Basics of polymeric scaffolds for tissue engineering

Journal of ASTM International

Volumn 3, Issue 9, 2006, Pages

  Agrawal, C Mauli ^a   Janell Carter, B S ^a   Ong, Joo L ^a  

^a University of Texas at San Antonio   (United States)

Author keywords

Biodegradable; Diffusion; Fabrication techniques; Permeability; Polymer; Porosity; Scaffold science; Surface modification; Surface properties; Tissue engineering

Indexed keywords

BIOREACTORS MIXING; DIFFUSION CHARACTERISTICS; FABRICATION TECHNIQUES; SCAFFOLD SCIENCE;

BIODEGRADABLE POLYMERS; DIFFUSION; MECHANICAL PERMEABILITY; POROSITY; SURFACE PROPERTIES; SURFACE TREATMENT; TISSUE ENGINEERING;

SCAFFOLDS;

EID: 34248204533     PISSN: None     EISSN: 1546962X     Source Type: Journal    
DOI: 10.1520/JAI100428     Document Type: Article

References (71)

1. Agrawal, C. M. and Ray, R. B., "Biodegradable Polymeric Scaffolds for Musculoskeletal Tissue Engineering," J. Biomed. Mater. Res., Vol. 55, No. 2, 2001, pp. 141-150.
2. Hutmacher, D., "Scaffolds in Tissue Engineering Bone and Cartilage," Biomaterials, Vol. 21, No. 24, 2000, pp. 2529-2543.
3. Wei, S., Darling, A., Starly, B., and Nam, J., "Computer-Aided Tissue Engineering: Overview, Scope, and Challenges," Biotechnol. Appl. Biochem., Vol. 39, 2004, pp. 29-47.
4. Schmitz, J. P. and Hollinger, J. O., "A Preliminary Study of the Osteogenic Potential of a Biodegradable Alloplastic-Osteoinductive Alloimplant," Clin. Orthop., No. 237, 1988, pp. 245-255.
5. Singhal, A. R., Agrawal, C. M., and Athanasiou, K. A., "Salient Degradation Features of a 50:50 PLA/PGA Scaffold for Tissue Engineering," Tissue Eng., Vol. 2, No. 3, 1996, pp. 197-207.
6. Athanasiou, K. A., Singhal, A. R., Agrawal, C. M., and Boyan, B. D., "In Vitro Biodegradation and Release Characteristics of Biodegradable Implants Containing Trypsin Inhibitor," Clin. Orthop., No. 315, 1995, pp. 272-281.
7. Heckman, J. D., Boyan, B. D., Aufdemorte, T. B., and Abbott, J. T., "The Use of Bone Morphogenetic Protein in the Treatment of Non-union in a Canine Model," J. Bone Jt. Surg., Am. Vol., Vol. 73, No. 5, 1991, pp. 750-764.
8. Ma, P. and Zhang, R., "Microtubular Architecture of Biodegradable Polymer Scaffolds," J. Biomed. Mater. Res., Vol. 56, No. 4, 2001, pp. 469-477.
9. Li, W., Laurencin, C. T., Caterson, E. J., Tuan, R. S., and Ko, F. K., "Electrospun Nanofiber Structure: A Novel Scaffold for Tissue Engineering," J. Biomed. Mater. Res., Vol. 60, No. 4, 2002, pp. 613-621.
10. Li, W., Tuli, R., Chukwuka, O., Derfoul, A., Danielson, K. G., Hall, D. J., and Tuan, R. S., "A Three-Dimensional Nanofibrous Scaffold for Cartilage Tissue Engineering Using Human Mesenchymal Stem Cells," Biomaterials, Vol. 26, No. 6, 2005, pp. 599-609.
11. Cooper, J. A., Lu, H. H., Ko, F. K., Freeman, J. W., and Laurencin, C. T., "Fiber-Based Tissue Engineered Scaffold for Ligament Replacement: Design Considerations and In Vitro Evaluation," Biomaterials, Vol. 26, No. 13, 2005, pp. 1523-1532.
12. Coombes, A. G. and Heckman, J. D., "Gel Casting of Resorbable Polymers. 1. Processing and Applications," Biomaterials, Vol. 1.3, No. 4, 1992, pp. 217-224.
