Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: Relevance to neuronal network perturbation

Human Molecular Genetics

Volumn 15, Issue 12, 2006, Pages 1949-1962

  Nakatani, Noriaki ^a   Hattori, Eiji ^a   Ohnishi, Tetsuo ^a   Dean, Brian ^b   Iwayama, Yoshimi ^a   Matsumoto, Izuru ^c   Kato, Tadafumi ^a   Osumi, Noriko ^d,e   Higuchi, Teruhiko ^f   Niwa, Shin Ichi ^g   Yoshikawa, Takeo ^a,e  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^f NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^g FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; 1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE 1B GAMMA; BINDING PROTEIN; CHEMOKINE; CHEMOKINE LIGAND 3; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HLA DR ANTIGEN; KATANIN B1; MESSENGER RNA; PROTEIN P80; PURINE RICH ELEMENT BINDING PROTEIN A; RAP1 GTPASE ACTIVATING PROTEIN 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REGULATOR PROTEIN; SOMATOSTATIN; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; AUTOPSY; BIPOLAR I DISORDER; CELL GROWTH; CLINICAL ARTICLE; COHORT ANALYSIS; CONSENSUS DEVELOPMENT; CONTROLLED STUDY; DOWN REGULATION; EMPIRICISM; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE LINKAGE DISEQUILIBRIUM; HAPLOTYPE; HUMAN; HUMAN TISSUE; MALE; MICROARRAY ANALYSIS; MOLECULAR GENETICS; NERVE CELL NETWORK; NERVOUS SYSTEM DEVELOPMENT; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; VALIDATION STUDY;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ALGORITHMS; BIPOLAR DISORDER; CASE-CONTROL STUDIES; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENOME, HUMAN; HLA-DR ANTIGENS; HUMANS; NADH DEHYDROGENASE; NEURAL PATHWAYS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PARIETAL LOBE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREFRONTAL CORTEX; RAP1 GTP-BINDING PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SOMATOSTATIN; TRANSCRIPTION FACTORS;

EID: 33745622166     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddl118     Document Type: Article

References (48)

