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Volumn 280, Issue , 2007, Pages 147-156

Ethyl pyruvate: A novel treatment for sepsis

Author keywords

[No Author keywords available]

Indexed keywords

PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; UNCLASSIFIED DRUG;

EID: 34247148911     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper
Times cited : (7)

References (40)
  • 1
    • 0030771914 scopus 로고    scopus 로고
    • Lipid peroxidation is involved in the activation of NF-kB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304
    • Bowie AG, Moynagh PN, O'Neill LAJ 1997 Lipid peroxidation is involved in the activation of NF-kB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. J Biol Chem 272:25941-25950
    • (1997) J Biol Chem , vol.272 , pp. 25941-25950
    • Bowie, A.G.1    Moynagh, P.N.2    O'Neill, L.A.J.3
  • 2
    • 0024600885 scopus 로고
    • Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Near-complete prevention of reperfusion contractile failure
    • Bunger R, Mallet RT, Hartman DA 1989 Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Near-complete prevention of reperfusion contractile failure. Eur J Biochem 180:221-233
    • (1989) Eur J Biochem , vol.180 , pp. 221-233
    • Bunger, R.1    Mallet, R.T.2    Hartman, D.A.3
  • 3
    • 0034661990 scopus 로고    scopus 로고
    • Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin
    • Chandel NS, Trzyna WC, McClintock DS, Schumacker PT 2000 Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J Immunol 165:1013-1021
    • (2000) J Immunol , vol.165 , pp. 1013-1021
    • Chandel, N.S.1    Trzyna, W.C.2    McClintock, D.S.3    Schumacker, P.T.4
  • 4
    • 0030030820 scopus 로고    scopus 로고
    • Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine
    • Cicalese L, Lee K, Schraut W, Watkins S, Borle A, Stanko R 1999 Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine. Am J Surg 171:97-100
    • (1999) Am J Surg , vol.171 , pp. 97-100
    • Cicalese, L.1    Lee, K.2    Schraut, W.3    Watkins, S.4    Borle, A.5    Stanko, R.6
  • 5
    • 23044475724 scopus 로고    scopus 로고
    • Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice
    • Dear JW, Kobayashi H, Jo SK et al 2005 Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice. Kidney Int 67:2159-2167
    • (2005) Kidney Int , vol.67 , pp. 2159-2167
    • Dear, J.W.1    Kobayashi, H.2    Jo, S.K.3
  • 6
    • 0032738998 scopus 로고    scopus 로고
    • Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia
    • Dobsak P, Courdertot-Masuyer C, Zeller M et al 1999 Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia. J Cardiovasc Pharmacol 34:651-659
    • (1999) J Cardiovasc Pharmacol , vol.34 , pp. 651-659
    • Dobsak, P.1    Courdertot-Masuyer, C.2    Zeller, M.3
  • 7
    • 0016188033 scopus 로고
    • Reaction of alantolactone, an allergenic sesquiterpene lactone, with some amino acids. Resultant loss of immunologic reactivity
    • Dupuis G, Mitchell JC, Towers GH 1974 Reaction of alantolactone, an allergenic sesquiterpene lactone, with some amino acids. Resultant loss of immunologic reactivity. Can J Biochem 52:575-581
    • (1974) Can J Biochem , vol.52 , pp. 575-581
    • Dupuis, G.1    Mitchell, J.C.2    Towers, G.H.3
  • 8
    • 0025354406 scopus 로고
    • Research review: Laboratory models of sepsis and septic shock
    • Fink MP, Heard SO 1990 Research review: laboratory models of sepsis and septic shock. J Surg Res 49:186-196
    • (1990) J Surg Res , vol.49 , pp. 186-196
    • Fink, M.P.1    Heard, S.O.2
  • 9
    • 0035955729 scopus 로고    scopus 로고
    • Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
    • Garcia-Pineres AJ, Castro V, Mora G et al 2001 Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J Biol Chem 276:39713-39720
    • (2001) J Biol Chem , vol.276 , pp. 39713-39720
