Age-dependent decrease of the lateral diffusion constant of proteins in the plasma membrane of hepatocytes as revealed by fluorescence recovery after photobleaching in tissue smears

Archives of Gerontology and Geriatrics

Volumn 5, Issue 2, 1986, Pages 131-146

  Zs Nagy, Imre ^a   Kitani, Kenichi ^a   Ohta, Minoru ^a   Zs Nagy, Valéria ^a   Imahori, Kazutomo ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

autofluorescence; cellular aging; FRAP method; lateral diffusion of membrane proteins; lipid peroxidation; membrane hypothesis of aging; membrane permeability

Indexed keywords

LIPID PEROXIDE; MEMBRANE PROTEIN;

AGE; ANIMAL CELL; AUTOFLUORESCENCE; BLEACHING; CELL AGING; CELL MEMBRANE; LATERAL DIFFUSION; LIVER; MEMBRANE PERMEABILITY; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; FEMALE; FLUORESCENCE; LIPID PEROXIDES; LIVER; MALE; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0022483238     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-4943(86)90016-6     Document Type: Article

References (54)

1. Mobility measurement by analysis of fluorescence photobleaching recovery kinetics
2. Accumulation and distribution of lipofuscin, amyloid and senile plaques in the aging nervous system
3. Anatomical changes in the nervous system
4. Low-level chemiluminescence of isolated hepatocytes
5. Low level chemiluminescence of biological systems
6. Rotational and lateral diffusion of membrane proteins
7. Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids
8. Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde
9. Lateral diffusion of membrane lipids and proteins is increased specifically in neurites of differentiating neuroblastoma cells
10. Lateral diffusion of membrane lipids and proteins during the cell cycle of neuroblastoma cells
11. Relationship of lipofuscin accumulation to aging
12. Lateral diffusion of surface immunoglobulin, Thy-1 antigen, and a lipid probe in lymphocyte plasma membranes
13. Surface modulation in cell recognition and cell growth
14. Rotational and translational diffusion in membranes
15. Measurement of fluorescent lipid peroxidation products in biological systems and tissues
16. Membrane-cytoskeleton interaction
17. Lateral mobility of band 3 in the human erythrocyte membrane studied by fluorescence photobleaching recovery: evidence for control by cytoskeletal interactions
18. + discrimination ratio
19. Lateral diffusion of an 80 000-dalton glycoprotein in the plasma membrane of murine fibroblasts: relationships to cell structure and function
20. Effect of malondialdehyde, a product of lipid peroxidation, on the function and stability of hemoglobin
21. Polylysines modified with malonaldehyde, hydroperoxylinoleic acid and monofunctional aldehydes.
22. The lack of relationship between fluorescence polarization and lateral diffusion in biological membranes
23. Effects of cholesterol evulsion on susceptibility to perfringolysin O of human erythrocytes
24. Transmembrane control of the receptors on normal and tumor cells
25. Physical-chemical and biochemical differences in liver plasma membranes in aging F-344 rats
26. Lateral distribution and diffusion of the C3b receptor of complement, HLA antigens, and lipid probes in peripheral blood leukocytes
27. Brownian motion in biological membranes
28. Activation of the calcium permeability of erythrocyte membranes by perfringolysin O
29. Lateral transport on cell membranes: Mobility of concanavalin A receptors on myoblasts
30. Mobility and distribution of a cell surface glycoprotein and its interaction with other membrane components
31. Lateral mobility of integral membrane proteins is increased in spehrocytic erythrocytes
32. Thiol-activated (oxygen-labile) cytolysins
33. Lateral diffusion of human histocompatibility antigens in isolated plasma membranes
34. Enhanced molecular diffusibility in muscle membrane blebs: release of lateral constraints
35. Photobleaching measurements of the lateral diffusion of lipids and proteins in artificial phospholipid bilayer membranes
36. Mobility and density of AgB, ‘Ia’, and Fc receptors on the surface of lymphocytes from young and old rats
37. Unconstrained lateral diffusion of concanavalin A receptors on bulbus lymphocytes
38. Lateral mobility in membranes as detected by fluorescence recovery after photobleaching
39. A membrane hypothesis of aging
40. The role of membrane structure and function in cellular aging: a review
41. Age-dependent decrease of the lateral mobility of cell membrane proteins measured by FRAP and its relevance to a permeability model
42. Hydroxyl free radical reactions with amino acids and proteins studied by electron spin resonance spectroscopy and spin trapping
43. Centrophenoxine increases the rates of total and mRNA synthesis in the brain cortex of old rats: an explanation of its action in terms of the membrane hypothesis of aging
44. Age-dependent decrease of cell membrane permeability of rat hepatocytes as revealed by in vivo Rb-uptake and release
45. An automated method for measuring lateral mobility of proteins in the plasma membrane of cells in compact tissues by means of fluorescence recovery after photobleaching
46. Verification of the membrane hypothesis of aging on the identified giant neurons of the snail Lymnaea stagnalis L. (Gastropoda, Pulmonata) by a combined application of intracellular electrophysiology and X-ray microanalysis