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Volumn 109, Issue 8, 2007, Pages 3432-3440

CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CORE BINDING FACTOR; CRE RECOMBINASE; PROTEIN KINASE LCK; PROTEIN MYH 11; UNCLASSIFIED DRUG;

EID: 34147112928     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-10-051508     Document Type: Article
Times cited : (17)

References (50)
  • 1
    • 0027220003 scopus 로고
    • PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
    • Ogawa E, Maruyama M, Kagoshima H, et al. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci U S A. 1993;90:6859-6863.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6859-6863
    • Ogawa, E.1    Maruyama, M.2    Kagoshima, H.3
  • 2
    • 0027184229 scopus 로고
    • Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha
    • Ogawa E, Inuzuka M, Maruyama M, et al. Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology. 1993;194:314-331.
    • (1993) Virology , vol.194 , pp. 314-331
    • Ogawa, E.1    Inuzuka, M.2    Maruyama, M.3
  • 3
    • 0027256023 scopus 로고
    • Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
    • Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol. 1993;13:3324-3339.
    • (1993) Mol Cell Biol , vol.13 , pp. 3324-3339
    • Wang, S.1    Wang, Q.2    Crute, B.E.3    Melnikova, I.N.4    Keller, S.R.5    Speck, N.A.6
  • 4
    • 0027373893 scopus 로고
    • Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia
    • Liu P, Tarle SA, Hajra A, et al. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science. 1993;261:1041-1044.
    • (1993) Science , vol.261 , pp. 1041-1044
    • Liu, P.1    Tarle, S.A.2    Hajra, A.3
  • 5
    • 0032983973 scopus 로고    scopus 로고
    • Solution structure of core binding factor beta and map of the CBF alpha binding site
    • Huang X, Peng JW, Speck NA, Bushweller JH. Solution structure of core binding factor beta and map of the CBF alpha binding site. Nat Struct Biol. 1999;6:624-627.
    • (1999) Nat Struct Biol , vol.6 , pp. 624-627
    • Huang, X.1    Peng, J.W.2    Speck, N.A.3    Bushweller, J.H.4
  • 6
    • 0032985363 scopus 로고    scopus 로고
    • Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta
    • Goger M, Gupta V, Kim WY, Shigesada K, Ito Y, Werner MH. Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta. Nat Struct Biol. 1999;6:620-623.
    • (1999) Nat Struct Biol , vol.6 , pp. 620-623
    • Goger, M.1    Gupta, V.2    Kim, W.Y.3    Shigesada, K.4    Ito, Y.5    Werner, M.H.6
  • 7
    • 0034660045 scopus 로고    scopus 로고
    • Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta
    • Warren AJ, Bravo J, Williams RL, Rabbitts TH. Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta. EMBO J. 2000;19:3004-3015.
    • (2000) EMBO J , vol.19 , pp. 3004-3015
    • Warren, A.J.1    Bravo, J.2    Williams, R.L.3    Rabbitts, T.H.4
  • 8
    • 0035831044 scopus 로고    scopus 로고
    • Structural analyses of DNA recognition by the AML1/ Runx-1 Runt domain and its allosteric control by CBFbeta
    • Tahirov TH, Inoue-Bungo T, Morii H, et al. Structural analyses of DNA recognition by the AML1/ Runx-1 Runt domain and its allosteric control by CBFbeta. Cell. 2001;104:755-767.
    • (2001) Cell , vol.104 , pp. 755-767
    • Tahirov, T.H.1    Inoue-Bungo, T.2    Morii, H.3
  • 9
    • 0035865459 scopus 로고    scopus 로고
    • Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation
    • Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y. Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. EMBO J. 2001;20:723-733.
    • (2001) EMBO J , vol.20 , pp. 723-733
    • Huang, G.1    Shigesada, K.2    Ito, K.3    Wee, H.J.4    Yokomizo, T.5    Ito, Y.6
  • 10
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996;84:321-330.
    • (1996) Cell , vol.84 , pp. 321-330
    • Okuda, T.1    van Deursen, J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 11
    • 0029918597 scopus 로고    scopus 로고
    • Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
    • Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A. 1996;93: 3444-3449.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 3444-3449
    • Wang, Q.1    Stacy, T.2    Binder, M.3    Marin-Padilla, M.4    Sharpe, A.H.5    Speck, N.A.6
  • 12
    • 0030588487 scopus 로고    scopus 로고
    • The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo
    • Wang Q, Stacy T, Miller JD, et al. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell. 1996;87:697-708.
