Pooled association genome scanning: Validation and use to identify addiction vulnerability loci in two samples

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 33, 2005, Pages 11864-11869

  Liu, Qing Rong ^a   Drgon, Tomas ^a   Walther, Donna ^a   Johnson, Catherine ^a   Poleskaya, Oxanna ^a   Hess, Judith ^a   Uhl, George R ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Complex genetics; Drug dependence; Linkage disequilibrium; Microarray; SNP

Indexed keywords

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE;

ADDICTION; ADULT; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DNA DETERMINATION; GENE CLUSTER; GENE CONTROL; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MOLECULAR GENETICS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SUBSTANCE ABUSE; VALIDATION PROCESS;

ADULT; AFRICA; AFRICAN AMERICANS; CASE-CONTROL STUDIES; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME; GENOMICS; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; SUBSTANCE-RELATED DISORDERS;

EID: 23844536467     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500329102     Document Type: Article

References (49)

1. Uhl, G. R., Elmer, G. I., Labuda, M. C. & Pickens, R. W. (1995) in Psychopharmacology: The Fourth Generation of Progress, eds. Gloom, F. E. & Kupfer, D. J. (Raven, New York), pp. 1793-2783.
2. Uhl, G. R., Gold, L. H. & Risch, N. (1997) Proc. Natl. Acad. Sci. USA 94, 2785-2786.
3. Uhl, G. R. (1999) Neuropsychopharmacology 20, 3-9.
4. Cadoret, R. J., Troughton, E., O'Gorman, T. W. & Heywood, E. (1986) Arch. Gen. Psychiatry 43, 1131-1136.
5. Cadoret, R. J., Yates, W. R., Troughton, E., Woodworth, G. & Stewart, M. A. (1995) Arch. Gen. Psychiatry 52, 42-52.
6. Goldberg, J., Henderson, W. G., Eisen, S. A., True, W., Ramakrishnan, V., Lyons, M. J. & Tsuang, M. T. (1993) Stat. Med. 12, 1693-1702.
7. Grove, W. M., Eckert, E. D., Heston, L., Bouchard, T. J., Jr., Segal, N. & Lykken, D. T. (1990) Biol. Psychiatry 27, 1293-1304.
8. Gynther, L. M., Carey, G., Gottesman, II, & Vogler, G. P. (1995) Psychiatry Res. 56, 213-220.
9. Tsuang, M. T., Lyons, M. J., Eisen, S. A., Goldberg, J., True, W., Lin, N., Meyer, J. M., Toomey, R., Faraone, S. V. & Eaves, L. (1996) Am. J. Med. Genet. 67, 473-477.
10. Tsuang, M. T., Lyons, M. J., Meyer, J. M., Doyle, T., Eisen, S. A., Goldberg, J., True, W., Lin, N., Toomey, R. & Eaves, L. (1998) Arch. Gen. Psychiatry 55, 967-972.
11. Karkowski, L. M., Prescott, C. A. & Kendler, K. S. (2000) Am. J. Med. Genet. 96, 665-670.
12. Kendler, K. S. & Prescott, C. A. (1998) Br. J. Psychiatry 173, 345-350.
13. Kendler, K. S., Karkowski, L. M., Corey, L. A., Prescott, C. A. & Neale, M. C. (1999) Br. J. Psychiatry 175, 351-356.
14. Woodward, C. E., Maes, H. H., Silberg, J. L., Meyer, J. M. & Eaves, L. J. (1996) NIDA Res. Monograph 162, 309.
15. Merikangas, K. R., Stolar, M., Stevens, D. E., Goulet, J., Preisig, M. A., Fenton, B., Zhang, H., O'Malley, S. S. & Rounsaville, B. J. (1998) Arch. Gen. Psychiatry 55, 973-979.
16. True, W, R., Heath, A. C., Scherrer, J. F., Xian, H., Lin, N., Eisen, S. A., Lyons, M. J., Goldberg, J. & Tsuang, M. T. (1999) Am. J. Med. Genet. 88, 391-397.
17. Cervino, A. C. & Hill, A. V. (2000) Am. J. Hum. Genet. 67, 120-132.
18. Sham, P. C., Cherny, S. S., Purcell, S. & Hewitt, J. K. (2000) Am. J Hum. Genet. 66, 1616-1630.
19. Risch, N. & Merikangas, K. (1996) Science 273, 1516-1517.
