Diacylglycerol on lipid metabolism

Current Opinion in Lipidology

Volumn 14, Issue 1, 2003, Pages 29-33

  Tada, Norio ^a,b   Yoshida, Hiroshi ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Diacylglycerol; Nutrition; Postprandial hyperlipidemia; Visceral fat accumulation

Indexed keywords

DIACYLGLYCEROL; TRIACYLGLYCEROL;

BODY FAT; BODY MASS; FOOD INTAKE; HUMAN; HYDROLYSIS; HYPERLIPIDEMIA; LIPID COMPOSITION; LIPID METABOLISM; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPOSE TISSUE; DIETARY FATS; DIGLYCERIDES; HUMANS; LIPID METABOLISM; LIPIDS;

ANIMALIA;

EID: 0037315132     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200302000-00006     Document Type: Review

References (31)

1. Baillie RA, Jump DB, Clarke SD. Specific effects of polyunsaturated fatty acids on gene expression. Curr Opin Lipidol 1996; 7:53-55.
2. Berge RK, Storve J, Tronstad KJ, et al. Metabolic effects of thia fatty acids. Curr Opin Lipidol 2002; 13:295-304.
3. Grundy SM, Ahrens Jr EH. The effects of unsaturated dietary fats on absorption, excretion, synthesis, and distribution of cholesterol in man. J Clin Invest 1970; 49:1135-1152.
4. Harris WS. Dietary fish oil and blood lipids. Curr Opin Lipidol 1996; 7:3-7.
5. Tinker LF, Parks EJ, Behr SR, et al. (n-3) Fatty acids supplementation in moderately hypertriglyceridemic adults changes postprandial lipid and apolipoprotein B responses to a standardized test meal. J Nutr 1999; 129:1126-1134.
6. Bach AC, Ingenbleek Y, Frey A. The usefulness of dietary medium-chain triglycerides in body weight control: fact or fancy? J Lipid Res 1996; 37:708-726.
7. Katan MB, Zock PL, Mensink RP. Dietary oils, serum lipoproteins, and coronary heart disease. Am J Clin Nutr 1995; 61 (Suppl 6):1368S-1373S.
8. Cha MC, Jones JH. Dietary fat type energy restriction interactively influence plasma leptin concentration in rats. J Lipid Res 1998; 39:1655-1660.
9. de Lorgeril M, Salen P, Martin JL, et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 1999; 99:779-785.
10. Watanabe H, Onizawa K, Taguchi H, et al. Nutritional characterization of diacylglycerols in rats. J Jpn Oil Chem Soc 1997; 46:301-307.
11. Hara K, Onizawa K, Honda H, et al. Dietary diacylglycerol-dependent reduction in serum triacylglycerol concentration in rats. Ann Nutr Metab 1993; 37:185-191.
12. Murase T, Mizuno T, Omachi T, et al. Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice. J Lipid Res 2001; 42:372-378. This article shows that dietary diacylglycerol (30% diacylglycerol + 13% sucrose) suppressed high fat and a high sucrose diet (30% triacylglycerol + 13% sucrose) induced body fat accumulation in C57BL/6J mice. Circulating leptin and insulin levels were also reduced to the respective control levels (5% triacylglycerol fed). High diacylglycerol feeding suppressed the elevation of leptin mRNA in adipose tissue and upregulated β-oxidation related genes.
13. Taguchi H, Watanabe H, Onizawa K, et al. Double-blind controlled study on the effects of diacylglycerol on postprandial serum and chylomicron triacylglycerol responses in healthy humans. J Am Coll Nutr 2000; 19:789-796.
14. Tada N, Watanabe H, Matsuo N, et al. Dynamics of postprandial remnant-lipoprotein particles in serum after loading of diacylglycerols. Clin Chim Acta 2001; 311:109-117. This was a randomized crossover designed experiment which revealed the beneficial effect of diacylglycerol oils on postprandial increase in remnant lipoproteins.
15. Nagao T, Watanabe H, Goto, N, et al. Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a double-blind controlled trial. J Nutr 2000; 130:792-797.
16. Murata M, Ide T, Hara K. Alteration by diacylglycerol of the transport and fatty acid composition of lymph chylomicron in rats. Biosci Biotech Biochem 1994; 58:1416-1419.
17. Murata M, Ide T, Hara K. Reciprocal responses to dietary diacytglycerol of hepatic enzymes of fatty acid synthesis and oxidation in the rat. Br J Nutr 1997; 77:107-121.
18. Yamamoto K, Asakawa H, Tokunaga K, et al. Long-term ingestion of dietary diacylglycerol lowers serum triacylglycerol in type II diabetic patients with hypertriglyceridemia. J Nutr 2001; 131:3204-3207. Adding 8 g diacylglycerol to ordinary triacylglycerol cooking oil per day for 12 weeks resulted in decreases in serum triacylglycerol and haemoglobin A1c levels compared with control (n = 8 each) in type II diabetic patients with hypertriglyceridemia.
