The broken genome: Genetic and pharmacologic approaches to breaking DNA

Annals of Medicine

Volumn 39, Issue 3, 2007, Pages 208-218

  Woo, Leslie L ^a   Onel, Kenan ^a   Ellis, Nathan A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Anticancer therapies; Bloom syndrome (BS); Cancer; DNA repair; Genomic instability; Recombination; RecQ helicases; Topoisomerase 3s; Topoisomerase inhibitors

Indexed keywords

ACTINOMYCIN DERIVATIVE; ANTHRACYCLINE DERIVATIVE; CAMPTOTHECIN; COUMARIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; ELLIPTICINE DERIVATIVE; EPIPODOPHYLLOTOXIN DERIVATIVE; ETOPOSIDE; FOSTRIECIN; GENE PRODUCT; IMATINIB; IRINOTECAN; RECQ HELICASE; TOPOTECAN;

ACUTE GRANULOCYTIC LEUKEMIA; BLOOM SYNDROME; BONE MARROW SUPPRESSION; BREAST CANCER; CANCER; CANCER SUSCEPTIBILITY; CELL ACTIVITY; CELL CYCLE; CELL CYCLE S PHASE; CELL NUCLEUS INCLUSION BODY; CELL STRESS; CHROMOSOMAL INSTABILITY; COLON CANCER; DISEASE MODEL; DNA DAMAGE; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME DEFICIENCY; ENZYME MECHANISM; GENE CONTROL; GENE FUNCTION; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETICS; GENOME; GENOMIC INSTABILITY; GLIOMA; HEAD AND NECK CANCER; HEMATOLOGIC MALIGNANCY; HEMORRHAGIC CYSTITIS; HUMAN; LUNG SMALL CELL CANCER; MOLECULAR EVOLUTION; MOLECULAR INTERACTION; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STOMACH CANCER;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CELL NUCLEUS; DISEASE MODELS, ANIMAL; DNA BREAKS; DNA HELICASES; DNA REPAIR ENZYMES; DNA TOPOISOMERASES; GENE DOSAGE; GENOME, HUMAN; GENOMIC INSTABILITY; HUMANS; NEOPLASMS; RECOMBINATION, GENETIC; RECQ HELICASES; S PHASE; SIGNAL TRANSDUCTION;

EID: 34247580152     PISSN: 07853890     EISSN: 16512219     Source Type: Journal    
DOI: 10.1080/08035250601167136     Document Type: Review

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