Effect of common excipients on Caco-2 transport of low-permeability drugs

Journal of Pharmaceutical Sciences

Volumn 90, Issue 11, 2001, Pages 1776-1786

  Rege, Bhagwant D ^a   Yu Lawrence, X ^b   Hussain, Ajaz S ^b   Polli, James E ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Bioavailability; Caco 2; Efflux; Excipients; Permeability

Indexed keywords

CIMETIDINE; DODECYL SULFATE SODIUM; EXCIPIENT; FUROSEMIDE; HYDROCHLOROTHIAZIDE;

ARTICLE; BIOEQUIVALENCE; CELL CULTURE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TRANSPORT; HUMAN; HUMAN CELL; PHYSICAL CHEMISTRY;

EID: 0035157333     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1127     Document Type: Article

References (19)

1. A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
2. Intestinal permeation enhancers
3. Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2
4. Net secretion of furosemide is subject to indomethacin inhibition, as observed in Caco-2 monolayers and excised rat jejunum
5. The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system
6. Intestinal absorption of drugs. III. The influence of taurocholate on the disappearance kinetics of hydrophilic and lipophilic drugs from the small intestine of the rat
7. Epithelial transport of drugs in cell culture. VIII: Effects of sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells
8. Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers
9. Effect of polyoxyl 35 castor oil and Polysorbate 80 on the intestinal absorption of digoxin in vitro
10. Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells
11. Influence of passive permeability on apparent P-glycoprotein kinetics
12. Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond
13. Cell cultures to access drug absorption enhancement
14. Prediction of dissolution-absorption relationships from a continuous dissolution/Caco-2 system
15. Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement
16. Intestinal absorption of octreotide: N-Tri-methyl chitosan chloride (TMC) ameliorates the permeability and absorption properties of the somatostatin analogue in vitro and in vivo
17. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
18. Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to the biopharmaceutics classification system.