Exercise-induced bronchoconstriction: Pathogenesis

Current Allergy and Asthma Reports

Volumn 5, Issue 2, 2005, Pages 116-122

  Anderson, Sandra D ^a   Kippelen, Pascale ^a  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CYTOKINE; INTERLEUKIN 1BETA; LEUKOTRIENE E4; NEUTROPHIL COLLAGENASE; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTAGLANDIN F2; TENASCIN;

ALLERGIC RHINITIS; ATHLETE; BRONCHOSPASM; BRONCHUS; BRONCHUS HYPERREACTIVITY; BRONCHUS MUSCLE; CYTOKINE RELEASE; DEHYDRATION; DISEASE EXACERBATION; EXERCISE INDUCED ASTHMA; HUMAN; HYPEREMIA; MICROANGIOPATHY; PATHOGENESIS; RESPIRATORY TRACT INJURY; REVIEW; VASCULARIZATION; VASOCONSTRICTION;

EID: 14744283636     PISSN: 15297322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11882-005-0084-y     Document Type: Review

References (54)

1. Anderson SD, Holzer K: Exercise-induced asthma: Is it the right diagnosis in elite athletes? J Allergy Clin Immunol 2000, 106:419-428.
2. Brannan JD, Gulliksson M, Anderson SD, et al.: Evidence of mast cell activation and leukotriene release after mannitol inhalation. Eur Respir J 2003, 22:491-496.
3. Caillaud C, Le Creff C, Legros P, et al.: Strenuous exercise increases plasmatic and urinary leukotriene E4 in cyclists. Can J Appl Physiol 2003, 28:793-806.
4. Mickleborough TD, Murray RL, Ionescu AA, et al.: Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med 2003, 168:1181-1189.
5. McFadden ER, Lenner KA, Strohl KP: Postexertional airway rewarming and thermally induced asthma. J Clin Invest 1986, 78:18-25.
6. Anderson SD: Is there a unifying hypothesis for exercise-induced asthma? J Allergy Clin Immunol 1984, 73: 60-665.
7. Daviskas E, Anderson SD, Gonda I, et al.: Changes in mucociliary clearance during and after isocapnic hyperventilation in asthmatic and healthy subjects. Eur Respir J 1995, 8: 42-751.
8. McFadden ER, Nelson JA, Skowronski ME, et al.: Thermally induced asthma and airway drying. Am J Respir Crit Care Med 1999, 160:221-226.
9. Kotaru C, Hejal RB, Finigan JH, et al.: Desiccation and hypertonicity of the airway surface fluid and thermally induced asthma. J Appl Physiol 2003, 94:227-233.
10. Freed AN, Davis MS: Hyperventilation with dry air increases airway surface fluid osmolality in canine peripheral airways. Am J Respir Crit Care Med 1999, 159:1101-1107.
11. Davis MS, Daviskas E, Anderson SD, et al.: Airway surface fluid desiccation during isocapnic hyperpnea. J Appl Physiol 2003, 94:2545-2547.
12. Anderson SD, Daviskas E: The mechanism of exercise-induced asthma is ⋯ J Allergy Clin Immunol 2000, 106:453-459.
13. Sue-Chu M, Larsson L, Bjermer L: Prevalence of asthma in young cross-country skiers in central Scandinavia: differences between Norway and Sweden. Respir Med 1996, 90:99-105.
14. Helenius IJ, Tikkanen HO, Sarna S, et al.: Asthma and increased bronchial responsiveness in elite athletes: atopy and sport event as risk factors. J Allergy Clin Immunol 1998, 101: 46-652.
15. Langdeau J-B, Turcotte H, Bowie DM, et al.: Airway hyperresponsiveness in elite athletes. Am J Respir Crit Care Med 2000, 161:1479-1484.
16. Rundell KW, Im J, Mayers LB, et al.: Self-reported symptoms and exercise-induced asthma in the elite athlete. Med Sci Sports Exerc 2001, 33:208-213.
17. Anderson SD, Fitch K, Perry CP, et al.: Responses to bronchial challenge submitted for approval to use inhaled beta2 agonists prior to an event at the 2002 Winter Olympics. J Allergy Clin Immunol 2003, 111:44-49.
