Etiology of exercise-induced asthma: Physical stress-induced transcription

Current Allergy and Asthma Reports

Volumn 7, Issue 1, 2007, Pages 27-32

  Hilberg, Thomas ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; CHEMOKINE; CORTICOSTEROID; CYTOKINE; GENE PRODUCT; GROWTH FACTOR; HISTAMINE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LEUKOTRIENE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LORATADINE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONTELUKAST; PEPTIDOLEUKOTRIENE; PLACEBO; PROSTAGLANDIN E2; PROTEIN ALOX5; PROTEIN ALOX5AP; PROTEIN P50; RANTES; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ASTHMA; CELL ACTIVITY; ENZYME ACTIVITY; EOSINOPHIL; EXERCISE INDUCED ASTHMA; GENETIC TRANSCRIPTION; HUMAN; MAST CELL; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PHYSICAL STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; TRANSCRIPTION REGULATION;

ASTHMA, EXERCISE-INDUCED; EOSINOPHILS; HISTAMINE; HUMANS; LEUKOTRIENES; MAST CELLS; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; STRESS; TRANSCRIPTION, GENETIC;

EID: 34247508550     PISSN: 15297322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11882-007-0027-x     Document Type: Review

References (50)

1. Hallstrand TS, Moody MW, Wurfel MM, et al.: Inflammatory basis of exercise-induced bronchoconstriction. Am J Respir Crit Care Med 2005, 172:679-686.
2. Rundell KW, Jenkinson DM: Exercise-induced bronchospasm in the elite athlete. Sports Med 2002, 32:583-600.
3. Storms WW. Review of exercise-induced asthma. Med Sci Sports Exerc 2003, 35:1464-1470.
4. Anderson SD, Kippelen P: Exercise-induced bronchoconstriction: pathogenesis. Curr Allergy Asthma Rep 2005, 5:116-122.
5. Anderson SD: How does exercise cause asthma attacks? Curr Opin Allergy Clin Immunol 2006, 6:37-42.
6. Freed AN, Davis MS: Hyperventilation with dry air increases airway surface fluid osmolatity in canine peripheral airways. Am J Respir Crit Care Med 1999, 159:1101-1107.
7. Ingenito EP, Pliss LB, Ingram RH Jr, Pichurko BM: Bronchoalveolar lavage cell and mediator responses to hyperpnea-induced bronchoconstriction in the guinea pig. Am Rev Respir Dis 1990, 141:1162-1166.
8. Omori C, Tagari P, Freed AN: Eicosanoids modulate hyperpnea-induced bronchoconstriction in canine peripheral airways. J Appl Physiol 1996, 81:1255-1263.
9. Jariour NN, Calhoun WJ: Exercise-induced asthma is not associated with mast cell activation or airway inflammation. J Allergy Clin Immunol 1992, 89:60-68.
10. Broide DH, Eisman S, Ramsdell JW, et al.: Airway levels of mast cell-derived mediators in exercisc-induced asthma. Am Rev Respir Dis 1990, 141:563-S68.
11. Mickleborough TD, Murray RL, Ionescu AA, Lindley MR: Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med 2003, 168:1181-1189.
12. Reiss TF, Hill JB, Harman E, et al.: Increased urinary excretion of LTE4 after exercise and attenuation of exercise-induced bronchospasm by montelukast, a cysteinyl leukotriene receptor antagonist. Thorax 1997, 52:1030-1035.
13. Anderson SD, Brannan JD: Exercise-induced asthma: is there still a case for histamine? J Allergy Clin Immunol 2002, 109:771-773.
14. Leff JA, Busse WW, Pearlman D, et al.: Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction. N Engl J Med 1998, 339:147-152.
15. Meltzer SS, Hasday JD, Cohn J, Bleecker ER: Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor. Am J Respir Crit Care Med 1996, 153:931-935.
16. Dahlen B, Roquet A, Inman MD, et al.: Influence of zafirlukast and loratadine on exercise-induced broncho-constriction. J Allergy Clin Immunol 2002, 109:789-793.
17. Caillaud C, Le Creff C, Legros P, Denjean A: Strenuous exercise increases plasmatic and urinary leukotriene E4 in cyclists. Can J Appl Physiol 2003, 28:793-806.
18. Peters-Golden M: Cell biology of the 5-lipoxygenase pathway. Am J Respir Crit Care Med 1998, 157:S227-231.
19. Werz O: 5-lipoxygenase: cellular biology and molecular pharmacology. Curr Drug Targets Inflamm Allergy 2002, 1:23-44.
20. Koshino T, Takano S, Houjo T, et al.: Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. Biochem Biophys Res Commun 1998, 247:510-513.
21. Cowburn AS, Holgate ST, Sampson AP: IL-5 increases expression of 5-lipoxygenase-activating protein and translocates 5-lipoxygenase to the nucleus in human blood eosinophils. J Immunol 1999, 163:456-465.