1. Goodwin, F.K. and Jamison, K.R. (1990) Manic-depressive Illness, Vol. 36. University Press, Oxford, NY, USA.
2. Schulze, T.G. and McMahon, F.J. (2003) Genetic linkage and association studies in bipolar affective disorder: A time for optimism. Am. J. Med. Genet. C. Semin. Med. Genet., 123, 36-47.
3. Iwamoto, K., Kakiuchi, C., Bundo, M., Ikeda, K. and Kato, T. (2004) Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Mol. Psychiat, 9, 406-416.
4. Tkachev, D., Mimmack, M.L., Ryan, M.M., Wayland, M., Freeman, T., Jones, P.B., Starkey, M., Webster, M.J., Yolken, R.H. and Balm, S. (2003) Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet, 362, 798-805.
5. Nakatani, N., Aburatani, H., Nishimura, K., Semba, J. and Yoshikawa, T. (2004) Comprehensive expression analysis of a rat depression model. Pharmacogenom. J., 4, 114-126.
6. Benjamini, Y. and Hochberg, Y. (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. J. Roy. Stat. Soc., B57, 289-300.
7. Iwamoto, K., Bundo, M. and Kato, T. (2005) Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum. Mol. Genet., 14, 241-253.
8. Mirnics, K., Middleton, A.F., Lewis, A.D. and Levit, P. (2001) Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends Neurosci., 24, 479-486.
9. Wahlestedt, C. (2001) Using genomics to understand the nervous system. Drug Discov. Today, 6, S81-S85.
10. Munakata, K., Iwamoto, K., Bundo, M. and Kato, T. (2005) Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia Biol. Psychiat., 57, 525-532.
11. Li, J.Z., Vawter, M.P., Walsh, D.M., Tomita, H., Evans, S.J., Choudary, P.V., Lopez, J.F., Avelar, A., Shokoohi, V., Chung, T. et al. (2004) Systemic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Hum. Mol. Genet., 13, 609-616.
12. Yacubova, E. and Komuro, H. (2003) Cellular and molecular mechanisms of cerebellar granule cell migration. Cell Biochem. Biophys., 37, 213-234.
13. Sharma, R.P., Bissette, G., Janicak, P.G., Davis, J.M. and Nemeroff, C.B. (1995) Elevation of CSF somatostatin concentrations in mania. Am. J. Psychiat., 152, 1807-1809.
14. Konradi, C., Eaton, M., MacDonald, M.L., Walsh, J., Benes, F.M. and Heckers, S. (2004) Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch. Gen. Psychiat., 61, 300-308.
15. Schwartz, J.P., Ji, Z. and Epelbaum, J. (1998) Somatostatin as a neurotrophic factor. Which receptor/second messenger transduction system is involved? Perspect. Dev. Neurobiol., 5, 427-435.
16. Halenbeck, R., Crosier, W.J., Clark, R., McCormick, F. and Koths, K. (1990) Purification, characterization, and western blot analysis of human GTPase-activating protein from native and recombinant sources. J. Biol. Chem., 265, 21922-21928.
17. Kitayama, H., Sugimoto, Y., Matsuzaki, T., Ikawa, Y. and Noda, M. (1989) A ras-related gene with transformation suppressor activity. Cell, 56, 77-84.
18. Greene, L.A. and Tischler, A.S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl Acad. Sci. USA, 73, 2424-2428.
19. Rydel, R.E. and Greene, L.A. (1987) Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells. J. Neurobiol., 7, 3639-3653.
20. Lu, L., Anneren, C., Reedquist, K.A., Bos, J.L. and Welsh, M. (2000) NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway. Exp. Cell Res., 259, 370-377.
21. Meng, J. and Casey, P.J. (2002) Activation of Gz attenuates Rap1-mediated differentiation of PC12 cell. J. Biol. Chem., 277, 43417-43424.
22. Dean, B., McLeod, M., Keriakous, D., McKenzie, J. and Scarr, E. (2002) Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol. Psychiat., 7, 1083-1091.
23. Arai, H., Koizumi, H., Aoki, J. and Inoue, K. (2002) Platelet-activating factor acetylhydrolase (PAF-AH). J. Biochem., 131, 635-640.
24. Sapir, T., Elbaum, M. and Reiner, O. (1997) Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. EMBO J., 16, 6977-6984.
25. Faulkner, N.E., Dujardin, D.L., Tai, C.Y., Vaughan, K.T., O'Connell, C.B., Wang, Y. and Vallee, R.B. (2000) A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function. Nat. Cell Biol., 2, 784-791.
26. Smith, D.S., Niethammer, M., Ayala, R., Zhou, Y., Gambello, M.J., Wynshaw-Boris, A. and Tsai, L.H. (2000) Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1. Nat. Cell Biol., 2, 767-775.
27. Feng, Y., Olson, E.C., Stukenberg, P.T., Flanagan, L.A., Kirschner, M.W. and Walsh, C.A. (2000) LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron, 28, 665-679.
