Promitogenic effects of ethanol, methanol, and ethanolamine in insulin- treated fibroblasts

Biochemical Pharmacology

Volumn 60, Issue 9, 2000, Pages 1391-1398

  Crilly, Karan S ^a   Benyhe, Sandor ^b   Kiss, Zoltan ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Choline; DNA synthesis; Ethanol; Ethanolamine; Insulin; Methanol

Indexed keywords

ALCOHOL; DNA; ETHANOLAMINE; METHANOL; MITOGENIC AGENT;

ANIMAL CELL; ARTICLE; BINDING SITE; CANCER; CARCINOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; METABOLISM; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR;

3T3 CELLS; ALCOHOLS; ANIMAL; BIOLOGICAL TRANSPORT; CHOLINERGIC AGENTS; DNA; DRUG INTERACTIONS; ETHANOL; ETHANOLAMINE; FIBROBLASTS; HEMICHOLINIUM 3; INSULIN; METHACHOLINE CHLORIDE; MICE; MITOGENS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0034333407     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00456-1     Document Type: Article

References (43)

1. Henderson G.I., Baskin G.S., Horbach J., Porter P., Schenker S. Arrest of epidermal growth factor-dependent growth in fetal hepatocytes after ethanol exposure. J Clin Invest. 84:1989;1287-1294.
2. Cook R.T., Keiner J., Yen A., Fishbaugh J. Ethanol induced growth inhibition and growth adaptation in vitro. Cell cycle delay in late G1. Alcohol Alcohol. 25:1990;33-43.
3. Resnicoff M., Sell C., Ambrose D., Baserga R., Rubin R. Ethanol inhibits the autophosphorylation of the insulin-like growth factor 1 (IGF-1) receptor and the IGF-1-mediated proliferation of 3T3 cells. J Biol Chem. 268:1993;21777-21782.
4. Resnicoff M., Rubini M., Baserga R., Rubin R. Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells. Lab Invest. 71:1994;657-662.
5. Luo J., Miller M.W. Ethanol inhibits basic fibroblast growth factor-mediated proliferation of C6 astrocytoma cells. J Neurochem. 67:1996;1448-1456.
6. Resnicoff M., Cui S., Coppola D., Hoek J.B., Rubin R. Ethanol-induced inhibition of cell proliferation is modulated by insulin-like growth factor-I receptor levels. Alcohol Clin Exp Res. 20:1996;961-966.
7. Luo J., Miller M.W. Growth factor-mediated neural proliferation Target of ethanol toxicity . Brain Res Rev. 27:1998;157-167.
8. Ewald S.J., Shao H. Ethanol increases apoptotic cell death of thymocytes in vitro. Alcohol Clin Exp Res. 17:1993;359-365.
9. Holownia A., Ledig M., Menez J.F. Ethanol-induced cell death in cultured rat astroglia. Neurotoxicol Teratol. 19:1997;141-146.
10. Bhave S.V., Hoffman P.L. Ethanol promotes apoptosis in cerebellar granule cells by inhibiting the trophic effect of NMDA. J Neurochem. 68:1997;578-586.
11. Luo J., West J.R., Pantazis N.J. Nerve growth factor and basic fibroblast growth factor protect rat cerebellar granule cells in culture against ethanol-induced cell death. Alcohol Clin Exp Res. 21:1997;1108-1120.
12. Cartwright M.M., Tessmer L.L., Smith S.M. Ethanol-induced neural crest apoptosis is coincident with their endogenous death, but is mechanistically distinct. Alcohol Clin Exp Res. 22:1998;142-149.
13. West J.R., Chen W.J.A., Pantazis N.J. Fetal alcohol syndrome The vulnerability of the developing brain and possible mechanisms of damage . Metab Brain Dis. 9:1994;291-322.
14. Shibley I.A. Jr, Pennington S.N. Metabolic and mitotic changes associated with the fetal alcohol syndrome. Alcohol Alcohol. 32:1997;423-434.
15. Leach R.E., Stachecki J.J., Armant D.R. Development of in vitro fertilized mouse embryos exposed during the preimplantation period Accelerated embryogenesis at subtoxic levels . Teratology. 47:1993;57-64.
16. Stachecki J.J., Yelian F.D., Schultz J.F., Leach R.E., Armant D.R. Blastocyst cavitation is accelerated by ethanol- or ionophore-induced elevation of intracellular calcium. Biol Reprod. 50:1994;1-9.
17. Miller M.W., Nowakowski R.S. Effect of prenatal exposure to ethanol of the cell cycle kinetics and growth fraction in the proliferative zones of fetal rat cerebral cortex. Alcohol Clin Exp Res. 15:1991;229-232.
18. Aroor A., Baker R.C. Negative and positive regulation of astrocyte DNA synthesis by ethanol. J Neurosci Res. 50:1997;1010-1017.
19. Simanowski U.A., Seitz H.K., Baier B., Kommerell B., Schmidt-Gayk H., Wright N.A. Chronic ethanol consumption selectively stimulates rectal cell proliferation in the rat. Gut. 27:1986;278-282.
