TLR2-mediated survival of Staphylococcus aureus in macrophages: A novel bacterial strategy against host innate immunity

Journal of Immunology

Volumn 178, Issue 8, 2007, Pages 4917-4925

  Watanabe, Ikuko ^a   Ichiki, Manami ^a   Shiratsuchi, Akiko ^a   Nakanishi, Yoshinobu ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; PATTERN RECOGNITION RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL SURVIVAL; CONTROLLED STUDY; ESCHERICHIA COLI; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; STAPHYLOCOCCUS AUREUS;

EID: 34247095700     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.8.4917     Document Type: Article

References (46)

1. Janeway, Jr., C. A. 2001. How the immune system works to protect the host from infection: a personal view. Proc. Natl. Acad. Sci. USA 98: 7461-7468.
2. Janeway, Jr., C. A., and R. Medzhitov. 2002. Innate immune recognition. Annu. Rev. Immunol. 20: 197-216.
3. Akira, S., S. Uematsu, and O. Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124: 783-801.
4. Chamaillard, M., S. E. Girardin, J. Viala, and D. J. Philpott. 2003. Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell. Microbiol. 5: 581-592.
5. Martinon, F., and J. Tschopp. 2005. NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26: 447-454.
6. Inohara, N., M. Chamaillard, C. McDonald, and G. Nuñez. 2005. NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu. Rev. Biochem. 74: 355-383.
7. Aderem, A., and D. M. Underbill. 1999. Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol. 17: 593-623.
8. Underbill, D. M., and A. Ozinsky. 2002. Phagocytosis of microbes: complexity in action. Annu. Rev. Immunol. 20: 825-852.
9. Stuart, L. M., and R. A. B. Ezekowitz. 2005. Phagocytosis; elegant complexity. Immunity 22: 539-550.
10. Gruenberg, J., and F. G. van der Goot. 2006. Mechanisms of pathogen entry through the endosomal compartments. Nat. Rev. Mol. Cell Biol. 7: 495-504.
11. Underhill, D. M., A. Ozinsky, A. M. Hajjar, A. Stevens, C. B. Wilson, M. Bassetti, and A. Aderem. 1999. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401: 811-815.
12. Shiratsuchi, A., I. Watanabe, O. Takeuchi, S. Akira, and Y. Nakanishi. 2004. Inhibitory effect of Toll-like receptor 4 on fusion between phagosomes and endosomes/lysosomes in macrophages. J Immunol. 172: 2039-2047.
13. Blander, J. M., and R. Medzhitov. 2004. Regulation of phagosome maturation by signals from Toll-like receptors. Science 304: 1014-1018.
14. Blander, J. M., and R. Medzhitov. 2006. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440: 808-812.
15. Blander, J. M. 2006. Coupling Toll-like receptor signaling with phagocytosis: potentiation of antigen presentation. Trends Immunol. 28: 19-25.
16. Blander, J. M. 2007. Signalling and phagocytosis in the orchestration of host defence. Cell. Microbiol. 9: 290-299.
17. Yates, R. M., and D. G. Russell. 2005. Phagosome maturation proceeds independently of stimulation of Toll-like receptors 2 and 4. Immunity 23: 409-417.
18. Chen, K., P. Iribarren, J. Hu, J. Chen, W. Gong, E. H. Cho, S. Lockett, N. M. Dunlop, and J. M. Wang. 2006. Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid β peptide. J. Biol. Chem. 281: 3651-3659.
19. Luther, K., A. Torosantucci, A. A. Brakhage, J. Heesemann, and F. Ebel. 2007. Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 β-glucan receptor and Toll-like receptor 2. Cell. Microbiol. 9: 368-381.
20. Neal, M. D., C. Leaphart, R. Levy, J. Prince, T. R. Billiar, S. Watkins, J. Li, S. Cetin, H. Ford, A. Schreiber, and D. J. Hackam. 2006. Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J. Immunol. 176: 3070-3079.
21. Takeuchi, O., K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, K. Takeda, and S. Akira. 1999. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11: 443-451.
22. Sing, A., D. Rost, N. Tvardovskaia, A. Roggenkamp, A. Wiedemann, C. J. Kirschning, M. Aepfelbacher, and J. Heesemann. 2002. Yersinia V-antigen exploits Toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression. J. Exp. Med. 196: 1017-1024.
23. Netea, M. G., R. Sutmuller, C. Hermann, C. A. A. Van der Graaf, J. W. M. Van der Meer, J. H. van Krieken, T. Hartung, G. Adema, and B. J. Kullberg. 2004. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J. Immunol. 172: 3712-3718.