20. Schork, N. J., Nath, S. K., Fallin, D. & Chakravarti, A. (2000) Am. J. Hum. Genet. 67, 1208-1218.
21. Barcellos, L. F., Klitz, W., Field, L. L., Tobias, R., Bowcock, A. M., Wilson, R., Nelson, M. P., Nagatomi, J. & Thomson, G. (1997) Am. J. Hum. Genet. 61, 734-747.
22. Germer, S., Holland, M. J. & Higuchi, R. (2000) Genome Res. 10, 258-266.
23. Hacia, J. G., Fan, J. B., Ryder, O., Jin, L., Edgemon, K., Ghandour, G., Mayer, R. A., Sun, B., Hsie, L., Robbins, C. M., et al. (1999) Nat. Genet. 22, 164-167.
24. Uhl, G. R., Liu, Q. R., Walther, D., Hess, J. & Naiman, D. (2001) Am. J. Hum. Genet. 69, 1290-1300.
25. Uhl, G. R., Liu, Q. R. & Naiman, D. (2002) Trends Genet. 18, 420-425.
26. Uhl, G. R. (2004) Neuropharmacohgy 47, Suppl. 1, 140-147.
27. Smith, S. S., O'Hara, B. F., Persico, A. M., Gorelick, D. A., Newlin, D. B., Viahov, D., Solomon, L., Pickens, R. & Uhl, G. R. (1992) Arch. Gen. Psychiatry 49, 723-727.
28. Persico, A. M., Bird, G., Gabbay, F. H. & Uhl, G. R. (1996) Biol. Psychiatry 40, 776-784.
29. Bansal, A. (2001) Lancet 358, 2016.
30. Uhl, G. R. (2004) Ann. N.Y. Acad. Sci. 1025, 1-13.
31. Butcher, L. M., Meaburn, E., Liu, L., Fernandes, C., Hill, L., Al-Chalabi, A., Plomin, R., Schalkwyk, L. & Craig, I. W. (2004) Behav. Genet. 34, 549-555.
32. Osier, M., Pakstis, A. J., Kidd, J. R., Lee, J. F., Yin, S. J., Ko, H. C, Edenberg, H. J., Lu, R. B. & Kidd, K. K. (1999) Am. J. Hum. Genet. 64, 1147-1157.
33. Long, J. C., Knowler, W. C., Hanson, R. L., Robin, R. W., Urbanek, M., Moore, E., Bennett, P. H. & Goldman, D. (1998) Am. J. Med. Genet. 81, 216-221.
34. Furuichi, T., Furutama, D., Hakamata, Y., Nakai, J., Takeshima, H. & Mikoshiba, K. (1994) J. Neurosci. 14, 4794-4805.
35. Balschun, D., Wolfer, D. P., Bertocchini, F., Barone, V., Conti, A., Zuschratter, W., Missiaen, L., Lipp, H. P., Frey, J. U. & Sorrentino, V. (1999) EMBO J. 18, 5264-5273.
36. Yuasa, K., Ohgaru, T., Asahina, M. & Omori, K. (2001) Eur. J. Biochem. 268, 4440-4448.
37. Craxton, M. (2001) Genomics 77, 43-49.
38. Ishida, N. & Kawakita, M. (2004) Pflügers Arch. 447, 768-775.
39. Cherukuri, A., Carter, R. H., Brooks, S., Bornmann, W., Finn, R., Dowd, C. S. & Pierce, S. K. (2004) J. Biol. Chem. 279, 31973-31982.
40. Serru, V., Dessen, P., Boucheix, C. & Rubinstein, E. (2000) Biochim. Biophys. Acta 1478, 159-163.
41. Gasca, S., Hill, D. P., Klingensmith, J. & Rossant, J. (1995) Dev. Genet. 17, 141-154.
42. Carroll, E. A., Gerrelli, D., Gasca, S., Berg, E., Beier, D. R., Copp, A. J. & Klingensmith, J. (2003) Dev. Biol. 262, 16-31.
43. Tzouanacou, E., Tweedie, S. & Wilson, V. (2003) Mol. Cell. Biol. 23, 8553-8552.
44. Wood, J. D., Yuan, J., Margolis, R. L., Colomer, V., Duan, K., Kushi, J., Kaminsky, Z., Kleiderlein, J. J., Sharp, A. H. & Ross, C. A. (1998) Mol. Cell. Neurosci. 11, 149-160.
45. Gramolini, A. O., Wu, J. & Jasmin, B. J. (2000) Microsc. Res. Technol. 49, 90-100.
46. Hu, R. J., Lee, M. P., Connors, T. D., Johnson, L. A., Burn, T. C., Su, K., Landes, G. M, & Feinberg, A. P. (1997) Genomics 46, 9-17.
47. Nicolas, E., Morales, V., Magnaghi-Jaulin, L., Harel-Bellan, A., Richard-Foy, H. & Trouche, D. (2000) J. Biol. Chem. 275, 9797-9804.
48. Kattenstroth, G., Tantalaki, E., Sudhof, T. C., Gottmann, K. & Missler, M. (2004) Proc. Natl. Acad. Sci. USA 101, 2607-2612.
49. Ishiguro, H., Liu, Q.-R., Gong, J.-P., Hall, S., Ujike, H., Morales, M., Sakurai, T., Grumet, M. & Uhl, G. R. (2005) Neuropsychopharmacology, in press.