Molecular genetics of nicotine dependence and abstinence: Whole genome association using 520,000 SNPs

BMC Genetics

Volumn 8, Issue , 2007, Pages

  Uhl, George R ^a   Liu, Qing Rong ^a   Drgon, Tomas ^a   Johnson, Catherine ^a   Walther, Donna ^a   Rose, Jed E ^a,b  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; BETA DEFENSIN; BINDING PROTEIN; CADHERIN; CONTACTIN; DNA; FIBROBLAST GROWTH FACTOR; G PROTEIN COUPLED RECEPTOR; GLUTAMATE RECEPTOR; HISTAMINE RECEPTOR; IMMUNOGLOBULIN; MECAMYLAMINE; NEUROTRANSMITTER; NICOTINE PATCH; NUCLEAR FACTOR; PARATHYROID HORMONE; PHOSPHODIESTERASE IV; PLACEBO; PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE; REGULATOR PROTEIN; RNA; SEMAPHORIN; SODIUM PROTON EXCHANGE PROTEIN; VOLTAGE GATED POTASSIUM CHANNEL;

ADULT; ARTICLE; BEHAVIOR THERAPY; CELL ADHESION; CIGARETTE SMOKING; CONTROLLED STUDY; DATA ANALYSIS; DRUG DOSE COMPARISON; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HERITABILITY; HUMAN; HUMAN CELL; INDIVIDUALIZATION; MAJOR CLINICAL STUDY; MALE; MARKER GENE; MOLECULAR GENETICS; MOLECULAR MECHANICS; NICOTINE REPLACEMENT THERAPY; PATIENT CARE; POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING CESSATION; SUBSTANCE ABUSE; TOBACCO DEPENDENCE; TRANSCRIPTION REGULATION; TREATMENT OUTCOME; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; GENOME; RANDOMIZED CONTROLLED TRIAL; WITHDRAWAL SYNDROME;

ADULT; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SMOKING CESSATION; SUBSTANCE WITHDRAWAL SYNDROME; TOBACCO USE DISORDER;

EID: 34247327670     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-8-10     Document Type: Article

References (57)

