Effects of triacylglycerol and diacylglycerol oils on blood clearance, tissue uptake, and hepatic apolipoprotein B secretion in mice

Journal of Lipid Research

Volumn 48, Issue 5, 2007, Pages 1108-1121

  Yasunaga, Koichi ^a   Saito, Shinichiro ^a   Zhang, Yuan Li ^a   Hernandez Ono, Antonio ^a   Ginsberg, Henry N ^a  

^a College of Physicians and Surgeons ^*  (United States)

Author keywords

Chylomicron metabolism; Lipoprotein metabolism; Triglycerides

Indexed keywords

ACYLGLYCEROL; APOLIPOPROTEIN B; APOLIPOPROTEIN E; CHYLOMICRON; DIACYLGLYCEROL; FATTY ACID; LIPID EMULSION; LIPOPROTEIN LIPASE; MONOACYLGLYCEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTRAVENOUS FEEDING; LIPID HYDROLYSIS; LIPID METABOLISM; LIPID TRANSPORT; LIPOLYSIS; LIPOPROTEIN METABOLISM; LIVER CELL; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN SECRETION; TRIACYLGLYCEROL BLOOD LEVEL;

ADMINISTRATION, ORAL; ANIMALS; APOLIPOPROTEINS B; CHYLOMICRONS; DIGLYCERIDES; EMULSIONS; GLYCERIDES; HYDROLYSIS; LIVER; MALE; MICE; MICE, INBRED C57BL; OILS; OXIDATION-REDUCTION; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RNA, MESSENGER; TRIGLYCERIDES;

EID: 34248192212     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600524-JLR200     Document Type: Article

References (39)