13. Coombes, A. G. and Heckman, J. D., "Gel Casting of Resorbable Polymers. 2. In-Vitro Degradation of Bone Graft Substitutes," Biomaterials, Vol. 13, No. 5, 1992, pp. 297-307.
14. Agrawal, C. M., Bert, J., Heckman, J. D., and Boyan, B. D., "Protein Release Kinetics of a Biodegradable Implant for Fracture Non-unions," Tissue Eng., Vol. 16, No. 16, 1995, pp. 1255-1260.
15. Agrawal, C. M., Kennedy, M. E., and Micallef, D. M., "The Effects of Ultrasound Irradiation on a Biodegradable 50-50 % Copolymer of Polylactic and Polyglycolic Acids," J. Biomed. Mater. Res., Vol. 28, No. 8, 1994, pp. 851-859.
16. Coombes, A. G. A., Rizzi, S. C., Williamson, M., Barralet, J. E., Downes, S., and Wallace, W. A., "Precipitation Casting of Polycaprolactone for Applications in Tissue Engineering and Drug Delivery," Biomaterials, Vol. 25, No. 2, 2004, pp. 315-325.
17. Nof, M. and Shea, L., "Drug-Releasing Scaffolds Fabricated From Drug-Loaded Microspheres," J. Biomed. Mater. Res., Vol. 59, No. 2, 2002, pp. 349-356.
18. Mercier, M. R., Constantino, H. R., Tracy, M. A., and Bonassar, L. J., "Poly(lactide-co-glycolide) Microspheres as a Moldable Scaffold for Cartilage Tissue Engineering," Biomaterials, Vol. 26, No. 14, 2005, pp. 1945-1952.
19. Borden, M., Attawia, M., Khan, Y., and Laurencin, C. T., "Tissue Engineered Microsphere-Based Matrices for Bone Repair: Design and Evaluation," Biomaterials, Vol. 23, No. 2, 2002, pp. 551-559.
20. Mikos, A. G., Sarakinos, G., Leite, S. M., Vacanti, J. P., and Langer, R., "Laminated Three-Dimensional Biodegradable Foams for Use in Tissue Engineering," Biomaterials, Vol. 14, No. 5, 1.993, pp. 323-330.
21. Freed, L., Marquis, J. C., Nohria, A., Emmanual, J., Mikos, A. G., and Langer, R., "Neocartilage Formation In Vitro and In Vivo Using Cells Cultured on Synthetic Biodegradable Polymers," J. Biomed. Mater. Res., Vol. 27, No. 1, 1993, pp. 11-23.
22. Yoon, J. and Park, T., "Degradation Behaviors of Biodegradable Macroporous Scaffolds Prepared by Gas Foaming of Effervescent Salts," J. Biomed. Mater. Res., Vol. 55, No. 3, 2001, pp. 401-408.
23. Mooney, D. J., Baldwin, D. F., Suh, N. P., Vacanti, J. P., and Langer, R., "Novel Approach to Fabricate Porous Sponges of Poly(D,L-lactic-co- glycolic acid) Without the Use of Organic Solvents," Biomaterials, Vol. 17, No. 14, 1996, pp. 1417-1422.
24. Harris, L. D., Kim, B. S., and Mooney, D. J., "Open Pore Biodegradable Matrices Formed With Gas Foaming," J. Biomed. Mater. Res., Vol. 42, No. 3, 1998, pp. 396-402.
25. Barry, J. J. A., Gidda, H. S., Scotchford, C. A., and Howdle, S. M., "Porous Methacrylate Scaffolds: Supercritical Fluid Fabrication and In Vitro Chondrocyte Responses," Biomaterials, Vol. 25, No. 17, 2004, pp. 3559-3568.
26. Giordano, R. A., Wu, B. M., Borland, S. W., Cima, L. G., Sachs, E. M., and Cima, M. J., "Mechanical Properties of Dense Polylactic Acid Structures Fabricated by Three Dimensional Printing," J. Biomater. Sci., Polym. Ed., Vol. 8, No. 1, 1996, pp. 63-75.
27. Gomes, M., Ribeiro, A., Malafaya, P., Reis, R., and Cunha, A., "A New Approach Based on Injection Moulding to Produce Biodegradable Starch-Based Polymeric Scaffolds: Morphology, Mechanical and Degradation Behaviour," Biomaterials, Vol. 22, No. 9, 2001, pp. 883-889.
