What really declines with age? The Hayflick lecture for 2006 35th American Aging Association

Age

Volumn 29, Issue 1, 2007, Pages 1-14

  Kitani, Kenichi ^a  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

( )deprenyl; Aging rodents; Altered enzymes; Antioxidant enzymes; Hepatic microsomal P 450 functions; Maximal seizure response; Protein lateral diffusion coefficients of cell surface membranes; Sex and strain related differences; Tetrahydrocurcumin

Indexed keywords

OUABAIN; SUPEROXIDE DISMUTASE;

AGING; ANTIOXIDANT ACTIVITY; BILIARY EXCRETION; CELL TYPE; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; FRAIL ELDERLY; LIVER CELL MEMBRANE; LIVER FUNCTION; MALNUTRITION; NONHUMAN; PREDICTION; RETROSPECTIVE STUDY;

EID: 34247556036     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-006-9014-8     Document Type: Conference Paper

References (78)

1. Adelman RC (1975) Disruption in enzyme regulation during aging. In: Parke DV (ed) Enzyme Induction. Plenum Press, London, pp 303-311
2. Anderson KE, Conney AH, Kappas A (1982) Nutritional influences on chemical biotransformations in humans. Nutr Rev 40(6):161-171
3. Au WY, Dutt AK, DeSoyza N (1985) Theophylline kinetics in chronic obstructive airway disease in the elderly. Clin Pharmacol Ther 37(4):472-478
4. Bickford PC, Adams CE, Boyson SJ, Curella P, Gerhardt GA, Hero C et al (1997) Long-term treatment of male F344 rats with deprenyl: Assessment of effects on longevity, behavior, and brain function. Neurobiol Aging 18:309-318
5. Bonde J, Pedersen LE, Bodtker S, Angelo HR, Svendsen TL, Kampmann JP (1985) The influence of age and smoking on the elimination of disopyramide. Br J Clin Pharmacol 20:453-458
6. Brandfonbrener M, Landowne M, Shock NW (1955) Changes in cardiac output with age. Circulation 12:557-566
7. Carrillo MC, Kanai S, Kitani K, Ivy GO (2000) A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats. Life Sci 67:2539-2548
8. Carrillo MC, Kanai S, Miyasaka K, Kitai K (2002) A protein free diet uncovers the potential age-difference in the hepatic detoxifying system, glutathione S-transferase in female mice. Mech Ageing Dev 123:1617-1623
9. Carrillo MC, Kanai S, Sato Y, Kitani K (1992a) Age-related changes in antioxidant enzyme activities are region and organ selective as well as sex in the rat. Mech Ageing Dev 65:187-198
10. Carrillo MC, Kitani K, Kanai S, Sato Y, Nokubo M, Ohta M, Otsubo K (1989) Differences in the influence of diet on hepatic glutathione S-transferase activity and glutathione content between young and old C57 black female mice. Mech Ageing Dev 47:1-15
11. Carrillo MC, Nokubo M, Kitani K, Kanai S, Sato Y, Ohta M (1991) Different responses of subunit concentrations and enzyme activities of glutathione S-transferases (GSTs) to protein-free diet (PFD) between young and old rodent livers. In: Kitani K (ed) Liver and Aging-1990. Elsevier Science, Amsterdam, New York, Oxford, pp 75-86
12. Carrillo MC, Sato Y, Kanai S, Nokubo M, Kitani K (1992b) Difference in response of hepatic glutathione S-transferase activities to protein free diet between young and old C57 male mice. Mech Ageing Dev 65:301-311
13. Carrillo MC, Nokubo M, Sato Y, Kanai S, Ohta M, Kitani K (1990) Effect of protein-free diet on activities and subunits of glutathione S-transferase in livers of young and aged female rats. Mech Ageing Dev 56:237-251
14. Demetrius L (2004) Caloric restriction, metabolic rate, and entropy. J Gerontol Biol Sci 59A:902-915
15. Dirks AJ, Leeuwenburgh CL (2006) Calorie restriction in humans: Potential pitfalls and health concerns. Mech Ageing Dev 127:1-7
16. Fujita S, Chiba M, Suzuki M, Kitani K (1986) Effect of senescence on the hepatic metabolism of drugs affecting the central nervous system in rats and mice. In: Kitai K (ed) Liver and Aging-1986, Liver and Brain. Elsevier Science, Amsterdam, Oxford, New York, pp 115-126
