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Volumn 13, Issue 3, 2007, Pages 313-331

Production of brain-derived neurotrophic factor by mononuclear cells of patients with multiple sclerosis treated with glatiramer acetate, interferon-β 1a, and high doses of immunoglobulins

Author keywords

Brain derived neurotrophic factor; Glatiramer acetate; Immunoglobulins; Interferon beta 1a; Multiple sclerosis; Peripheral blood mononuclear cells

Indexed keywords

BETA1A INTERFERON; BRAIN DERIVED NEUROTROPHIC FACTOR; GAMMA INTERFERON; GLATIRAMER; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; METHYLPREDNISOLONE; MYELIN BASIC PROTEIN; PHYTOHEMAGGLUTININ;

EID: 34248177331     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458506070146     Document Type: Article
Times cited : (62)

References (57)
  • 1
    • 0034767139 scopus 로고    scopus 로고
    • Physiological approaches to neuroprotection: Boosting of protective autoimmunity
    • Schwartz M. Physiological approaches to neuroprotection: boosting of protective autoimmunity. Surv Ophthalmol 2001; 45: S256-60.
    • (2001) Surv Ophthalmol , vol.45
    • Schwartz, M.1
  • 2
    • 0033049143 scopus 로고    scopus 로고
    • Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
    • Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 1999; 5: 49-55.
    • (1999) Nat Med , vol.5 , pp. 49-55
    • Moalem, G.1    Leibowitz-Amit, R.2    Yoles, E.3    Mor, F.4    Cohen, I.R.5    Schwartz, M.6
  • 3
    • 0034691136 scopus 로고    scopus 로고
    • T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies
    • Kipnis J, Yoles E, Porat Z, Cohen A, Mor F, Sela M et al. T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies. Proc Natl Acad Sci USA 2000; 97: 7446-51.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7446-7451
    • Kipnis, J.1    Yoles, E.2    Porat, Z.3    Cohen, A.4    Mor, F.5    Sela, M.6
  • 4
    • 0034661765 scopus 로고    scopus 로고
    • Neuroprotection by encephalomyelitis: Rescue of mechanically injured neurons and neurotrophin production by CNS-infiltrating T and natural killer cells
    • Hammarberg H, Lidman O, Lundberg C, Eltayeb SY, Gielen AW, Muhallab S et al. Neuroprotection by encephalomyelitis: rescue of mechanically injured neurons and neurotrophin production by CNS-infiltrating T and natural killer cells. J Neurosci 2000; 20: 5283-91.
    • (2000) J Neurosci , vol.20 , pp. 5283-5291
    • Hammarberg, H.1    Lidman, O.2    Lundberg, C.3    Eltayeb, S.Y.4    Gielen, A.W.5    Muhallab, S.6
  • 5
    • 0028916844 scopus 로고
    • Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease
    • Ikeda K, Klinkosz B, Greene T, Cedarbaum JM, Wong V, Lindsay RM et al. Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease. Ann Neurol 1995; 37: 505-11.
    • (1995) Ann Neurol , vol.37 , pp. 505-511
    • Ikeda, K.1    Klinkosz, B.2    Greene, T.3    Cedarbaum, J.M.4    Wong, V.5    Lindsay, R.M.6
  • 6
    • 0031984426 scopus 로고    scopus 로고
    • Neuronal control of the immune response in the central nervous system: Linking brain immunity to neurodegeneration
    • Neumann H, Wekerle H. Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration. J Neuropathol Exp Neurol 1998; 57: 1-9.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 1-9
    • Neumann, H.1    Wekerle, H.2
  • 7
    • 0034710340 scopus 로고    scopus 로고
    • The neuroprotective effect of inflammation: Implications for the therapy of multiple sclerosis
    • Hohlfeld R, Kerschensteiner M, Stadelmann C, Lassmann H, Wekerle H. The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. J Neuroimmunol 2000; 107: 161-66.
    • (2000) J Neuroimmunol , vol.107 , pp. 161-166
    • Hohlfeld, R.1    Kerschensteiner, M.2    Stadelmann, C.3    Lassmann, H.4    Wekerle, H.5
  • 8
    • 0035977427 scopus 로고    scopus 로고
    • Mast cells differentially express and release active high molecular weight neurotrophins
    • Skaper SD, Pollock M, Facci L. Mast cells differentially express and release active high molecular weight neurotrophins. Brain Res Mol Brain Res 2001; 97: 177-85.
