Regulation of the renal sodium-dependent phosphate cotransporter NaPi 2 (Npt2) in acute renal failure due to ischemia and reperfusion

Nephron - Physiology

Volumn 100, Issue 1, 2005, Pages

  Rubinger, Dvora ^a   Wald, Hanna ^a   Gimelreich, Dimitri ^a   Halaihel, Nabil ^b   Rogers, Thomas ^b   Levi, Moshe ^c   Popovtzer, Mordecai M ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Acute renal failure; Cell injury; Ischemia and reperfusion; Parathyroidectomy; Type IIa NaPi cotransporter; Urinary phosphate excretion

Indexed keywords

MESSENGER RNA; NPT2 PROTEIN; PROTEIN SUBUNIT; SODIUM PHOSPHATE COTRANSPORTER; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CLAMP; ARTICLE; BRUSH BORDER; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; DOWN REGULATION; HYPERPHOSPHATEMIA; IMMUNOHISTOCHEMISTRY; KIDNEY ARTERY STENOSIS; KIDNEY CORTEX; KIDNEY FAILURE; KIDNEY ISCHEMIA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; LABELING INDEX; MALE; NONHUMAN; PARATHYROID GLAND; PARATHYROIDECTOMY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SODIUM TRANSPORT;

ANIMALS; GENE EXPRESSION REGULATION; KIDNEY FAILURE, ACUTE; MALE; PARATHYROIDECTOMY; PHOSPHATES; RATS; RATS, WISTAR; REPERFUSION INJURY; RNA, MESSENGER; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE IIA;

EID: 18744394944     PISSN: 16602137     EISSN: None     Source Type: Journal    
DOI: 10.1159/000084463     Document Type: Article

References (47)

