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Volumn 40, Issue 6, 2007, Pages 1529-1535

The bone-protective effect of the phytoestrogen genistein is mediated via ERα-dependent mechanisms and strongly enhanced by physical activity

Author keywords

Estrogen receptor alpha; Estrogen receptor beta; Estrogens; Genistein; Phytoestrogens

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENISTEIN; PHYTOESTROGEN;

EID: 34249072897     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2007.02.006     Document Type: Article
Times cited : (79)

References (46)
  • 1
    • 0028333891 scopus 로고
    • Skeletal effects of estrogen
    • (Review)
    • Turner R.T., Riggs B.L., and Spelsberg T.C. Skeletal effects of estrogen. Endocr. Rev. 15 3 (1994) 275-300 (Review)
    • (1994) Endocr. Rev. , vol.15 , Issue.3 , pp. 275-300
    • Turner, R.T.1    Riggs, B.L.2    Spelsberg, T.C.3
  • 2
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • (Review)
    • Riggs B.L., Khosla S., and Melton L.J. Sex steroids and the construction and conservation of the adult skeleton. Endocr. Rev. 23 3 (2002) 279-302 (Review)
    • (2002) Endocr. Rev. , vol.23 , Issue.3 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton, L.J.3
  • 4
    • 0021741166 scopus 로고
    • 17 beta-Estradiol for postmenopausal estrogen replacement therapy
    • Nichols K.C., Schenkel L., and Benson H. 17 beta-Estradiol for postmenopausal estrogen replacement therapy. Obstet. Gynecol. Surv. 39 4 (1984) 230-245
    • (1984) Obstet. Gynecol. Surv. , vol.39 , Issue.4 , pp. 230-245
    • Nichols, K.C.1    Schenkel, L.2    Benson, H.3
  • 5
    • 0033022695 scopus 로고    scopus 로고
    • The menopause
    • (Review)
    • Greendale G.A., Lee N.P., and Arriola E.R. The menopause. Lancet 353 9152 (1999) 571-580 (Review)
    • (1999) Lancet , vol.353 , Issue.9152 , pp. 571-580
    • Greendale, G.A.1    Lee, N.P.2    Arriola, E.R.3
  • 6
    • 0031703641 scopus 로고    scopus 로고
    • Variation in the efficacy of hormone replacement therapy in the prevention of hip fracture. Swedish Hip Fracture Study Group
    • Michaelsson K., Baron J.A., Johnell O., Persson I., and Ljunghall S. Variation in the efficacy of hormone replacement therapy in the prevention of hip fracture. Swedish Hip Fracture Study Group. Osteoporos. Int. 8 6 (1998) 540-546
    • (1998) Osteoporos. Int. , vol.8 , Issue.6 , pp. 540-546
    • Michaelsson, K.1    Baron, J.A.2    Johnell, O.3    Persson, I.4    Ljunghall, S.5
  • 7
    • 0042018741 scopus 로고    scopus 로고
    • Breast cancer and hormone-replacement therapy in the Million Women Study
    • Million Women Study Collaborators
    • Beral V., and Million Women Study Collaborators. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362 9382 (2003) 419-427
    • (2003) Lancet , vol.362 , Issue.9382 , pp. 419-427
    • Beral, V.1
  • 8
    • 0037827267 scopus 로고    scopus 로고
    • Prevention of osteoporosis and uterine effects in postmenopausal women taking raloxifene for 5 years
    • Jolly E.E., Bjarnason N.H., Neven P., Plouffe Jr. L., Johnston Jr. C.C., Watts S.D., et al. Prevention of osteoporosis and uterine effects in postmenopausal women taking raloxifene for 5 years. Menopause 10 4 (2003) 337-344
    • (2003) Menopause , vol.10 , Issue.4 , pp. 337-344
    • Jolly, E.E.1    Bjarnason, N.H.2    Neven, P.3    Plouffe Jr., L.4    Johnston Jr., C.C.5    Watts, S.D.6
