Changes in the expression pattern of the nitrergic system of ovine cerebellum affected by scrapie

Journal of Neuropathology and Experimental Neurology

Volumn 66, Issue 3, 2007, Pages 196-207

  Fernández, Ana Patricia ^a   Serrano, Julia ^a   Rodrigo, José ^a   Monleón, Eva ^b   Monzón, Marta ^b   Vargas, Antonia ^b   Badiola, Juan José ^b   Martínez Murillo, Ricardo ^a   Martínez, Alfredo ^a  

^a INSTITUTO CAJAL   (Spain)

^b UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

Cerebellum; Nitric oxide synthase; Nitrotyrosine; Prion disease; Sheep; Transmissible spongiform encephalopathy

Indexed keywords

3 NITROTYROSINE; INDUCIBLE NITRIC OXIDE SYNTHASE; 3-NITROTYROSINE; DRUG DERIVATIVE; NEURONAL NITRIC OXIDE SYNTHASE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CEREBELLUM; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MACROGLIA; MICROGLIA; NITRATION; NITRERGIC NERVE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; SCRAPIE; SHEEP; WESTERN BLOTTING; ANIMAL; GENE EXPRESSION; METABOLISM; METHODOLOGY; PATHOLOGY; PHYSIOLOGY;

ANIMALS; BLOTTING, WESTERN; CEREBELLUM; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; SCRAPIE; SHEEP; TYROSINE;

EID: 34247110845     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jnen.0000248557.37832.b4     Document Type: Article

References (53)