    • (1996) Cell , vol.87 , pp. 697-708
    • Wang, Q.1    Stacy, T.2    Miller, J.D.3
  • 13
    • 0033036971 scopus 로고    scopus 로고
    • Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
    • North T, Gu TL, Stacy T, et al. Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development. 1999;126:2563-2575.
    • (1999) Development , vol.126 , pp. 2563-2575
    • North, T.1    Gu, T.L.2    Stacy, T.3
  • 14
    • 0036786875 scopus 로고    scopus 로고
    • Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11
    • Kundu M, Chen A, Anderson S, et al. Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. Blood. 2002;100:2449-2456.
    • (2002) Blood , vol.100 , pp. 2449-2456
    • Kundu, M.1    Chen, A.2    Anderson, S.3
  • 15
    • 0034610754 scopus 로고    scopus 로고
    • Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31
    • Namba K, Abe M, Saito S, et al. Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31. Oncogene. 2000;19:106-114.
    • (2000) Oncogene , vol.19 , pp. 106-114
    • Namba, K.1    Abe, M.2    Saito, S.3
  • 16
    • 0031782323 scopus 로고    scopus 로고
    • The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates
    • Adya N, Stacy T, Speck NA, Liu PP. The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates. Mol Cell Biol. 1998;18:7432-7443.
    • (1998) Mol Cell Biol , vol.18 , pp. 7432-7443
    • Adya, N.1    Stacy, T.2    Speck, N.A.3    Liu, P.P.4
  • 17
    • 2942602706 scopus 로고    scopus 로고
    • Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11
    • Shigesada K, van de Sluis B, Liu PP. Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11. Oncogene. 2004;23: 4297-4307.
    • (2004) Oncogene , vol.23 , pp. 4297-4307
    • Shigesada, K.1    van de Sluis, B.2    Liu, P.P.3
  • 18
    • 16144362555 scopus 로고    scopus 로고
    • Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11
    • Castilla LH, Wijmenga C, Wang Q, et al. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. Cell. 1996;87:687-696.
    • (1996) Cell , vol.87 , pp. 687-696
    • Castilla, L.H.1    Wijmenga, C.2    Wang, Q.3
  • 19
    • 18744362426 scopus 로고    scopus 로고
    • Cbfbeta interacts with Runx2 and has a critical role in bone development
    • Kundu M, Javed A, Jeon JP, et al. Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet. 2002;32:639-644.
    • (2002) Nat Genet , vol.32 , pp. 639-644
    • Kundu, M.1    Javed, A.2    Jeon, J.P.3
  • 20
    • 0030831130 scopus 로고    scopus 로고
    • Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    • Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997;91:661-672.
    • (1997) Cell , vol.91 , pp. 661-672
    • Kondo, M.1    Weissman, I.L.2    Akashi, K.3
  • 21
    • 17444396980 scopus 로고    scopus 로고
    • Molecular genetics of T cell development
    • Rothenberg EV, Taghon T. Molecular genetics of T cell development. Annu Rev Immunol. 2005;23: 601-649.
    • (2005) Annu Rev Immunol , vol.23 , pp. 601-649
    • Rothenberg, E.V.1    Taghon, T.2
  • 22
    • 0034992643 scopus 로고    scopus 로고
    • Regulation of lineage commitment during lymphocyte development
    • Staal FJ, Clevers HC. Regulation of lineage commitment during lymphocyte development. Int Rev Immunol. 2001;20:45-64.
    • (2001) Int Rev Immunol , vol.20 , pp. 45-64
    • Staal, F.J.1    Clevers, H.C.2
  • 23
    • 3042734665 scopus 로고    scopus 로고
    • Selection of the T-cell repertoire: Receptor-controlled checkpoints in T-cell development
    • von Boehmer H. Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development. Adv Immunol. 2004;84:201-238.
    • (2004) Adv Immunol , vol.84 , pp. 201-238
    • von Boehmer, H.1
  • 24
    • 18744398397 scopus 로고    scopus 로고
    • Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    • Taniuchi I, Osato M, Egawa T, et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell. 2002;111:621-633.