17. Fujita S, Uesugi T, Kitagawa H, Suzuki T, Kitani K (1982) Hepatic microsomal monooxygenase and azoreductase activities in aging Fischer-344 rats. Importance of sex difference for aging study. In: Kitani K (ed) Liver and Aging-1982, Liver and Drugs. Elsevier/North-Holland Biomedical Press, Amsterdam, Oxford, New York, pp 55-71
18. Gallagher IM, Clow A, Glover V (1998) Long term administration of (-)deprenyl increases mortality in male Wistar rats. J Neural Transm (Suppl) 52:315-320
19. Goto S, Takahashi R, Kumiyama A, Radak Z, Hayashi T, Takenouchi M et al. (2001) Implications of protein degradation in aging. Ann NY Acad Sci 928:54-64
20. Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 12:257-263
21. Harman D (1994) Free-radical theory of aging. Increasing the functional life span. In: Zs.-Nagy I, Harman D, Kitani K (eds) Pharmacology of Aging Processes. Methods of Assessment and Potential Interventions. Vol. 717 Ann NY Acad Sci, New York, pp 1-15
22. Ikeno Y, Cortez L, Lew C, Qi W, Chaudhur A, Richardson A (2005) Cu/Zn SOD transgenic rats show reduced oxidative damage and increased survival. Abstract, 34th Annual Meeting of the American Aging Association, Oakland, P32
23. Ishigami A, Goto S (1990) Age-related change in the degradation rate of ovalbumin microinjected into mouse liver parenchymal cells. Arch Biochem Biophys 277:189-195
24. Ivy GO, Kanai S, Ohta M, Ihara Y, Kitani K (1991a) Leupeptin causes an accumulation of lipofuscin-like substances and ubiquitin immunoreactivity in liver cells of young rats: a possible model for hepatocellular aging. In: Kitani K (ed) Liver and Aging-1990. Elsevier Science, Amsterdam, New York, Oxford, pp 109-122
25. Ivy GO, Kanai S, Ohta M, Sato Y, Otsubo K, Kitani K (1991b) Leupeptin causes an accumulation of lipofuscin-like substances in liver cells of young rats. Mech Ageing Dev 57:213-231
26. Ivy GO, Kanai S, Ohta M, Smith G, Sato Y, Kobayashi M et al (1990) Lipofuscin-like substances accumulate rapidly in brain, retina and internal organs with cysteine protease inhibition. In: Porta EA (ed) Lipofuscin and ceroid pigments. Plenum Press, New York, pp 31-47
27. Ivy GO, Schottler F, Wenzel J, Baudry M, Lynch G (1984) Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain. Science 226:985-987
28. Kamataki T, Maeda K, Shimada M, Kitani K, Nagai T, Kato R (1985) Age-related alteration in the activities of drug-metabolizing enzymes and contents of sex-specific forms of cytochrome P-450 in liver microsomes from male and female rats. J Pharmacol Exp Ther 233:222-228
29. Kato R, Vassanelli P, Frontino G, Chiesara E (1964) Variation in the activity of liver misrosomal drug-metabolizing enzymes in rats in relation to the age. Biochem Pharmacol 13:1037-1051
30. Kitani K (1988) Drugs and the ageing liver. Life Chem Rep 6:143-230
31. Kitani K (1991a) Aging of the liver: facts and theories. Arch Gerontol Geriatr 12:133-154
32. Kitani K (1999) Lateral mobility of proteins and lipids of cell surface membranes during aging: do the data support "The Membrane Hypothesis of Aging"? Mech Ageing Dev 107:299-322
33. Kitani K (ed) (1978) Liver and Aging-1978. Elsevier/North-Holland Biomedical Press, Amsterdam, Oxford, New York
34. Kitani K (ed) (1982) Liver and Aging-1982. Liver and Drugs, Elsevier Biochemical Press, Amsterdam, Oxford, New York
35. Kitani K (ed) (1986) Liver and Aging-1986. Liver and Brain, Elsevier Science Publishers, B.V., Amsterdam, Oxford, New York
36. Kitani K (ed.) (1991b) Liver and Aging-1990. Elsevier Science Publishers, B.V., Amsterdam, Oxford, New York
