Co-expression of human adenosine deaminase and multidrug resistance using a bicistronic retroviral vector

Human Gene Therapy

Volumn 9, Issue 3, 1998, Pages 287-293

  Zhou, Y I ^a   Aran, Josep ^a   Gottesman, Michael M ^b   Pastan, Ira ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; GLYCOPROTEIN P; MESSENGER RNA; VINCRISTINE;

ARTICLE; DRUG RESISTANCE; ENCEPHALOMYOCARDITIS VIRUS; GENE THERAPY; HUMAN; HUMAN CELL; METABOLIC DISORDER; NONHUMAN; RETROVIRUS; RIBOSOME; TARGET CELL;

ADA; ENCEPHALOMYOCARDITIS VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0032501958     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.3-287     Document Type: Article

References (10)

1. ADAM, M.A., RAMESH, N., MILLER, A.D., and OSBORNE, W.A. (1991). Internal initiation of translation in retroviral vector carrying picornavirus 5′ nontranslated regions. J. Virol. 65, 4985-4990.
2. ARAN, J.M., GOTTESMAN, M.M., and PASTAN, I. (1994). Drug-selected co-expression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector. Proc. Natl. Acad. Sci. USA 91, 3176-3180.
3. ARAN, J., LICHT, T., GOTTESMAN, M.M., and PASTAN, I. (1996). Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy. Hum. Gene Then 7, 2165-2175.
4. BLAESE, R.M. (1993). Development of gene therapy for immunodeficiency: adenosine deaminase deficiency. Pediatr. Res. 33, (Suppl.) S49-S55.
5. BLAESE, R.M., CULVER, K.W., MILLER, A.D., CARTER, C.S., FLEISHER, T., CLERICI, M., SHEARER, G., CHANG, L., CHIANG, Y., TOLSTOCHEV, P., GREENBLATT, J.J., ROSENBERG, S.A., KLEIN, H., BERGER, M., MULLEN, C.A., RAMSEY, W.J., MUUL, L., MORGAN, R.A., and ANDERSON, F.W. (1995). T lymphocyte-directed gene therapy for ADA-SCID: Initial trial results after 4 years. Science 270, 475-480.
6. BUNNELL, B.A., MUUL, L., DONAHUE, R.E., BLAESE, R.M., and MORGAN, R. (1995). High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes. Proc. Natl. Acad. Sci. USA 92, 7739-7743.
7. GEORGES, E., BRADLEY, G., GARIEPY, J., and LING, V. (1990). Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies. Proc. Natl. Acad. Sci. USA 87, 152-156.
8. GERMANN, U.A., GOTTESMAN, M., and PASTAN, I. (1989). Expression of a multidrug resistance-adenosine deaminase fusion gene. J. Biol. Chem. 264, 7418-7424.
9. GOTTESMAN, M.M., HRYCYNA, C.A., SCHOENLEIN, P.V., GERMANN, U.A., and PASTAN, I. (1995). Genetic analysis of the multidrug transporter. Annu. Rev. Genet. 29, 607-649.
10. HIRSCHHORN, R. (1993). Overview of biochemical abnormalities and molecular genetics of adenosine deaminase deficiency. Pediatr. Res. 33 (Suppl.), S35-S41.