1. May RC, Stivelman JC, Marosie BJ: Metabolic and electrolyte disturbances in acute renal failure; in Brenner BM, Lazarus JH (eds): Acute Renal Failure, ed 3. New York, Churchill Livingstone, 1993, pp 107-128.
2. Dolson GM: Electrolyte abnormalities before and after the onset of acute renal failure. Miner Electrolyte Metab 1991;17:133-140.
3. Massry SG, Smogorzewski M: Metabolic and endocrine abnormalities in acute renal failure; in Massry, Glascock (eds): Textbook of Nephrology, 3rd ed., Williams & Wilkins, 1995, chapt 51, vol 2, pp 1004-1013.
4. Popovtzer MM, Massry S, Willamil M, Kleeman CR: Renal handling of phosphorus in oliguric and nonoliguric mercury-induced acute renal failure in rats. J Clin Invest 1971;50:2347-2354.
5. Levi M, Kempson SA, Lötscher M, Biber J, Mürer H: Molecular regulation of renal phosphate transport. J Membr Biol 1996;154:1-9.
6. Mürer H, Forster I, Hilfiker H, Pfister M, Kaissling B, Lötscher M, Biber J: Cellular/molecular control of renal Na/Pi cotransport. Kidney Int 1998;65:S2-S10.
7. Kempson SA, Lötscher M, Kaissling B, Biber J, Mürer H, Levi M: Parathyroid hormone action on phosphate transporter mRNA and protein in rat renal proximal tubule. Am J Physiol 1995;95:1909-1914.
8. Pfister MF, Hilfiker H, Forgo J, Lederer E, Biber J, Mürer H: Cellular mechanisms involved in the acute adaptation of OK cell Na/Pi cotransport to high or low Pi medium. Pflügers Arch 1998;435:713-719.
9. Lötscher M, Kaissling B, Biber J, Mürer H, Levi M: Role of microtubules in the rapid regulation of renal phosphate transport in response to acute alterations in dietary phosphate content. J Clin Invest 1997;99:1302-1312.
10. Sorribas V, Lötscher M, Löffing J, Biber J, Kaissling B, Mürer H, Levi M: Cellular mechanisms of age-related decrease in renal phosphate reabsorption. Kidney Int 1996;50:855-863.
11. Ambühl P, Zajicek HK, Wang H, Puttaparthi K, Levi M: Regulation of renal phosphate transport by acute and chronic metabolic acidosis in the rat. Kidney Int 1998;53:1288-1298.
12. Levi M, Shayman J, Abe A, Gross SK, McCluer RH, Biber J, Mürer H, Lötscher M, Cronin RE: Dexamethasone modulates rat renal brush border membrane phosphate transporter mRNA and protein abundance and glycosphingolipid composition. J Clin Invest 1995;96:207-216.
13. Prahu S, Levi M, Dwarakanath V, Arar M, Biber J, Mürer H, Baum M: Effect of glucocorticoids on neonatal rabbit renal cortical Na/Pi mRNA and protein abundance. Pediatr Res 1997;42:20-24.
14. Alcalde AI, Sarasa M, Raldua D, Aramayona J, Morales R, Biber J, Mürer H, Levi M, Sorribas V: Role of thyroid hormone in regulation of renal phosphate transport in young and aged rats. Endocrinology 1999;140:1544-1551.
15. Pfister MF, Ruf I, Stange G, Ziegler U, Lederer E, Biber J, Mürer H: Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter. Proc Natl Acad Sci USA 1998;95:1909-1914.
16. Kempson SA, Lötscher M, Kaissling B, Biber J, Mürer H, Levi M: Parathyroid hormone action on phosphate transporter mRNA and protein in rat renal proximal tubules. Am J Physiol 1995;268:F784-F791.
17. Lötscher M, Scarpetta Y, Levi M, Halaihel N, Wang H, Zajicek HK, Biber J, Mürer H, Kaissling B: Rapid downregulation of rat renal Na/Pi cotransporter in response to parathyroid hormone involves microtubule rearrangement. J Clin Invest 1999;104:483-494.
18. Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS: Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci USA 1998;95:5372-5377.
19. +/phosphate cotransport and cotransporter gene expression. J Clin Invest 1999;104:679-686.
20. Laouari D, Friedlander G, Burtin M, Silve C, Dechaux M, Garabedian M, Kleinecht C: Subtotal nephrectomy alters tubular function. Kidney Int 1991;52:1550-1560.
21. Dranitzki-Elhalel M, Wald H, Rubinger D, Gal-Moscovici A, Levi ML, Popovtzer MM: Regulation of NaPi-2 mRNA and transporter protein in chronic renal failure: Role of parathyroid hormone and dietary phosphate (abstract). J Am Soc Nephrol 2000;11:617A.
22. Kwon TH, Frøkiaer J, Fernandez-Llama P, Maunsbach AB, Knepper MA, Nielsen S: Altered expression of Na transporters NHE-3, NaPi-II, Na-K-ATPase, BSC-1, and TSC in CRF rat kidneys. Am J Physiol 1999;277:F257-F270.
23. + transporters in kidneys of rats with ischemia-induced acute renal failure. Am J Physiol 2000;278:F925-F939.
