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Volumn 3, Issue 3, 2006, Pages 295-301

Molecular Genetics of Addiction Vulnerability

Author keywords

Association genome scanning; cell adhesion molecules; haplotypes; linkage; memory; substance dependence

Indexed keywords

ADDICTION; ALLELE; ANXIETY; ARTICLE; ASSOCIATION; ATTENTION DISTURBANCE; BRAIN REGION; BRAIN SIZE; CELL ADHESION; DISEASE PREDISPOSITION; DRUG ABUSE; GENE LOCUS; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME; HAPLOTYPE; HUMAN; INFORMATION; LABORATORY; MEMORY; MOLECULAR CLONING; MOLECULAR GENETICS; PAIN; RISK ASSESSMENT; SEIZURE; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP; SUBSTANCE ABUSE;

EID: 33745338482     PISSN: 15455343     EISSN: 15455351     Source Type: Journal    
DOI: 10.1016/j.nurx.2006.05.006     Document Type: Article
Times cited : (42)

References (45)
  • 1
    • 4644261556 scopus 로고    scopus 로고
    • Molecular genetic underpinnings of human substance abuse vulnerability. likely contributions to understanding addiction as a mnemonic process
    • Uhl G.R. Molecular genetic underpinnings of human substance abuse vulnerability. likely contributions to understanding addiction as a mnemonic process. Neuropharmacology 47 (2004) S140-S147
    • (2004) Neuropharmacology , vol.47
    • Uhl, G.R.1
  • 2
    • 0033695676 scopus 로고    scopus 로고
    • Addiction, dopamine, and the molecular mechanisms of memory
    • Berke J.D., and Hyman S.E. Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25 (2000) 515-532
    • (2000) Neuron , vol.25 , pp. 515-532
    • Berke, J.D.1    Hyman, S.E.2
  • 3
    • 0036881834 scopus 로고    scopus 로고
    • Common molecular and cellular substrates of addiction and memory
    • Nestler E.J. Common molecular and cellular substrates of addiction and memory. Neurobiol Learn Mem 78 (2002) 637-647
    • (2002) Neurobiol Learn Mem , vol.78 , pp. 637-647
    • Nestler, E.J.1
  • 4
    • 28044440308 scopus 로고    scopus 로고
    • Nonmedical use and abuse of scheduled medications prescribed for pain, pain-related symptoms, and psychiatric disorders. patterns, user characteristics, and management options
    • Smith M.Y., and Woody G. Nonmedical use and abuse of scheduled medications prescribed for pain, pain-related symptoms, and psychiatric disorders. patterns, user characteristics, and management options. Curr Psychiatry Rep 7 (2005) 337-343
    • (2005) Curr Psychiatry Rep , vol.7 , pp. 337-343
    • Smith, M.Y.1    Woody, G.2
  • 5
    • 0002394107 scopus 로고
    • Genetic influences in drug abuse
    • Bloom F.E., and Kupfer D.J. (Eds), Raven Press, New York
    • Uhl G.R., Elmer G., and Pickens R. Genetic influences in drug abuse. In: Bloom F.E., and Kupfer D.J. (Eds). Psychopharmacology. the fourth generation (1995), Raven Press, New York 1793-1806
    • (1995) Psychopharmacology. the fourth generation , pp. 1793-1806
    • Uhl, G.R.1    Elmer, G.2    Pickens, R.3
  • 6
    • 0036683617 scopus 로고    scopus 로고
    • Substance abuse vulnerability loci. converging genome scanning data
    • Uhl G.R., Liu Q.R., and Naiman D. Substance abuse vulnerability loci. converging genome scanning data. Trends Genet 18 (2002) 420-425
    • (2002) Trends Genet , vol.18 , pp. 420-425
    • Uhl, G.R.1    Liu, Q.R.2    Naiman, D.3
  • 7
    • 0032891298 scopus 로고    scopus 로고
    • Molecular genetics of substance abuse vulnerability. a current approach
    • Uhl G.R. Molecular genetics of substance abuse vulnerability. a current approach. Neuropsychopharmacology 20 (1999) 3-9
    • (1999) Neuropsychopharmacology , vol.20 , pp. 3-9