28. Agrawal, C. M., McKinney, J. S., Huang, D., and Athanasiou, K. A., "The Use of the Vibrating Particle Technique to Fabricate Highly Permeable Biodegradable Scaffolds," C. M. Agrawal, J. Parr, and S. Lin, Eds., Synthetic Bioabsorbable Polymers for Implants, ASTM STP 1396, ASTM, International, West Conshohocken, PA, 2000.
29. Ishaug-Riley, S., "Bone Formation by Three-Dimensional Stromal Osteoblast Culture in Biodegradable Polymer Scaffolds," J. Biomed. Mater. Res., Vol. 36, No. 1, 1997, pp. 17-28.
30. Goldstein, A. S., Juarez, T., Helmke, C. D., Gustin, M. C., and Mikos, A. G., "Effect of Convection on Osteoblastic Cell Growth and Function in Biodegradable Polymer Foam Scaffolds," Biomaterials, Vol. 22, No. 11, 2001, pp. 1279-1288.
31. Mooney, D. J., McNamara, K., Hern, D., Vacanti, J. P., and Langer, R., "Stabilized Polyglycolic Acid Fibre-Based Tubes for Tissue Engineering," Biomaterials, Vol. 17, No. 2, 1996, pp. 115-124.
32. Kim, B. S. and Mooney, D. J., "Development of Biocompatible Synthetic Extracellular Matrices for Tissue Engineering," Trends Biotechnol., Vol. 16, No. 5, 1998, pp. 224-230.
33. Vacanti, J. P., "Beyond Transplantation. Third Annual Samuel Jason Mixter Lecture," Arch. Surg. (Chicago), Vol. 123, No. 5, 1988, pp. 545-549.
34. Vacanti, J. P., Morse, M. A., Saltzman, W. M., Domb, A. J., Perez-Atayde, A., Langer, R., Mazzoni, C. L., and Breuer, C., "Selective Cell Transplantation Using Bioabsorbable Artificial Polymers as Matrices," J. Pediatr. Surg., Vol. 23, No. 1 Pt. 2, 1988, pp. 3-9.
35. van Tienen, T., Heijkants, R., Buma, P., de Groot, J., Pennings, A., and Veth, R., "Tissue Ingrowth and Degradation of Two Biodegradable Porous Polymers with Different Porosities and Pore Sizes," Biomaterials, Vol. 23, No. 8, 2002, pp. 1731-1738.
36. Freed, L. E., Vunjak-Novakovic, G., Biron, R. J., Eagles, D. B., Lesnoy, D. C., Barlow, S. K., and Langer, R., "Biodegradable Polymer Scaffolds for Tissue Engineering," Biotechnology, Vol. 12, No. 7, 1994, pp. 689-693.
37. Agrawal, C. M., McKinney, J., Lanctot, D., and Athanasiou, K., "Effects of Fluid Flow on the In Vitro Degradation Kinetics of Biodegradable Scaffolds for Tissue Engineering," Biomaterials, Vol. 21, No. 23, 2000, pp. 2443-2452.
38. Athanasiou, K. A., Schmitz, J. P., and Agrawal, C. M., "The Effects of Porosity on Degradation of PLA-PGA Implants," Tissue Eng., Vol. 4, 1998, pp. 53-63.
39. Itälä, A., Ylänen, H. O., Ekholm, C., Karisson, K. H., and Aro, H. T., "Pore Diameter of More Than 100 μm is Not Requisite for Bone Ingrowth in Rabbits," J. Biomed. Mater. Res., Part B: Appl. Biomater., Vol. 58, 2001, pp. 679-683.
40. Ishaug-Riley, S. L., Crane-Kruger, G. M., Yaszemski, M. J., and Mikos, A. G., "Three-Dimensional Culture of Rat Calvarial Osteoblasts in Porous Biodegradable Polymers," Biomaterials, Vol. 19, No. 15, 1998, pp. 1405-1412.
41. Peter, S. J., Miller, M. J., Yasko, A. W., Yaszemski, M. J., and Mikos, A. G., "Polymer Concepts in Tissue Engineering," J. Biomed. Mater. Res., Vol. 43, No. 4, 1998, pp. 422-427.