  • 9
    • 1542346451 scopus 로고    scopus 로고
    • Endocrine prevention of breast cancer using selective oestrogen receptor modulators (SORMs)
    • (Review)
    • Lo S.S., and Vogel V.G. Endocrine prevention of breast cancer using selective oestrogen receptor modulators (SORMs). Best Pract. Res. Clin. Endocrinol. Metab. 18 1 (2004) 97-111 (Review)
    • (2004) Best Pract. Res. Clin. Endocrinol. Metab. , vol.18 , Issue.1 , pp. 97-111
    • Lo, S.S.1    Vogel, V.G.2
  • 11
    • 0034052849 scopus 로고    scopus 로고
    • An update on estrogen receptors
    • (Review)
    • Gustafsson J.A. An update on estrogen receptors. Semin. Perinatol. 24 1 (2000) 66-69 (Review)
    • (2000) Semin. Perinatol. , vol.24 , Issue.1 , pp. 66-69
    • Gustafsson, J.A.1
  • 12
    • 0041878673 scopus 로고    scopus 로고
    • What pharmacologists can learn from recent advances in estrogen signalling
    • (Review)
    • Gustafsson J.A. What pharmacologists can learn from recent advances in estrogen signalling. Trends Pharmacol. Sci. 24 9 (2003) 479-485 (Review)
    • (2003) Trends Pharmacol. Sci. , vol.24 , Issue.9 , pp. 479-485
    • Gustafsson, J.A.1
  • 13
    • 18844429222 scopus 로고    scopus 로고
    • Reflections on the discovery and significance of estrogen receptor beta
    • (Review)
    • Koehler K.F., Helguero L.A., Haldosen L.A., Warner M., and Gustafsson J.A. Reflections on the discovery and significance of estrogen receptor beta. Endocr. Rev. 26 3 (2005) 465-478 (Review)
    • (2005) Endocr. Rev. , vol.26 , Issue.3 , pp. 465-478
    • Koehler, K.F.1    Helguero, L.A.2    Haldosen, L.A.3    Warner, M.4    Gustafsson, J.A.5
  • 15
    • 0031039888 scopus 로고    scopus 로고
    • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    • Kuiper G.G., Carlsson B., Grandien K., Enmark E., Haggblad J., Nilsson S., et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138 3 (1997) 863-870
    • (1997) Endocrinology , vol.138 , Issue.3 , pp. 863-870
    • Kuiper, G.G.1    Carlsson, B.2    Grandien, K.3    Enmark, E.4    Haggblad, J.5    Nilsson, S.6
  • 16
    • 0033649898 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators (SERMs) in clinical practice
    • (Review)
    • Plouffe Jr. L. Selective estrogen receptor modulators (SERMs) in clinical practice. J. Soc. Gynecol. Investig. 7 1 Suppl. (2000) S38-S46 (Review)
    • (2000) J. Soc. Gynecol. Investig. , vol.7 , Issue.1 SUPPL
    • Plouffe Jr., L.1
  • 17
    • 23944500879 scopus 로고    scopus 로고
    • Skeletal and nonskeletal effects of raloxifene
    • Gluck O., and Maricic M. Skeletal and nonskeletal effects of raloxifene. Curr. Osteoporos. Rep. 1 3 (2003) 123-128
    • (2003) Curr. Osteoporos. Rep. , vol.1 , Issue.3 , pp. 123-128
    • Gluck, O.1    Maricic, M.2
  • 18
    • 24044490608 scopus 로고    scopus 로고
    • Urogenital effects of selective estrogen receptor modulators: a systematic review
    • Albertazzi P., and Sharma S. Urogenital effects of selective estrogen receptor modulators: a systematic review. Climacteric 8 3 (2005) 214-220
    • (2005) Climacteric , vol.8 , Issue.3 , pp. 214-220
    • Albertazzi, P.1    Sharma, S.2
  • 19
    • 0037186894 scopus 로고    scopus 로고
    • Tissue-specific estrogenic response and molecular mechanisms
    • (Review)
