Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: Transgenic TK2, mtDNA, and antiretrovirals

American Journal of Pathology

Volumn 170, Issue 3, 2007, Pages 865-874

  Hosseini, Seyed H ^a   Kohler, James J ^a   Haase, Chad P ^a   Tioleco, Nina ^a   Stuart, Tami ^a   Keebaugh, Erin ^a   Ludaway, Tomika ^a   Russ, Rodney ^a   Green, Elgin ^a   Long, Robert ^a   Wang, Liya ^b   Eriksson, Staffan ^b   Lewis, William ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CYTOCHROME C OXIDASE; INDINAVIR; LAMIVUDINE; MITOCHONDRIAL DNA; POLYPEPTIDE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SUCCINATE DEHYDROGENASE; THYMIDINE KINASE; THYMIDINE KINASE 1; THYMIDINE KINASE 2; UNCLASSIFIED DRUG; ZIDOVUDINE; ISOENZYME; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; HEART PERFORMANCE; IMMUNOBLOTTING; MITOCHONDRIAL TOXICITY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENICS; ANIMAL; DRUG EFFECT; ENZYMOLOGY; HEART MUSCLE; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MITOCHONDRION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENE; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION;

ANIMALS; DNA, MITOCHONDRIAL; ECHOCARDIOGRAPHY; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MYOCARDIUM; PEPTIDES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUCCINATE DEHYDROGENASE; THYMIDINE KINASE; TRANSGENES; UP-REGULATION;

EID: 34247853571     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2007.060655     Document Type: Article

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