1. Karkowski LM Prescott CA Kendler KS Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs Am J Med Genet 2000 96 5 665-670 10.1002/ 1096-8628(20001009)96:5<665::AID-AJMG13>3.0.CO;2-O 11054775
2. Tsuang MT Lyons MJ Meyer JM Doyle T Eisen SA Goldberg J True W Lin N Toomey R Eaves L Co-occurrence of abuse of different drugs in men: The role of drug-specific and shared vulnerabilities Arch Gen Psychiatry 1998 55 11 967-972 10.1001/archpsyc.55.11.967 9819064
3. Uhl GR Elmer GI Labuda MC Pickens RW Genetic influences in drug abuse Psychopharmacology: The Fourth Generation of Progress New York, Raven Press Gloom FE, Kupfer DJ 1995 1793-2783
4. True WR Heath AC Scherrer JF Xian H Lin N Eisen SA Lyons MJ Goldberg J Tsuang MT Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms Am J Med Genet 1999 88 4 391-397 10.1002/ (SICI)1096-8628(19990820)88:4<391::AID-AJMG17>3.0.CO;2-L 10402507
5. Heatherton TF Kozlowski LT Frecker RC Fagerstrom KO The Fagerstrom Test for Nicotine Dependence: A revision of the Fagerstrom Tolerance Questionnaire Br J Addict 1991 86 9 1119-1127 10.1111/ j.1360-0443.1991.tb01879.x 1932883
6. Swan GE Carmelli D Rosenman RH Fabsitz RR Christian JC Smoking and alcohol consumption in adult male twins: Genetic heritability and shared environmental influences J Subst Abuse 1990 2 1 39-50 2136102
7. Maes HH Sullivan PF Bulik CM Neale MC Prescott CA Eaves LJ Kendler KS A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence Psychol Med 2004 34 7 1251-1261 10.1017/S0033291704002405 15697051
8. Carmelli D Swan GE Robinette D Fabsitz RR Heritability of substance use in the NAS-NRC Twin Registry Acta Genet Med Gemellol (Roma) 1990 39 1 91-98 2392895
9. Li MD Cheng R Ma JZ Swan GE A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins Addiction 2003 98 1 23-31 10.1046/j.1360-0443.2003.00295.x 12492752
10. Xian H Scherrer JF Madden PA Lyons MJ Tsuang M True WR Eisen SA The heritability of failed smoking cessation and nicotine withdrawal in twins who smoked and attempted to quit Nicotine Tob Res 2003 5 2 245-254 10.1080/14622200307225 12745498
11. Broms U Silventoinen K Madden PA Heath AC Kaprio J Genetic architecture of smoking behavior: A study of Finnish adult twins Twin Res Hum Genet 2006 9 1 64-72 10.1375/183242706776403046 16611469
12. Bergen AW Yang XR Bai Y Beerman MB Goldstein AM Goldin LR Genomic regions linked to alcohol consumption in the Framingham Heart Study BMC Genet 2003 4 Suppl 1 S101 10.1186/1471-2156-4-S1-S101 14975169
13. Duggirala R Almasy L Blangero J Smoking behavior is under the influence of a major quantitative trait locus on human chromosome 5q Genet Epidemiol 1999 17 Suppl 1 S139-44 10597426
14. Ehlers CL Wilhelmsen KC Genomic screen for loci associated with tobacco usage in Mission Indians BMC Med Genet 2006 7 9 1386651 16472381 10.1186/ 1471-2350-7-9
15. Gelernter J Liu X Hesselbrock V Page GP Goddard A Zhang H Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking Am J Med Genet B Neuropsychiatr Genet 2004 128 1 94-101 10.1002/ajmg.b.30019 15211640
16. Li MD Ma JZ Cheng R Dupont RT Williams NJ Crews KM Payne TJ Elston RC A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population BMC Genet 2003 4 Suppl 1 S103 10.1186/ 1471-2156-4-S1-S103 14975171
17. Saccone NL Neuman RJ Saccone SF Rice JP Genetic analysis of maximum cigarette-use phenotypes BMC Genet 2003 4 Suppl 1 S105 10.1186/ 1471-2156-4-S1-S105 14975173
18. Straub RE Sullivan PF Ma Y Myakishev MV Harris-Kerr C Wormley B Kadambi B Sadek H Silverman MA Webb BT Neale MC Bulik CM Joyce PR Kendler KS Susceptibility genes for nicotine dependence: A genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study Mol Psychiatry 1999 4 2 129-144 10.1038/sj.mp.4000518 10208445
19. Sullivan PF Neale BM van den Oord E Miles MF Neale MC Bulik CM Joyce PR Straub RE Kendler KS Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics Am J Med Genet B Neuropsychiatr Genet 2004 126 1 23-36 10.1002/ajmg.b.20138 15048644
20. Swan GE Hops H Wilhelmsen KC Lessov-Schlaggar CN Cheng LS Hudmon KS Amos CI Feiler HS Ring HZ Andrews JA Tildesley E Benowitz N A genome-wide screen for nicotine dependence susceptibility loci Am J Med Genet B Neuropsychiatr Genet 2006 141 4 354-360 16671072
