Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia

International Journal of Neuropsychopharmacology

Volumn 8, Issue 4, 2005, Pages 515-522

  Kakiuchi, Chihiro ^a   Ishiwata, Mizuho ^a   Kametani, Mizue ^a   Nelson, Cheryl ^a   Iwamoto, Kazuya ^a   Kato, Tadafumi ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Bipolar disorder; Deletions; Frontal cortex; Mitochondrial DNA; Schizophrenia

Indexed keywords

CELL NUCLEUS DNA; DNA POLYMERASE; MITOCHONDRIAL DNA;

ADULT; AGE DISTRIBUTION; ARTICLE; BIPOLAR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DNA REPLICATION; FEMALE; FRONTAL CORTEX; GENE DELETION; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; MALE; MEDICAL ASSESSMENT; MITOCHONDRIAL DNA DEPLETION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SEX DIFFERENCE; UPREGULATION;

ADULT; AGING; BIPOLAR DISORDER; CELL NUCLEUS; CEREBRAL CORTEX; CHROMOSOMES, HUMAN, X; DNA REPLICATION; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; FEMALE; GENOME, HUMAN; HUMANS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SEQUENCE DELETION; SEX CHARACTERISTICS;

EID: 25844454917     PISSN: 14611457     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1461145705005213     Document Type: Article

References (43)

