Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: Substrate recognition, conformational change, and cooperativity

Journal of Biological Chemistry

Volumn 282, Issue 11, 2007, Pages 8487-8497

  Ciulli, Alessio ^a   Chirgadze, Dimitri Y ^a   Smith, Alison G ^a   Blundell, Tom L ^a   Abell, Chris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

KETOPANTOATE; PANTOATE; PRECATALYTIC TERNARY COMPLEX; PROTEIN MOLECULES;

ANTIBIOTICS; BIOSYNTHESIS; COMPLEXATION; CRYSTAL STRUCTURE; ENZYMES; HERBICIDES; VITAMINS;

ESCHERICHIA COLI;

ASPARAGINE; ENZYME; GLUTAMINE; HYDROGEN; HYDROXYL GROUP; KETOPANTOATE REDUCTASE; LYSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SERINE; UNCLASSIFIED DRUG; 2 DEHYDROPANTOATE 2 REDUCTASE; 2-DEHYDROPANTOATE 2-REDUCTASE; ALCOHOL DEHYDROGENASE; AMINO ACID; PANTOTHENIC ACID;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME STRUCTURE; ESCHERICHIA COLI; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; PROTEIN DOMAIN; STEADY STATE; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; KINETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI;

ALCOHOL OXIDOREDUCTASES; AMINO ACIDS; BINDING SITES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; KINETICS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NADP; PANTOTHENIC ACID; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 34247252410     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611171200     Document Type: Article

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