19. Maki KC, Davidson MH, Tsushima R, et al. Consumption of diacylglycerol oil as part of a mildly reduced-energy diet enhances loss of body weight and fat compared with a triacylglycerol control oil. Am J Clin Nutr 2003; 76:1230-1236. A randomised, double-blind, parallel intervention trial with 131 overweight or obese men which shows an ingestion of foods containing diacylglycerol oil during 24 weeks promotes weight loss and body fat reduction and may be useful as an adjunct to diet therapy in the management of obesity.
20. Meguro S, Higashi K, Hase T, et al. Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect. Eur J Clin Nutr 2001; 55: 513-517. This was a randomized crossover designed trial with 12 healthy normolipidemic or moderately hypercholesterolemic men which showed hypocholesterolemic activity of mayonnaise containing phytosterols (500 g/day) dissolved in diacylglycerol (10 g/day) superior to that containing phytosterols (500 g/day) dissolved in triacylglycerol (10 g/day). Higher solubilized phytosterol into the diacylglycerol may interfere with dietary cholesterol in the process of micene formation in the intestinal lumen.
21. Murase T, Aoki M, Wakisaka T, et al. Anti-obesity effect of dietary diacylglycerol in C57BL/6J mice: dietary diacylglycerol stimulates intestinal lipid metabolism. J Lipid Res 2002; 43:1312-1319. This article shows less body fat accumulation during 8 months of diacylglycerol feeding to C57BL/6J mice. The authors also found that diacylglycerol feeding stimulates β-oxidation and lipid metabolism-related gene expression and uncoupling protein-2 messenger RNA in the small intestine of C57BL/6J mice within the first 10 days of feeding.
22. Matsuo N, Tokimitsu I. Metabolic characteristics of diacylglycerol: an edible oil that is less likely to become body fat. Inform 2001; 12:1098-1102. This is a good review article focussing on the metabolic effects of diacylglycerol on body fat.
23. Yang L-Y, Kuksis A. Apparent convergence (at 2-monoacylglycerol level) of phosphatidic acid and 2-monoacylglycerol pathways of synthesis of chylomicron triacylglycerols. J Lipid Res 1991; 32:1173-1186.
24. Bierbach H. Triacylglycerol biosynthesis in human small intestinal mucosa. Acyl-CoA: monoglyceride acyltransferase. Digestion 1983; 28:138-147.
25. Buhman KK, Smith SJ, Stone SJ, et al. DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J Biol Chem 2002; 277:25474-25479.
26. Taguchi H, Ohmachi T, Nagao T, et al. Dietary diacylglycerol suppresses high fat diet-induced hepatic fat accumulation and microsomal triacylglycerol transfer protein activity in rats. J Nutr Biochem (in press).
27. Taguchi H, Nagao T, Watanabe H, et al. Energy value and digestibility of dietary oil containing mainly 1,3-diacylglycerol are similar to those of triacylglycerol. Lipid 2001; 36:379-382. From the results showing the similar energy value and digestibility of the diacylglycerol and the triacylglycerol, the authors speculate that the reduced fat accumulation by diacylglycerol is caused by the different metabolic fates after absorption into the enterocytes.
28. Vanden Heuvel JP. Peroxisome proliferator-activated receptors: a critical link among fatty acids, gene expression and carcinogenesis. J Nutr 1999; 129:575S-580S.
29. Gervois P, Pineda I, Fruchart J-C, et al. Regulation of lipid and lipoprotein metabolism by PPAR activators. Clin Chem Lab Med 2000; 38: 3-11.
30. Soni MG, Kimura H, Burdock GA. Chronic study of diacylglycerol oil in rats. Food Chem Toxicol 2001; 39:317-329. This article shows the safety of 2 years administration of diacylglycerol to male and female Sprague-Dawley rats. Authors found no toxicologically significant or treatment-related effects of diacylglycerol oil consumption at levels up to 5.3% in the diet in this 2 year chronic rat study.
31. Watanabe H, Onizawa K, Naito S, et al. Fat-soluble vitamin status is not affected by diacylglycerol consumption. Ann Nutr Metab 2001; 45:259-264.