메뉴 건너뛰기




Volumn 15, Issue 5, 2007, Pages 912-920

Rapamycin-regulated control of antiangiogenic tumor therapy following rAAV-mediated gene transfer

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; PARVOVIRUS VECTOR; RAPAMYCIN; VASCULOTROPIN INHIBITOR;

EID: 34247208499     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.sj.6300079     Document Type: Article
Times cited : (18)

References (42)
  • 1
    • 1942537842 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Transcription regulatory systems
    • Toniatti, C, Bujard, H, Cortese, R and Ciliberto, G (2004). Gene therapy progress and prospects: Transcription regulatory systems. Gene Ther 11: 649-657.
    • (2004) Gene Ther , vol.11 , pp. 649-657
    • Toniatti, C.1    Bujard, H.2    Cortese, R.3    Ciliberto, G.4
  • 2
    • 22644442838 scopus 로고    scopus 로고
    • Regulatable gene expression systems for gene therapy applications: Progress and future challenges
    • Goverdhana, S, Puntel, M, Xiong, W, Zirger, JM, Barcia, C and Curtin, JF et al. (2005). Regulatable gene expression systems for gene therapy applications: Progress and future challenges. Mol Ther 12: 189-211.
    • (2005) Mol Ther , vol.12 , pp. 189-211
    • Goverdhana, S.1    Puntel, M.2    Xiong, W.3    Zirger, J.M.4    Barcia, C.5    Curtin, J.F.6
  • 3
    • 0036810868 scopus 로고    scopus 로고
    • Dimerizer-regulated gene expression
    • Pollock, R and Clackson, T (2002). Dimerizer-regulated gene expression. Curr Opin Biotechnol 13: 459-467.
    • (2002) Curr Opin Biotechnol , vol.13 , pp. 459-467
    • Pollock, R.1    Clackson, T.2
  • 4
    • 13544262341 scopus 로고    scopus 로고
    • Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer
    • Rivera, VM, Gao, GP, Grant RL, Schnell, MA, Zoltick, PW and Rozamus, LW et al. (2005). Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer. Blood 105: 1424-1430.
    • (2005) Blood , vol.105 , pp. 1424-1430
    • Rivera, V.M.1    Gao, G.P.2    Grant, R.L.3    Schnell, M.A.4    Zoltick, P.W.5    Rozamus, L.W.6
  • 5
    • 29944446086 scopus 로고    scopus 로고
    • Rapamycin control of transgene expression from a single AAV vector in mouse salivary glands
    • Wang, J, Voutetakis, A, Papa, M, Rivera, VM, Clackson, T and Lodde, BM et al. (2005). Rapamycin control of transgene expression from a single AAV vector in mouse salivary glands. Gene Ther 13: 187-190.
    • (2005) Gene Ther , vol.13 , pp. 187-190
    • Wang, J.1    Voutetakis, A.2    Papa, M.3    Rivera, V.M.4    Clackson, T.5    Lodde, B.M.6
  • 6
    • 28844475010 scopus 로고    scopus 로고
    • Dimerizer regualation of AADC expression and behavioral response in AAV-transduced 6-OHDA lesioned rats
    • Sanftner, LM, Rivera, VM, Suzuki, BM, Feng, L, Berk, L and Zhou, S et al. (2006). Dimerizer regualation of AADC expression and behavioral response in AAV-transduced 6-OHDA lesioned rats. Mol Ther 13 167-174.
    • (2006) Mol Ther , vol.13 , pp. 167-174
    • Sanftner, L.M.1    Rivera, V.M.2    Suzuki, B.M.3    Feng, L.4    Berk, L.5    Zhou, S.6
  • 7
    • 14844331756 scopus 로고    scopus 로고
    • Long-term inducible gene expression in the eye via adeno-associated virus gene transfer in nonhuman primates
    • Lebherz, C, Auricchio, A, Maguire, AM, Rivera, VM, Tang, W and Grant, RL et al. (2005). Long-term inducible gene expression in the eye via adeno-associated virus gene transfer in nonhuman primates. Hum Gene Ther 16: 178-186.
