Clinical and pathological features of experimental scrapie in Irish Blackface Mountain sheep

Research in Veterinary Science

Volumn 80, Issue 1, 2006, Pages 71-78

  Sharpe, Ann ^a   McElroy, M ^a   Bassett, H ^b   Sweeney, T ^b  

^a CENTRAL VETERINARY RESEARCH LABORATORY   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Blackface Mountain sheep; Prion protein; Scrapie

Indexed keywords

PRION PROTEIN;

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BREED; CLINICAL FEATURE; GENOTYPE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; NONHUMAN; RETICULOENDOTHELIAL SYSTEM; SCRAPIE; SHEEP DISEASE;

ANIMALS; CAUDATE NUCLEUS; IMMUNOHISTOCHEMISTRY; IRELAND; POSTMORTEM CHANGES; SCRAPIE; SHEEP;

ANIMALIA; OVIS ARIES;

EID: 27744469790     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rvsc.2005.04.005     Document Type: Article

References (38)

1. AFSSA, 2004. Available from: http://www.afssa.fr/ftp/afssa/actu/ CommuniqueARR90104.pdf.
2. Sc in gut-associated lymphoid and nervous tissues of scrapie susceptible sheep from a Romanov flock with natural scrapie Journal of General Virology 81 2000 3115-3126
3. Sc in placentas of ewes exposed to natural scrapie: Influence of foetal PrP genotype and effect on ewe to lamb transmission Journal of General Virology 83 2002 2607-2616
4. S.L. Benestad P. Sarradin B. Thu M.A. Tranulis B. Bratberg Cases of scrapie with unusual features in Norway and designation of a new type, Nor98 Veterinary Record 153 2003 202-208
5. A. Bossers R. de Vries M.A. Smits Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP Journal of Virology 74 2000 1407-1414
6. CSO Livestock Survey, 2004. Available from: http://www.cso.ie/ publications/agriculture/livestock.pdf.
7. A.G. Dickinson J.T. Stamp C.C. Renwick Maternal and lateral transmission of scrapie in sheep Journal of Comparative Pathology 84 1974 19-25
8. J.M. Elsen Y. Amigues F. Schelcher V. Cucrocq O. Andereoletti F. Eychenne J.V. Tien Khang J.P. Poivey F. Lantier J.L. Laplanche Genetic susceptibility and transmission factors in scrapie: Detailed analysis of an epidemic in a closed flock of Romanov Archives of Virology 144 1999 431-445
9. W. Goldmann N. Hunter G. Smith J.D. Foster J. Hope PrP genotype and agent effects in scrapie; change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie Journal of General Virology 75 1994 989-995
10. L. Gonzalez S. Martin M. Jeffrey Distinct profiles of PrP(d) immunoreactivity in the brain of scrapie and BSE-infected sheep: implications for differential cell targeting and PrP processing Journal of General Virology 84 2003 1339-1350
11. W.S. Gordon Louping ill, tick-borne fever and scrapie Veterinary Record 58 1946 516-520
12. A. Healy E. Weavers M. McElroy M. Gomez-Parada J.D. Collins E. O'Doherty T. Sweeney M.L. Doherty The clinical neurology of scrapie in Irish sheep Journal of Veterinary Internal Medicine 17 2003 908-916
13. A.M. Healy D. Hannon K.L. Morgan E. Weavers J.D. Collins M.L. Doherty A paired case-control study of risk factors for scrapie in Irish sheep flocks Preventative Veterinary Medicine 64 2004 73-83
14. A.M. Healy K.L. Morgan D. Hannon J.D. Collins E. Weavers M.L. Doherty Postal questionnaire survey of scrapie in sheep flocks in Ireland Veterinary Record 155 2004 493-494
15. A. Hoek R.D. Eglin C. Van Coller M. Ali L.J. Hoinville Scrapie: improving notification Veterinary Record 148 2001 516
16. N. Hunter W. Goldmann J.D. Foster D. Cairns G. Smith Natural scrapie and PrP genotype: Case control studies in British sheep Veterinary Record 141 1997 137-140
17. M. Jeffrey C.M. Goodsir A. Holliman R.J. Higgins M.E. Bruce P. McBride J.R. Fraser Determination of the frequency and distribution of vascular and parenchymal amyloid with polyclonal and N terminal specific PrP antibodies in scrapie affected sheep and mice Veterinary Record 142 1998 534-537
18. M. Jeffrey S. Martin J.R. Thomson W.S. Dingwall I. Begara-McGorum L. Gonzalez Onset and distribution of tissue PrP accumulation in scrapie affected Suffolk sheep as demonstrated by sequential necropsies and tonsillar biopsies Journal of Comparative Pathology 125 2001 48-57