    • Garcia-Pineres, A.J.1    Castro, V.2    Mora, G.3
  • 10
    • 14344255881 scopus 로고    scopus 로고
    • Ethyl pyruvate inhibits NF-{kappa} B-dependent signaling by directly targeting p65
    • Han Y, Englert JA, Yang R, Delude RL, Fink MP 2005 Ethyl pyruvate inhibits NF-{kappa} B-dependent signaling by directly targeting p65. J Pharmacol Exp Ther 312:1097-1115
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 1097-1115
    • Han, Y.1    Englert, J.A.2    Yang, R.3    Delude, R.L.4    Fink, M.P.5
  • 11
    • 24944460440 scopus 로고    scopus 로고
    • Ethyl pyruvate improves systemic and hepato-splanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia
    • Hauser B, Kick J, Asfar P et al 2005 Ethyl pyruvate improves systemic and hepato-splanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia. Crit Care Med 33:2034-2042
    • (2005) Crit Care Med , vol.33 , pp. 2034-2042
    • Hauser, B.1    Kick, J.2    Asfar, P.3
  • 12
    • 0028199079 scopus 로고
    • Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive alpha-methylenebutyrolactone functions
    • Hay AJB, Hamburger M, Hostettmann K, Hoult JRS 1994 Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive alpha-methylenebutyrolactone functions. Br J Pharmacol 112:9-12
    • (1994) Br J Pharmacol , vol.112 , pp. 9-12
    • Hay, A.J.B.1    Hamburger, M.2    Hostettmann, K.3    Hoult, J.R.S.4
  • 13
    • 0001077696 scopus 로고
    • Notice sur l'action de l'eau oxygénée sur les acétoniques et sur le dicétones 1.2.
    • Holleman MAF 1904 Notice sur l'action de l'eau oxygénée sur les acétoniques et sur le dicétones 1.2. Recl Trav Chim Pays-bas Belg 23:169-171
    • (1904) Recl Trav Chim Pays-bas Belg , vol.23 , pp. 169-171
    • Holleman, M.A.F.1
  • 14
    • 26944449700 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain
    • Kim JB, Yu YM, Kim SW, Lee JK 2005 Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. Brain Res 1060:188-192
    • (2005) Brain Res , vol.1060 , pp. 188-192
    • Kim, J.B.1    Yu, Y.M.2    Kim, S.W.3    Lee, J.K.4
  • 16
    • 0001112989 scopus 로고    scopus 로고
    • The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65
    • Lyss G, Knorre A, Schmidt TJ, Pahl HL, Merfort I 1998 The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem 273:33508-33516
    • (1998) J Biol Chem , vol.273 , pp. 33508-33516
    • Lyss, G.1    Knorre, A.2    Schmidt, T.J.3    Pahl, H.L.4    Merfort, I.5
  • 17
    • 0142249406 scopus 로고    scopus 로고
    • Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice
    • Miyaji T, Hu X, Yuen PST et al 2003 Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int 64:1620-1631
    • (2003) Kidney Int , vol.64 , pp. 1620-1631
    • Miyaji, T.1    Hu, X.2    Yuen, P.S.T.3
  • 18
    • 84961006890 scopus 로고
    • Metabolic studies on heart mitochondria. II. The inhibitory action of parapyruvate on the tricarboxylic acid cycle
    • Montgomery CM, Webb JL 1956 Metabolic studies on heart mitochondria. II. The inhibitory action of parapyruvate on the tricarboxylic acid cycle. J Biol Chem 221:359-368
    • (1956) J Biol Chem , vol.221 , pp. 359-368
    • Montgomery, C.M.1    Webb, J.L.2
  • 19
    • 0033630565 scopus 로고    scopus 로고
    • IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling
    • Parikh AA, Moon MR, Pritts TA et al 2000 IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling. Shock 13:8-13
    • (2000) Shock , vol.13 , pp. 8-13
    • Parikh, A.A.1    Moon, M.R.2    Pritts, T.A.3
  • 20
    • 0026326943 scopus 로고
    • Hydrogen peroxide-induced renal injury. A protective role for pyruvate in vitro and in vivo
    • Salahudeen AK, Clark EC, Nath KA 1991 Hydrogen peroxide-induced renal injury. A protective role for pyruvate in vitro and in vivo. J Clin Invest 88:1886-1893
    • (1991) J Clin Invest , vol.88 , pp. 1886-1893