1. Johnson RT, Gibbs CJ Jr. Creutzfeldt-Jakob disease and related transmissible spongiform encephalopathies. N Engl J Med 1998;339:1994-2004
2. Wang V, Chuang TC, Hsu YD, et al. Nitric oxide induces prion protein via MEK and p38 MAPK signaling. Biochem Biophys Res Commun 2005;333:95-100
3. Williams ES, Young S. Neuropathology of chronic wasting disease of mule deer (Odocoileus hemionus) and elk (Cervus elaphus nelsoni). Vet Pathol 1993;30:36-45
4. Monleon E, Monzon M, Hortells P, et al. Approaches to scrapie diagnosis by applying immunohistochemistry and rapid tests on central nervous and lymphoreticular systems. J Virol Methods 2005;125:165-71
5. sc in samples presenting a very advanced degree of autolysis (BSE liquid state) by immunocytochemistry. J Histochem Cytochem 2003;51:15-18
6. Spraker TR, Zink RR, Cummings BA, et al. Comparison of histological lesions and immunohistochemical staining of proteinase-resistant prion protein in a naturally occurring spongiform encephalopathy of free-ranging mule deer (Odocoileus hemionus) with those of chronic wasting disease of captive mule deer. Vet Pathol 2002;39:110-19
7. Wood JL, McGill IS, Done SH, et al. Neuropathology of scrapie: A study of the distribution patterns of brain lesions in 222 cases of natural scrapie in sheep, 1982-1991. Vet Rec 1997;140:167-74
8. Rodrigo J, Fernandez AP, Alonso D, et al. Nitric oxide in the rat cerebellum after hypoxia/ischemia. Cerebellum 2004;3:194-203
9. Knowles RG, Palacios M, Palmer RM, et al. Formation of nitric oxide from L-arginine in the central nervous system: A transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci U S A 1989;86:5159-62
10. Bredt DS, Hwang PM, Snyder SH. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 1990;347:768-70
11. Martinez A. Nitric oxide synthase in invertebrates. Histochem J 1995;27:770-76
12. Moncada S, Palmer RM, Higgs EA. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-42
13. Forstermann U, Schmidt HH, Pollock JS, et al. Isoforms of nitric oxide synthase: Characterization and purification from different cell types. Biochem Pharmacol 1991;42:1849-57
14. Nakane M, Schmidt HH, Pollock JS, et al. Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett 1993;316:175-80
15. Rodrigo J, Springall DR, Uttenthal O, et al. Localization of nitric oxide synthase in the adult rat brain. Philos Trans R Soc Lond B Biol Sci 1994;345:175-221
16. Rodrigo J, Fernandez AP, Serrano J, et al. Distribution and expression pattern of the nitrergic system in the cerebellum of the sheep. Neuroscience 2006;139:889-98
17. Garthwaite J, Charles SL, Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 1988;336:385-88
18. Garthwaite J. Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci 1991;14:60-67
19. Miki N, Kawabe Y, Kuriyama K. Activation of cerebral guanylate cyclase by nitric oxide. Biochem Biophys Res Commun 1977;75:851-56
20. Yoshikawa K, Kuriyama K. Characterization of cerebellar guanylate cyclase using N-methyl-N'-nitro-N-nitrosoguanidine: Presence of two different types of guanylate cyclase in soluble and particulate fractions. Biochim Biophys Acta 1980;628:377-87
21. Beckman JS. The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J Dev Physiol 1991;15:53-59
22. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly. Am J Physiol 1996;271:C1424-37
23. Ischiropoulos H, al-Mehdi AB. Peroxynitrite-mediated oxidative protein modifications. FEBS Lett 1995;364:279-82
24. Ye X, Meeker HC, Scallet AC, et al. Comparison of NADPH diaphorase activity in the brains of hamsters infected with scrapie strains 139H or 263K or with normal hamster brain homogenate. Histol Histopathol 2001;16:997-1004
25. Ju WK, Park KJ, Choi EK, et al. Expression of inducible nitric oxide synthase in the brains of scrapie-infected mice. J Neurovirol 1998;4:445-50
26. Kim JI, Ju WK, Choi JH, et al. Expression of cytokine genes and increased nuclear factor-Jκ activity in the brains of scrapie-infected mice. Brain Res Mol Brain Res 1999;73:17-27
27. Ovadia H, Rosenmann H, Shezen E, et al. Effect of scrapie infection on the activity of neuronal nitric-oxide synthase in brain and neuroblastoma cells. J Biol Chem 1996;271:16856-61
28. Carmona P, Monleon E, Monzon M, et al. Raman analysis of prion protein in blood cell membranes from naturally affected scrapie sheep. Chem Biol 2004;11:759-64
29. Monleon E, Monzon M, Hortells P, et al. Detection of PrPsc on lymphoid tissues from naturally affected scrapie animals: Comparison of three visualization systems. J Histochem Cytochem 2004;52:145-51
30. Uttenthal LO, Alonso D, Fernandez AP, et al. Neuronal and inducible nitric oxide synthase and nitrotyrosine immunoreactivities in the cerebral cortex of the aging rat. Microsc Res Tech 1998;43:75-88
31. Alonso D, Serrano J, Rodriguez I, et al. Effects of oxygen and glucose deprivation on the expression and distribution of neuronal and inducible nitric oxide synthases and on protein nitration in rat cerebral cortex. J Comp Neurol 2002;443:183-200
32. Rodrigo J, Alonso D, Fernandez AP, et al. Neuronal and inducible nitric oxide synthase expression and protein nitration in rat cerebellum after oxygen and glucose deprivation. Brain Res 2001;909:20-45
33. Radomski MW, Vallance P, Whitley G, et al. Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide. Cardiovasc Res 1993;27:1380-82
34. Wong BS, Pan T, Liu T, et al. Differential contribution of superoxide dismutase activity by prion protein in vivo. Biochem Biophys Res Commun 2000;273:136-39
35. Wong BS, Brown DR, Pan T, et al. Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities. J Neurochem 2001;79:689-98
36. Saxon DW, Beitz AJ. Cerebellar injury induces NOS in Purkinje cells and cerebellar afferent neurons. NeuroReport 1994;5:809-12
37. Abbott LC, Nahm SS. Neuronal nitric oxide synthase expression in cerebellar mutant mice. Cerebellum 2004;3:141-51
38. Forman LJ, Liu P, Nagele RG, et al. Augmentation of nitric oxide, superoxide, and peroxynitrite production during cerebral ischemia and reperfusion in the rat. Neurochem Res 1998;23:141-48
39. Jaiswal M, LaRusso NF, Gores GJ. Nitric oxide in gastrointestinal epithelial cell carcinogenesis: Linking inflammation to oncogenesis. Am J Physiol 2001;281:G626-34
40. Irie F, Hirabayashi Y. Ceramide prevents motoneuronal cell death through inhibition of oxidative signal. Neurosci Res 1999;35:135-44
41. Cho WS, Chae C. Evidence of nitric oxide synthase 2 activity in swine naturally infected with Actinobacillus pleuropneumoniae. Vet Pathol 2003;40:276-82
42. Rodrigo J, Fernandez-Vizarra P, Castro-Blanco S, et al. Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice. Neuroscience 2004;128:73-89
43. Acarin L, Peluffo H, Barbeito L, et al. Astroglial nitration after postnatal excitotoxic damage: Correlation with nitric oxide sources, cytoskeletal, apoptotic and antioxidant proteins. J Neurotrauma 2005;22:189-200
44. Keshet GI, Bar-Peled O, Yaffe D, et al. The cellular prion protein colocalizes with the dystroglycan complex in the brain. J Neurochem 2000;75:1889-97
45. Keshet GI, Ovadia H, Taraboulos A, et al. Scrapie-infected mice and PrP knockout mice share abnormal localization and activity of neuronal nitric oxide synthase. J Neurochem 1999;72:1224-31
46. Lindegren H, Ostlund P, Gyllberg H, et al. Loss of lipopolysaccharide- induced nitric oxide production and inducible nitric oxide synthase expression in scrapie-infected N2a cells. J Neurosci Res 2003;71:291-99
47. Fernandez-Vizarra P, Fernandez AP, Castro-Blanco S, et al. Expression of nitric oxide system in clinically evaluated cases of Alzheimer's disease. Neurobiol Dis 2004;15:287-305
48. Ferrante RJ, Kowall NW, Beal MF, et al. Selective sparing of a class of striatal neurons in Huntington's disease. Science 1985;230:561-63
49. Duncan AJ, Heales SJ. Nitric oxide and neurological disorders. Mol Aspects Med 2005;26:67-96
50. Akyol O, Zoroglu SS, Armutcu F, et al. Nitric oxide as a physiopathological factor in neuropsychiatric disorders. In Vivo 2004;18:377-90
51. Serrano J, Encinas JM, Salas E, et al. Hypobaric hypoxia modifies constitutive nitric oxide synthase activity and protein nitration in the rat cerebellum. Brain Res 2003;976:109-19
52. Sharpe A, McElroy M, Bassett H, et al. Clinical and pathological features of experimental scrapie in Irish Blackface Mountain sheep. Res Vet Sci 2006;80:71-78
53. Sc in rectal biopsy and necropsy samples from sheep with experimental scrapie. J Comp Pathol 2006;134:115-25