    • (2005) Hum Gene Ther , vol.16 , pp. 178-186
    • Lebherz, C.1    Auricchio, A.2    Maguire, A.M.3    Rivera, V.M.4    Tang, W.5    Grant, R.L.6
  • 8
    • 0026030568 scopus 로고
    • Chemistry and biology of the immunophilins and their immunosuppressive ligands
    • Schreiber, S L (1991). Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251: 283-287.
    • (1991) Science , vol.251 , pp. 283-287
    • Schreiber, S.L.1
  • 9
    • 0026063950 scopus 로고
    • Use of rapamycin for the suppression of alloimmune reactions in vivo: Schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on host-versus-graft and graft-versus-host reactions
    • Morris, RE, Meiser, BM, Wu, J, Shorthouse, R and Wang, J (1991). Use of rapamycin for the suppression of alloimmune reactions in vivo: Schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on host-versus-graft and graft-versus-host reactions. Transplant Proc 23: 521-524.
    • (1991) Transplant Proc , vol.23 , pp. 521-524
    • Morris, R.E.1    Meiser, B.M.2    Wu, J.3    Shorthouse, R.4    Wang, J.5
  • 11
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre, S, Kroemer, G and Raymond, E (2006). Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Disc 5: 671-688.
    • (2006) Nat Rev Drug Disc , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 12
    • 18744407590 scopus 로고    scopus 로고
    • A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance
    • Xing, D and Orsulic, S (2005). A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance. Proc Natl Acad Sci USA 102: 6936-6941.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6936-6941
    • Xing, D.1    Orsulic, S.2
  • 13
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba, M, von Breitenbuch, P, Steinbauer, M, Koehl, G, Flegel, S and Homburg, M et al. (2002). Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med 8: 128-135.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    von Breitenbuch, P.2    Steinbauer, M.3    Koehl, G.4    Flegel, S.5    Homburg, M.6
  • 14
    • 10744227749 scopus 로고    scopus 로고
    • Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: A multicenter, double-blind, placebo-controlled trial
    • Moss, RB, Rodman, DM, Spencer, LT, Aitken, ML, Zeitlin, PL and Waltz, D et al. (2004). Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: A multicenter, double-blind, placebo-controlled trial. Chest 125: 509-521.
    • (2004) Chest , vol.125 , pp. 509-521
    • Moss, R.B.1    Rodman, D.M.2    Spencer, L.T.3    Aitken, M.L.4    Zeitlin, P.L.5    Waltz, D.6
  • 15
    • 0013442744 scopus 로고    scopus 로고
    • AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B
    • Manno, CS, Chew, AJ, Hutchison, S, Larson, PJ, Herzog, RW and Arruda, VR et al. (2003). AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B. Blood 101: 2963-2972.
    • (2003) Blood , vol.101 , pp. 2963-2972
    • Manno, C.S.1    Chew, A.J.2    Hutchison, S.3    Larson, P.J.4    Herzog, R.W.5    Arruda, V.R.6
  • 16
    • 0037143294 scopus 로고    scopus 로고
    • Clinical protocol. Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA) to the human brain
    • Janson, C, Mcphee, S, Bilaniuk, L, Haselgrove, J, Testaiuti, M and Freese, A et al. (2002). Clinical protocol. Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA) to the human brain. Hum Gene Ther 13 1391-1412.
    • (2002) Hum Gene Ther , vol.13 , pp. 1391-1412
    • Janson, C.1    Mcphee, S.2    Bilaniuk, L.3    Haselgrove, J.4    Testaiuti, M.5    Freese, A.6
  • 18
    • 0029257496 scopus 로고
    • The cryptic life style of adeno-associated virus
    • Berns, KI and Linden, RM (1995). The cryptic life style of adeno-associated virus. Bioessays 17: 237-245.
