1H NMR monitoring of the canine metabolic profile after oral administration of xenobiotics using multivariate statistics

Molecular Pharmaceutics

Volumn 4, Issue 2, 2007, Pages 258-268

  Constantinou, Maria A ^a   Vertzoni, Maria ^a   Reppas, Christos ^a   Tsantili Kakoulidou, Anna ^a   Mikros, Emmanuel ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

1H NMR spectroscopy; Canine plasma; Ketoconazole; Lycopene; Metabolic profile; Nifedipine; Oleuropein; Orthogonal signal correction (OSC); Partial least squares discriminant analysis (PLS DA); Principal component analysis (PCA)

Indexed keywords

KETOCONAZOLE; LYCOPENE; NIFEDIPINE; OLEUROPEIN; XENOBIOTIC AGENT; CAROTENOID; PROTON; PYRAN DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CHEMOMETRIC ANALYSIS; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; MULTIVARIATE ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SINGLE DRUG DOSE; ANIMAL; BLOOD; COMPUTER SIMULATION; EVALUATION; FORECASTING; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; PLASMA;

ADMINISTRATION, ORAL; ANIMALS; CAROTENOIDS; COMPUTER SIMULATION; DOGS; FEMALE; FORECASTING; MAGNETIC RESONANCE SPECTROSCOPY; METABOLISM; MULTIVARIATE ANALYSIS; NIFEDIPINE; PLASMA; PROTONS; PYRANS; XENOBIOTICS;

EID: 34247392489     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp060069z     Document Type: Article

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