18. Rundell KW: High levels of airborne ultrafine and fine particulate matter in indoor ice arenas. Inhal Toxicol 2003, 15:237-250.
19. Pliss LB, Ingenito EP, Ingram RH, et al.: Assessment of bronchoalveolar cell and mediator response to isocapnic hyperpnea in asthma. Am Rev Respir Dis 1990, 142:73-78.
20. Hallstrand TS, Moody MM, Aitken ML, Henderson WR: Characteristics of airway inflammation in the exercise-induced bronchoconstriction asthma sub-phenotype (abstract). Am J Respir Crit Care Med 2004, A817.
21. Omori C, Schofield BH, Mitzner W, et al.: Hyperpnea with dry air causes time-dependent alterations in mucosal morphology and bronchovascular permeability. J Appl Physiol 1995, 78: 043-1051.
22. Davis MS, Freed AN: Repeated hyperventilation causes peripheral airways inflammation, hyperreactivity, and impaired bronchodilation in dogs. Am J Respir Crit Care Med 2001, 164: 85-789.
23. Omori C, Schofield BH, Mitzner W, et al.: A beta2-adrenergic agonist inhibits dry air-induced injury in canine peripheral airways. J Appl Physiol 1995, 78:2169-2179.
24. Persson CGA, Erjefalt JS: Airway epithelial restitution after shedding and denudation. In The Lung, 2nd ed. Edited by Crystal RG, West JB, Weibel ER, Barnes PJ. New York: Raven Press; 1997:2611-2627.
25. Sue-Chu M, Larsson L, Moen T, et al.: Bronchoscopy and bronchoalveolar lavage findings in cross-country skiers with and without "ski asthma." Eur Respir J 1999, 13:626-632.
26. Larsson K, Tornling G, Gavhed D, et al.: Inhalation of cold air increases the number of inflammatory cells in the lungs in healthy subjects. Eur Respir J 1998, 12:825-830.
27. Karjalainen E-M, Laitinen A, Sue-Chu M, et al.: Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine. Am J Respir Crit Care Med 2000, 161:2086-2091.
28. Bonsignore MR, Morici G, Riccobono L, et al.: Airway inflammation in nonasthmatic amateur runners. Am J Physiol Lung Cell Mol Physiol 2001, 281:L668-L676.
29. Obase Y, Helenius I, Rytila P, et al.: MMP-8 and TIMP-1 expressions in induced sputum in elite hockey players and non-athletes with and without asthma (abstract). Eur Respir J 2004, 24(Supp 48):ASM.
30. Kanazawa H, Hirata K, Yoshikawa J: Involvement of vascular endothelial growth factor in exercise induced bronchoconstriction in asthmatic patients. Thorax 2002, 57:885-888.
31. Johnson PR, Burgess JK: Airway smooth muscle and fibroblasts in the pathogenesis of asthma. Curr Allergy Asthma Rep 2004, 4:102-108.
32. Sue-Chu M, Brannan JD, Anderson SD, et al.: Airway responsiveness to methacholine, adenosine monophosphate (AMP), mannitol, eucapnic voluntary hyperpnea and sport specific field exercise challenge in cross country ski athletes (abstract). Eur Respir J 2002, ASM.
33. Helenius IJ, Tikkanen HO, Haahtela T: Occurrence of exercise induced bronchospasm in elite runners: dependence on atopy and exposure to cold air and pollen. Br J Sports Med 1998, 32: 25-129.
34. Page S, Ammit AJ, Black JL, et al.: Human mast cells and airway smooth muscle cell interactions: implications for asthma. Am J Physiol Lung Cell Mol Physiol 2001, 281:L1313-L1323.
35. Carroll NG, Mutavdzic S, James AL: Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 2002, 19:879-885.
