Structure-based inhibitor design for an enzyme that binds different steroids: A potent inhibitor for human type 5 17β-hydroxysteroid dehydrogenase

Journal of Biological Chemistry

Volumn 282, Issue 11, 2007, Pages 8368-8379

  Qiu, Wei ^a,b   Zhou, Ming ^a   Mazumdar, Mausumi ^a   Azzi, Arezki ^a   Ghanmi, Dalila ^a   Luu The, Van ^a   Labrie, Fernand ^a   Lin, Sheng Xiang ^a,c  

^a CANADIAN INSTITUTES OF HEALTH RESEARCH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROPHOBIC INTERACTIONS; PROTEIN LOOPS; SUBSTRATE TERNARY COMPLEX;

CARBOXYLIC ACIDS; CRYSTAL STRUCTURE; HYDROGEN BONDS; HYDROPHOBICITY; MOLECULAR MODELING; SYNTHESIS (CHEMICAL); TISSUE;

ENZYME INHIBITION;

3 CARBOXAMIDO 1,3,5(10) ESTRATRIEN 17 SPIRO 2' (5',5' DIMETHYL 6' OXO)TETRAHYDROPYRAN; AMIDE; EM 1404; HYDROGEN; LACTONE; MACROGOL; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE INHIBITOR; STEROID; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG; 17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 5, HUMAN; 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 5, HUMAN; ENZYME INHIBITOR; FLUFENAMIC ACID; HYDROXYSTEROID DEHYDROGENASE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER THERAPY; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; HORMONE DEPENDENCE; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; BINDING COMPETITION; CHEMISTRY; CONFORMATION; MOLECULAR GENETICS; PROTEIN BINDING;

17-HYDROXYSTEROID DEHYDROGENASES; AMINO ACID SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; FLUFENAMIC ACID; HUMANS; HYDROGEN BONDING; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NADP; PROTEIN BINDING;

EID: 34247218025     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606784200     Document Type: Article

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