37. Kitani K (2005) Nutritional interventions in aging and age-associated disorders. In: Rattan SIS (ed) Aging Interventions and Therapies. World Scientific Publishers, Singapore, pp 219-245
38. Kitani K, Goto S (2005) Interview, "My involvement in aging research was just a series of coincidences". An interview with Kenichi Kitani. Bipogerontology 6:211-221
39. Kitani K, Osawa T (2005) Tetrahydrocurcumin (TC) feeding increases the life span of genetically contaminated C57BL male mice. Abtract, 34th Annual Meeting of the American Aging association, Oakland, USA, p34
40. Kitani K, Yokozawa T (2003) Green tea polyphenol (sunphenon) prolongs the average life span of male C57/BL mice. Abstract, 32nd Annual Meeting of American Aging Association, P8
41. Kitani K, Kanai S, Miura R, Morita Y, Kasahara M (1978) The effect of aging on the biliary excretion of ouabain in the rat. Exp Gerontol 13:9-17
42. Kitani K, Kanai S, Miyasaka K, Carrillo MC, Ivy GO (2005) Dose-dependency of life span prolongation of F344/DuCrj rats injected with (-)deprenyl. Biogerontology 6:1-6
43. Kitani K, Kanai S, Miyasaka K, Carrillo MC, Ivy GO (2006) The necessity of having a proper dose of (-)deprenyl (D) to prolong the life spans of rats explains discrepancies among different studies in the past. Ann New York Acad Sci 1067:375-382
44. Kitani K, Kanai S, Sato Y, Ohta M, Ivy GO, Carrillo MC (1993) Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats. Further evidence. Life Sci 52:281-288
45. Kitani K, Klotz U, Kanai S, Sato Y, Ohta M, Nokubo M (1989) Age-related differences in the coordination disturbance and anticonvulsant effect of oxazepam in mice. Arch Gerontol Geriatr 9:31-43
46. Kitani K, Masuda Y, Sato Y, Kanai S, Ohta M, Nokubo M (1984) Increased anticonvulsant effect of phenytoin in aging BDF1 mice. J Pharmacol Exp Ther 229:231-236
47. Kitani K, Minami C, Isobe K, Maehara K, Kanai S and Ivy GO et al (2002a) Why(-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti aging effects. Mech Ageing Dev 123?:1087-1100
48. Kitani K, Minami C, Yamamoto T, Kanai S, Ivy GO, Carrillo MC (2002b) Pharmacological interventions in aging and age-associated disorders. Potentials of propargylamines for human use. Ann New York Acad Sci 959:295-307
49. Kitani K, Ohta M, Kanai S, Sato Y, Nokubo M, Zs.-Nagy I (1991) Age-induced restricted mobility of proteins in hepatocyte surface membranes: A possible determinant of membrane transport function. In: Kitani K (ed) Liver and Aging-1990. Elsevier Science, Amsterdam, New York, Oxford, pp 305-318
50. Kitani K, Sato Y, Kanai S, Nokubo M, Ohta M, Masuda Y (1985a) Age related increased threshold for electroshock seizure in BDF1 mice. Life Sci 36:657-662
51. Kitani K, Sato Y, Kanai S, Nokubo M, Ohta M, Masuda Y (1985b) Increased anticonvulsant effect of phenobarbital with age in mice - A possible pharmacological index for brain aging. Life Sci 37:1451-1460
52. Kitani K, Sato Y, Kanai M, Nokubo M, Ohta M, Masuda Y (1987) Increasing anticonvulsant effect of AD-810 (Zonisamide) in aging BDF1 mice. Life Sci 41:1339-1344
53. Kitani K, Zs.-Nagy I, Kanai S, Sato Y and Ohta M (1988) Correlation between the biliary excretion of ouabain and the lateral mobility of hepatocyte plasma membrane proteins in the rat - The effects of age and spironolactone pretreatment. Hepatology 8:125-131
54. Knoll J (1988) The striatal dopamine dependency of life span in male rats: longevity study with (-)deprenyl. Mech Ageing Dev 46:237-262
55. Lindeman RD, Tobin J, Shock NW (1985) Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 33(4):276-285
56. Martin GM (1997) The Werner mutation: does it lead to a "public" or "private" mechanism of aging? Mol Med 3:356-358
57. Milgram NW, Racine RJ, Nellis P, Mendonca A, Ivy GO (1990) Maintenance of L-deprenyl prolongs life in aged male rats. Life Sci 47:415-420