    • (2001) Brain Res Mol Brain Res , vol.97 , pp. 177-185
    • Skaper, S.D.1    Pollock, M.2    Facci, L.3
  • 9
    • 0037369638 scopus 로고    scopus 로고
    • Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases
    • Kerschensteiner M, Stadelmann C, Dechant G, Wekerle H, Hohlfeld R. Neurotrophic cross-talk between the nervous and immune systems: implications for neurological diseases. Ann Neurol 2003; 53: 292-304.
    • (2003) Ann Neurol , vol.53 , pp. 292-304
    • Kerschensteiner, M.1    Stadelmann, C.2    Dechant, G.3    Wekerle, H.4    Hohlfeld, R.5
  • 10
    • 12744260011 scopus 로고    scopus 로고
    • The neuroprotective role of inflammation in nervous system injuries
    • Correale J, Villa A. The neuroprotective role of inflammation in nervous system injuries. J Neurol 2004; 251: 1304-16.
    • (2004) J Neurol , vol.251 , pp. 1304-1316
    • Correale, J.1    Villa, A.2
  • 11
    • 0034700868 scopus 로고    scopus 로고
    • Autoimmune T cells as potential neuroprotective therapy for spinal cord injury
    • Hauben E, Nevo U, Yoles E, Moalem G, Agranov E, Mor F et al. Autoimmune T cells as potential neuroprotective therapy for spinal cord injury. Lancet 2000; 355: 286-87.
    • (2000) Lancet , vol.355 , pp. 286-287
    • Hauben, E.1    Nevo, U.2    Yoles, E.3    Moalem, G.4    Agranov, E.5    Mor, F.6
  • 12
    • 0030053351 scopus 로고    scopus 로고
    • Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury
    • Holtzman DM, Sheldon RA, Jaffe W, Cheng Y, Ferriero DM. Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol 1996; 39: 114-22.
    • (1996) Ann Neurol , vol.39 , pp. 114-122
    • Holtzman, D.M.1    Sheldon, R.A.2    Jaffe, W.3    Cheng, Y.4    Ferriero, D.M.5
  • 13
    • 5744233877 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor
    • Binder DK, Scharfman HE. Brain-derived neurotrophic factor. Growth Factors 2004; 22: 123-31.
    • (2004) Growth Factors , vol.22 , pp. 123-131
    • Binder, D.K.1    Scharfman, H.E.2
  • 14
    • 3042700000 scopus 로고    scopus 로고
    • Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plasticity and survival: From genes to phenotype
    • Marini AM, Jiang X, Wu X, Tian F, Zhu D, Okagaki P et al. Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plasticity and survival: from genes to phenotype. Restor Neurol Neurosci 2004; 22: 121-30.
    • (2004) Restor Neurol Neurosci , vol.22 , pp. 121-130
    • Marini, A.M.1    Jiang, X.2    Wu, X.3    Tian, F.4    Zhu, D.5    Okagaki, P.6
  • 15
    • 0029436825 scopus 로고
    • Neurotrophic factors and amyotrophic lateral sclerosis
    • Askanas V. Neurotrophic factors and amyotrophic lateral sclerosis. Adv Neurol 1995; 68: 241-44.
    • (1995) Adv Neurol , vol.68 , pp. 241-244
    • Askanas, V.1
  • 16
    • 0242499433 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor controls dopamine D3 receptor expression: Therapeutic implications in Parkinson's disease
    • Guillin O, Griffon N, Bezard E, Leriche L, Diaz J, Gross C et al. Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson's disease. Eur J Pharmacol 2003; 480: 89-95.
    • (2003) Eur J Pharmacol , vol.480 , pp. 89-95
    • Guillin, O.1    Griffon, N.2    Bezard, E.3    Leriche, L.4    Diaz, J.5    Gross, C.6
  • 17
    • 0035239020 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
    • Murer MG, Yan Q, Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 2001; 63: 71-124.
    • (2001) Prog Neurobiol , vol.63 , pp. 71-124
    • Murer, M.G.1    Yan, Q.2    Raisman-Vozari, R.3
  • 18
    • 2542447305 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease: Prospects of neuroprotective and restorative therapies
    • Fernandez-Espejo E. Pathogenesis of Parkinson's disease: prospects of neuroprotective and restorative therapies. Mol Neurobiol 2004; 29: 15-30.