    • (2002) Cell , vol.111 , pp. 621-633
    • Taniuchi, I.1    Osato, M.2    Egawa, T.3
  • 25
    • 0038610795 scopus 로고    scopus 로고
    • Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis
    • Woolf E, Xiao C, Fainaru O, et al. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Proc Natl Acad Sci U S A. 2003;100:7731-7736.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7731-7736
    • Woolf, E.1    Xiao, C.2    Fainaru, O.3
  • 26
    • 30344446665 scopus 로고    scopus 로고
    • Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia
    • Kuo YH, Landrette SF, Heilman SA, et al. Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell. 2006;9:57-68.
    • (2006) Cancer Cell , vol.9 , pp. 57-68
    • Kuo, Y.H.1    Landrette, S.F.2    Heilman, S.A.3
  • 27
    • 0037624909 scopus 로고    scopus 로고
    • Cbf beta is involved in maturation of all lineages of hematopoietic cells during embryogenesis except erythroid
    • Kundu M, Liu PP. Cbf beta is involved in maturation of all lineages of hematopoietic cells during embryogenesis except erythroid. Blood Cells Mol Dis. 2003;30:164-169.
    • (2003) Blood Cells Mol Dis , vol.30 , pp. 164-169
    • Kundu, M.1    Liu, P.P.2
  • 28
    • 0028242609 scopus 로고
    • A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
    • Sawada S, Scarborough JD, Killeen N, Littman DR. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell. 1994;77:917-929.
    • (1994) Cell , vol.77 , pp. 917-929
    • Sawada, S.1    Scarborough, J.D.2    Killeen, N.3    Littman, D.R.4
  • 29
    • 0036864610 scopus 로고    scopus 로고
    • Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation
    • Taniuchi I, Sunshine MJ, Festenstein R, Littman DR. Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation. Mol Cell. 2002;10:1083-1096.
    • (2002) Mol Cell , vol.10 , pp. 1083-1096
    • Taniuchi, I.1    Sunshine, M.J.2    Festenstein, R.3    Littman, D.R.4
  • 30
    • 18244365863 scopus 로고    scopus 로고
    • A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
    • Lee PP, Fitzpatrick DR, Beard C, et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity. 2001;15:763-774.
    • (2001) Immunity , vol.15 , pp. 763-774
    • Lee, P.P.1    Fitzpatrick, D.R.2    Beard, C.3
  • 31
    • 0025751550 scopus 로고
    • bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
    • Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell. 1991;67:879-888.
    • (1991) Cell , vol.67 , pp. 879-888
    • Sentman, C.L.1    Shutter, J.R.2    Hockenbery, D.3    Kanagawa, O.4    Korsmeyer, S.J.5
  • 32
    • 0027406812 scopus 로고
    • Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes
    • Shinkai Y, Koyasu S, Nakayama K, et al. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science. 1993;259:822-825.
    • (1993) Science , vol.259 , pp. 822-825
    • Shinkai, Y.1    Koyasu, S.2    Nakayama, K.3
  • 33
    • 0032578394 scopus 로고    scopus 로고
    • Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
    • Levanon D, Goldstein RE, Bernstein Y, et al. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc Natl Acad Sci U S A. 1998;95:11590-11595.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11590-11595
    • Levanon, D.1    Goldstein, R.E.2    Bernstein, Y.3
  • 34
    • 0028066834 scopus 로고
    • A transcriptional silencer controls the developmental expression of the CD4 gene
    • Siu G, Wurster AL, Duncan DD, Soliman TM, Hedrick SM. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 1994;13:3570-3579.
    • (1994) EMBO J , vol.13 , pp. 3570-3579
    • Siu, G.1    Wurster, A.L.2    Duncan, D.D.3    Soliman, T.M.4    Hedrick, S.M.5
  • 35
    • 0032878921 scopus 로고    scopus 로고
    • The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia
    • Castilla LH, Garrett L, Adya N, et al. The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia. Nat Genet. 1999;23:144-146.
    • (1999) Nat Genet , vol.23 , pp. 144-146
    • Castilla, L.H.1    Garrett, L.2    Adya, N.3
  • 36
    • 22144447520 scopus 로고    scopus 로고
    • Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype
    • Growney JD, Shigematsu H, Li Z, et al. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood. 2005;106:494-504.
    • (2005) Blood , vol.106 , pp. 494-504
    • Growney, J.D.1    Shigematsu, H.2    Li, Z.3
  • 37
    • 33845994697 scopus 로고    scopus 로고
    • T lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFβ dosage
    • Talebian L, Li Z, Guo Y, et al. T lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFβ dosage. Blood. 2007;109:11-21.