    • Salahudeen, A.K.1    Clark, E.C.2    Nath, K.A.3
  • 21
    • 0029881475 scopus 로고    scopus 로고
    • Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers
    • Salzman AL, Denenberg AG, Ueta I, O'Connor M, Linn SC, Szabo C 1996 Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers. Am J Physiol 270:G565-573
    • (1996) Am J Physiol , vol.270
    • Salzman, A.L.1    Denenberg, A.G.2    Ueta, I.3    O'Connor, M.4    Linn, S.C.5    Szabo, C.6
  • 22
    • 3042704829 scopus 로고    scopus 로고
    • Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction
    • Sappington PL, Fink ME, Yang R, Delude RL, Fink MP 2003a Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction. Shock 20:521-528
    • (2003) Shock , vol.20 , pp. 521-528
    • Sappington, P.L.1    Fink, M.E.2    Yang, R.3    Delude, R.L.4    Fink, M.P.5
  • 23
    • 0037213248 scopus 로고    scopus 로고
    • Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated Caco-2 enterocytic monolayers
    • Sappington PL, Han X, Yang R, Delude RL, Fink MP 2003b Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated Caco-2 enterocytic monolayers. J Pharmacol Exp Ther 304:464-476
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 464-476
    • Sappington, P.L.1    Han, X.2    Yang, R.3    Delude, R.L.4    Fink, M.P.5
  • 24
    • 27544456819 scopus 로고    scopus 로고
    • The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro
    • Sappington PL, Cruz RJ Jr, Harada T et al 2005 The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro. Biochem Pharmacol 70:1579-1592
    • (2005) Biochem Pharmacol , vol.70 , pp. 1579-1592
    • Sappington, P.L.1    Cruz Jr, R.J.2    Harada, T.3
  • 25
    • 0032696632 scopus 로고    scopus 로고
    • Toxic activities of sesquiterpene lactones: Structural and biochemical aspects
    • Schmidt TJ 1999 Toxic activities of sesquiterpene lactones: structural and biochemical aspects. Curr Org Chem 3:577-608
    • (1999) Curr Org Chem , vol.3 , pp. 577-608
    • Schmidt, T.J.1
  • 26
    • 0343485104 scopus 로고    scopus 로고
    • Helenanolide type sesquiterpene lactones. Part 5: The role of glutathione addition under physiological conditions
    • Schmidt TJ, Lyss G, Pahl HL, Merfort I 1999 Helenanolide type sesquiterpene lactones. Part 5: the role of glutathione addition under physiological conditions. Bioorg Med Chem 7:2849-2855
    • (1999) Bioorg Med Chem , vol.7 , pp. 2849-2855
    • Schmidt, T.J.1    Lyss, G.2    Pahl, H.L.3    Merfort, I.4
  • 27
    • 0022930702 scopus 로고
    • Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappaB by a posttranslational mechanism
    • Sen R, Baltimore D 1986 Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappaB by a posttranslational mechanism. Cell 47:921-928
    • (1986) Cell , vol.47 , pp. 921-928
    • Sen, R.1    Baltimore, D.2
  • 28
    • 0035879279 scopus 로고    scopus 로고
    • Pyruvate inhibits hepatic ischemia-reperfusion injury in rats
    • Sileri P, Schena S, Morini S et al 2001 Pyruvate inhibits hepatic ischemia-reperfusion injury in rats. Transplantation 72:27-30
    • (2001) Transplantation , vol.72 , pp. 27-30
    • Sileri, P.1    Schena, S.2    Morini, S.3
  • 29
    • 0034883436 scopus 로고    scopus 로고
    • Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats
    • Sims CA, Wattanasirichaigoon S, Menconi MJ, Ajami AM, Fink MP 2001 Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats. Crit Care Med 29:1513-1518
    • (2001) Crit Care Med , vol.29 , pp. 1513-1518
    • Sims, C.A.1    Wattanasirichaigoon, S.2    Menconi, M.J.3    Ajami, A.M.4    Fink, M.P.5
  • 30
    • 0017256209 scopus 로고
    • Relative reactivities of sulfhydryl groups with N-acetyl dehydroalanine and N-acetyl dehydroalanine methyl ester
    • Snow JT, Finley JW, Friedman M 1976 Relative reactivities of sulfhydryl groups with N-acetyl dehydroalanine and N-acetyl dehydroalanine methyl ester. Int J Peptide Protein Res 8:57-64