42. Goldstein, A. S., Zhu, G., Morris, G. E., Meszlenyi, R. K., and Mikos, A. G., "Effect of Osteoblastic Culture Conditions on the Structure of Poly(DL-lactic-co-glycolic acid) Foam Scaffolds," Tissue Eng., Vol. 5, No. 5, 1999, pp. 421-433.
43. Nam, Y. S. and Park, T. G., "Porous Biodegradable Polymeric Scaffolds Prepared by Thermally Induced Phase Separation," J. Biomed. Mater. Res., Vol. 47, No. 1, 1999, pp. 8-17.
44. Vunjak-Novakovic, G., Freed, L., Biron, R., and Langer, R., "Effects of Mixing on the Composition and Morphology of Tissue-Engineered Cartilage," AIChE J., Vol. 42, No. 3, 1996, pp. 850-860.
45. Gooch, K., Kwon, J., Blunk, T., Langer, R., Freed, L., and Vunjak-Novakovic, G., "Effects of Mixing Intensity on Tissue-Engineered Cartilage," Biotechnol. Bioeng., Vol. 72, No. 4, 2001, pp. 402-407.
46. Carrier, R., Rupnick, M., Langer, R., Schoen, F., Freed, L., and Vunjak-Novakovic, G., "Effects of Oxygen on Engineered Cardiac Muscle," Biotechnol. Bioeng., Vol. 78, No. 6, 2002, pp. 617-625.
47. Freed, L. E., Vunjak-Novakovic, G., and Langer, R., "Cultivation of Cell-Polymer Cartilage Implants in Bioreactors," J. Cell. Biochem., Vol. 51, No. 3, 1993, pp. 257-264.
48. Vunjak-Novakovic, G., Martin, I., Obradovic, B., Treppo, S., Grodzinsky, A. J., Langer, R., and Freed, L. E., "Bioreactor Cultivation Conditions Modulate the Composition and Mechanical Properties of Tissue-Engineering Cartilage," J. Orthop. Res., Vol. 17, No. 1, 1999, pp. 130-138.
49. Burg, K. J. L., W. D. Holder, J., Culberson, C. R., Beiler, R. J., Greene, K. G., Loebsack, A. B., Roland, W. D., Eiselt, P., Mooney, D. J., and Halberstadt, C. R., "Comparative Study of Seeding Methods for Three-Dimensional Polymeric Scaffolds," J. Biomed. Mater. Res., Vol. 51, No. 4, 2000, pp. 642-649.
50. Hynes, R. O., "Integrins, Versatility, Modulation, and Signaling in Cell Adhesion," Cell, Vol. 69, No. 1, 1992, pp. 11-25.
51. d'Avis, P., Hessle, H., Cardenas, J., Mullen, D., Malaney, T., Paulson, G., Pierschbacher, M., and Ingram, R. T., "Potent, Integrin Selective RGD-Containing Peptides Promote Cell-Specific Adhesion on Three Dimensional Collagen Matrices," Transactions of the Society for Biomaterials XXI, 1998.
52. Dee, K. C., Andersen, T. T., and Bizios, R., "Design and Function of Novel Osteoblast-Adhesive Peptides for Chemical Modification of Biomaterials," J. Biomed. Mater. Res., Vol. 40, No. 3, 1998, pp. 371-377.
53. Garcia, A. J., Ducheyne, P., and Boettiger, D., "Cell Adhesion Strength Increases Linearly With Adsorbed Fibronectin Surface Density," Tissue Eng., Vol. 3, No. 2, 1997, pp. 197-206.
54. Jeschke, B., Meyer, J., Jonczyk, A., Kessler, H., Adamietz, P., Meenen, N., Kantlehner, M., Goepfert, C., and Nies, B., "RGD-Peptides for Tissue Engineering of Articular Cartilage," Biomaterials, Vol. 23, No. 16, 2002, pp. 3455-3463.
55. Bisson, I., Kosinski, M., Ruault, S., Gupta, B., Hilborn, J., Wurm, F., and Frey, P., "Acrylic Acid Grafting and Collagen Immobilization on Poly(ethylene terephthalate) Surfaces for Adherence and Growth of Human Bladder Smooth Muscle Cells," Biomaterials, Vol. 23, No. 15, 2002, pp. 3149-3158.