    • (1995) Bioessays , vol.17 , pp. 237-245
    • Berns, K.I.1    Linden, R.M.2
  • 19
    • 1542369977 scopus 로고    scopus 로고
    • From virus evolution to vector revolution: Use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy
    • Grimm, D and Kay, MA (2003). From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy. Curr Gene Ther 3: 281-304.
    • (2003) Curr Gene Ther , vol.3 , pp. 281-304
    • Grimm, D.1    Kay, M.A.2
  • 20
    • 0031969428 scopus 로고    scopus 로고
    • Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers
    • Jooss, K, Yang, Y, Fisher, KJ and Wilson, JM (1998). Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers. J Virol 72: 4212-4223.
    • (1998) J Virol , vol.72 , pp. 4212-4223
    • Jooss, K.1    Yang, Y.2    Fisher, K.J.3    Wilson, J.M.4
  • 21
    • 85207648699 scopus 로고    scopus 로고
    • III, CR, Yang, CQ, Bidlingmaier, SM, Gonzales, JN, Burns, DS and Bartholomew, RM et al. (1997). Optimization of the human factor VIII complementary DNA expression plasmid for gene therapy of hemophilia A. Blood Coagul Fibrinolysis 8 (Suppl 2): 523-530.
    • III, CR, Yang, CQ, Bidlingmaier, SM, Gonzales, JN, Burns, DS and Bartholomew, RM et al. (1997). Optimization of the human factor VIII complementary DNA expression plasmid for gene therapy of hemophilia A. Blood Coagul Fibrinolysis 8 (Suppl 2): 523-530.
  • 22
    • 0029944122 scopus 로고    scopus 로고
    • Angiostatin induces and sustains dormancy of human primary tumors in mice
    • O'Reilly, MS, Holmgren, L, Chen, C and Folkman, J (1996). Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 2: 689-692.
    • (1996) Nat Med , vol.2 , pp. 689-692
    • O'Reilly, M.S.1    Holmgren, L.2    Chen, C.3    Folkman, J.4
  • 23
    • 1142299564 scopus 로고    scopus 로고
    • Anti-tumor efficacy of human angiostatin using liver-mediated adeno-associated virus gene therapy
    • Lalani, AS, Chang, B, Lin, J, Case, SS, Luan, B and Wu-Prior, WW et al. (2004). Anti-tumor efficacy of human angiostatin using liver-mediated adeno-associated virus gene therapy. Mol Ther 9 56-66.
    • (2004) Mol Ther , vol.9 , pp. 56-66
    • Lalani, A.S.1    Chang, B.2    Lin, J.3    Case, S.S.4    Luan, B.5    Wu-Prior, W.W.6
  • 26
    • 33645896141 scopus 로고    scopus 로고
    • AAV serotype 8-mediated gene delivery of a soluble VEGF receptor to the CNS for the treatment of glioblastoma
    • Harding, TC, Lalini, AS, Roberts, BN, Yendluri, S, Laun, B and Koprivnikar, KE et al. (2006). AAV serotype 8-mediated gene delivery of a soluble VEGF receptor to the CNS for the treatment of glioblastoma. Mol Their 13: 956-966.
    • (2006) Mol Their , vol.13 , pp. 956-966
    • Harding, T.C.1    Lalini, A.S.2    Roberts, B.N.3    Yendluri, S.4    Laun, B.5    Koprivnikar, K.E.6
  • 27
  • 28
    • 0032949030 scopus 로고    scopus 로고
    • Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer
    • Ye, X, Rivera, VM, Zoltick, P, Cerasoli Jr, F, Schnell, MA and Gao, G et al. (1999). Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer. Science 283: 88-91.