    • (1976) Int J Peptide Protein Res , vol.8 , pp. 57-64
    • Snow, J.T.1    Finley, J.W.2    Friedman, M.3
  • 31
    • 0347758406 scopus 로고    scopus 로고
    • Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured LPSstimulated RAW 264.7 cells
    • Song M, Kellum JA, Kaldas H, Fink MP 2004 Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured LPSstimulated RAW 264.7 cells. J Pharmacol Exp Ther 308:307-316
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 307-316
    • Song, M.1    Kellum, J.A.2    Kaldas, H.3    Fink, M.P.4
  • 32
    • 0036599639 scopus 로고    scopus 로고
    • Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats
    • Tawadrous ZS, Delude RL, Fink MP 2002 Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats. Shock 17:473-477
    • (2002) Shock , vol.17 , pp. 473-477
    • Tawadrous, Z.S.1    Delude, R.L.2    Fink, M.P.3
  • 33
    • 12744269330 scopus 로고    scopus 로고
    • Ethyl pyruvate ameliorates liver ischemia-reperfusion injury by decreasing hepatic necrosis and apoptosis
    • Tsung A, Kaizu T, Nakao A et al 2005 Ethyl pyruvate ameliorates liver ischemia-reperfusion injury by decreasing hepatic necrosis and apoptosis. Transplantation 27:196-204
    • (2005) Transplantation , vol.27 , pp. 196-204
    • Tsung, A.1    Kaizu, T.2    Nakao, A.3
  • 34
    • 0037125985 scopus 로고    scopus 로고
    • Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
    • Ulloa L, Ochani M, Yang H et al 2002 Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci USA 99:12351-12356
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12351-12356
    • Ulloa, L.1    Ochani, M.2    Yang, H.3
  • 35
    • 0031838461 scopus 로고    scopus 로고
    • Prevention of intracellular oxidative stress to lens by pyruvate and its ester
    • Varma SD, Devamanoharan PS, Ali AH 1998 Prevention of intracellular oxidative stress to lens by pyruvate and its ester. Free Rad Res 28:131-135
    • (1998) Free Rad Res , vol.28 , pp. 131-135
    • Varma, S.D.1    Devamanoharan, P.S.2    Ali, A.H.3
  • 36
    • 0037616308 scopus 로고    scopus 로고
    • Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock
    • Venkataraman R, Kellum JA, Song M, Fink MP 2002 Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock. Shock 18:507-512
    • (2002) Shock , vol.18 , pp. 507-512
    • Venkataraman, R.1    Kellum, J.A.2    Song, M.3    Fink, M.P.4
  • 37
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang H, Bloom O, Zhang M et al 1999 HMG-1 as a late mediator of endotoxin lethality in mice. Science 285:248-251
    • (1999) Science , vol.285 , pp. 248-251
    • Wang, H.1    Bloom, O.2    Zhang, M.3
  • 38
    • 0036088799 scopus 로고    scopus 로고
    • Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock
    • Yang R, Gallo DJ, Baust JJ et al 2002 Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 283:G212-222
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283
    • Yang, R.1    Gallo, D.J.2    Baust, J.J.3
  • 39
    • 9144241208 scopus 로고    scopus 로고
    • Reversing established sepsis with antagonists of endogenous HMGB1
    • Yang H, Wang H, Li J et al 2004 Reversing established sepsis with antagonists of endogenous HMGB1. Proc Natl Acad Sci USA 101:296-301
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 296-301
    • Yang, H.1    Wang, H.2    Li, J.3
  • 40
    • 26444558061 scopus 로고    scopus 로고
    • Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window
    • Yu YM, Kim JB, Lee KW, Kim SY, Han PL, Lee JK 2005 Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. Stroke 36:2238-2243
    • (2005) Stroke , vol.36 , pp. 2238-2243
    • Yu, Y.M.1    Kim, J.B.2    Lee, K.W.3    Kim, S.Y.4    Han, P.L.5    Lee, J.K.6


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