Computational and analytical modeling of cationic lipid-DNA complexes

Biophysical Journal

Volumn 92, Issue 9, 2007, Pages 3228-3240

  Farago, Oded ^a   Grønbech Jensen, Niels ^b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; LIPID;

ARTICLE; COMPLEX FORMATION; COMPUTER MODEL; MATHEMATICAL ANALYSIS; MOLECULAR MODEL; MONTE CARLO METHOD; POISSON DISTRIBUTION; X RAY DIFFRACTION;

EID: 34247555456     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.106.096990     Document Type: Article

References (51)

1. Felgner, P. L., and G. Rhodes. 1991. Gene therapeutics. Nature. 349:351-352.
2. Smyth-Templeton, N., and D. D. Lasic, editors. 2000. Gene Therapy. Therapeutic Mechanisms and Strategies. Marcel Dekker, New York.
3. Smith, A. E. 1995. Viral vectors in gene therapy. Annu. Rev. Microbiol. 49:807-838.
4. Kay, M. A., J. C. Glorioso, and L. Naldini. 2001. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat. Med. 7:33-40.
5. Felgner, P. L., M. J. Heller, P. Lehn, J.-P. Behr, and F. C. Szoka, editors. 1996. Artificial self-assembling systems for gene delivery. American Chemical Society, Washington DC.
6. Huang, L., M. C. Hung, and E. Wagner, editors. 1999. Non-Viral Vectors for Gene Therapy. Academic Press, San Diego, CA.
7. Mahato, R. I., and S. W. Kim, editors. 2002. Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics. Taylor and Francis, London and New York.
8. Felgner, P. L. 1997. Nonviral strategies for gene therapy. Sci. Am. 276:102-106.
9. Kamiya, H., H. Tsuchiya, J. Yamazaki, and H. Harashima. 2001. Intracellular trafficking and transgene expression of viral and non-viral gene vectors. Adv. Drug Deliv. Rev. 52:153-164.
10. Edelstein, M. L., M. R. Abedi, J. Wixon, and R. M. Edelstein. 2004. Gene therapy clinical trials worldwide 1989-2004 - an overview. J. Gene Med. 6:597-602.
11. Willard, H. F. 2000. Genomics and gene therapy - artificial chromosomes coming to life. Science. 290:1308-1309.
12. Ewert, K., N. L. Slack, A. Ahmad, H. M. Evans, A. J. Lin, C. E. Samuel, and C. R. Safinya. 2004. Cationic lipid-DNA complexes for gene therapy: understanding the relationship between complex structure and gene delivery pathways at the molecular level. Curr. Med. Chem. 11:133-149.
13. Koltover, I., T. Salditt, J. O. Rädler, and C. R. Safinya. 1997. Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes. Science. 275:810-814.
14. Rädler, J. O., I. Koltover, T. Salditt, and C. R. Safinya. 1998. An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery. Science. 281:78-81.
15. Harries, D., S. May, W. M. Gelbart, and A. Ben-Shaul. 1998. Structure, stability, and thermodynamics of lamellar DNA-lipid complexes. Biophys. J. 75:159-173.
16. May, S., D. Harries, and A. Ben-Shaul. 2000. The phase behavior of cationic lipid-DNA complexes. Biophys. J. 78:1681-1697.
17. Lasic, D. D., H. Strey, M. C. A. Stuart, R. Podgornik, and P. M. D. Frederik. 1997. The structure of DNA-liposome complexes. J. Am. Chem. Soc. 119:832-833.
18. Safinya, C. R. 2001. Structures of lipid-DNA complexes: supramolecular assembly and gene delivery. Curr. Opin. Struct. Biol. 11:440-448.
19. Clark, P. R., and E. M. Hersh. 1999. Cationic lipid-mediated gene transfer: current concepts. Curr. Opin. Mol. Ther. 1:158-176.
20. Chesnoy, S., and L. Huang. 2000. Structure and function of lipid-DNA complexes for gene delivery. Annu. Rev. Biophys. Biomol. Struct. 29:27-47.
21. Ferber, D. 2001. Gene therapy: safer and virus-free? Science. 294:1638-1642.
22. Alper, J. 2002. Drug delivery - breaching the membrane. Science. 296:838-839.
23. Marshall, E. 2000. Biomedicine - gene therapy on trial. Science. 288:951-957.
24. Marshall, E. 2002. Gene therapy - what to do when clear success comes with an unclear risk? Science. 298:510-511.
25. May, S., and A. Ben-Shaul. 2004. Modeling of cationic lipid-DNA complexes. Curr. Med. Chem. 11:151-167.
26. Bruinsma, R. 1998. Electrostatics of DNA cationic lipid complexes: isoelectric instability. Eur. Phys. J. B. 4:75-88.
