The role of mitochondrial dysfunction in bipolar disorder

Drug News and Perspectives

Volumn 19, Issue 10, 2006, Pages 597-602

  Kato, Tadafumi ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIDEPRESSANT AGENT; CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN A; G PROTEIN COUPLED RECEPTOR; LITHIUM; MITOCHONDRIAL DNA; PYRUVIC ACID; TRIACETYLURIDINE; UNCLASSIFIED DRUG; URIDINE; VALPROIC ACID; TRANQUILIZER;

BIPOLAR DISORDER; CALCIUM SIGNALING; CALCIUM TRANSPORT; CARDIOMYOPATHY; CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA; CLINICAL TRIAL; COMORBIDITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA POLYMORPHISM; DRUG EFFECT; DRUG INHIBITION; ENDOPLASMIC RETICULUM; GENE DELETION; GENE EXPRESSION; HAPLOTYPE; HEREDITY; HUMAN; MITOCHONDRIAL GENE; MITOCHONDRION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REVIEW; SINGLE STRAND CONFORMATION POLYMORPHISM; UPREGULATION; ANIMAL; BRAIN; DISEASE MODEL; DRUG DESIGN; ENERGY METABOLISM; GENETIC POLYMORPHISM; GENETICS; METABOLISM; MOUSE; MUTATION; PATHOPHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; BIPOLAR DISORDER; BRAIN; CALCIUM SIGNALING; COMORBIDITY; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; DRUG DESIGN; ENERGY METABOLISM; GENES, MITOCHONDRIAL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MUTATION; POLYMORPHISM, GENETIC; TRANQUILIZING AGENTS;

EID: 34247585240     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2006.19.10.1068006     Document Type: Review

References (54)

