Crystal structure of Escherichia coli ketopantoate reductase at 1.7 Å resolution and insight into the enzyme mechanism

Biochemistry

Volumn 40, Issue 48, 2001, Pages 14493-14500

  Matak Vinkovic D ^a,b   Vinkovic M ^a,c   Saldanha, S A ^a   Ashurst, J L ^a   von Delft, F ^a   Inoue, T ^a,d   Miguel, R N ^a   Smith, A G ^a   Blundell, T L ^a   Abell, C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c PLIVA CROATIA LTD   (Croatia)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANTS;

BIOSYNTHESIS; CATALYSIS; CLONING; CRYSTAL STRUCTURE; ENZYMES; PROTEINS;

ESCHERICHIA COLI;

BACTERIAL ENZYME; KETOPANTOATE REDUCTASE; OXIDOREDUCTASE; PANTOTHENIC ACID; PHOSPHOGLUCONATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELENOMETHIONINE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME KINETICS; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE EXPRESSION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; ESCHERICHIA COLI; GENE EXPRESSION; KINETICS; MOLECULAR SEQUENCE DATA; NADP; PLASMIDS; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SELENOMETHIONINE; SEQUENCE HOMOLOGY, AMINO ACID;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0035807790     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi011020w     Document Type: Article

References (43)