    • Diel P. Tissue-specific estrogenic response and molecular mechanisms. Toxicol. Lett. 127 1-3 (2002) 217-224 (Review)
    • (2002) Toxicol. Lett. , vol.127 , Issue.1-3 , pp. 217-224
    • Diel, P.1
  • 20
    • 19744365947 scopus 로고    scopus 로고
    • Molecular mechanism of action of selective estrogen receptor modulator in target tissues
    • (Review)
    • Ohmichi M., Tasaka K., Kurachi H., and Murata Y. Molecular mechanism of action of selective estrogen receptor modulator in target tissues. Endocr. J. 52 2 (2005) 161-167 (Review)
    • (2005) Endocr. J. , vol.52 , Issue.2 , pp. 161-167
    • Ohmichi, M.1    Tasaka, K.2    Kurachi, H.3    Murata, Y.4
  • 21
    • 0037301242 scopus 로고    scopus 로고
    • Phytoestrogens-mechanism of action and effect on bone markers and bone mineral density
    • (Review)
    • Fitzpatrick L.A. Phytoestrogens-mechanism of action and effect on bone markers and bone mineral density. Endocrinol. Metab. Clin. N. Am. 32 1 (2003) 233-252 (Review)
    • (2003) Endocrinol. Metab. Clin. N. Am. , vol.32 , Issue.1 , pp. 233-252
    • Fitzpatrick, L.A.1
  • 22
    • 0031816540 scopus 로고    scopus 로고
    • Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists
    • Barkhem T., Carlsson B., Nilsson Y., Enmark E., Gustafsson J., and Nilsson S. Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. Mol. Pharmacol. 54 1 (1998) 105-112
    • (1998) Mol. Pharmacol. , vol.54 , Issue.1 , pp. 105-112
    • Barkhem, T.1    Carlsson, B.2    Nilsson, Y.3    Enmark, E.4    Gustafsson, J.5    Nilsson, S.6
  • 23
    • 0033198735 scopus 로고    scopus 로고
    • Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist
    • Pike A.C., Brzozowski A.M., Hubbard R.E., Bonn T., Thorsell A.G., Engstrom O., et al. Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist. EMBO J. 18 17 (1999) 4608-4618
    • (1999) EMBO J. , vol.18 , Issue.17 , pp. 4608-4618
    • Pike, A.C.1    Brzozowski, A.M.2    Hubbard, R.E.3    Bonn, T.4    Thorsell, A.G.5    Engstrom, O.6
  • 24
    • 3042840787 scopus 로고    scopus 로고
    • Dissecting physiological roles of estrogen receptor alpha and beta with potent selective ligands from structure-based design
    • Hillisch A., Peters O., Kosemund D., Muller G., Walter A., Schneider B., et al. Dissecting physiological roles of estrogen receptor alpha and beta with potent selective ligands from structure-based design. Endocrinol. 18 7 (2004) 1599-1609
    • (2004) Endocrinol. , vol.18 , Issue.7 , pp. 1599-1609
    • Hillisch, A.1    Peters, O.2    Kosemund, D.3    Muller, G.4    Walter, A.5    Schneider, B.6
  • 26
    • 22744459921 scopus 로고    scopus 로고
    • 2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats
    • 2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats. Cardiovasc. Res. 67 4 (2005) 604-612
    • (2005) Cardiovasc. Res. , vol.67 , Issue.4 , pp. 604-612
    • Pelzer, T.1    Jazbutyte, V.2    Hu, K.3    Segerer, S.4    Nahrendorf, M.5    Nordbeck, P.6
  • 27
    • 3042662336 scopus 로고    scopus 로고
    • The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and proliferation in the rat is associated with a substance specific modulation of uterine gene expression
    • Diel P., Geis R.B., Caldarelli A., Schmidt S., Leschowsky U.L., Voss A., et al. The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and proliferation in the rat is associated with a substance specific modulation of uterine gene expression. Mol. Cell. Endocrinol. 30 221(1-2) (2004) 21-32
