The use of an in vitro dissolution and absorption system to evaluate oral absorption of two weak bases in pH-independent controlled-release formulations

European Journal of Pharmaceutical Sciences

Volumn 26, Issue 1, 2005, Pages 1-8

  Sugawara, Mitsuru ^a,b   Kadomura, Shota ^b   He, Xin ^b   Takekuma, Yoh ^a   Kohri, Naonori ^c   Miyazaki, Katsumi ^a,b  

^a HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Gastric pH; In vitro system; Oral absorption; pH independent controlled release preparations

Indexed keywords

ALBENDAZOLE; DIPYRIDAMOLE;

ACHLORHYDRIA; ALKALINITY; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG FORMULATION; DRUG GRANULE; DRUG SOLUBILITY; ELUTION; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; IN VITRO STUDY; MONOLAYER CULTURE; PH MEASUREMENT; PREDICTION; PRIORITY JOURNAL; STOMACH ABSORPTION; STOMACH ACID SECRETION; STOMACH EPITHELIUM; STOMACH PH; SUSTAINED DRUG RELEASE; TABLET FORMULATION;

ACHLORHYDRIA; ADMINISTRATION, ORAL; ALBENDAZOLE; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DEXTRANS; DIFFUSION CHAMBERS, CULTURE; DIPYRIDAMOLE; FLUORESCEIN-5-ISOTHIOCYANATE; GASTRIC ACID; GASTRIC MUCOSA; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; POLYMERS; SOLUBILITY;

EID: 23244432152     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.02.017     Document Type: Article

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