    • (2004) Mol Neurobiol , vol.29 , pp. 15-30
    • Fernandez-Espejo, E.1
  • 19
    • 5444260683 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor as a drug target for CNS disorders
    • Pezet S, Malcangio M. Brain-derived neurotrophic factor as a drug target for CNS disorders. Expert Opin Ther Targets 2004; 8: 391-99.
    • (2004) Expert Opin Ther Targets , vol.8 , pp. 391-399
    • Pezet, S.1    Malcangio, M.2
  • 20
    • 0025279814 scopus 로고
    • Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain
    • Hofer M, Pagliusi SR, Hohn A, Leibrock J, Barde YA. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J 1990; 9: 2459-64.
    • (1990) EMBO J , vol.9 , pp. 2459-2464
    • Hofer, M.1    Pagliusi, S.R.2    Hohn, A.3    Leibrock, J.4    Barde, Y.A.5
  • 21
    • 0029892470 scopus 로고    scopus 로고
    • Physiology of the neurotrophins
    • Lewin GR, Barde Y-A. Physiology of the neurotrophins. Annu Rev Neurosci 1996; 19: 289-317.
    • (1996) Annu Rev Neurosci , vol.19 , pp. 289-317
    • Lewin, G.R.1    Barde, Y.-A.2
  • 22
    • 0033152935 scopus 로고    scopus 로고
    • Cutting edge: Clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors
    • Besser M, Wank R. Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors. J Immunol 1999; 162: 6303-306.
    • (1999) J Immunol , vol.162 , pp. 6303-6306
    • Besser, M.1    Wank, R.2
  • 24
    • 0033103608 scopus 로고    scopus 로고
    • Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation?
    • Kerschensteiner M, Gallmeier E, Behrens L, Leal VV, Misgeld T, Klinkert WE et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 1999; 189: 865-70.
    • (1999) J Exp Med , vol.189 , pp. 865-870
    • Kerschensteiner, M.1    Gallmeier, E.2    Behrens, L.3    Leal, V.V.4    Misgeld, T.5    Klinkert, W.E.6
  • 25
    • 0026439389 scopus 로고
    • The cognitive paradigm and the immunological homunculus
    • Cohen IR. The cognitive paradigm and the immunological homunculus. Immunol Today 1992; 13: 490-94.
    • (1992) Immunol Today , vol.13 , pp. 490-494
    • Cohen, I.R.1
  • 26
    • 0036154041 scopus 로고    scopus 로고
    • BDNF and gp145trkB in multiple sclerosis brain lesions: Neuroprotective interactions between immune and neuronal cells?
    • Stadelmann C, Kerschensteiner M, Misgeld T, Bruck W, Hohlfeld R, Lassmann H. BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells? Brain 2002; 125: 75-85.
    • (2002) Brain , vol.125 , pp. 75-85
    • Stadelmann, C.1    Kerschensteiner, M.2    Misgeld, T.3    Bruck, W.4    Hohlfeld, R.5    Lassmann, H.6
  • 27
    • 0036849269 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in patients with multiple sclerosis
    • Sarchielli P, Greco L, Stipa A, Floridi A, Gallai V. Brain-derived neurotrophic factor in patients with multiple sclerosis. J Neuroimmunol 2002; 132: 180-88.
    • (2002) J Neuroimmunol , vol.132 , pp. 180-188
    • Sarchielli, P.1    Greco, L.2    Stipa, A.3    Floridi, A.4    Gallai, V.5
  • 28
    • 0037616364 scopus 로고    scopus 로고
    • Increased brain-derived neurotrophic factor expression in white blood cells of relapsing-remitting multiple sclerosis patients
    • Gielen A, Khademi M, Muhallab S, Olsson T, Piehl F. Increased brain-derived neurotrophic factor expression in white blood cells of relapsing-remitting multiple sclerosis patients. Scand J Immunol 2003; 57: 493-97.
    • (2003) Scand J Immunol , vol.57 , pp. 493-497
    • Gielen, A.1    Khademi, M.2    Muhallab, S.3    Olsson, T.4    Piehl, F.5
  • 30
    • 0037327755 scopus 로고    scopus 로고
    • Effect of immunomodulatory drugs on in vitro production of brain-derived neurotrophic factor
    • Petereit HF, Lindemann H, Schoppe S. Effect of immunomodulatory drugs on in vitro production of brain-derived neurotrophic factor. Mult Scler 2003; 9: 16-20.