    • (2004) Mol. Cell. Endocrinol. , vol.30 , Issue.221 1-2 , pp. 21-32
    • Diel, P.1    Geis, R.B.2    Caldarelli, A.3    Schmidt, S.4    Leschowsky, U.L.5    Voss, A.6
  • 28
    • 27644474249 scopus 로고    scopus 로고
    • Tissue-specific modulation of cyclooxygenase-2 (Cox-2) expression in the uterus and the v. cava by estrogens and phytoestrogens
    • Hertrampf T., Schmidt S., Laudenbach-Leschowsky U., Seibel J., and Diel P. Tissue-specific modulation of cyclooxygenase-2 (Cox-2) expression in the uterus and the v. cava by estrogens and phytoestrogens. Mol. Cell. Endocrinol. 243 1-2 (2005) 51-57
    • (2005) Mol. Cell. Endocrinol. , vol.243 , Issue.1-2 , pp. 51-57
    • Hertrampf, T.1    Schmidt, S.2    Laudenbach-Leschowsky, U.3    Seibel, J.4    Diel, P.5
  • 31
    • 0035654437 scopus 로고    scopus 로고
    • Estrogen receptors and endocrine diseases: lessons from estrogen receptor knockout mice
    • (Review)
    • Mueller S.O., and Korach K.S. Estrogen receptors and endocrine diseases: lessons from estrogen receptor knockout mice. Curr. Opin. Pharmacol. 1 6 (2001) 613-619 (Review)
    • (2001) Curr. Opin. Pharmacol. , vol.1 , Issue.6 , pp. 613-619
    • Mueller, S.O.1    Korach, K.S.2
  • 32
    • 3042543745 scopus 로고    scopus 로고
    • Effects of isoflavones (soy phyto-estrogens) on serum lipids: a meta-analysis of randomized controlled trials
    • Yeung J., and Yu T.F. Effects of isoflavones (soy phyto-estrogens) on serum lipids: a meta-analysis of randomized controlled trials. Nutr. J. 19 2 (2003) 15
    • (2003) Nutr. J. , vol.19 , Issue.2 , pp. 15
    • Yeung, J.1    Yu, T.F.2
  • 33
    • 0037233212 scopus 로고    scopus 로고
    • Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity
    • Ogawa S., Chan J., Gustafsson J.A., Korach K.S., and Pfaff D.W. Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity. Endocrinology 144 1 (2003) 230-239
    • (2003) Endocrinology , vol.144 , Issue.1 , pp. 230-239
    • Ogawa, S.1    Chan, J.2    Gustafsson, J.A.3    Korach, K.S.4    Pfaff, D.W.5
  • 34
    • 0034900562 scopus 로고    scopus 로고
    • Effects of the phytoestrogen coumestrol on locomotor and fear-related behaviors in female mice
    • Garey J., Morgan M.A., Frohlich J., McEwen B.S., and Pfaff D.W. Effects of the phytoestrogen coumestrol on locomotor and fear-related behaviors in female mice. Horm. Behav. 40 1 (2001) 65-76
    • (2001) Horm. Behav. , vol.40 , Issue.1 , pp. 65-76
    • Garey, J.1    Morgan, M.A.2    Frohlich, J.3    McEwen, B.S.4    Pfaff, D.W.5
  • 35
    • 0036096405 scopus 로고    scopus 로고
    • Genistein affects ER beta- but not ER alpha-dependent gene expression in the hypothalamus
    • Patisaul H.B., Melby M., Whitten P.L., and Young L.J. Genistein affects ER beta- but not ER alpha-dependent gene expression in the hypothalamus. Endocrinology 143 6 (2002) 2189-2197
    • (2002) Endocrinology , vol.143 , Issue.6 , pp. 2189-2197
    • Patisaul, H.B.1    Melby, M.2    Whitten, P.L.3    Young, L.J.4
  • 36
    • 27744586293 scopus 로고    scopus 로고
    • Betaeta-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats
    • Walf A.A., and Frye C.A. Betaeta-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats. Neuropsychopharmacology 30 9 (2005) 1598-1609