    • Uhl, G.R.1
  • 8
    • 0032888659 scopus 로고    scopus 로고
    • Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women
    • Kendler K.S., Karkowski L.M., Corey L.A., Prescott C.A., and Neale M.C. Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women. Br J Psychiatry 175 (1999) 351-356
    • (1999) Br J Psychiatry , vol.175 , pp. 351-356
    • Kendler, K.S.1    Karkowski, L.M.2    Corey, L.A.3    Prescott, C.A.4    Neale, M.C.5
  • 9
    • 0031719020 scopus 로고    scopus 로고
    • Cocaine use, abuse and dependence in a population-based sample of female twins
    • Kendler K.S., and Prescott C.A. Cocaine use, abuse and dependence in a population-based sample of female twins. Br J Psychiatry 173 (1999) 345-350
    • (1999) Br J Psychiatry , vol.173 , pp. 345-350
    • Kendler, K.S.1    Prescott, C.A.2
  • 10
    • 0031017378 scopus 로고    scopus 로고
    • Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949
    • Kendler K.S., Prescott C.A., Neale M.C., and Pedersen N.L. Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949. Arch Gen Psychiatry 54 (1997) 178-184
    • (1997) Arch Gen Psychiatry , vol.54 , pp. 178-184
    • Kendler, K.S.1    Prescott, C.A.2    Neale, M.C.3    Pedersen, N.L.4
  • 11
    • 0033861385 scopus 로고    scopus 로고
    • Tobacco consumption in Swedish twins reared apart and reared together
    • Kendler K.S., Thornton L.M., and Pedersen N.L. Tobacco consumption in Swedish twins reared apart and reared together. Arch Gen Psychiatry 57 (2000) 886-892
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 886-892
    • Kendler, K.S.1    Thornton, L.M.2    Pedersen, N.L.3
  • 13
    • 0033588285 scopus 로고    scopus 로고
    • Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms
    • True W.R., Heath A.C., Scherrer J.F., Xian H., Lin N., Eisen S.A., et al. Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. Am J Med Genet 88 (1999) 391-397
    • (1999) Am J Med Genet , vol.88 , pp. 391-397
    • True, W.R.1    Heath, A.C.2    Scherrer, J.F.3    Xian, H.4    Lin, N.5    Eisen, S.A.6
  • 15
    • 0029763154 scopus 로고    scopus 로고
    • Genetic influences on DSM-III-R drug abuse and dependence. a study of 3,372 twin pairs
    • Tsuang M.T., Lyons M.J., Eisen S.A., Goldberg J., True W., Lin N., et al. Genetic influences on DSM-III-R drug abuse and dependence. a study of 3,372 twin pairs. Am J Med Genet 67 (1996) 473-477
    • (1996) Am J Med Genet , vol.67 , pp. 473-477
    • Tsuang, M.T.1    Lyons, M.J.2    Eisen, S.A.3    Goldberg, J.4    True, W.5    Lin, N.6
  • 17
    • 17344367165 scopus 로고    scopus 로고
    • Co-occurrence of abuse of different drugs in men. the role of drug-specific and shared vulnerabilities
    • Tsuang M.T., Lyons M.J., Meyer J.M., Doyle T., Eisen S.A., Goldberg J., et al. Co-occurrence of abuse of different drugs in men. the role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry 55 (1998) 967-972
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 967-972
    • Tsuang, M.T.1    Lyons, M.J.2    Meyer, J.M.3    Doyle, T.4    Eisen, S.A.5    Goldberg, J.6
  • 19
    • 0037022623 scopus 로고    scopus 로고
    • Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness
    • Geschwind D.H., Miller B.L., DeCarli C., and Carmelli D. Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness. Proc Natl Acad Sci USA 99 (2002) 3176-3181
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3176-3181
    • Geschwind, D.H.1    Miller, B.L.2    DeCarli, C.3    Carmelli, D.4
  • 20
    • 0035686219 scopus 로고    scopus 로고