    • (2003) Mult Scler , vol.9 , pp. 16-20
    • Petereit, H.F.1    Lindemann, H.2    Schoppe, S.3
  • 31
    • 29444451569 scopus 로고    scopus 로고
    • Neurotrophic factors in relapsing remitting and secondary progressive multiple sclerosis patients during interferon beta therapy
    • Caggiula M, Batocchi AP, Frisullo G, Angelucci F, Patanella AK, Sancricca C et al. Neurotrophic factors in relapsing remitting and secondary progressive multiple sclerosis patients during interferon beta therapy. Clin Immunol 2006; 118: 77-82.
    • (2006) Clin Immunol , vol.118 , pp. 77-82
    • Caggiula, M.1    Batocchi, A.P.2    Frisullo, G.3    Angelucci, F.4    Patanella, A.K.5    Sancricca, C.6
  • 32
    • 0036845819 scopus 로고    scopus 로고
    • Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: Implications for multiple sclerosis therapy. Brain-derived neurotrophic factor
    • Ziemssen T, Kumpfel T, Klinkert WE, Neuhaus O, Hohlfeld R. Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy. Brain-derived neurotrophic factor. Brain 2002; 125: 2381-91.
    • (2002) Brain , vol.125 , pp. 2381-2391
    • Ziemssen, T.1    Kumpfel, T.2    Klinkert, W.E.3    Neuhaus, O.4    Hohlfeld, R.5
  • 33
    • 0345763039 scopus 로고    scopus 로고
    • Neuroprotection and glatiramer acetate: The possible role in the treatment of multiple sclerosis
    • Ziemssen T. Neuroprotection and glatiramer acetate: the possible role in the treatment of multiple sclerosis. Adv Exp Med Biol 2004; 541: 111-34.
    • (2004) Adv Exp Med Biol , vol.541 , pp. 111-134
    • Ziemssen, T.1
  • 34
    • 20444414520 scopus 로고    scopus 로고
    • Secretion of brain-derived neurotrophic factor by glatiramer acetate-reactive T-helper cell lines: Implications for multiple sclerosis therapy
    • Ziemssen T, Kumpfel T, Schneider H, Klinkert WE, Neuhaus O, Hohlfeld R. Secretion of brain-derived neurotrophic factor by glatiramer acetate-reactive T-helper cell lines: implications for multiple sclerosis therapy. J Neurol Sci 2005; 233: 109-12.
    • (2005) J Neurol Sci , vol.233 , pp. 109-112
    • Ziemssen, T.1    Kumpfel, T.2    Schneider, H.3    Klinkert, W.E.4    Neuhaus, O.5    Hohlfeld, R.6
  • 35
    • 0344198593 scopus 로고    scopus 로고
    • Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor in situ
    • Aharoni R, Kayhan B, Eilam R, Sela M, Arnon R. Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor in situ. Proc Natl Acad Sci USA 2003; 100: 14157-62.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14157-14162
    • Aharoni, R.1    Kayhan, B.2    Eilam, R.3    Sela, M.4    Arnon, R.5
  • 36
    • 24744435759 scopus 로고    scopus 로고
    • Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis
    • Aharoni R, Arnon R, Eilam R. Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis. J Neurosci 2005; 25: 8217-28.
    • (2005) J Neurosci , vol.25 , pp. 8217-8228
    • Aharoni, R.1    Arnon, R.2    Eilam, R.3
  • 37
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis
    • McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001; 5O: 121-27.
    • (2001) Ann Neurol , vol.5 O , pp. 121-127
    • McDonald, W.I.1    Compston, A.2    Edan, G.3    Goodkin, D.4    Hartung, H.P.5    Lublin, F.D.6
  • 38
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An Expanded Disability Status Scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983; 33: 1444-52.
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 39
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: Results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    • Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996; 46: 907-11.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 40
    • 0032736730 scopus 로고    scopus 로고
    • Responsiveness of the Scripps neurologic rating scale during a multiple sclerosis clinical trial
    • Koziol JA, Lucero A, Sipe JC, Romine JS, Beutler E. Responsiveness of the Scripps neurologic rating scale during a multiple sclerosis clinical trial. Can J Neurol Sci 1999; 26: 283-89.