    • (2007) Blood , vol.109 , pp. 11-21
    • Talebian, L.1    Li, Z.2    Guo, Y.3
  • 38
    • 21844440323 scopus 로고    scopus 로고
    • Unique features of the pre-T-cell receptor alpha-chain: Not just a surrogate
    • von Boehmer H. Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate. Nat Rev Immunol. 2005;5:571-577.
    • (2005) Nat Rev Immunol , vol.5 , pp. 571-577
    • von Boehmer, H.1
  • 39
    • 27944440404 scopus 로고    scopus 로고
    • The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3
    • Peterson LF, Boyapati A, Ranganathan V, et al. The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3. Mol Cell Biol. 2005;25:10205-10219.
    • (2005) Mol Cell Biol , vol.25 , pp. 10205-10219
    • Peterson, L.F.1    Boyapati, A.2    Ranganathan, V.3
  • 40
    • 2442496452 scopus 로고    scopus 로고
    • AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression
    • Bernardin-Fried F, Kummalue T, Leijen S, Collector MI, Ravid K, Friedman AD. AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression. J Biol Chem. 2004;279:15678-15687.
    • (2004) J Biol Chem , vol.279 , pp. 15678-15687
    • Bernardin-Fried, F.1    Kummalue, T.2    Leijen, S.3    Collector, M.I.4    Ravid, K.5    Friedman, A.D.6
  • 41
    • 9144229104 scopus 로고    scopus 로고
    • Requirement for cyclin D3 in lymphocyte development and T cell leukemias
    • Sicinska E, Aifantis I, Le Cam L, et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell. 2003;4:451-461.
    • (2003) Cancer Cell , vol.4 , pp. 451-461
    • Sicinska, E.1    Aifantis, I.2    Le Cam, L.3
  • 42
    • 0031302576 scopus 로고    scopus 로고
    • Dissociation of cytokine signals for proliferation and apoptosis
    • Shi Y, Wang R, Sharma A, et al. Dissociation of cytokine signals for proliferation and apoptosis. J Immunol. 1997;159:5318-5328.
    • (1997) J Immunol , vol.159 , pp. 5318-5328
    • Shi, Y.1    Wang, R.2    Sharma, A.3
  • 43
    • 0033199317 scopus 로고    scopus 로고
    • Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fasmediated activation-induced cell death
    • Van Parijs L, Refaeli Y, Lord JD, Nelson BH, Abbas AK, Baltimore D. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fasmediated activation-induced cell death. Immunity. 1999;11:281-288.
    • (1999) Immunity , vol.11 , pp. 281-288
    • Van Parijs, L.1    Refaeli, Y.2    Lord, J.D.3    Nelson, B.H.4    Abbas, A.K.5    Baltimore, D.6
  • 44
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 1995;3:521-530.
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 45
    • 11144353866 scopus 로고    scopus 로고
    • Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia
    • Castilla LH, Perrat P, Martinez NJ, et al. Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia. Proc Natl Acad Sci U S A. 2004;101:4924-4929.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4924-4929
    • Castilla, L.H.1    Perrat, P.2    Martinez, N.J.3
  • 46
    • 0942287734 scopus 로고    scopus 로고
    • VWRPY motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development
    • Nishimura M, Fukushima-Nakase Y, Fujita Y, et al. VWRPY motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development. Blood. 2004; 103:562-570.
    • (2004) Blood , vol.103 , pp. 562-570
    • Nishimura, M.1    Fukushima-Nakase, Y.2    Fujita, Y.3
  • 47
    • 20144367473 scopus 로고    scopus 로고
    • Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development
    • Kawazu M, Asai T, Ichikawa M, et al. Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development. J Immunol. 2005; 174:3526-3533.
    • (2005) J Immunol , vol.174 , pp. 3526-3533
    • Kawazu, M.1    Asai, T.2    Ichikawa, M.3
  • 48
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3:730-737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 50
    • 11844301355 scopus 로고    scopus 로고
    • Clonality analysis of cell lineages in acute myeloid leukemia with inversion 16
    • Chang H, Nayar R, Li D, Sutherland DR. Clonality analysis of cell lineages in acute myeloid leukemia with inversion 16. Cancer Genet Cytogenet. 2005;156:175-178.
    • (2005) Cancer Genet Cytogenet , vol.156 , pp. 175-178
    • Chang, H.1    Nayar, R.2    Li, D.3    Sutherland, D.R.4


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