaine-sulphobutylether 7-β-cyclodextrin complex in sheep [4]

European Journal of Anaesthesiology

Volumn 19, Issue 4, 2002, Pages 308-310

  Estebe, Jean Pierre ^a   Ecoffey, C ^a   Dollo, G ^a   Le Corre, P ^a   Chevanne, F ^a   Le Verge, R ^a  

^a Hotel Dieu CHU Rennes   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CYCLODEXTRIN SULFOBUTYL ETHER; BUPIVACAINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; EPIDURAL ANESTHESIA; LETTER; MOTOR ACTIVITY; MOTOR NERVE BLOCK; NONHUMAN; PHARMACODYNAMICS; SHEEP;

EID: 0036552284     PISSN: 02650215     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003643-200204000-00015     Document Type: Letter

References (6)

1. Inclusion complexation of amide-typed local anaesthetics with β-cyclodextrin and its derivatives. I. Physicochemical characterization
2. Inclusion complexation of amide-typed local anaesthetics with beta- cyclodextrin and its derivatives. II. Evaluation of affinity constants and in vitro transfer rate constants
3. Controlled systemic absorption and increase anesthetic effect of bupivacaine following epidural administration of bupivacaine-hydroxypropyl-beta-cyclodextrin complex
4. Inclusion complexation of amide-typed local anesthetics with β-cyclodextrin and its derivatives. III. Biopharmaceutics of bupivacaine-SBE7-β CD complex following percutaneous sciatic nerve administration in rabbits
5. High- performance liquid chromatographic determination of bupivacaine in plasma samples for biopharmaceutical studies and application to seven other local anaesthetics
6. Biphasic drug absorption from the epidural space of the dog may limit the utility of a slow release medium molecular weight hyaluronic acid-lidocaine ionic complex formulation