58. Ohta M, Kanai S, Sato Y, Kitani K (1988) Age-dependent decrease in the hepatic uptake and biliary excretion of ouabain in rats. Biochem Pharmacol 37:935-942
59. Ohta M, Kitani K (1990) Age-dependent decrease in the hepatic uptake of taurocholic acid resembles that for ouabain. Biochem Pharmacol 39:1223-1228
60. Rao G, Xia E and Richardson A (1990) Effect of age on the expression of antioxidant enzymes in male Fischer 344 rats. Mech Ageing Dev 53:49-60
61. Reiss U, Gershon D (1978) Methionine sulfoxide reductase: A novel protective enzyme in liver and its potentially significant role in aging. In: Kitani K (ed) Liver and Aging-1978. Elsevier North-Holland, Amsterdam, pp 55-61
62. Rikans LE, Snowden CD, Moore DR (1991) Sex-dependent differences in the effect of aging on antioxidant defense mechanisms of rat liver. Biochim Biophys Acta 1074:195-200
63. Rodeheffer RJ, Gerstenblith G, Becker LC, Fleg JL, Weisfeidt ML, Lakatta EG (1984) Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a dimished heart rate. Circulation 69:203-213
64. Rowe JW, Andres R, Tobin JD, Norris AH, Shock NW (1976) The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. J Gerontol 31(2):155-163
65. Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M et al (2005) Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308:1909
66. Semsei I, Rao G, Richardson A (1991) Expression of superoxide dismutase and catalase in rat brain as a function of age. Mech Ageing Dev 58:13-19
67. Sonne J, Dossing M, Loft S, Andreasen PB (1985) Antipyrine clearance in pneumonia. Clin Pharmacol Ther 37(6):701-704
68. Williams LR, Carter DB, Dunn E, Conner JR (1995) Indicators of oxidative stress in aged Fischer 344 rats: potential for neurotrophic treatment. In: Hannin I, Fischer A, Yoshida M (eds) Alzheimer's and Parkinson's Disease: Recent Advances. Plenum Pub Corp, New York, pp 641-646
69. Wulf J, Cutler RG (1975) Altered protein hypothesis of mammalian aging process I. Thermal stability of glucose-6-phosphate dehydroenase in C57BL/6J mouse tissues. Exp Gerontol 10:101-117
70. Wynne HA, Cope LH, Herd B, Rawlins MD, James OF, Woodhouse KW (1990) The association of age and frailty with paracetamol conjugation in man. Age Ageing 19:419-424
71. Zs.-Nagy I (1991) The horizons of interdisciplinary synthesis in experimental gerontology. A review. Arch Gerontol Geriatr 12:329-349
72. Zs.-Nagy I (1994) The membrane hypothesis of aging. CRC Press, Boca Raton, FL
73. Zs.-Nagy I (2001) Enzyme activities in the light of membrane hypothesis of aging [Answer to K. Kitani, Mech Ageing Dev. 107 (1999) 299-322]. Mech Ageing Dev 122:811-821
74. Zs.-Nagy I, Cutler RG, Kitani K, Ohta M (1993) Comparison of the lateral diffusion constant of hepatocyte membrane proteins in two wild mouse strains of considerably different longevity: FRAP studies on liver smears. J Gerontol Biological Sci 48:B86-B92
75. Zs.-Nagy I, Kitani K, Ohta M and Imahori K (1986) Age-dependent decrease of the lateral diffusion constant of proteins in the plasma membrane of hepatocytes as revealed by fluorescence recovery after photo bleaching in tissue smears. Arch Gerontol Geriatr 5:131-146
76. Zs.-Nagy I, Ohta M, Kitani K and Imahori K (1984) An automated method for measuring lateral mobility of proteins in the plasma membrane of cells. Microskopie 41:12-25
77. Zs.-Nagy I, Tanaka S, Kitani K (1998) Age-dependence of the lateral diffusion coefficient of Con-A-receptor protein in the skeletal muscle membrane of C57BL/6J mice. Mech Ageing Dev 101:257-268
78. Zs.-Nagy I, Tanaka S, Kitani K (1999) Age-dependence of the lateral diffusion coefficient of Con-A-receptor protein in the plasma membrane of ex vivo prepared brain cortical cells of BN/BiRijHsd rats. Exp Brain Res 124:233-240