The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound

Biochemistry

Volumn 44, Issue 25, 2005, Pages 8930-8939

  Lobley, Carina M C ^a   Ciulli, Alessio ^a   Whitney, Heather M ^a   Williams, Glyn ^b   Smith, Alison G ^a   Abell, Chris ^a   Blundell, Tom L ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CALORIMETRY; CATALYSIS; CONFORMATIONS; CRYSTAL STRUCTURE; DISSOCIATION; ENZYMES; ESCHERICHIA COLI; MATHEMATICAL MODELS; MOLECULAR DYNAMICS; THERMODYNAMICS; TITRATION;

APOENZYMES; DISSOCIATION CONSTANTS; ENZYME CATALYSIS; KETOPANTOATE REDUCTASE (KPR);

ENZYME KINETICS;

KETOPANTOATE OXIDOREDUCTASE; LYSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; ENTROPY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; ESCHERICHIA COLI; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; LIPOPHILICITY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS;

ALCOHOL OXIDOREDUCTASES; CALORIMETRY; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ESCHERICHIA COLI; MODELS, MOLECULAR; MUTATION; NADP; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, QUATERNARY; TITRIMETRY;

ESCHERICHIA COLI;

EID: 21744450445     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0502036     Document Type: Article

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