    • (1999) Can J Neurol Sci , vol.26 , pp. 283-289
    • Koziol, J.A.1    Lucero, A.2    Sipe, J.C.3    Romine, J.S.4    Beutler, E.5
  • 41
    • 0034521309 scopus 로고    scopus 로고
    • Sensitivity and reproducibility of volume change measurements of different brain portions on magnetic resonance imaging in patients with multiple sclerosis
    • Rovaris M, Inglese M, van Schijndel RA, Sormani MP, Rodegher M, Comi G et al. Sensitivity and reproducibility of volume change measurements of different brain portions on magnetic resonance imaging in patients with multiple sclerosis. J Neurol 2000; 247: 960-65.
    • (2000) J Neurol , vol.247 , pp. 960-965
    • Rovaris, M.1    Inglese, M.2    van Schijndel, R.A.3    Sormani, M.P.4    Rodegher, M.5    Comi, G.6
  • 42
    • 0142074862 scopus 로고    scopus 로고
    • Glatiramer acetate-reactive T cells produce brain-derived neurotrophic factor
    • Chen M, Valenzuela RM, Dhib-Jalbut S. Glatiramer acetate-reactive T cells produce brain-derived neurotrophic factor. J Neurol Sci 2003; 215: 37-44.
    • (2003) J Neurol Sci , vol.215 , pp. 37-44
    • Chen, M.1    Valenzuela, R.M.2    Dhib-Jalbut, S.3
  • 43
    • 27744601129 scopus 로고    scopus 로고
    • Clinical and immune responses correlate in glatiramer acetate therapy of multiple sclerosis
    • Weder C, Baltariu GM, Wyler KA, Gober HJ, Lienert C, Schluep M et al. Clinical and immune responses correlate in glatiramer acetate therapy of multiple sclerosis. Eur J Neurol 2005; 12: 869-78.
    • (2005) Eur J Neurol , vol.12 , pp. 869-878
    • Weder, C.1    Baltariu, G.M.2    Wyler, K.A.3    Gober, H.J.4    Lienert, C.5    Schluep, M.6
  • 44
    • 0034691165 scopus 로고    scopus 로고
    • Multiple sclerosis: Comparison of copolymer-1-reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells Proc
    • Neuhaus O, Farina C, Yassouridis A, Wiendl H, Then Bergh F, Dose T et al. Multiple sclerosis: comparison of copolymer-1-reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells Proc Natl Acad Sci USA 2000; 97: 7452-57.
    • (2000) Natl Acad Sci USA , vol.97 , pp. 7452-7457
    • Neuhaus, O.1    Farina, C.2    Yassouridis, A.3    Wiendl, H.4    Then Bergh, F.5    Dose, T.6
  • 45
    • 0035049725 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with Copaxone (COP). Elispot assay detects COP-induced interleukin-4 and interferon-7 response in blood cells
    • Farina C, Bergh FT, Albrecht H, Meinl E, Yassouridis A, Neuhaus O et al. Treatment of multiple sclerosis with Copaxone (COP). Elispot assay detects COP-induced interleukin-4 and interferon-7 response in blood cells. Brain 2001; 124: 705-19.
    • (2001) Brain , vol.124 , pp. 705-719
    • Farina, C.1    Bergh, F.T.2    Albrecht, H.3    Meinl, E.4    Yassouridis, A.5    Neuhaus, O.6
  • 46
    • 14544275414 scopus 로고    scopus 로고
    • Oral glatiramer acetate in experimental autoimmune encephalomyelitis: Clinical and immunological studies
    • Teitelbaum D, Aharoni R, Klinger E, Kreitman R, Raymond E, Malley A et al. Oral glatiramer acetate in experimental autoimmune encephalomyelitis: clinical and immunological studies. Ann N Y Acad Sci 2004; 1029: 239-49.
