Gene expression differences in bipolar disorder revealed by cDNA array analysis of post-mortem frontal cortex

Journal of Neurochemistry

Volumn 79, Issue 4, 2001, Pages 826-834

  Bezchlibnyk, Yarema B ^a   Wang, Jun Feng ^a   McQueen, Glenda M ^a   Trevor Young, L ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Bipolar disorder; CDNA array; Frontal cortex; Gene expression; Post mortem brain; Transforming growth factor

Indexed keywords

CASPASE 8; COMPLEMENTARY DNA; GENE PRODUCT; MESSENGER RNA; TRANSDUCER OF ERBB2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CADAVER; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; FEMALE; FRONTAL CORTEX; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; MALE; MANIC DEPRESSIVE PSYCHOSIS; NEUROPROTECTION; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGE FACTORS; BIPOLAR DISORDER; CARRIER PROTEINS; CASPASE 8; CASPASE 9; CASPASES; DOWN-REGULATION; FEMALE; FRONTAL LOBE; GENE EXPRESSION PROFILING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 7; MITOGEN-ACTIVATED PROTEIN KINASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOLIPASE C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 0035179492     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00628.x     Document Type: Article

References (69)

1. An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia
2. Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor
3. A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives
4. The hematopoietic cytokine, colony-stimulating factor 1, is also a growth factor in the CNS: Congenital absence of CSF-1 in mice results in abnormal microglial response and increased neuron vulnerability to injury
5. Microglial-neuronal interactions in synaptic damage and recovery
6. Transforming growth factor beta has neurotrophic actions on sensory neurons in vitro and is synergistic with nerve growth factor
7. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
8. Mood stabilizers regulate cytoprotective and mRNA-binding proteins in the brain: Long-term effects on cell survival and transcript stability
9. Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity
10. Caspases: The executioners of apoptosis
11. Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder
12. Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma
13. G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: Effects of diagnosis, suicide, and treatment at the time of death
14. Increased hippocampal supragranular Timm staining in subjects with bipolar disorder
15. Subgenual prefrontal cortex abnormalities in mood disorders
16. Increased prefrontal sulcal prominence in relatively young patients with unipolar major depression
17. TGF-beta 1 is an organizer of responses to neurodegeneration
18. Mice, microarrays, and the genetic diversity of the brain
19. Understanding manicdepressive illness
20. Synaptic and plasticity-associated proteins in anterior frontal cortex in severe mental illness
21. Activity and injurydependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system
22. Initiation and adaptation: A paradigm for understanding psychotropic drug action
23. Transforming growth factor-beta inhibits apoptosis induced by beta-amyloid peptide fragment 25-35 in cultured neuronal cells
24. The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms
25. Schizophrenia and bipolar disorder: Findings from studies of the Stanley Foundation Brain Collection
26. Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-beta
27. Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humans
28. Transplantation of activated macrophages overcomes central nervous system regrowth failure
29. Patterning and specification of the cerebral cortex
30. Transforming growth factor-beta 1 stimulates expression of nerve growth factor in the rat CNS
31. Transforming growth factor-beta: Neuronal and glial expression in CNS degenerative diseases
32. Transforming growth factor-beta 1 and basic fibroblast growth factor in the injured CNS
33. Long-term action of lithium: A role for transcriptional and posttranscriptional factors regulated by protein kinase C
34. Signaling: Cellular insights into the pathophysiology of bipolar disorder
35. The nature of bipolar disorder
36. Transforming growth factor beta 1 is a potent survival factor for rat embryo motoneurons in culture
37. The TGF-b family and its composite receptors
38. Strategies for the generation of neuronal diversity in the developing central nervous system
39. Cytokines in inflammatory brain lesions: Helpful and harmful
40. Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGF beta
41. Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide
42. Regulation of thrombospondin in the regenerating mouse facial motor nucleus
43. Lithium-induced increase in human brain grey matter
44. TGF-beta 1 mRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acidinduced neurodegeneration
45. Effects of lithium on second messenger systems in the brain
46. Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine
47. Glial reduction in the subgenual prefrontal cortex in mood disorders
48. Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
49. Sensitization, kindling, and anticonvulsants in mania
50. A speculative model of affective illness cyclicity based on patterns of drug tolerance observed in amygdala-kindled seizures
51. Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons
52. Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons
53. Activated macrophage/microglial cells can promote the regeneration of sensory axons into the injured spinal cord
54. Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth
55. Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
56. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression
57. Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
58. Transforming growth factors-beta protect primary rat hippocampal neuronal cultures from degeneration induced by beta-amyloid peptide
59. Transforming growth factor-beta protects human hNT cells from degeneration induced by beta-amyloid peptide: Involvement of the TGF-beta type II receptor
60. The transforming growth factorsβ
61. Astrocyte-derived TGF-beta 2 and NGF differentially regulate neural recognition molecule expression by cultured astrocytes
62. Diversity and cell type specificity of local excitatory connections to neurons in layer 3B of monkey primary visual cortex
63. Transforming growth factor-beta 1 inhibits tumor necrosis factor-alpha/lymphotoxin production and adoptive transfer of disease by effector cells of autoimmune encephalomyelitis
64. Brain magnetic resonance imaging of structural abnormalities in bipolar disorder
65. Structural brain abnormalities in bipolar affective disorder. Ventricular enlargement and focal signal hyperintensities
66. Cytokines in neural regeneration
67. Signal transduction abnormalities in bipolar disorder
68. Serotonergic hyperinnervation of the frontal cortex in an animal model of depression, the bulbectomized rat