    • (1999) Science , vol.283 , pp. 88-91
    • Ye, X.1    Rivera, V.M.2    Zoltick, P.3    Cerasoli Jr, F.4    Schnell, M.A.5    Gao, G.6
  • 29
    • 0038365487 scopus 로고    scopus 로고
    • Regulated expression of erythropoietin from an AAV vector safely improves the anemia of beta-thalassemia in a mouse model
    • Johnston, J, Tazelaar, J, Rivera, VM, Clackson, T, Gao, GP and Wilson, JM (2003). Regulated expression of erythropoietin from an AAV vector safely improves the anemia of beta-thalassemia in a mouse model. Mol Ther 7: 493-497.
    • (2003) Mol Ther , vol.7 , pp. 493-497
    • Johnston, J.1    Tazelaar, J.2    Rivera, V.M.3    Clackson, T.4    Gao, G.P.5    Wilson, J.M.6
  • 30
    • 0034170820 scopus 로고    scopus 로고
    • IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector
    • Mizuguchi, H, Xu, Z, Ishii-Watabe, A, Uchida, E and Hayakawa, T (2000). IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector. Mol Ther 1: 376-382.
    • (2000) Mol Ther , vol.1 , pp. 376-382
    • Mizuguchi, H.1    Xu, Z.2    Ishii-Watabe, A.3    Uchida, E.4    Hayakawa, T.5
  • 31
    • 0035880772 scopus 로고    scopus 로고
    • Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs
    • Hennecke, M, Kwissa, M, Metzger, K, Oumard, A, Kroger, A and Schirmbeck, R et al. (2001). Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs. Nucleic Acids Res 29: 3327-3334.
    • (2001) Nucleic Acids Res , vol.29 , pp. 3327-3334
    • Hennecke, M.1    Kwissa, M.2    Metzger, K.3    Oumard, A.4    Kroger, A.5    Schirmbeck, R.6
  • 32
    • 0034221233 scopus 로고    scopus 로고
    • Comparison of bicistronic retroviral vectors containing internal ribosome entry sites (IRES) using expression of human interleukin-12 (IL-12) as a readout
    • Harries, M, Phillipps, N, Anderson, R, Prentice, G and Collins, M (2000). Comparison of bicistronic retroviral vectors containing internal ribosome entry sites (IRES) using expression of human interleukin-12 (IL-12) as a readout. J Gene Med 2: 243-249.
    • (2000) J Gene Med , vol.2 , pp. 243-249
    • Harries, M.1    Phillipps, N.2    Anderson, R.3    Prentice, G.4    Collins, M.5
  • 33
    • 0032501958 scopus 로고    scopus 로고
    • Co-expression of human adenosine deaminase and multidrug resistance using a blcistronic retroviral vector
    • Zhou, Y, Aran, J, Gottesman, MM and Pastan, I (1998). Co-expression of human adenosine deaminase and multidrug resistance using a blcistronic retroviral vector. Hum Gene Ther 9: 287-293.
    • (1998) Hum Gene Ther , vol.9 , pp. 287-293
    • Zhou, Y.1    Aran, J.2    Gottesman, M.M.3    Pastan, I.4
  • 34
    • 0030751962 scopus 로고    scopus 로고
    • Comparison of picomaviral IRES-driven internal initiation of translation in cultured cells of different origins
    • Borman, AM, Le Mercier, P, Girard, M and Kean, KM (1997). Comparison of picomaviral IRES-driven internal initiation of translation in cultured cells of different origins. Nucleic Acids Res 25: 925-932.
    • (1997) Nucleic Acids Res , vol.25 , pp. 925-932
    • Borman, A.M.1    Le Mercier, P.2    Girard, M.3    Kean, K.M.4
  • 35
    • 0031956963 scopus 로고    scopus 로고
    • Recognition of picomavirus internal ribosome entry sites within cells; influence of cellular and viral proteins
    • Roberts, LO, Seamons, RA and Belsham, GJ (1998). Recognition of picomavirus internal ribosome entry sites within cells; influence of cellular and viral proteins. RNA 4: 520-529.