21. Uhl GR Liu QR Walther D Hess J Naiman D Polysubstance abuse-vulnerability genes: Genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms Am J Hum Genet 2001 69 6 1290-1300 1235541 11704927 10.1086/324467
22. Liu QR Drgon T Walther D Johnson C Poleskaya O Hess J Uhl GR Pooled association genome scanning: Validation and use to identify addiction vulnerability loci in two samples Proc Natl Acad Sci U S A 2005 102 33 11864-11869 1183486 16091475 10.1073/pnas.0500329102
23. Macgregor S Visscher PM Montgomery G Analysis of pooled DNA samples on high density arrays without prior knowledge of differential hybridization rates Nucleic Acids Res 2006 34 7 e55 1440945 16627870 10.1093/nar/gkl136
24. Meaburn E Butcher LM Schalkwyk LC Plomin R Genotyping pooled DNA using 100K SNP microarrays: A step towards genomewide association scans Nucleic Acids Res 2006 34 4 e27 1368655 16478714 10.1093/nar/gnj027
25. Craig DW Huentelman MJ Hu-Lince D Zismann VL Kruer MC Lee AM Puffenberger EG Pearson JM Stephan DA Identification of disease causing loci using an array-based genotyping approach on pooled DNA BMC Genomics 2005 6 138 1262713 16197552 10.1186/1471-2164-6-138
26. Butcher LM Meaburn E Knight J Sham PC Schalkwyk LC Craig IW Plomin R SNPs, microarrays and pooled DNA: Identification of four loci associated with mild mental impairment in a sample of 6000 children Hum Mol Genet 2005 14 10 1315-1325 10.1093/hmg/ddi142 15800012
27. Butcher LM Meaburn E Dale PS Sham P Schalkwyk LC Craig IW Plomin R Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms Mol Psychiatry 2005 10 4 384-392 10.1038/sj.mp.4001589 15452586
28. Bang-Ce Y Peng Z Bincheng Y Songyang L Estimation of relative allele frequencies of single-nucleotide polymorphisms in different populations by microarray hybridization of pooled DNA Anal Biochem 2004 333 1 72-78 10.1016/j.ab.2004.05.016 15351282
29. Sham P Bader JS Craig I O'Donovan M Owen M DNA Pooling: A tool for large-scale association studies Nat Rev Genet 2002 3 11 862-871 10.1038/ nrg930 12415316
30. Hinds DA Seymour AB Durham LK Banerjee P Ballinger DG Milos PM Cox DR Thompson JF Frazer KA Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels Hum Genomics 2004 1 6 421-434 15606997
31. Liu QR Drgon T Johnson C Walther D Hess J Uhl GR Addiction molecular genetics: 639,401 SNP whole genome association reveals many cell adhesion gene variants Am J Med Genet B Neuropsychiatr Genet, in press 2006
32. Uhl GR Molecular genetics of addiction vulnerability NeuroRx 2006 3 3 295-301 10.1016/j.nurx.2006.05.006 16815213
33. Li MD The genetics of nicotine dependence Curr Psychiatry Rep 2006 8 2 158-164 16539894
34. Wang D Ma JZ Li MD Mapping and verification of susceptibility loci for smoking quantity using permutation linkage analysis Pharmacogenomics J 2005 5 3 166-172 10.1038/sj.tpj.6500304 15724146
35. Goode EL Badzioch MD Kim H Gagnon F Rozek LS Edwards KL Jarvik GP Multiple genome-wide analyses of smoking behavior in the Framingham Heart Study BMC Genet 2003 4 Suppl 1 S102 10.1186/1471-2156-4-S1-S102 14975170
36. Bierut LJ Rice JP Goate A Hinrichs AL Saccone NL Foroud T Edenberg HJ Cloninger CR Begleiter H Conneally PM Crowe RR Hesselbrock V Li TK Nurnberger JI Jr. Porjesz B Schuckit MA Reich T A genomic scan for habitual smoking in families of alcoholics: Common and specific genetic factors in substance dependence Am J Med Genet A 2004 124 1 19-27 10.1002/ajmg.a.20329 14679582
37. Kipmen-Korgun D Osibow K Zoratti C Schraml E Greilberger J Kostner GM Jurgens G Graier WF T-cadherin mediates low-density lipoprotein-initiated cell proliferation via the Ca(2+)-tyrosine kinase-Erk1/2 pathway J Cardiovasc Pharmacol 2005 45 5 418-430 10.1097/ 01.fjc.0000157458.91433.86 15821437
38. Philippova M Ivanov D Allenspach R Takuwa Y Erne P Resink T RhoA and Rac mediate endothelial cell polarization and detachment induced by T-cadherin Faseb J 2005 19 6 588-590 15703273
39. Hug C Wang J Ahmad NS Bogan JS Tsao TS Lodish HF T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/ adiponectin Proc Natl Acad Sci U S A 2004 101 28 10308-10313 478568 15210937 10.1073/pnas.0403382101