20. Simanowski U.A., Stickel F., Maier H., Gärtner U., Seitz H.K. Effect of alcohol on gastrointestinal cell regeneration as a possible mechanism in alcohol-associated carcinogenesis. Alcohol. 12:1995;111-115.
21. Blot W.J. Alcohol and cancer. Cancer Res. 52:1992;2119s-2123s.
22. Longnecker M.P. Alcohol consumption and risk of cancer in humans An overview . Alcohol. 12:1995;87-96.
23. Longnecker M.P., Enger S.M. Epidemiologic data on alcoholic beverage consumption and risk of cancer. Clin Chim Acta. 246:1996;121-141.
24. Ringborg U. Alcohol and risk of cancer. Alcohol Clin Exp Res. 22:1998;323S-328S.
25. Przylipiak A., Rabe T., Hafner J., Przylipiak M., Runnebaum B. Influence of ethanol on in vitro growth of human mammary carcinoma cell line MCF-7. Arch Gynecol Obstet. 258:1996;137-140.
26. Kornfehl J., Temmel A., Formanek M., Knerer B. Effects of ethanol treatment on proliferation and differentiation in a head and neck squamous cell carcinoma cell line. Alcohol Clin Exp Res. 23:1999;1102-1107.
27. McKillop I.H., Vyas N., Schmidt C.M., Cahill P.A., Sitzmann J.V. Enhanced Gi-protein-mediated mitogenesis following chronic ethanol exposure in a rat model of experimental hepatocellular carcinoma. Hepatology. 29:1999;412-420.
28. Kiss Z., Anderson W.H., Mukherjee J.J. Ethanol potentiates the stimulatory effects of insulin and phosphocholine on mitogenesis by a zinc-dependent and rapamycin-sensitive mechanism in fibroblasts and JB6 cells. Biochem J. 330:1998;819-826.
29. Mukherjee J.J., Huang J.S., Getman C., Kiss Z. Bombesin promotes synergistic stimulation of DNA synthesis by ethanol and insulin in fibroblasts. Arch Biochem Biophys. 362:1999;183-189.
30. Huang J.S., Mukherjee J.J., Kiss Z. Ethanol potentiates the mitogenic effects of sphingosine 1-phosphate by a zinc- and calcium-dependent mechanism in fibroblasts. Arch Biochem Biophys. 366:1999;131-138.
31. 2+ and other cell cycle initiators in fibroblasts. Biochem J. 346:2000;241-247.
32. She Q.B., Huang J.S., Mukherjee J.J., Crilly K.S., Kiss Z. The possible mechanism of synergistic effects of ethanol, zinc and insulin on DNA synthesis in NIH 3T3 fibroblasts. FEBS Lett. 460:1999;199-202.
33. Crilly K.S., Li J., Anderson W.H., Kiss Z. Potentiation of calcium-mediated stimulation of DNA synthesis by ethanol in human and mouse fibroblasts. Alcohol Clin Exp Res. 23:1999;785-790.
34. Kiss Z., Crilly K.S., Chung T. Stimulation of DNA synthesis in untransformed cells by the antiviral and antitumoral compound tricyclodecan-9-yl-xanthogenate (D609). Biochem Pharmacol. 55:1998;915-918.
35. Kiss Z. Direct proof that phorbol ester accelerates the use of choline phosphate for phosphatidylcholine synthesis in intact cells. Arch Biochem Biophys. 335:1996;191-196.
36. Li C., Peoples R., Weight F.F. Alcohol action on a neuronal membrane receptor Evidence for a direct interaction with the receptor protein . Proc Natl Acad Sci USA. 91:1994;8200-8204.
37. Malewicz B., Mukherjee J.J., Crilly K.S., Baumann W.J., Kiss Z. Phosphorylation of ethanolamine, methylethanolamine, and dimethylethanolamine by overexpressed ethanolamine kinase in NIH 3T3 cells decreases the co-mitogenic effects of ethanolamines and promotes cell survival. Eur J Biochem. 253:1998;10-19.
38. Kiss Z., Anderson W.B. ATP stimulates the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells. J Biol Chem. 265:1990;7345-7350.
39. Channareddy S., Jose S.S., Eryomin V.A., Rubin E., Taraschi T., Janes N. Saturable ethanol binding in rat liver microsomes. J Biol Chem. 271:1996;17625-17628.
40. Channareddy S., Nguyen N.T., Janes N. Saturable ethanol binding in rat liver mitochondria. Biochim Biophys Acta. 1463:2000;291-300.
41. Lewohl J.M., Wilson W.R., Mayfield R.D., Brozowski S.J., Morrisett R.A., Harris R.A. G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action. Nat Neurosci. 2:2000;1084-1090.
42. + channels. Nat Neurosci. 2:2000;1091-1097.
43. Lasner M., Roth L.G., Chen C.H. Structure-functional effects of a series of alcohols on acetylcholinesterase-associated membrane vesicles Elucidation of factors contributing to the alcohol action . Arch Biochem Biophys. 317:1995;391-396.