    • Heritability of hippocampal size in elderly twin men. equivalent influence from genes and environment
    • Sullivan E.V., Pfefferbaum A., Swan G.E., and Carmelli D. Heritability of hippocampal size in elderly twin men. equivalent influence from genes and environment. Hippocampus 11 (2001) 754-762
    • (2001) Hippocampus , vol.11 , pp. 754-762
    • Sullivan, E.V.1    Pfefferbaum, A.2    Swan, G.E.3    Carmelli, D.4
  • 21
    • 0037388692 scopus 로고    scopus 로고
    • Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed
    • Posthuma D., Baare W.F., Hulshoff Pol H.E., Kahn R.S., Boomsma D.I., and De Geus E.J. Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed. Twin Res 6 (2003) 131-139
    • (2003) Twin Res , vol.6 , pp. 131-139
    • Posthuma, D.1    Baare, W.F.2    Hulshoff Pol, H.E.3    Kahn, R.S.4    Boomsma, D.I.5    De Geus, E.J.6
  • 22
    • 0032496340 scopus 로고    scopus 로고
    • Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population
    • Long J.C., Knowler W.C., Hanson R.L., Robin R.W., Urbanek M., Moore E., et al. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81 (1998) 216-221
    • (1998) Am J Med Genet , vol.81 , pp. 216-221
    • Long, J.C.1    Knowler, W.C.2    Hanson, R.L.3    Robin, R.W.4    Urbanek, M.5    Moore, E.6
  • 25
    • 0032947801 scopus 로고    scopus 로고
    • Susceptibility genes for nicotine dependence. a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study
    • Straub R.E., Sullivan P.F., Ma Y., Myakishev M.V., Harris-Kerr C., Wormley B., et al. Susceptibility genes for nicotine dependence. a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study. Mol Psychiatry 4 (1999) 129-144
    • (1999) Mol Psychiatry , vol.4 , pp. 129-144
    • Straub, R.E.1    Sullivan, P.F.2    Ma, Y.3    Myakishev, M.V.4    Harris-Kerr, C.5    Wormley, B.6
  • 26
    • 0033868423 scopus 로고    scopus 로고
    • Alcoholism susceptibility loci. confirmation studies in a replicate sample and further mapping
    • Foroud T., Edenberg H.J., Goate A., Rice J., Flury L., Koller D.L., et al. Alcoholism susceptibility loci. confirmation studies in a replicate sample and further mapping. Alcohol Clin Exp Res 24 (2000) 933-945
    • (2000) Alcohol Clin Exp Res , vol.24 , pp. 933-945
    • Foroud, T.1    Edenberg, H.J.2    Goate, A.3    Rice, J.4    Flury, L.5    Koller, D.L.6
  • 27
    • 21444445695 scopus 로고    scopus 로고
    • Genomewide linkage scan for cocaine dependence and related traits. significant linkages for a cocaine-related trait and cocaine-induced paranoia
    • Gelernter J., Panhuysen C., Weiss R., Brady K., Hesselbrock V., Rounsaville B., et al. Genomewide linkage scan for cocaine dependence and related traits. significant linkages for a cocaine-related trait and cocaine-induced paranoia. Am J Med Genet 136 (2005) 45-52
    • (2005) Am J Med Genet , vol.136 , pp. 45-52
    • Gelernter, J.1    Panhuysen, C.2    Weiss, R.3    Brady, K.4    Hesselbrock, V.5    Rounsaville, B.6
  • 28
    • 3042806901 scopus 로고    scopus 로고
    • Results of a genomewide linkage scan. support for chromosomes 9 and 11 loci increasing risk for cigarette smoking
    • Gelernter J., Liu X., Hesselbrock V., Page G.P., Goddard A., and Zhang H. Results of a genomewide linkage scan. support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. Am J Med Genet 128 (2004) 94-101
    • (2004) Am J Med Genet , vol.128 , pp. 94-101
    • Gelernter, J.1    Liu, X.2    Hesselbrock, V.3    Page, G.P.4    Goddard, A.5    Zhang, H.6
  • 29
    • 20744456329 scopus 로고    scopus 로고
    • Mapping and verification of susceptibility loci for smoking quantity using permutation linkage analysis