28. Niethammer, M., Smith, D.S., Ayala, R., Peng, J., Ko, J., Lee, M.S., Morabito, M. and Tsai, L.H. (2000) NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron, 28, 697-711.
29. Sasaki, S., Shionoya, A., Ishida, M., Gambello, M.J., Yingling, J., Wynshaw-Boris, A. and Hirotsune, S. (2000) A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron, 28, 681-696.
30. Morris, J.A., Kandpal, G., Ma, L. and Austin, C.P. (2003) DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAPIA, MIPT3, ATF4/5 and NUDEL: Regulation and loss of interaction with mutation. Hum. Mol. Genet., 12, 1591-1608.
31. Jun, T.Y., Pae, C.U., Chae, J.H., Pyo, C.W. and Han, H. (2002) Human leukocyte antigen alleles in patients with bipolar disorder in the Korean population. Psychiat. Clin. Neurosci., 56, 453-457.
32. Gomez, J.A., Majumder, P., Nagarajan, U.M. and Boss, J.M. (2005) X box-like sequences in the MHC class II region maintain regulatory function. J. Immunol., 175, 1030-1040.
33. Kakiuchi, C., Iwamoto, K., Ishiwata, M., Bundo, M., Kasahara, T., Kusumi, I., Tsujita, T., Okazaki, Y., Nanko, S., Kunugi, H. et al. (2003) Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nat. Genet., 35, 171-175.
34. Bose, H.S., Pescovitz, O.H. and Miller, W.L. (1997) Spontaneous feminization in a 46,XX female patient with congenital lipoid adrenal hyperplasia due to a homozygous frameshift mutation in the steroidogenic acute regulatory protein. J. Clin. Endocr. Metab., 82, 1511-1515.
35. Gallia, G.L., Johnson, E.M. and Khalili, K. (2000) Pur-alpha: A multifunctional single-stranded DNA-and RNA-binding protein. Nucleic Acids Res., 28, 3197-3205.
36. McNally, F.J. and Vale, R.D. (1993) Identification of katanin, an ATPase that severs and disassembles stable microtubules. Cell, 75, 419-429.
37. Karry, R., Klein, E. and Ben Shachar, D. (2004) Mitochondrial complex I subunits expression is altered in schizophrenia: A postmortem study. Biol. Psychiat., 55, 676-684.
38. Detera-Wadleigh, S.D., Badner, J.A., Berrettini, W.H., Yoshikawa, T., Goldin, L.R., Turner, G., Rollins, D.Y., Moses, T., Sanders, A.R., Karkera, J.D. et al. (1999) A high density genome scan detects evidence for a bipolar susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc. Natl Acad. Sci. USA, 96, 5604-5609.
39. Washizuka, S., Iwamoto, K., Kazuno, A., Kakiuchi, C., Mori, K., Kametani, M., Yamada, K., Kunugi, H., Tajima, O., Akiyama, T. et al. (2004) Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health Pedigrees. Biol. Psychiat., 56, 483-489.
40. de Bakker, P.I., Yelensky, R., Pe'er, I., Gabriel, S.B., Daly, M.J. and Altshuler, D. (2005) Efficiency and power in genetic association studies. Nat. Genet., 37, 1217-1223.
41. Gould, T.D., Quiroz, J.A., Singh, J., Zarate, C.A. and Manji, H.K. (2004) Emerging experimental therapeutics for bipolar disorder: Insights from the molecular and cellular actions of current mood stabilizers. Mol. Psychiat, 9, 734-755.
42. Keks, N.A., Hill, C., Opeskin, K., Copolov, D.L. and Dean, B. (1999) Psychiatric diagnosis after death: The problems of accurate diagnosis from the case history review and relative interviews. In Kleinman, J.E. and Hyde, T.M. (eds), Using CNS Tissue in Psychiatric Research., Harwood Academic Press, Amsterdam, pp. 19-37.
43. Aoki-Suzuki, M., Yamada, K., Meerabux, J., Iwayama-Shigeno, Y., Ohba, H., Iwamoto, K., Takao, H., Toyota, T., Suto, Y., Nakatani, N. et al. (2005) A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. Biol. Psychiat., 57, 382-393.
44. Nurnberger, J.I., Jr., DePaulo, J.R., Gershon, F.S., Reich, T., Blehar, M.C., Edenberg, H.J., Foroud, T., Miller, M., Bowman, E., Mayeda, A. et al. (1997) Genomic survey of bipolar illness in the NIMH genetics initiative pedigrees: A preliminary report. Am. J. Med. Genet., 74, 227-237.
45. Carlson, C.S., Eberle, M.A., Rieder, M.J., Yi, Q., Kruglyak, L. and Nickerson, D.A. (2004) Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am. J. Hum. Genet., 74, 106-120.
46. Altshuler, D., Brooks, L.D., Chakravarti, A., Collins, F.S., Daly, M.J. and Donnelly, P.A. (2005) Haplotype map of the human genome. Nature, 437, 1299-1320.
47. Lin, S., Chakravarti, A. and Cutler, D.J. (2004) Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies. Nat. Genet., 36, 1181-1188.
48. Dudbridge, F. (2003) Pedigree disequilibrimn tests for multilocus haplotypes. Genet. Epidemiol., 25, 115-121.