24. Xiao Y, Desrosiers RR, Beauliveau R: Effect of ischemia-reperfusion on the renal brush-border membrane sodium-dependent phosphate cotransproter NaPi-2. Can J Physiol Pharmacol 2001;79:206-212.
25. i transport in aged rat. Am J Physiol 1989;256:F85-F94.
26. i cotransport in weaned and suckling rats. Am J Physiol 1999;276:F72-F78.
27. Kempson SA, Lötscher M, Kaissling B, Biber J, Mürer H, Levi M: Parathyroid hormone action on phosphate transporter mRNA and protein in rat proximal tubules. Am J Physiol 1995;268:F784-F791.
28. Kilav R, Silver J, Biber J, Mürer H, Naveh-Many T: Coordinate regulation of rat renal parathyroid hormone receptor mRNA and NaPi cotransporter mRNA and protein. Am J Physiol 1995;268:F1071-F1022.
29. Olgaard K, Schwartz J, Arbelaez M, Slatopolsky E: Impaired skeletal response to parathyroid hormone in uremia: The role of phosphorus. Contrib Nephrol. Basel, Karger, 1985, vol 49, pp 31-37.
30. Keusch I, Traebert M, Lötscher M, Kaissling B, Mürer H, Biber J: Parathyroid hormone and dietary phosphate provoke a lysosomal routing of the proximal tubule NaPi cotransporter type II. Kidney Int 1998;54:1224-1232.
31. Pfister F, Lederer E, Forgo U, Ziegler U, Lötscher M, Quabius ES, Biber J, Mürer H: Parathyroid hormone-dependent degradation of type II Na/Pi cotransporters. J Biol Chem 1997;272:20125-20130.
32. Zhao N, Tenenhouse HS: Npt2 gene disruption confers resistance to the inhibitory action of parathyroid hormone on renal sodium-phosphate cotransport. Endocrinology 2000;141:2159-2165.
33. Di Mari JF, Davis R, Safirstein RL: MAPK activation determines renal epithelial cell survival during oxidative injury. Am J Physiol 1999;277:F195-F203.
34. Lederer ED, Sohi SS, McLeisch KR: Parathyroid hormone stimulates extracellular signal-regulated kinase (ERK) activity through two independent signal transduction pathways: Role of ERK in sodium-phosphate cotransport. J Am Soc Nephrol 2000;11:222-231.
35. Segawa H, Kaneko I, Takahashi A, Kuwahata M, Ito M, Ohkido I, Tatsumi S, Miyamoto K: Growth-related renal type II Na/Pi cotransporter. J Biol Chem 2002;277:19665-19672.
36. Bonventre JV, Weinberg JM: Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 2003;14:2199-2210.
37. Ouenellette AJ, Malt RA, Sukhatme WB, Bonventre JV: Expression of two 'immediate early' genes, Erg-1 and cFos, in response to renal ischemia and during compensatory renal hypertrophy in mice. J Clin Invest 1990;85:766-771.
38. Racusen LC: Renal histopathology and urine cytology and cytopathology; in Goligorsky MS, Stein JH (eds): Acute Renal Failure: New Concepts and Therapeutic Strategies, New York, Churchill Livingstone, 1995, pp 193-229.
39. Rosenberg ME, Paller MS: Differential gene expression in the recovery from ischemic renal injury. Kidney Int 1991;39:1156-1161.
40. Persy VP, Verstrepen WA, Ysebaert DK, De Greef KE, De Broe ME: Differences in osteopontin up-regulation between proximal and distal tubules after renal ischemia/reperfusion. Kidney Int 1999;56:601-611.
41. Rosenberger C, Mandriota S, Jurgensen JS, Wiesener MS, Hørstrup JH, Frei U, Ratcliffe PJ, Maxwell PH, Bachmann S, Eckardt KU: Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 2002;13:1721-1732.
42. Eickelberg O, Seebach F, Riordan M, Thulin G, Mann A, Reidy KH, Van Why SK, Kashgarian M, Siegel N: Functional activation of heat shock factor and hypoxia-inducible factor in the kidney. J Am Soc Nephrol 2002;13:2094-2101.
43. Yoshida T, Kurella M, Beato F, Min H, Ingelfinger JR, Stears RL, Swinford RD, Gullans SR, Tang SS: Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. Kidney Int 2002;61:1646-1654.
44. +-ATPase and suppression of NHE-3. Kidney Int 1997;51:1106-1115.
45. Wang Z, Rabb H, Haq M, Schull GE, Soleimani M: A possible molecular basis of natriuresis during ischemic reperfusion injury in the kidney. J Am Soc Nephrol 1998;9:605-613.
46. Gimelreich D, Popovtzer MM, Wald H, Pizov G, Berlatzky Y, Rubinger D: Regulation of ROMK and channel-inducing factor in acute renal failure due to ischemic reperfusion injury. Kidney Int 2001;59:1812-1820.
47. Kim GH, Martin SW, Fernandez-Llama P, Masilamani S, Packer RK, Knepper MA: Long-term regulation of renal Na-dependent cotransporters and EnaC: Response to altered acid-base intake. Am J Physiol Renal Physiol 2000;279:F459-F467.