19. M. Jeffrey I. Begara-McGorum S. Clark S. Martin J. Clark M. Chaplin L. Gonzalez Occurrence and distribution of infection specific PrP in tissues of clinical scrapie cases and cull sheep from scrapie affected farms in Shetland Journal of Comparative Pathology 127 2002 264-273
20. National Scrapie Plan (NSP), 2004. Available from: http://www.defra.gov.uk/animalh/bse/bse-science/scrapie/nsp/nsp.html.
21. E. O'Doherty M. Aherne S. Ennis E. Weavers J.F. Roche T. Sweeney Prion protein polymorphisms in pedigree sheep in Ireland Research in Veterinary Science 70 2001 51-56
22. K.I. O'Rourke T.V. Baszler J.M. Miller T.R. Spraker I. Sadler-Riggleman D.P. Knowles Monoclonal antibody F89/160.1.5 defines a conserved epitope on the ruminant prion protein Journal of Clinical Microbiology 36 1998 1750-1755
23. Sc in nictitating membrane lymphoid tissue of sheep Veterinary Record 142 1998 489-491
24. K.I. O'Rourke T.V. Baszler T.E. Besser J.M. Miller R.C. Cutlip G.A.H. Wells S.J. Ryder S.M. Parish A.N. Hamir N.E. Cockett A. Jenny D.P. Knowles Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissue Journal of Clinical Microbiology 38 2000 3254-3259
25. P.A. Palsson Rida in Iceland and its epidemiology In: S.B. Prusiner W.J. Hadlow (Eds.) Slow transmissible diseases of the nervous system vol. 1 1979 Academic Press New York 357-366
26. I..H. Pattison M.N. Hoare J..N. Jebbett W.A. Watson Spread of scrapie to sheep and goats by oral dosing with foetal membranes from scrapie affected sheep Veterinary Record 90 1972 465-468
27. I.H. Pattison M.N. Hoare J.N. Jebbett W.A. Watson Further observations on the production of scrapie in sheep by oral dosing with foetal membranes from scrapie-affected sheep British Veterinary Journal 130 1974 65-67
28. Regulation (EC) No. 999/2001. Available from: http://europa.eu.int/eur-lex/pri/en/oj/dat/2001/l_147/ l_14_14720010531en00040.pdf.
29. B.E.C. Schreuder L.J.M. van Keulen M.E.W. Vromans J.P.M. Langeveld M.A. Smits Preclinical test for prion diseases Nature 381 1996 563
30. Sc detection in the preclinical diagnosis of scrapie Veterinary Record 142 1998 564-568
31. S. Sigurdarson Epidemiology of scrapie in Iceland and experience with control measures In: R. Bradley M. Savey B. Marchant (Eds.) Sub-acute spongiform encephalopathies Proceedings of a seminar in the CEC Agricultural Research Programme, Brussels 1991 Kluwer Academic Publishers Dordrecht 233-242
32. C.M.A. Thuring M.C. McElroy T. Sweeney E. Weavers Suitability of protuberances on the third eyelids of sheep as a biopsy site for lymphoid follicles Veterinary Record 147 2000 631-632
33. C.M.A. Thuring M.A. Crowe H. Mc Allister B. Earley J.F. Roche T. Sweeney Evaluation of peripheral lymphoreticular biopsy techniques and their clinical side effects in sheep Veterinary Record 150 2002 97-102
34. L.J.M. van Keulen B.E.C. Schreuder R.H. Meloen M. Poelon-Van den Berg G. Mooij-Harkes M.E.W. Vromans J.P.M. Langeveld Immunohistochemical detection and localistion of prion protein in brain tissue of sheep with natural scrapie Veterinary Pathology 32 1995 299-308
35. L.J.M. van Keulen B.E.C. Schreuder R.H. Meloen G. Mooij-Harkes M.E.W. Vromans J.P.M. Langeveld Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie Journal of Clinical Microbiology 34 1996 1228-1231
36. L.J. van Keulen B.E. Schreuder M.E. Vromans J.P. Langeveld M.A. Smits Scrapie-associated prion protein in the gastrointestinal tract of sheep with natural scrapie Journal of Comparative Pathology 121 1999 55-63
37. G.A.H. Wells I.S. Mc Gill Recently described scrapie-like encephalopathies of animals: Case definitions Research in Veterinary Science 53 1992 1-10
38. J.L. Wood I.S. McGill S.H. Done R. Bradley Neuropathology of scrapie: A study of the distribution patterns of brain lesions in 222 cases of natural scrapie in sheep 1982-1991 Veterinary Record 140 1997 167-174