    • (2005) Neuropsychopharmacology , vol.30 , Issue.9 , pp. 1598-1609
    • Walf, A.A.1    Frye, C.A.2
  • 37
    • 0038013575 scopus 로고    scopus 로고
    • Sex steroids and bone: current perspectives
    • (Review)
    • Balasch J. Sex steroids and bone: current perspectives. Hum. Reprod. Updat. 9 3 (2003) 207-222 (Review)
    • (2003) Hum. Reprod. Updat. , vol.9 , Issue.3 , pp. 207-222
    • Balasch, J.1
  • 38
    • 4544269903 scopus 로고    scopus 로고
    • Evaluation of the preventive effect of isoflavone extract on bone loss in ovariectomized rats
    • Lee Y.B., Lee H.J., Kim K.S., Lee J.Y., Nam S.Y., Cheon S.H., et al. Evaluation of the preventive effect of isoflavone extract on bone loss in ovariectomized rats. Biosci. Biotechnol. Biochem. 68 5 (2004) 1040-1045
    • (2004) Biosci. Biotechnol. Biochem. , vol.68 , Issue.5 , pp. 1040-1045
    • Lee, Y.B.1    Lee, H.J.2    Kim, K.S.3    Lee, J.Y.4    Nam, S.Y.5    Cheon, S.H.6
  • 41
    • 0034799329 scopus 로고    scopus 로고
    • The role of phytoestrogens in the prevention and treatment of osteoporosis in ovarian hormone deficiency
    • Arjmandi B.H. The role of phytoestrogens in the prevention and treatment of osteoporosis in ovarian hormone deficiency. J. Am. Coll. Nutr. 20 5 Suppl. (2001) 398S-402S
    • (2001) J. Am. Coll. Nutr. , vol.20 , Issue.5 SUPPL
    • Arjmandi, B.H.1
  • 42
    • 0042785118 scopus 로고    scopus 로고
    • Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies
    • (Review)
    • Setchell K.D., and Lydeking-Olsen E. Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Am. J. Clin. Nutr. 78 3 Suppl. (2003) 593S-609S (Review)
    • (2003) Am. J. Clin. Nutr. , vol.78 , Issue.3 SUPPL
    • Setchell, K.D.1    Lydeking-Olsen, E.2
  • 44
    • 0037249209 scopus 로고    scopus 로고
    • Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells
    • Zhou S., Turgeman G., Harris S.E., Leitman D.C., Komm B.S., Bodine P.V., et al. Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells. Mol. Endocrinol. 17 1 (2003 (Jan)) 56-66
    • (2003) Mol. Endocrinol. , vol.17 , Issue.1 , pp. 56-66
    • Zhou, S.1    Turgeman, G.2    Harris, S.E.3    Leitman, D.C.4    Komm, B.S.5    Bodine, P.V.6
  • 45
    • 0037334198 scopus 로고    scopus 로고
    • Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production
    • Jia T.L., Wang H.Z., Xie L.P., Wang X.Y., and Zhang R.Q. Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production. Biochem. Pharmacol. 65 5 (2003) 709-715
    • (2003) Biochem. Pharmacol. , vol.65 , Issue.5 , pp. 709-715
    • Jia, T.L.1    Wang, H.Z.2    Xie, L.P.3    Wang, X.Y.4    Zhang, R.Q.5
  • 46
    • 33744940840 scopus 로고    scopus 로고
    • Combined effects of physical activity, dietary isoflavones and 17beta-estradiol on movement drive, body weight and bone mineral density in ovariectomized female rats
    • Hertrampf T., Degen G.H., Kaid A.A., Laudenbach-Leschowsky U., Seibel J., and Di Virgilio A.L. Combined effects of physical activity, dietary isoflavones and 17beta-estradiol on movement drive, body weight and bone mineral density in ovariectomized female rats. Planta Med. 72 6 (2006 (May)) 484-487
    • (2006) Planta Med. , vol.72 , Issue.6 , pp. 484-487
    • Hertrampf, T.1    Degen, G.H.2    Kaid, A.A.3    Laudenbach-Leschowsky, U.4    Seibel, J.5    Di Virgilio, A.L.6


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