56. Cai, K., Yao, K., Lin, S., Yang, Z., Li, X., Xie, H., Qing, T., and Gao, L., "Poly(D,L-lactic acid) Surfaces Modified by Silk Fibroin: Effects of the Culture of Osteoblast In Vitro," Biomaterials, Vol. 23, No. 4, 2002, pp. 1153-1160.
57. Quirk, R., Chan, W., Davies, M., Tendler, J., and Shakesheff, K., "Poly(L-lysine)-GRGDS as a Biomimetic Surface Modifier for Poly(lactic acid)," Biomaterials, Vol. 22, No. 8, 2001, pp. 865-872.
58. El-Amin, S. F., Kofron, M. D., Attawia, M. A., Lu, H. H., Tuan, R. S., and Laurencin, C. T., "Molecular Recognition of Osteoblasts for Tissue Engineered Bone Repair," Clin. Orthop. Relat. Res., Vol. 427, 2004, pp. 220-225.
59. Amstein, C. F. and Hartman, P. A., "Adaptation of Plastic Surfaces for Tissue Culture by Glow Discharge," J. Clin. Microbiol., Vol. 2, No. 1, 1975, pp. 46-54.
60. Hesby, R. M., Haganman, C. R., and Stanford, C. M., "Effects of Radio Frequency Glow Discharge on Impression Material Surface Wettability," J. Prosthet. Dent., Vol. 77, No. 4, 1997, pp. 414-422.
61. Curtis, A. S., Forrester, J. V., Mclnnes, C., and Lawrie, F., "Adhesion of Cells to Polystyrene Surfaces," J. Cell Biol., Vol. 97, No. 5 Pi. 1, 1983, pp. 1500-1506.
62. Curtis, A. S. and McMurray, H., "Conditions for Fibroblast Adhesion Without Fibronectin," J. Cell. Sci., Vol. 86, 1986, pp. 25-33.
63. Ramsey, W. S., Hertl, W., Nowlan, E. D., and Binkowski, N. J., "Surface Treatments and Cell Attachment," In Vitro, Vol. 20, No. 20, 1984, pp. 802-808.
64. Khang, G., Jeon, J. H., Lee, J. W., Cho, S. C., and Lee, H. B., "Cell and Platelet Adhesions on Plasma Glow Discharge-Treated Poly(lactide-co-glycolide)," Biomed. Mater. Eng., Vol. 7, No. 6, 1997, pp. 357-368.
65. Chim, H., Ong, J. L., Schantz, J., Hutmacher, D., and Agrawal, C. M., "Efficacy of Glow Discharge Gas Plasma Treatment as a Surface Modification Process for Three-Dimensional Poly (D,L-lactide) Scaffolds," J. Biomed. Mater. Res., Vol. 65, No. 3, 2003, pp. 327-335.
66. Ayala, D., Ong, J. L., Agrawal, C. M., Boland, E., and Carnes, D., "Angiogenesis on Porous Polylactic Acid Scaffolds," J. Dent. Res., Vol. 82, Special Issue A, 2003, Abstract #0339.
67. Bailey, S., Polan, J., Goswami, N., Munoz, O., Jundt, C., and Agrawal, M., "Gas-Plasma Implants Promote Angiogenesis in the Nude Mouse Omental Model," International Academy of Cardiology, Medimond Publishing Co. Inc., Englewood, NJ, 2001.
68. Bailey, S., Polan, J., Feldman, M., and Agrawal, C., "Endothelial Seeding of Gas Plasma Treated Polymer," Cardiac and Vascular Regeneration, Angiogenesis and Myogenesis, Basic to Therapeutic, Vol. 1, No. 3, 2001, pp. 178-188.
69. Angelica, T., Chim, H., Ong, J. L., and Agrawal, C. M., "Glow-Discharged Gas Plasma Treatment of PLA for Tissue Engineering," Proceedings of the 21st Southern Biomedical Engineering Conference, 2002, 1 pp.
70. Shah, A., Yang, Y., Ong, J. L., Agrawal, C. M., "Effect of Glow Discharge Gas Plasma-Treated Films on Protein Adsorption and Cell Attachment," J. Dent. Res., Vol. 82, Special Issue A, 2003, Abstract #1546.
71. Karageorgiou, V. and Kaplan, D. "Porosity of 3D Biomaterial Scaffolds and Osteogenesis," Biomaterials, Vol. 26, No. 27, 2005, pp. 5474-5491.