    • (2004) Ann N Y Acad Sci , vol.1029 , pp. 239-249
    • Teitelbaum, D.1    Aharoni, R.2    Klinger, E.3    Kreitman, R.4    Raymond, E.5    Malley, A.6
  • 47
    • 5144233487 scopus 로고    scopus 로고
    • Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications
    • Arnon R, Aharoni R. Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications. Proc Natl Acad Sci USA 2004; 101: 14593-98.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 14593-14598
    • Arnon, R.1    Aharoni, R.2
  • 48
    • 10344251487 scopus 로고    scopus 로고
    • Combined treatment of glatiramer acetate and low doses of immunosuppressive drugs is effective in the prevention of graft rejection
    • Aharoni R, Yussim A, Sela M, Arnon R. Combined treatment of glatiramer acetate and low doses of immunosuppressive drugs is effective in the prevention of graft rejection. Int Immunopharmacol 2005; 5: 23-32.
    • (2005) Int Immunopharmacol , vol.5 , pp. 23-32
    • Aharoni, R.1    Yussim, A.2    Sela, M.3    Arnon, R.4
  • 49
    • 0034041863 scopus 로고    scopus 로고
    • Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis
    • Duda PW, Schmied MC, Cook SL, Krieger JI, Hafler DA. Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. J Clin Invest 2000; 105: 967-76.
    • (2000) J Clin Invest , vol.105 , pp. 967-976
    • Duda, P.W.1    Schmied, M.C.2    Cook, S.L.3    Krieger, J.I.4    Hafler, D.A.5
  • 52
    • 0037357642 scopus 로고    scopus 로고
    • In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis
    • Schmied M, Duda PW, Krieger JI, Trollmo C, Hafler DA. In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis. Clin Immunol 2003; 106: 163-74.
    • (2003) Clin Immunol , vol.106 , pp. 163-174
    • Schmied, M.1    Duda, P.W.2    Krieger, J.I.3    Trollmo, C.4    Hafler, D.A.5
  • 53
    • 0028943563 scopus 로고
    • Widespread neurotrophin receptor expression in the immune system and other nonneuronal rat tissues
    • Lomen-Hoerth C, Shooter EM. Widespread neurotrophin receptor expression in the immune system and other nonneuronal rat tissues. J Neurochem 1995; 64: 1780-89.
    • (1995) J Neurochem , vol.64 , pp. 1780-1789
    • Lomen-Hoerth, C.1    Shooter, E.M.2
  • 54
    • 0032404127 scopus 로고    scopus 로고
    • Transport of brain-derived neurotrophic factor across the blood-brain barrier
    • Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998; 37: 1553-61.
    • (1998) Neuropharmacology , vol.37 , pp. 1553-1561
    • Pan, W.1    Banks, W.A.2    Fasold, M.B.3    Bluth, J.4    Kastin, A.J.5
  • 55
    • 0034853968 scopus 로고    scopus 로고
    • European/ Canadian Glatiramer Acetate Study Group. Short-term brain volume change in relapsing-remitting multiple sclerosis: Effect of glatiramer acetate and implications
    • Rovaris M, Comi G, Rocca MA, Wolinsky JS, Filippi M; European/ Canadian Glatiramer Acetate Study Group. Short-term brain volume change in relapsing-remitting multiple sclerosis: effect of glatiramer acetate and implications. Brain 2001; 124: 1803-12.
    • (2001) Brain , vol.124 , pp. 1803-1812
    • Rovaris, M.1    Comi, G.2    Rocca, M.A.3    Wolinsky, J.S.4    Filippi, M.5
  • 56
    • 17744367204 scopus 로고    scopus 로고
    • Multiple Sclerosis Study Group and the MRI Analysis Center. United States open-label glatiramer acetate extension trial for relapsing multiple sclerosis: MRI and clinical correlates
    • Wolinsky JS, Narayana PA, Johnson KP; Multiple Sclerosis Study Group and the MRI Analysis Center. United States open-label glatiramer acetate extension trial for relapsing multiple sclerosis: MRI and clinical correlates. Mult Scler 2001; 7: 33-41.
    • (2001) Mult Scler , vol.7 , pp. 33-41
    • Wolinsky, J.S.1    Narayana, P.A.2    Johnson, K.P.3
  • 57
    • 20444416717 scopus 로고    scopus 로고
    • Can glatiramer acetate reduce brain atrophy development in multiple sclerosis?
    • Rovaris M, Comi G, Filippi M. Can glatiramer acetate reduce brain atrophy development in multiple sclerosis? J Neurol Sci 2005; 233: 139-43.
    • (2005) J Neurol Sci , vol.233 , pp. 139-143
    • Rovaris, M.1    Comi, G.2    Filippi, M.3


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