27. Harries, D., S. May, and A. Ben-Shaul. 2003. Curvature and charge modulations in lamellar DNA-lipid complexes. J. Phys. Chem. B. 107:3624-3630.
28. Lin, A. J., N. L. Slack, A. Ahmad, C. X. George, C. E. Samuel, and C. R. Safinya. 2003. Three-dimensional imaging of lipid gene-carriers: membrane charge density controls universal transfection behavior in lamellar cationic liposome-DNA complexes. Biophys. J. 84:3307-3316.
29. Ahmad, A., H. M. Evans, K. Ewert, C. X. George, C. E. Samuel, and C. R. Safinya. 2005. New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: lipid-DNA complexes for gene delivery. J. Gene Med. 7:739-748.
30. Bandyopadhyay, S., M. Tarek, and M. L. Klein. 1999. Molecular dynamics study of a lipid-DNA complex. J. Phys. Chem. B. 103:10075-10080.
31. Farago, O., N. Grønbech-Jensen, and P. Pincus. 2006. Mesoscale computer modeling of lipid-DNA complexes for gene therapy. Phys. Rev. Lett. 96:018102.
32. Farago, O. 2003. "Water-free" computer model for fluid bilayer membranes. J. Chem. Phys. 119:596-605.
33. Farago, O., and P. Pincus. 2004. Statistical mechanics of bilayer membrane with a fixed projected area. J. Chem. Phys. 120:2934-2950.
34. Lipowsky, R., and S. Grotehans. 1993. Hydration vs. protrusion forces between lipid bilayers. Europhys. Lett. 23:599-604.
35. Haleva, E., N. Ben-Tal, and H. Diamant. 2004. Increased concentration of polyvalent phospholipids in the adsorption domain of a charged protein. Biophys. J. 86:2165-2178.
36. Helfrich, W. 1973. Elastic properties of lipid bilayers - theory and possible experiments. Z. Naturforsch. 28C:693-703.
37. Wagner, K., E. Keyes, T. W. Kephart, and G. Edwards. 1997. Analytical Debye-Hückel model for electrostatic potentials around dissolved DNA. Biophys. J. 73:21-30.
38. Grønbech-Jensen, N., G. Hummer, and K. M. Beardmore. 1997. Lekner summation of Coulomb interactions in partially periodic systems. Mol. Phys. 92:941-945.
39. Mashl, R. J., and N. Grønbech-Jensen. 1998. Effective interactions between rigid polyelectrolytes and like-charged planar surfaces. J. Chem. Phys. 109:4617-4623.
40. Groot, R. D., and K. L. Rabone. 2001. Mesoscopic simulation of cell membrane damage, morphology change and rupture by nonionic surfactants. Biophys. J. 81:725-736.
41. Koltover, I., T. Salditt, and C. R. Safinya. 1999. Phase diagram, stability, and overcharging of lamellar cationic lipid-DNA self-assembled complexes. Biophys. J. 77:915-924.
42. Lau, A. W. C., and P. Pincus. 1999. Binding of oppositely charged membranes and membrane reorganization. Eur. Phys. J. B. 10:175-180.
43. Boal, D. 2002. Mechanics of the Cell. Cambridge University Press, Cambridge, UK.
44. Tolpekina, T. V., W. K. den Otter, and W. J. Briels. 2004. Simulations of stable pores in membranes: system size dependence and line tension. J. Chem. Phys. 121:8014-8020.
45. Strey, H. H., R. Podgornik, D. C. Rau, and V. A. Persegian. 1998. DNA-DNA interactions. Curr. Opin. Struct. Biol. 8:309-313.
46. Rau, D. C., B. K. Lee, and V. A. Persegian. 1984. Measurement of the repulsive force between poly-electrolyte molecules in ionic solution: hydration forces between parallel DNA double helices. Proc. Natl. Acad. Sci. USA. 81:2621-2625.
47. Podgornik, R., D. C. Rau, and V. A. Parsegian. 1989. The action of intermolecular forces on the organization of DNA double helices: fluctuation-enhanced decay of electrostatic double-layer and hydration forces. Macromolecules. 22:1780-1786.
48. Schiessel, H., and H. Aranda-Espinoza. 2001. Electrostatically induced undulations of lamellar DNA-lipid complexes. Eur. Phys. J. E. 5:499-506.
49. Rowlinson, J. S., and B. Widom. 1982. Molecular Theory of Capillarity. Oxford University Press, Oxford, UK.
50. Lindahl, E., and O. Edholm. 2000. Mesoscopic undulations and thickness fluctuations in lipid bilayers from molecular dynamics simulations. Biophys. J. 79:426-433.
51. Marrink, S. J., and A. E. Mark. 2001. Effect of undulations on surface tension in simulated bilayers. J. Phys. Chem. B. 105:6122-6127.