1. Kato, T. and Kato, N. Mitochondrial dysfunction in bipolar disorder. Bipolar Disord 2000, 2: 180-90.
2. Yamawaki, S., Kagaya, A., Tawara, Y. and Inagaki, M. Intracellular calcium signaling systems in the pathophysiology of affective disorders. Life Sci 1998, 62: 1665-70.
3. Emamghoreishi, M., Schlichter, L., Li, P.P. et al. High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder. Am J Psychiatry 1997, 154: 976-82.
4. Kato, T., Ishiwata, M., Mori, K. et al. Mechanisms of altered Ca2+ signalling in transformed lymphoblastoid cells from patients with bipolar disorder. Int J Neuropsychopharmacol 2003, 6: 379-89.
5. Hahn, C.G., Gomez, G., Restrepo, D. et al. Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorder. Am J Psychiatry 2005, 162: 616-8.
6. McCurdy, R.D., Feron, F., Perry, C. et al. Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses. Schizophr Res 2006, 82: 163-73.
7. Kato, T., Kuratomi, G. and Kato, N. Genetics of bipolar disorder. Drugs Today (Barc) 2005, 41: 335-44.
8. Kato, T., Inubushi, T. and Kato, N. Molecular genetics of bipolar disorder and depression. Psychiatry Clin Neurosci 2007, 61: 3-19.
9. Dager, S.R., Friedman, S.D., Parow, A. et al. Brain metabolic alterations in medication-free patients with bipolar disorder. Arch Gen Psychiatry 2004, 61: 450-8.
10. Stork, C. and Renshaw, P.F. Mitochondrial dysfunction in bipolar disorder: Evidence from magnetic resonance spectroscopy research. Mol Psychiatry 2005, 10: 900-19.
11. Kato, T., Takahashi, S., Shioiri, T. and Inubushi, T. Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy. J Affect Disord 1993, 27: 53-9.
12. McMahon, F.J., Stine, O.C., Meyers, D.A., Simpson, S.G. and DePaulo, J.R. Patterns of maternal transmission in bipolar affective disorder. Am J Hum Genet 1995, 56: 1277-86.
13. Suomalainen, A., Majander, A., Haltia, M. et al. Multiple deletions of mitochondrial DNA in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia. J Clin Invest 1992, 90: 61-6.
14. Stine, O.C., Luu, S. and Zito, M. The possible association between affective disorder and partially deleted mitochondrial DNA. Biol Psychiatry 1993, 33: 141-2.
15. Kato, T. and Takahashi, Y. Deletion of leukocyte mitochondrial DNA in bipolar disorder. J Affect Disord 1996, 37: 67-73.
16. Kato, T., Winokur, G., McMahon, F.J., DePaulo, J.R. and Crowe, R.R. Quantitative analysis of leukocyte mitochondrial DNA deletion in affective disorders. Biol Psychiatry 1997, 42: 311-6.
17. Kakiuchi, C., Ishiwata, M., Kametani, M., Nelson, C., Iwamoto, K. and Kato, T. Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia. Int J Neuropsychopharmacol 2005, 8: 515-22.
18. Kirk, R., Furlong, R.A., Amos, W. et al. Mitochondrial genetic analyses suggest selection against maternal lineages in bipolar affective disorder. Am J Hum Genet 1999, 65: 508-18.
19. McMahon, F.J., Chen, Y.S., Patel, S. et al. Mitochondrial DNA sequence diversity in bipolar affective disorder. Am J Psychiatry 2000, 157: 1058-64.
20. Kato, T., Kunugi, H., Nanko, S. and Kato, N. Association of bipolar disorder with the 5178 polymorphism in mitochondrial DNA. Am J Med Genet 2000, 96: 182-6.
21. Kato, T., Kunugi, H., Nanko, S. and Kato, N. Mitochondrial DNA polymorphisms in bipolar disorder. J Affect Disord 2001, 62: 151-64.
22. Kazuno, A.A., Munakata, K., Nagai, T. et al. Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics. PLoS Genet 2006, 2(8): e128.
23. Munakata, K., Tanaka, M., Mori, K. et al. Mitochondrial DNA 3644T→C mutation associated with bipolar disorder. Genomics 2004, 84: 1041-50.
24. Kazuno, A.A., Munakata, K., Mori, K. et al. Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'. Psychiatry Clin Neurosci 2005, 59: 497-503.
25. Bezchlibnyk, Y.B., Wang, J.F., McQueen, G.M. and Young, L.T. Gene expression differences in bipolar disorder revealed by cDNA array analysis of post-mortem frontal cortex. J Neurochem 2001, 79: 826-34.
26. Iwamoto, K., Kakiuchi, C., Bundo, M., Ikeda, K. and Kato, T. Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Mol Psychiatry 2004, 9: 406-16.
27. Konradi, C., Eaton, M., MacDonald, M.L., Walsh, J., Benes, F.M. and Heckers, S. Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch Gen Psychiatry 2004, 61: 300-8.
28. Schweitzer, A. Pegging pathology on mitochondrial dysfunction. Scientist 2004, 18: 28.
29. Iwamoto, K., Bundo, M. and Kato, T. Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet 2005, 14: 241-53.
30. Sun, X., Wang, J.F., Tseng, M. and Young, L.T. Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder. J Psychiatry Neurosci 2006, 31: 189-96.
31. Li, J.Z., Vawter, M.P., Walsh, D.M. et al. Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Hum Mol Genet 2004, 13: 609-16.
32. Tomita, H., Vawter, M.P., Walsh, D.M. et al. Effect of agonal and postmortem factors on gene expression profile: Quality control in microarray analyses of postmortem human brain. Biol Psychiatry 2004, 55: 346-52.
33. Vawter, M.P., Tomita, H., Meng, F. et al. Mitochondrial-related gene expression changes are sensitive to agonal-pH state: Implications for brain disorders. Mol Psychiatry 2006, 11: 615, 63-79.
34. Munakata, K., Iwamoto, K., Bundo, M. and Kato, T. Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia. Biol Psychiatry 2005, 57: 525-32.
35. Nonaka, S., Hough, C.J. and Chuang, D.M. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. Proc Natl Acad Sci U S A 1998, 95: 2642-7.
36. Chen, G., Zeng, W.Z., Yuan, P.X. et al. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. J Neurochem 1999, 72: 879-82.
37. Chen, G., Huang, L.D., Jiang, Y.M. and Manji, H.K. The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3. J Neurochem 1999, 72: 1327-30.
38. Zhou, R., Gray, N.A., Yuan, P. et al. The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers. J Neurosci 2005, 25: 4493-502.
39. Lai, J.S., Zhao, C., Warsh, J.J. and Li, P.P. Cytoprotection by lithium and valproate varies between cell types and cellular stresses. Eur J Pharmacol 2006, 539: 18-26.
40. Nakatani, N., Aburatani, H., Nishimura, K., Semba, J. and Yoshikawa, T. Comprehensive expression analysis of a rat depression model. Pharmacogenomics J 2004, 4: 114-26.
41. Karry, R., Klein, E. and Ben Shachar, D. Mitochondrial complex I subunits expression is altered in schizophrenia: A postmortem study. Biol Psychiatry 2004, 55: 676-84.
42. Nakatani, N., Hattori, E., Ohnishi, T. et al. Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: Relevance to neuronal network perturbation. Hum Mol Genet 2006, 15: 1949-62.
43. Washizuka, S., Kakiuchi, C., Mori, K. et al. Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder. Am J Med Genet 2003, 120B: 72-8.
44. Washizuka, S., Iwamoto, K., Kazuno, A.A. et al. Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees. Biol Psychiatry 2004, 56: 483-9
45. Siciliano, G. Tessa, A., Petrini, S. et al. Autosomal dominant external ophthalmoplegia and bipolar affective disorder associated with a mutation in the ANT1 gene. Neuromuscul Disord 2003, 13: 162-5.
46. Kato, T. The other, forgotten genome: Mitochondrial DNA and mental disorders. Mol Psychiatry 2001, 6: 625-33.
47. Miyaoka, H., Suzuki, Y., Taniyama, M. et al. Mental disorders in diabetic patients with mitochondrial transfer RNA(Leu) (UUR) mutation at position 3243. Biol Psychiatry 1997, 42: 524-6.
48. Boles, R.G., Burnett, B.B., Gleditsch, K. et al. A high predisposition to depression and anxiety in mothers and other matrilineal relatives of children with presumed maternally inherited mitochondrial disorders. Am J Med Genet B Neuropsychiatr Genet 2005, 137: 20-4.
49. Burnett, B.B., Gardner, A. and Boles, R.G. Mitochondrial inheritance in depression, dysmotility and migraine? J Affect Disord 2005, 88: 109-16.
50. Kasahara, T., Kubota, M., Miyauchi, T. et al. Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Mol Psychiatry 2006, 11: 577-93, 523.
51. King, M.P. and Attardi, G. Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation. Science 1989, 246: 500-3.
52. Carlezon, W.A., Jr., Mague, S.D., Parow, A.M., Stoll, A.L., Cohen, B.M. and Renshaw, P.F. Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats. Biol Psychiatry 2005, 57: 343-50.
53. Mott, J.L., Zhang, D. and Zassenhaus, H.P. Mitochondrial DNA mutations, apoptosis, and the misfolded protein response. Rejuvenation Res 2005, 8: 216-26.
54. Mott, J.L., Zhang, D., Chang, S.W. and Zassenhaus, H.P. Mitochondrial DNA mutations cause resistance to opening of the permeability transition pore. Biochim Biophys Acta 2006, 1757: 596-603.