1,2,4-Thiadiazole: A novel cathepsin B inhibitor

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 24, 2003, Pages 5529-5537

  Leung Toung, Regis ^a   Wodzinska, Jolanta ^a   Li, Wanren ^a   Lowrie, Jayme ^a   Kukreja, Rahul ^a   Desilets, Denis ^a   Karimian, Khashayar ^a   Tam, Tim Fat ^a  

^a Apotex Research Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

(3 METHOXY 1,2,4 THIADIAZOL 5 YL)CARBAMOYLLEUCYLPROLINE; 1,2,4 THIADIAZOLE DERIVATIVE; 3 METHOXY 5 (N CARBOBENZYLOXYPHENYLALANINAMIDO) 1,2,4 THIADIAZOLE; 3 METHOXY 5 (N CARBOBENZYLOXYPHENYLALANYLALANINAMIDO) 1,2,4 THIADIAZOLE; CATHEPSIN B INHIBITOR; CATHEPSIN H; CATHEPSIN S; CYSTEINE; N (3 CARBOXY 1,2,4 THIADIAZOL 5 YL)LEUCYLPROLINE; N (3 METHOXYL 1,2,4 THIADIAZOL 5 YL)LEUCYLPROLINE; N (3 METHYL 1,2,4 THIADIAZOL 5 YL)LEUCYLPROLINE; N (3 PHENYL 1,2,4 THIADIAZOL 5 YL)LEUCYLPROLINE; N 1 ISOAMYL N 2 [[(3 METHOXY 1,2,4 THIADIAZOL 5 YL)AMINO]CARBONYL]LEUCINAMIDE; PAPAIN; PEPTIDE HYDROLASE INHIBITOR; SULFUR; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; DISULFIDE BOND; DOSE TIME EFFECT RELATION; DRUG BINDING SITE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; KINETICS; MOLECULAR RECOGNITION; PHARMACOPHORE; SUBSTITUTION REACTION;

FELIS CATUS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0344851547     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.09.040     Document Type: Article

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