36. Brannan JD, Gulliksson M, Anderson SD, et al.: Eformoterol fumarate and sodium cromoglycate (SCG) inhibit the airway response to inhaled mannitol in asthmatics by mast cell inhibition (abstract). J Allergy Clin Immunol 2004, 113(2).
37. Crummy F, Livingston M, Ennis M, et al.: Mast cell mediator release in non-asthmatic subjects after endobronchial adenosine challenge. J Allergy Clin Immunol 2004, 114:34-39.
38. Kalra S, Swystun VA, Bhagat R, et al.: Inhaled corticosteroids do not prevent the development of tolerance to the bronchoprotective effect of salmeterol. Chest 1996, 109: 53-956.
39. Chong LK, Suvarna K, Chess-Williams R, et al.: Desensitization of beta2-adrenoceptor-mediated responses by short-acting beta2-adrenoceptor agonists in human lung mast cells. Br J Pharmacol 2003, 138:512-520.
40. Scola AM, Chong LK, Suvarna SK, et al.: Desensitisation of mast cell beta2-adrenoceptor-mediated responses by salmeterol and formoterol. Br J Pharmac 2004, 141:163-171.
41. Anderson SD, Brannan JD: Long-acting beta2-adrenoceptor agonists and exercise-induced asthma: lessons to guide us in the future. Paediatr Drugs 2004, 6:161-175.
42. Evans DW, Salome CM, King GG, et al.: Effect of regular inhaled salbutamol on airway responsiveness and airway inflammation in rhinitic non-asthmatic subjects. Thorax 1997, 52:136-142.
43. Aldridge RE, Hancox RJ, Robin Taylor D, et al.: Effects of terbutaline and budesonide on sputum cells and bronchial hyperresponsiveness in asthma. Am J Respir Crit Care Med 2000, 161:1459-1464.
44. Polosa R, Ciamarra I, Mangano G, et al.: Bronchial hyperresponsiveness and airway inflammation markers in non-asthmatics with allergic rhinitis. Eur Respir J 2000, 15:30-35.
45. Hancox RJ, Subbarao P, Kamada D, et al.: Beta2-agonist tolerance and exercise-induced bronchospasm. Am J Respir Crit Care Med 2002, 165:1068-1070.
46. Swystun VA, Gordon JR, Davis EB, et al.: Mast cell tryptase release and asthmatic responses to allergen increase with regular use of salbutamol. J Allergy Clin Immunol 2000, 106: 7-64.
47. Anderson SD, Brannan JD: Methods for 'indirect' challenge tests including exercise, eucapnic voluntary hyperpnea and hypertonic aerosols. Clin Rev Allergy Immunol 2003, 24:63-90.
48. Mannix ET, Manfredi F, Farber MO: A comparison of two challenge tests for identifying exercise-induced bronchospasm in figure skaters. Chest 1999, 115:649-653.
49. Holzer K, Anderson SD, Chan H-K, et al.: Mannitol as a challenge test to identify exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med 2003, 167: 34-547.
50. Rundell KW, Anderson SD, Spiering BA, et al.: Field exercise vs laboratory eucapnic voluntary hyperventilation to identify airway hyperresponsiveness in elite cold weather athletes. Chest 2004, 125:909-915.
51. Brannan JD, Koskela H, Anderson SD, et al.: Responsiveness to mannitol in asthmatic subjects with exercise- and hyperventilation-induced asthma. Am J Respir Crit Care Med 1998, 158:1120-1126.
52. Anderson SD, Brannan J, Spring J, et al.: A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. Am J Respir Crit Care Med 1997, 156: 58-765.
53. Koskela H, Di Sciascio M, Anderson SD, et al.: Nasal hyperosmolar challenge with a dry powder of mannitol in patients with allergic rhinitis. Evidence for epithelial cell involvement. Clin Exp Allergy 2000, 30:1627-1636.
54. Kanazawa H, Asai K, Hirata K, et al.: Vascular involvement in exercise-induced airway narrowing in patients with bronchial asthma. Chest 2002, 122:166-170.