Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells

Parasitology International

Volumn 54, Issue 1, 2005, Pages 59-64

  Nara, Takeshi ^a   Kamei, Yuto ^b   Tsubouchi, Akiko ^a   Annoura, Takeshi ^a   Hirota, Kenichiro ^a   Iizumi, Kyoichi ^a   Dohmoto, Yuki ^b   Ono, Takeaki ^b   Aoki, Takashi ^a  

^a JUNTENDO UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

Author keywords

De novo pyrimidine biosynthesis; Dihydroorotate dehydrogenase; Marine algae extracts; Trypanosoma cruzi

Indexed keywords

ALCOHOL; ANTITRYPANOSOMAL AGENT; DIHYDROOROTATE DEHYDROGENASE; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; FUCUS EVANESCENS EXTRACT; METHANOL; PELVETIA BABINGTONII EXTRACT; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; BROWN ALGA; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; GREEN ALGA; HELA CELL; HOST CELL; HUMAN; HUMAN CELL; INFECTION RATE; MAMMAL CELL; NONHUMAN; PARASITE DEVELOPMENT; PRIORITY JOURNAL; PROTOZOON; RED ALGA; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ALGAE; FUCUS EVANESCENS; MAMMALIA; PELVETIA; PHAEOPHYCEAE; PROTOZOA; RHODOPHYTA; SILVETIA BABINGTONII; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 13844276417     PISSN: 13835769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.parint.2004.11.001     Document Type: Article

References (22)

1. J.A. Urbina Chemotherapy of chagas disease Curr. Pharm. Des. 8 2002 287 295
2. J.A. Urbina, and R. Docampo Specific chemotherapy of chagas disease: controversies and advances Trends Parasitol. 19 2003 495 501
3. W.E. Gutteridge, and M. Gaborak A re-examination of purine and pyrimidine synthesis in the three main forms of Trypanosoma cruzi Int. J. Biochem. 10 1979 415 422
4. G. Gao, T. Nara, J. Nakajima-Shimada, and T. Aoki Novel organization and sequences of five genes encoding all six enzymes for de novo pyrimidine biosynthesis in Trypanosoma cruzi J. Mol. Biol. 285 1999 149 161
5. T. Nara, T. Hshimoto, and T. Aoki Evolutionary implications of the mosaic pyrimidine-biosynthetic pathway in eukaryotes Gene 257 2000 209 222
6. E. Takashima, D.K. Inaoka, A. Osanai, T. Nara, M. Odaka, and T. Aoki Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi Mol. Biochem. Parasitol. 122 2002 189 200
7. Annoura T., Nara, T., Makiuchi T., Hashimoto T., Aoki T. The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions. J. Mol. Evol. [in press]
8. H. Harada, T. Noro, and Y. Kamei Selective antitumor activity in vitro from marine algae from Japan coasts Biol. Pharm. Bull. 20 1997 541 546
9. A. Isnansetyo, M. Horikawa, and Y. Kamei In vitro anti-methicillin- resistant Staphylococcus aureus activity of 2,4-diacetylphloroglucinol produced by Pseudomonas sp. AMSN isolated from a marine alga J. Antimicrob. Chemother. 47 2001 724 725
10. T. Nakano, T. Noro, and Y. Kamei In vitro promoting activity of human interferon β production by extracts of marine algae from Japan Cytotechnology 25 1997 237 239
11. J.J. Sims, M.S. Donnell, J.V. Leary, and G.H. Lacy Antimicrobial agents from marine algae Antimicrob. Agents Chemother. 7 1975 320 321
12. Y. Kaneda, K. Nagakura, and T. Goutsu Lipid composition of three morphological stages of Trypanosoma cruzi Comp. Biochem. Physiol., B 83 1986 533 536
13. J. Nakajima-Shimada, Y. Hirota, and T. Aoki Inhibition of Trypanosoma cruzi growth in mammalian cells by purine and pyrimidine analogs Antimicrob. Agents Chemother. 40 1996 2455 2458
14. H. Harada, and Y. Kamei Dose-dependent selective cytotoxicity of extracts from marine green alga, Cladophoropsis vaucheriaeformis, against mouse leukemia L1210 cells Biol. Pharm. Bull. 21 1998 386 389
15. T. Nara, Y. Hirayama-Noguchi, G. Gao, E. Murai, T. Annoura, and T. Aoki Diversity of aspartate carbamoyltransferase genes of Trypanosoma cruzi Int. J. Parasitol. 33 2003 845 852
16. D. Karibian Dihydroorotate dehydrogenase (Escherichia coli) Methods Enzymol. 51 1978 58 63
17. S.F. Chen, R.L. Ruben, and D.L. Dexter Mechanism of action of the novel anticancer agent 6-fluoro-2-(2′-fluoro-1,1′-biphenyl-4-yl)-3-methyl- 4-quinolinecarboxylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis Cancer Res. 46 1986 5014 5019
18. I. Ittarat, W. Asawamahasakda, M.S. Bartlett, J.W. Smith, and S.R. Meshnick Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase Antimicrob. Agents Chemother. 39 1995 325 328
19. K. Rückemann, L.D. Fairbanks, E.A. Carrey, C.M. Hawrylowicz, D.F. Richards, B. Kirschbaum, and H.A. Simmonds Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans J. Biol. Chem. 273 1998 21682 21691
20. S. Sanders, and V. Harisdangkul Leflunomide for the treatment of rheumatoid arthritis and autoimmunity Am. J. Med. Sci. 323 2002 190 193
21. J.E. McLean, E.A. Neidhardt, T.H. Grossman, and L. Hedstrom Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase Biochemistry 40 2001 2194 2200
22. J. Baldwin, A.M. Farajallah, N.A. Malmquist, P.K. Rathod, and M.A. Phillips Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity J. Biol. Chem. 277 2002 41827 41834