    • (1998) RNA , vol.4 , pp. 520-529
    • Roberts, L.O.1    Seamons, R.A.2    Belsham, G.J.3
  • 36
    • 0035866358 scopus 로고    scopus 로고
    • Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy
    • Geoerger, B, Kerr, K, Tang, CB, Fung, KM, Powell, B and Sutton, LN et al. (2001). Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy. Cancer Res 61: 1527-1532.
    • (2001) Cancer Res , vol.61 , pp. 1527-1532
    • Geoerger, B.1    Kerr, K.2    Tang, C.B.3    Fung, K.M.4    Powell, B.5    Sutton, L.N.6
  • 37
    • 85207650479 scopus 로고    scopus 로고
    • Reardon, D, Friedman, H, Yung, WKA, Brada, M, Conrad, C and Provenzale, J et al. (2004). A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM). J Clin Oncol 22 (14S) abstr 1513.
    • Reardon, D, Friedman, H, Yung, WKA, Brada, M, Conrad, C and Provenzale, J et al. (2004). A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM). J Clin Oncol 22 (14S) abstr 1513.
  • 38
    • 0001506423 scopus 로고    scopus 로고
    • A phase I trial of PTK787/ZK 222584 (PTK/ZK), a novel oral VEGFR TK inhibitor in recurrent glioblastoma
    • abstr 315
    • Yung, WKA, Friedman, H, Jackson, E, Provenzale, J, Leeds, N and Conrad, C et al. (2002). A phase I trial of PTK787/ZK 222584 (PTK/ZK), a novel oral VEGFR TK inhibitor in recurrent glioblastoma. Proc Am Soc Clin Oncol 21, abstr 315.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Yung, W.K.A.1    Friedman, H.2    Jackson, E.3    Provenzale, J.4    Leeds, N.5    Conrad, C.6
  • 39
    • 13944269599 scopus 로고    scopus 로고
    • Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition
    • Goudar, RK, Shi, Q Hjelmeland, MD, Keir, ST, McLendon, RE and Wikstrand, CJ et al. (2005). Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther 4: 101-112.
    • (2005) Mol Cancer Ther , vol.4 , pp. 101-112
    • Goudar, R.K.1    Shi, Q.2    Hjelmeland, M.D.3    Keir, S.T.4    McLendon, R.E.5    Wikstrand, C.J.6
  • 40
    • 0036664935 scopus 로고    scopus 로고
    • Pharmacological regulation of protein expression from adeno-associated viral vectors in the eye
    • Auricchio, A, Rivera, VM, Clackson, T, O'Connor, EE, Maguire, AM and Tolentino, MJ et al. (2002). Pharmacological regulation of protein expression from adeno-associated viral vectors in the eye. Mol Ther 6: 238-242.
    • (2002) Mol Ther , vol.6 , pp. 238-242
    • Auricchio, A.1    Rivera, V.M.2    Clackson, T.3    O'Connor, E.E.4    Maguire, A.M.5    Tolentino, M.J.6
  • 41
    • 0023672976 scopus 로고
    • The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two other sites
    • Costa, RH, Lai, E, Grayson, DR and Darnell Jr, JE (1988). The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two other sites. Mol Cell Biol 8: 81-90.
    • (1988) Mol Cell Biol , vol.8 , pp. 81-90
    • Costa, R.H.1    Lai, E.2    Grayson, D.R.3    Darnell Jr, J.E.4
  • 42
    • 2642642141 scopus 로고    scopus 로고
    • Production of high-titer recombinant adeno-associated virus vectors in them absence of helper adenovirus
    • Xiao, X, Li, J and Samulski, RJ (1998). Production of high-titer recombinant adeno-associated virus vectors in them absence of helper adenovirus. J Virol 72: 2224-2232.
    • (1998) J Virol , vol.72 , pp. 2224-2232
    • Xiao, X.1    Li, J.2    Samulski, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.