1. Tada, N., and H. Yoshida. 2003. Diacylglycerol on lipid metabolism. Curr. Opin. Lipidol. 14: 29-33.
2. Murata, M., K. Hara, and T. Ide. 1994. Alteration by diacylglycerols of the transport and fatty acid composition of lymph chylomicron in rats. Biosci. Biotechnol. Biochem. 58: 1416-1419.
3. Taguchi, H., H. Watanabe, K. Onizawa, T. Nagao, N. Gotoh, T. Yasukawa, R. Tsushima, H. Shimasaki, and H. Itakura. 2000. Double-blind controlled study on the effects of the dietary diacylglycerol on postprandial serum and chylomicron triacylglycerol responses in healthy humans. J. Am. Coll. Nutr. 19: 789-796.
4. Takase, H., K. Shoji, T. Hase, and I. Tokimitsu. 2005. Effect of diacylglycerol on postprandial lipid metabolism in non-diabetic subjects with and without insulin resistance. Atherosclerosis. 180: 197-204.
5. Tada, N., K. Shoji, M. Takeshita, H. Watanabe, H. Yoshida, T. Hase, N. Matsuo, and I. Tokimitsu. 2005. Effects of diacylglycerol ingestion on postprandial hyperlipidemia in diabetes. Clin. Chim. Acta. 353: 87-94.
6. Taguchi, H., T. Nagao, H. Watanabe, K. Onizawa, N. Matsuo, I. Tokimitsu, and H. Itakura. 2001. Energy value and digestibility of dietary oil containing mainly 1,3-diayclglycerol are similar to those of triacylglycerol. Lipids. 36: 379-382.
7. Kondo, H., T. Hase, T. Murase, and I. Tokimitsu. 2003. Digestion and assimilation features of dietary DAG in the rat small intestine. Lipids. 38: 25-30.
8. Yanagita, T., I. Ikeda, Y. M. Wang, and H. Nakagiri. 2004. Comparison of the lymphatic transport of radiolabeled 1,3-dioleoylglycerol and trioleoylglycerol in rats. Lipids. 39: 827-832.
9. Osaki, N., S. Meguro, N. Yajima, N. Matsuo, I. Tokimitsu, and H. Shimasaki. 2005. Metabolites of dietary triacylglycerol and diacylglycerol during the digestion process in rats. Lipids. 40: 281-286.
10. Karpe, F., and M. Hultin. 1995. Endogenous triglyceride-rich lipoproteins accumulate in rat plasma when competing with a chylomicron-like triglyceride emulsion for a common lipolytic pathway. J. Lipid Res. 36: 1557-1566.
11. Hultin, M., C. Carneheim, K. Rosenqvist, and T. Olivecrona. 1995. Intravenous lipid emulsions: removal mechanisms as compared to chylomicrons. J. Lipid Res. 36: 2174-2184.
12. Deckelbaum, R. J., J. A. Hamilton, A. Moser, G. Bengtsson-Olivecrona, E. Butbul, Y. A. Carpentier, A. Gutman, and T. Olivecrona. 1990. Medium-chain versus long-chain triacylglycerol emulsion hydrolysis by lipoprotein lipase and hepatic lipase: implications for the mechanisms of lipase action. Biochemistry. 29: 1136-1142.
13. Hultin, M., A. Mullertz, M. A. Zundel, G. Olivecrona, T. T. Hansen, R. J. Deckelbaum, Y. A. Carpentier, and T. Olivecrona. 1994. Metabolism of emulsions containing medium- and long-chain triglycerides or interesterified triglycerides. J. Lipid Res. 35: 1850-1860.
14. Oliveira, F. L., S. C. Rumsey, E. Schlotzer, I. Hansen, Y. A. Carpentier, and R. J. Deckelbaum. 1997. Triglyceride hydrolysis of soy oil vs fish oil emulsions. J. Parenter. Enteral Nutr. 21: 224-229.
15. Treskova, E., Y. A. Carpentier, R. Ramakrishnan, M. Al-Haideri, T. Seo, and R. J. Deckelbaum. 1999. Blood clearance and tissue uptake of intravenous lipid emulsions containing long-chain and mediumchain triglycerides and fish oil in a mouse model. J. Parenter. Enteral Nutr. 23: 253-259.
16. Qi, K., T. Seo, M. Al-Haideri, T. S. Worgall, T. Vogel, Y. A. Carpentier, and R. J. Deckelbaum. 2002. Omega-3 triglycerides modify blood clearance and tissue targeting pathways of lipid emulsions. Biochemistry. 41: 3119-3127.
17. Murase, T., T. Mizuno, T. Omachi, K. Onizawa, Y. Komine, H. Kondo, T. Hase, and I. Tokimitsu. 2001. Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice. J. Lipid Res. 42: 372-378.
18. Murase, T., M. Aoki, T. Wakisaka, T. Hase, and I. Tokimitsu. 2002. Anti-obesity effect of dietary diacylglycerol in C57BL/6J mice: dietary diacylglycerol stimulates intestinal lipid metabolism. J. Lipid Res. 43: 1312-1319.
19. Shimada, A., and K. Ohashi. 2003. Interfacial and emulsifying properties of diacylglycerol. Food Sci. Technol. Res. 9: 142-147.
20. Zhang, Y. L., A. Hernandez-Ono, C. Ko, K. Yasunaga, L. S. Huang, and H. N. Ginsberg. 2004. Regulation of hepatic apolipoprotein B-lipoprotein assembly and secretion by the availability of fatty acids. I. Differential response to the delivery of fatty acids via albumin or remnant-like emulsion particles. J. Biol. Chem. 279: 19362-19374.
21. Huge-Jensen, B., D. R. Galluzo, and R. R. Jensen. 1988. Studies on free and immobilized lipase from Mucor miehei. J. Am. Oil Chem. Soc. 65: 906-910.
22. Watanabe, T., M. Shimizu, M. Sugiura, M. Sato, J. Kohori, N. Yamada, and K. Nakanishi. 2003. Optimization of reaction conditions for the production of DAG using immobilized 1,3-regiospecific lipase Lipozyme IM. J. Am. Oil Chem. Soc. 80: 1201-1207.
23. Nakajima, Y. 2004. Water-retaining ability of diacylglycerol. J. Am. Oil Chem. Soc. 81: 907-912.
24. Folch, J., M. Lees, and G. H. Sloane Stanley. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226: 497-509.
25. Peterson, J., W. Y. Fujimoto, and J. D. Brunzell. 1992. Human lipoprotein lipase: relationship of activity, heparin affinity, and conformation as studied with monoclonal antibodies. J. Lipid Res. 33: 1165-1170.
26. Carr, T. P., C. J. Andersen, and L. L. Rudel. 1993. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin. Biochem. 26: 39-42.
27. Siri, P., N. Candela, Y. L. Zhang, C. Ko, S. Eusufzai, H. N. Ginsberg, and L. S. Huang. 2001. Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity, and insulin resistance. J. Biol. Chem. 276: 46064-46072.
28. Scanu, A. M. 1965. Factors affecting lipoprotein metabolism. Adv. Lipid Res. 3: 63-138.
29. Otway, S., and D. S. Robinson. 1967. The use of a non-ionic detergent (Triton WR1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions. J. Physiol. 190: 321-332.
30. Zhang, Y. L., A. Hernandez-Ono, P. Siri, S. Weisberg, D. Conlon, M. J. Graham, R. M. Crooke, L. S. Huang, and H. N. Ginsberg. 2006. Aberrant hepatic expression of PPARγ2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. J. Biol. Chem. 281: 37603-37615.
31. Tajima, S., S. Yokoyama, and A. Yamamoto. 1983. Effect of lipid particle size on association of apolipoproteins with lipid. J. Biol. Chem. 258: 10073-10082.
32. Rensen, P. C., N. Herijgers, M. H. Netscher, S. C. Meskers, M. van Eck, and T. J. van Berkel. 1997. Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo. J. Lipid Res. 38: 1070-1084.
33. Qi, K., M. Al-Haideri, T. Seo, Y. A. Carpentier, and R. J. Deckelbaum. 2003. Effects of particle size on blood clearance and tissue uptake of lipid emulsions with different triglyceride compositions. J. Parenter. Enteral Nutr. 27: 58-64.
34. Dichek, H. L., K. Qian, and N. Agrawal. 2003. The bridging function of hepatic lipase clears plasma cholesterol in LDL receptordeficient "apoB-48-only" and "apoB-100-only" mice. J. Lipid Res. 45: 551-560.
35. Saito, H., T. Minamida, I. Arimoto, T. Handa, and K. Miyajima. 1996. Physical state of surface and core lipids in lipid emulsions and apolipoprotein binding to the emulsion surface. J. Biol. Chem. 271: 15515-15520.
36. Arimoto, I., C. Matsumoto, M. Tanaka, K. Okuhira, H. Saito, and T. Handa. 1998. Surface composition regulates clearance from plasma and triolein lipolysis of lipid emulsions. Lipids. 33: 773-779.
37. 2-treated egg yolk. J. Am. Oil Chem. Soc. 81: 993-998.
38. Brunzell, J. D., W. R. Hazzard, D. Porte, Jr., and E. L. Bierman. 1973. Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man. J. Clin. Invest. 52: 1578-1585.
39. Yamamoto, K., H. Asakawa, K. Tokunaga, S. Meguro, H. Watanabe, I. Tokimitsu, and N. Yagi. 2005. Effects of diacylglycerol administration on serum triacylglycerol in a patient homozygous for complete lipoprotein lipase deletion. Metabolism. 54: 67-71.