40. Ivanov DB Philippova MP Tkachuk VA Structure and functions of classical cadherins Biochemistry (Mosc) 2001 66 10 1174-1186 10.1023/ A:1012445316415 11736639
41. Fredette BJ Miller J Ranscht B Inhibition of motor axon growth by T-cadherin substrata Development 1996 122 10 3163-3171 8898229
42. Takeuchi T Misaki A Liang SB Tachibana A Hayashi N Sonobe H Ohtsuki Y Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells J Neurochem 2000 74 4 1489-1497 10.1046/ j.1471-4159.2000.0741489.x 10737605
43. Feil S Zimmermann P Knorn A Brummer S Schlossmann J Hofmann F Feil R Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina Neuroscience 2005 135 3 863-868 10.1016/ j.neuroscience.2005.06.051 16154279
44. Demyanenko GP Halberstadt AI Pryzwansky KB Werner C Hofmann F Maness PF Abnormal neocortical development in mice lacking cGMP-dependent protein kinase I Brain Res Dev Brain Res 2005 160 1 1-8 10.1016/ j.devbrainres.2005.07.013 16154207
45. Sokolowski MB Genes for normal behavioral variation: Recent clues from flies and worms Neuron 1998 21 3 463-466 10.1016/S0896-6273(00)80556-5 9768833
46. Weitzdoerfer R Hoeger H Engidawork E Engelmann M Singewald N Lubec G Lubec B Neuronal nitric oxide synthase knock-out mice show impaired cognitive performance Nitric Oxide 2004 10 3 130-140 10.1016/ j.niox.2004.03.007 15158692
47. Itzhak Y Martin JL Black MD Huang PL The role of neuronal nitric oxide synthase in cocaine-induced conditioned place preference Neuroreport 1998 9 11 2485-2488 10.1097/00001756-199808030-00011 9721919
48. Kleppisch T Wolfsgruber W Feil S Allmann R Wotjak CT Goebbels S Nave KA Hofmann F Feil R Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory J Neurosci 2003 23 14 6005-6012 12853418
49. Johnson C Drgon T Liu QR Walther D Edenberg H Rice J Foroud T Uhl GR Pooled association genome scanning for alcohol dependence using 104,268 SNPs: Validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism Am J Med Genet B Neuropsychiatr Genet 2006 141 8 844-853 16894614
50. Bossert JM Ghitza UE Lu L Epstein DH Shaham Y Neurobiology of relapse to heroin and cocaine seeking: An update and clinical implications Eur J Pharmacol 2005 526 1-3 36-50 10.1016/j.ejphar.2005.09.030 16289451
51. Bierut LJ Madden PA Breslau N Johnson EO Hatsukami D Pomerleau OF Swan GE Rutter J Bertelsen S Fox L Fugman D Goate AM Hinrichs AL Konvicka K Martin NG Montgomery GW Saccone NL Saccone SF Wang JC Chase GA Rice JP Ballinger DG Novel genes identified in a high-density genome wide association study for nicotine dependence Hum Mol Genet 2007 16 1 24-35 10.1093/hmg/ddl441 17158188
52. Saccone SF Hinrichs AL Saccone NL Chase GA Konvicka K Madden PA Breslau N Johnson EO Hatsukami D Pomerleau O Swan GE Goate AM Rutter J Bertelsen S Fox L Fugman D Martin NG Montgomery GW Wang JC Ballinger DG Rice JP Bierut LJ Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs Hum Mol Genet 2007 16 1 36-49 10.1093/hmg/ddl438 17135278
53. Smith SS O'Hara BF Persico AM Gorelick DA Newlin DB Vlahov D Solomon L Pickens R Uhl GR Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers Arch Gen Psychiatry 1992 49 9 723-727 1355337
54. Persico AM Bird G Gabbay FH Uhl GR D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: Enhanced frequencies in psychostimulant-preferring polysubstance abusers Biol Psychiatry 1996 40 8 776-784 10.1016/0006-3223(95)00483-1 8894071
55. Johnson C Drgon T Liu QR Walther D Edenberg HJ Rice J Foroud T Uhl GR Pooled association genome scanning for alcohol dependence using 104,268 SNPs: Validation and use to identify alcoholism vulnerability loci in unrelated individuals from the Collaborative Study on the Genetics of Alcoholism Am J Med Genet, in press 2006
56. Drgon T Liu QR Johnson C Walther D Hishimoto A Ujike H Komiyama T Harano M Sekine Y Inada T Ozaki N Iyo M Iwata N Yamada M Sora I Uhl GR Addiction molecular genetics in Japanese methamphetamine-dependent individuals: Pooled association genome scanning identifies addiction vulnerability loci and genes Submitted 2006
57. Dupont WD Plummer WD Jr. Power and sample size calculations. A review and computer program Control Clin Trials 1990 11 2 116-128 10.1016/ 0197-2456(90)90005-M 2161310