    • Wang D., Ma J.Z., and Li M.D. Mapping and verification of susceptibility loci for smoking quantity using permutation linkage analysis. Pharmacogenomics J 5 (2005) 166-172
    • (2005) Pharmacogenomics J , vol.5 , pp. 166-172
    • Wang, D.1    Ma, J.Z.2    Li, M.D.3
  • 30
    • 34248652381 scopus 로고    scopus 로고
    • Mapping susceptibility loci for alcohol consumption using number of grams of alcohol consumed per day as a phenotype measure
    • Ma J.Z., Zhang D., Dupont R.T., Dockter M., Elston R.C., and Li M.D. Mapping susceptibility loci for alcohol consumption using number of grams of alcohol consumed per day as a phenotype measure. BMC Genet 31 (2003) S104
    • (2003) BMC Genet , vol.31
    • Ma, J.Z.1    Zhang, D.2    Dupont, R.T.3    Dockter, M.4    Elston, R.C.5    Li, M.D.6
  • 31
    • 85061110559 scopus 로고    scopus 로고
    • Framingham Heart Study. a genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population
    • Li M.D., Ma J.Z., Cheng R., Dupont R.T., Williams N.J., Crews K.M., et al. Framingham Heart Study. a genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population. BMC Genet 31 (2003) S103
    • (2003) BMC Genet , vol.31
    • Li, M.D.1    Ma, J.Z.2    Cheng, R.3    Dupont, R.T.4    Williams, N.J.5    Crews, K.M.6
  • 32
    • 34248661820 scopus 로고    scopus 로고
    • Framingham Heart Study. genomic regions linked to alcohol consumption in the Framingham Heart Study
    • Bergen A.W., Yang X.R., Bai Y., Beerman M.B., Goldstein A.M., and Goldin L.R. Framingham Heart Study. genomic regions linked to alcohol consumption in the Framingham Heart Study. BMC Genet 31 (2003) S101
    • (2003) BMC Genet , vol.31
    • Bergen, A.W.1    Yang, X.R.2    Bai, Y.3    Beerman, M.B.4    Goldstein, A.M.5    Goldin, L.R.6
  • 33
    • 10444266005 scopus 로고    scopus 로고
    • Molecular genetics of substance abuse vulnerability. remarkable recent convergence of genome scan results
    • Uhl G.R. Molecular genetics of substance abuse vulnerability. remarkable recent convergence of genome scan results. Ann NY Acad Sci 1025 (2004) 1-13
    • (2004) Ann NY Acad Sci , vol.1025 , pp. 1-13
    • Uhl, G.R.1
  • 34
    • 0035209299 scopus 로고    scopus 로고
    • Polysubstance abuse-vulnerability genes. genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms
    • Uhl G.R., Liu Q.R., Walther D., Hess J., and Naiman D. Polysubstance abuse-vulnerability genes. genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. Am J Hum Genet 69 (2001) 1290-1300
    • (2001) Am J Hum Genet , vol.69 , pp. 1290-1300
    • Uhl, G.R.1    Liu, Q.R.2    Walther, D.3    Hess, J.4    Naiman, D.5
  • 35
    • 23844536467 scopus 로고    scopus 로고
    • Pooled association genome scanning. validation and use to identify addiction vulnerability loci in two samples
    • Liu Q.R., Drgon T., Walther D., Johnson C., Poleskaya O., Hess J., et al. Pooled association genome scanning. validation and use to identify addiction vulnerability loci in two samples. Proc Natl Acad Sci USA 102 (2005) 11864-11869
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11864-11869
    • Liu, Q.R.1    Drgon, T.2    Walther, D.3    Johnson, C.4    Poleskaya, O.5    Hess, J.6
  • 36
    • 33745400936 scopus 로고    scopus 로고
    • Johnson C, Drgon T, Liu Q-R, Walther D, Edenberg H, Rice J, Foroud T, Uhl GR. Pooled association genome scanning for alcohol dependence using 104,268 SNPS: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the Collaborative Study on the Genetics of Alcoholism. American J Med Genetics (Part B) (in press).