22. Hilberg T, Deigner HP, Moller E, et al.: Transcription in response to physical stress-dues to the molecular mechanisms of exercise-induced asthma. FASEB J 2005, 11:1492-1494.
23. Aoi W, Ichiishi E, Sakamoto N, et al.: Effect of exercise on hepatic gene expression in rats: a microarray analysis. Life Sci 2004, 75:3117-3128.
24. Long YC, Widegren U, Zierath JR: Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle. Proc Nutr Soc 2004, 63:227-232.
25. Chan MH, McGee SL, Watt MJ, et al.: Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction. FASEB J 2004, 18:1785-1787.
26. Widegren U, Ryder JW, Zierath JR: Mitogen-activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction. Acta Physiol Scand 2001, 172:227-238.
27. Kumar S, Boehm J, Lee JC: p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2003, 2:717-726.
28. Adams JL, Badger AM, Kumar S, Lee JC: p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines. Prog Med Chem 2001, 38:1-60.
29. Barnes PJ: Transcription factors in airway diseases. Lab Invest 2006, 86:867-872.
30. Barnes PJ, Karin M: Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997, 336:1066-1071.
31. Kumar A, Takada Y, Boriek AM, Aggarwal BB: Nuclear factor-kappaB: its role in health and disease. J Mol Med 2004, 82:434-448.
32. Ji LL, Gomez-Cabrera MC, Steinhafel N, Vina J: Acute exercise activates nuclear factor (NF)-kappaB signaling pathway in rat skeletal muscle. FASEB J 2004, 18:1499-1506.
33. Vider J, Laaksonen DE, Kilk A, et al.: Physical exercise induces activation of NF-kappaB in human peripheral blood lymphocytes. Antioxid Redox Signal 2001, 3:1131-1137.
34. Weiss C, Bierhaus A, Kinscherf R, et al.: Tissue factor-dependent pathway is not involved in exercise-induced formation of thrombin and fibrin. J Appl Physiol 2002, 92:211-218.
35. Popescu FD: New asthma drugs acting on gene expression. J Cell Mol Med 2003, 7:475-486.
36. Desmet C, Gosset P, Henry E, et al.: Treatment of experimental asthma by decoy-mediated local inhibition of activator protein-1. Am J Respir Crit Care Med 2005, 172:671-678.
37. Hollander J, Fiebig R, Gore M, et al.: Superoxide dismutase gene expression is activated by a single bout of exercise in rat skeletal muscle. Pflugers Arch 2001, 442:426-434.
38. Barnes PJ: Drugs for asthma. Br J Pharmacol 2006, 147(Suppl 1):S297-S303.
39. Kips JC, Tournoy KG, Pauwels RA: New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5. Eur Respir J 2001, 17:499-506.
40. Wynn TA: IL-13 effector functions. Annu Rev Immunol 2003, 21:425-456.
41. Chavez J, Young HW, Corry DB, Lieberman MW: Interactions between leukotriene C4 and interleukin 13 signaling pathways in a mouse model of airway disease. Arch Pathol Lab Med 2006, 130:440-446.
42. Pedersen BK, Hoffman-Goetz L: Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 2000, 80:1055-1081.
43. Suzuki K, Nakaji S, Kurakake S, et al.: Exhaustive exercise and type-1/type-2 cytokine balance with special focus on interleukin-12 p40/ p7O. Exerc Immunol Rev 2003, 9:48-57.
44. Peake JM, Suzuki K, Hordern M, et al.: Plasma cytokine changes in relation to exercise intensity and muscle damage. Eur J Appl Physiol 2005, 95:514-521.
45. Tahan F, Karaaslan C, Aslan A, et al.: The role of chemokines in exercise-induced bronchoconstriction in asthma. Ann Allergy Asthma Immunol 2006, 96:819-825.
46. Furuichi S, Hashimoto S, Gon Y, et al.: p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate interleukin-8 and RANTES production in hyperosmolarity stimulated human bronchial epithelial cells. Respirology 2002, 7:193-200.
47. Hashimoto S, Gon Y, Matsumoto K, et al.: Inhalant corticosteroids inhibit hyperosmolarity-induced, and cooling and rewarming-induced interleukin-8 and RANTES production by human bronchial epithelial cells. Am J Respir Crit Care Med 2000, 162:1075-1080.
48. Mucci P, Durand F, Lebel B, et al.: Interleukins 1-beta, -8, and histamine increases in highly trained, exercising athletes. Med Sci Sports Exerc 2000, 32:1094-1100.
49. Sampson AP: The role of eosinophils and neutrophils in inflammation. Clin Exp Allergy 2000, 30(Suppl 1):22-27.
50. Holgate ST. The role of mast cells and basophils in inflammation. Clin Exp Allergy 2000, 30(Suppl 1):28-32.