24. Burns, E., G. Bachrach, L. Shapira, and G. Nussbaum. 2006. Cutting edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption. J. Immunol. 177: 8296-8300.
25. Shiratsuchi, A., S. Osada, S. Kanazawa, and Y. Nakanishi. 1998. Essential role of phosphatidylserine externalization in apoptosing cell phagocytosis by macrophages. Biochem. Biophys. Res. Commun. 246: 549-555.
26. Hed, J. 1986. Methods for distinguishing ingested from adhering particles. Methods Enzymol. 132: 198-204.
27. Osada, Y., A. Shiratsuchi, and Y. Nakanishi. 2006. Involvement of mitogen-activated protein kinases in class B scavenger receptor type I-induced phagocytosis of apoptotic cells. Exp. Cell Res. 312: 1820-1830.
28. Halliwell, B. 2006. Phagocyte-derived reactive species: salvation or suicide? Trends Biochem. Sci. 31: 509-515.
29. Wardenburg, J. B., W. A. Williams, and D. Missiakas. 2006. Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins. Proc. Natl. Acad. Sci. USA 103: 13831-13836.
30. Bittencourt, V. C. B., R. T. Figueiredo, R. B. da Silva, D. S. Mourão-Sá, P. L. Fernandez, G. L. Sassaki, B. Mulloy, M. T. Bozza, and E. Barreto-Bergter. 2006. An α-glucan of Pseudallescheria boydii is involved in fungal phagocytosis and Toll-like receptor activation. J. Biol. Chem. 281: 22614-22623.
31. Mullaly, S. C., and P. Kubes. 2006. The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol. 177: 8154-8163.
32. Geiszt, M., and T. L. Leto. 2004. The Nox family of NAD(P)H oxidases: host defense and beyond. J. Biol. Chem. 279: 51715-51718.
33. Daniel, D. S., G. Dai, C. R. Singh, D. R. Lindsey, A. K. Smith, S. Dhandayuthapani, R. L. Hunter, Jr., and C. Jagannath. 2006. The reduced bactericidal function of complement C5-deficient murine macrophages is associated with defects in the synthesis and delivery of reactive oxygen radicals to mycobacterial phagosomes. J Immunol. 177: 4688-4698.
34. Ernst, J. D. 2000. Bacterial inhibition of phagocytosis. Cell. Microbiol. 2: 379-386.
35. Pizarro-Cerdá, J., and P. Cossart. 2004. Subversion of phosphoinositide metabolism by intracellular bacterial pathogens. Nat. Cell Biol. 6: 1026-1033.
36. Coombes, B. K., Y. Valdez, and B. B. Finlay. 2004. Evasive maneuvers by secreted bacterial proteins to avoid innate immune responses. Curr. Biol. 14: R856-R867.
37. Rottner, K., T. E. B. Stradal, and J. Wehland. 2005. Bacteria-host-cell interactions at the plasma membrane: stories on actin cytoskeleton subversion. Dev. Cell 9: 3-17.
38. Shintani, T., and D. J. Klionsky. 2004. Autophagy in health and disease: a double-edged sword. Science 306: 990-995.
39. 2 integrin adhesive activity and promote binding to and internalization by macrophages. Infect. Immun. 74: 5658-5666.
40. Ackerman, A. L., and P. Cresswell. 2004. Cellular mechanisms governing cross-presentation of exogenous antigens. Nat. Immunol. 5: 678-684.
41. Erwig, L.-P., K. A. McPhilips, M. W. Wynes, A. Ivetic, A. J. Ridley, and P. M. Henson. 2006. Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins. Proc. Natl. Acad. Sci. USA 103: 12825-12830.
42. Stuart, L. M., J. Deng, J. M. Silver, K. Takahashi, A. A. Tseng, E. J. Hennessy, R. A. B. Ezekowitz, and K. J. Moore. 2005. Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol. 170: 477-485.
43. Kocks, C., J. H. Cho, N. Nehme, J. Ulvila, A. M. Pearson, M. Meister, C. Strom, S. L. Conto, C. Hetru, L. M. Stuart, et al. 2005. Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell 123: 335-346.
44. Philips, J. A., E. J. Rubin, and N. Perrimon. 2005. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science 309: 1251-1253.
45. Jehle, A. W., S. J. Gardai, S. Li, P. Linsel-Nitschke, K. Morimoto, W. J. Janssen, R. W. Vandivier, N. Wang, S. Greenberg, B. M. Dale, et al. 2006. ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J. Cell Biol. 174: 547-556.
46. Thoeni, G., P. Stoitzner, G. Brandacher, N. Romani, C. Heufler, G. Werner-Felmayer, and E. R. Werner. 2005. Tetrahydro-4-aminobiopterin attenuates dendritic cell-induced T cell priming independently from inducible nitric oxide synthase. J. Immunol. 174: 7584-7591.