  • 37
    • 30344454380 scopus 로고    scopus 로고
    • Neuroligins and neurexins. linking cell adhesion, synapse formation and cognitive function
    • Dean C., and Dresbach T. Neuroligins and neurexins. linking cell adhesion, synapse formation and cognitive function. Trends Neurosci 29 (2006) 21-29
    • (2006) Trends Neurosci , vol.29 , pp. 21-29
    • Dean, C.1    Dresbach, T.2
  • 38
    • 33244494176 scopus 로고    scopus 로고
    • NrCAM in addiction vulnerability. positional cloning, drug-regulation, haplotype-specific expression and altered drug reward in knockout mice
    • Ishiguro H., Liu Q.R., Gong J.P., Hall F.S., Ujike H., Morales M., et al. NrCAM in addiction vulnerability. positional cloning, drug-regulation, haplotype-specific expression and altered drug reward in knockout mice. Neuropsychopharmacology 31 (2006) 572-584
    • (2006) Neuropsychopharmacology , vol.31 , pp. 572-584
    • Ishiguro, H.1    Liu, Q.R.2    Gong, J.P.3    Hall, F.S.4    Ujike, H.5    Morales, M.6
  • 39
    • 0035904240 scopus 로고    scopus 로고
    • Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development
    • Sakurai T., Lustig M., Babiarz J., Furley A.J., Tait S., Brophy P.J., et al. Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development. J Cell Biol 154 (2001) 1259-1273
    • (2001) J Cell Biol , vol.154 , pp. 1259-1273
    • Sakurai, T.1    Lustig, M.2    Babiarz, J.3    Furley, A.J.4    Tait, S.5    Brophy, P.J.6
  • 40
    • 13544277155 scopus 로고    scopus 로고
    • Mutation screening and association analysis of six candidate genes for autism on chromosome 7q
    • Bonora E., Lamb J.A., Barnby G., Sykes N., Moberly T., Beyer K.S., et al. Mutation screening and association analysis of six candidate genes for autism on chromosome 7q. Eur J Hum Genet 13 (2005) 198-207
    • (2005) Eur J Hum Genet , vol.13 , pp. 198-207
    • Bonora, E.1    Lamb, J.A.2    Barnby, G.3    Sykes, N.4    Moberly, T.5    Beyer, K.S.6
  • 42
    • 33745407776 scopus 로고    scopus 로고
    • The microarray data analysis process. from raw data to biological significance
    • Olson N.E. The microarray data analysis process. from raw data to biological significance. NeuroRx 3 (2006) 371-381
    • (2006) NeuroRx , vol.3 , pp. 371-381
    • Olson, N.E.1
  • 43
  • 44
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey J.D., and Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100 (2003) 9440-9445
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 45
    • 1542306717 scopus 로고    scopus 로고
    • The burden of complex genetics in brain disorders
    • Uhl G.R., and Grow R.W. The burden of complex genetics in brain disorders. Arch Gen Psychiatry 61 (2004) 223-239
    • (2004) Arch Gen Psychiatry , vol.61 , pp. 223-239
    • Uhl, G.R.1    Grow, R.W.2


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