1. APA (1994). Diagnostic and Statistical Manual of Mental Disorders (4th edn). Washington, DC: American Psychiatric Association.
2. Altshuler LL, Curran JG, Hauser P, Mintz J, Denicoff K, Post R (1995). T2 hyperintensities in bipolar disorder: magnetic resonance imaging comparison and literature meta-analysis. American Journal of Psychiatry 152, 1139-1144.
3. Ben-Shachar D (2002). Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine. Journal of Neurochemistry 83, 1241-1251.
4. Cavelier L, Jazin EE, Eriksson I, Prince J, Bave U, Oreland L, Gyllensten U (1995). Decreased cytochrome-c oxidase activity and lack of age-related accumulation of mitochondrial DNA deletions in the brains of schizophrenics. Genomics 29, 217-224.
5. Chomyn A, Attardi G (2003). MtDNA mutations in aging and apoptosis. Biochemical and Biophysical Research Communications 304, 519-529.
6. Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, Wallace DC (1992). Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nature Genetics 2, 324-329.
7. Deicken RF, Fein G, Weiner MW (1995). Abnormal frontal lobe phosphorous metabolism in bipolar disorder. American Journal of Psychiatry 152, 915-918.
8. Dror N, Klein E, Karry R, Sheinkman A, Kirsh Z, Mazor M, Tzukerman M, Ben-Shachar D (2002). State-dependent alterations in mitochondrial complex I activity in platelets: a potential peripheral marker for schizophrenia. Molecular Psychiatry 7, 995-1001.
9. 31P magnetic resonance chemical shift imaging. Acta Psychiatrica Scandinavia 86, 455-462.
10. Goldstein JM, Faraone SV, Chen WJ, Tolomiczencko GS, Tsuang MT (1990). Sex differences in the familial transmission of schizophrenia. British Journal of Psychiatry 156, 819-826.
11. Graziewicz MA, Day BJ, Copeland WC (2002). The mitochondrial DNA polymerase as a target of oxidative damage. Nucleic Acids Research 30, 2817-2824.
12. Hayashi J, Ohta S, Kikuchi A, Takemitsu M, Goto Y, Nonaka I (1991). Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proceedings of National Academy of Sciences USA 88, 10614-10618.
13. He L, Chinnery PF, Durham SE, Blakely EL, Wardell TM, Borthwick GM, Taylor RW, Turnbull DM (2002). Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR. Nucleic Acids Research 30, e68.
14. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP (2003). Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4, 249-264.
15. Iwamoto K, Kakiuchi C, Bundo M, Ikeda K, Kato T (2004). Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Molecular Psychiatry 9, 406-414.
16. Kato T, Inubushi T, Kato N (1998a). Magnetic resonance spectroscopy in affective disorders. Journal of Neuropsychiatry and Clinical Neuroscience 10, 133-147.
17. Kato T, Kato N (2000). Mitochondrial dysfunction in bipolar disorder. Bipolar Disorder 2, 180-190.
18. Kato T, Kunugi H, Nanko S, Kato N (2000). Association of bipolar disorder with the 5178 polymorphism in mitochondrial DNA. American Journal of Medical Genetics 96, 182-186.
19. Kato T, Kunugi H, Nanko S, Kato N (2001). Mitochondrial DNA polymorphisms in bipolar disorder. Journal of Affective Disorders 62, 151-164.
20. 31P-MRS in bipolar disorder: a confirmation in drug-free patients and correlation with white matter hyperintensity. European Archives of Psychiatry and Clinical Neuroscience 248, 301-306.
21. Kato T, Stine OC, McMahon FJ, Crowe RR (1997). Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder. Biological Psychiatry 42, 871-875.
22. 7Li magnetic resonance spectroscopy. Journal of Affective Disorders 27, 53-59.
23. Kato T, Takahashi S, Shioiri T, Murashita J, Hamakawa H, Inubushi T (1994). Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. Journal of Affective Disorders 31, 125-133.
24. Kegeles LS, Humaran TJ, Mann JJ (1998). In vivo neurochemistry of the brain in schizophrenia as revealed by magnetic resonance spectroscopy. Biological Psychiatry 44, 382-398.
25. Konradi C, Eaton M, MacDonald ML, Walsh J, Benes FM, Heckers S (2004). Molecular evidence for mitochondrial dysfunction in bipolar disorder. Archives of General Psychiatry 61, 300-308.
26. Leung A, Chue P (2000). Sex differences in schizophrenia, a review of the literature. Acta Psychiatrica Scandinavia (Suppl.) 401, 3-38.
27. Marchbanks RM, Ryan M, Day IN, Owen M, McGuffin P, Whatley SA (2003). A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress. Schizophrenia Research 65, 33-38.
28. Melberg A, Arnell H, Dahl N, Stalberg E, Raininko R, Oldfors A, Bakall B, Lundberg PO, Holme E (1996). Anticipation of autosomal dominant progressive external ophthalmoplegia with hypogonadism. Muscle and Nerve 19, 1561-1569.
29. Mulcrone J, Whatley SA, Ferrier IN, Marchbanks RM (1995). A study of altered gene expression in frontal cortex from schizophrenic patients using differential screening. Schizophrenia Research 14, 203-213.
30. Murashita J, Kato T, Shioiri T, Inubushi T, Kato N (2000). Altered brain energy metabolism in lithium-resistant bipolar disorder detected by photic stimulated 31P-MR spectroscopy. Psychological Medicine 30, 107-115.
31. Oexle K, Zwirner A (1997). Advanced telomere shortening in respiratory chain disorders. Human Molecular Genetics 6, 905-908.
32. Prayson RA, Wang N (1998). Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS) syndrome: an autopsy report. Archives of Pathology and Laboratory Medicine 122, 978-981.
33. Rango M, Bozzali M, Prelle A, Scarlato G, Bresolin N (2001). Brain activation in normal subjects and in patients affected by mitochondrial disease without clinical central nervous system involvement: a phosphorus magnetic resonance spectroscopy study. Journal of Cerebral Blood Flow and Metabolism 21, 85-91.
34. Shimizu A, Kurachi M, Yamaguchi N, Torii H, Isaki K (1987). Morbidity risk of schizophrenia to parents and siblings of schizophrenic patients. Japanese Journal of Psychiatry and Neurology 41, 65-70.
35. Siciliano G, Tessa A, Petrini S, Mancuso M, Bruno C, Grieco GS, Malandrini A, DeFlorio L, Martini B, Federico A, Nappi G, Santorelli FM, Murri L (2003). Autosomal dominant external ophthalmoplegia and bipolar affective disorder associated with a mutation in the ANT1 gene. Neuromuscular Disorders 13, 162-165.
36. Soong NW, Hinton DR, Cortopassi G, Arnheim N (1992). Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nature Genetics 2, 318-323.
37. Suomalainen A, Majander A, Haltia M, Somer H, Lonnqvist J, Savontaus ML, Peltonen L (1992). Multiple deletions of mitochondrial DNA in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia. Journal of Clinical Investigation 90, 61-66.
38. Uranova N, Orlovskaya D, Vikhreva O, Zimina I, Kolomeets N, Vostrikov V, Rachmanova V (2001). Electron microscopy of oligodendroglia in severe mental illness. Brain Research Bulletin 55, 597-610.
39. Van Goethem G, Dermaut B, Lofgren A, Martin JJ, Van Broeckhoven C (2001). Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions. Nature Genetics 28, 211-212.
40. Volz HR, Riehemann S, Maurer I, Smesny S, Sommer M, Rzanny R, Holstein W, Czekalla J, Sauer H (2000). Reduced phosphodiesters and high-energy phosphates in the frontal lobe of schizophrenic patients: a (31)P chemical shift spectroscopic-imaging study. Biological Psychiatry 47, 954-961.
41. Washizuka S, Kakiuchi C, Mori K, Kunugi H, Tajima O, Akiyama T, Nanko S, Kato T (2003). Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder. American Journal of Medical Genetics 120B, 72-78.
42. Winokur G, Reich T (1970). Two genetic factors in manic-depressive disease. Comprehensive Psychiatry 11, 93-99.
43. Wolyniec PS, Pulver AE, McGrath JA, Tam D (1992). Schizophrenia: gender and familial risk. Journal of Psychiatric Research 26, 17-27.