Human osteoblasts produce cathepsin K

Bone

Volumn 38, Issue 6, 2006, Pages 769-777

  Mandelin, Jami ^a,b,c   Hukkanen, Mika ^a,c   Li, Tian Fang ^a   Korhonen, Matti ^a   Liljeström, Mikko ^a,b,c   Sillat, Tarvo ^a   Hanemaaijer, Roeland ^d   Salo, Jari ^b   Santavirta, Seppo ^b   Konttinen, Yrjö T ^b,c,e  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c ORTON ORTHOPAEDIC HOSPITAL   (Finland)

^d TNO   (Netherlands)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Cathepsin K; Cytokines; Osteoblasts; Osteoporosis; Stromal cells

Indexed keywords

ANTIBODY; CATHEPSIN K; COLLAGEN TYPE 1; MESSENGER RNA;

ARTICLE; BONE MATRIX; CELL ISOLATION; CONTROLLED STUDY; CULTURE MEDIUM; FEMUR NECK; FRACTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOCYTE; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SAMPLING; TRABECULAR BONE; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; CALCIFICATION, PHYSIOLOGIC; CATHEPSIN K; CATHEPSINS; CELL DIFFERENTIATION; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASE 13; MESENCHYMAL STEM CELLS; OSTEOCLASTS; OSTEOPROTEGERIN; RANK LIGAND; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33749370681     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2005.10.017     Document Type: Article

References (39)

1. Harada S., and Rodan G.A. Control of osteoblast function and regulation of bone mass. Nature 423 (2003) 349-355
2. Boyle W.J., Simonet W.S., and Lacey D.L. Osteoclast differentiation and activation. Nature 423 (2003) 337-342
3. Rodan G.A., Raisz L.G., and Bilezikian J.P. Pathophysiology of osteoporosis. In: Bilezikian J.P., Raisz L.G., and Rodan G.A. (Eds). Principles of bone biology (2002), Academic Press, San Diego, CA 1275-1290
4. Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93 (1998) 165-176
5. Vaananen H.K., Zhao H., Mulari M., and Halleen J.M. The cell biology of osteoclast function. J. Cell Sci. 113 (2000) 377-381
6. Blair H.C., Teitelbaum S.L., Ghiselli R., and Gluck S. Osteoclastic bone resorption by a polarized vacuolar proton pump. Science 245 (1989) 855-857
7. Gelb B.D., Shi G.P., Chapman H.A., and Desnick R.J. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 273 (1996) 1236-1238
8. Yamaza T., Goto T., Kamiya T., Kobayashi Y., Sakai H., and Tanaka T. Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur. Bone 23 (1998) 499-509
9. Hou W.S., Li W., Keyszer G., Weber E., Levy R., Klein M.J., et al. Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum. 46 (2002) 663-674
10. Mulari M.T., Qu Q., Harkonen P.L., and Vaananen H.K. Osteoblast-like cells complete osteoclastic bone resorption and form new mineralized bone matrix in vitro. Calcif. Tissue Int. 75 (2004) 253-261
11. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
12. Lindeman J.H.N., Hanemaaijer R., Mulder A., Dijkstra P.D.S., Szuhai K., Bromme D., et al. Cathepsin K is the principal protease in giant cell tumor. Am. J. Pathol. 165 (2004) 593-600
13. Konttinen Y.T., Mandelin J., Li T.F., Salo J., Lassus J., Liljestrom M., et al. Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis. Arthritis Rheum. 46 (2002) 953-960
14. Stahle-Backdahl M., Sandstedt B., Bruce K., Lindahl A., Jimenez M.G., Vega J.A., et al. Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis. Lab. Invest. 76 (1997) 717-728
15. Johansson N., Saarialho-Kere U., Airola K., Herva R., Nissinen L., Westermarck J., et al. Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development. Dev. Dyn. 208 (1997) 387-397
16. Hofbauer L.C., Lacey D.L., Dunstan C.R., Spelsberg T.C., Riggs B.L., and Khosla S. Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells. Bone 25 (1999) 255-259
17. Garnero P., Borel O., Byrjalsen I., Ferreras M., Drake F.H., McQueney M.S., et al. The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J. Biol. Chem. 273 (1998) 32347-32352
18. Bromme D., Okamoto K., Wang B.B., and Biroc S. Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme. J. Biol. Chem. 271 (1996) 2126-2132
19. Kiviranta R., Morko J., Uusitalo H., Aro H.T., Vuorio E., and Rantakokko J. Accelerated turnover of metaphyseal trabecular bone in mice overexpressing cathepsin K. J. Bone Miner. Res. 16 (2001) 1444-1452
20. Littlewood-Evans A., Kokubo T., Ishibashi O., Inaoka T., Wlodarski B., Gallagher J.A., et al. Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry. Bone 20 (1997) 81-86
21. Mandelin J., Li T.-F., Hukkanen M., Liljestrom M., Salo J., Santavirta S., et al. Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kB ligand, osteoprotegerin, and cathepsin K. J. Rheumatol. 32 (2005) 713-720
22. Everts V., Delaisse J.M., Korper W., Jansen D.C., Tigchelaar-Gutter W., Saftig P., et al. The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation. J. Bone Miner. Res. 17 (2002) 77-90
23. Parikka V., Vaananen A., Risteli J., Salo T., Sorsa T., Vaananen H.K., et al. Human mesenchymal stem cell derived osteoblasts degrade organic bone matrix in vitro by matrix metalloproteinases. Matrix Biol. 24 (2005) 438-447
24. Everts V., Hou W.S., Rialland X., Tigchelaar W., Saftig P., Bromme D., et al. Cathepsin K deficiency in pycnodysostosis results in accumulation of non-digested phagocytosed collagen in fibroblasts. Calcif. Tissue Int. 73 (2003) 380-386
25. Jimenez M.J., Balbin M., Lopez J.M., Alvarez J., Komori T., and Lopez-Otin C. Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol. Cell. Biol. 19 (1999) 4431-4442
26. Paloneva J., Mandelin J., Kiialainen A., Bohling T., Prudlo J., Hakola P., et al. DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. J. Exp. Med. 198 (2003) 669-675
27. Aubin J.E. Regulation of osteoblast formation and function. Rev. Endocr. Metab. Disord. 2 (2001) 81-94
28. Jimi E., Akiyama S., Tsurukai T., Okahashi N., Kobayashi K., Udagawa N., et al. Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. J. Immunol. 163 (1999) 434-442
29. Fuller K., Murphy C., Kirstein B., Fox S.W., and Chambers T.J. TNFalpha potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL. Endocrinology 143 (2002) 1108-1118
30. Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest Dec 2000;106(12):1481-8.
31. Simonet W.S., Lacey D.L., Dunstan C.R., Kelley M., Chang M.S., Luthy R., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89 (1997) 309-319
32. Kiviranta R., Morko J., Alatalo S.L., NicAmhlaoibh R., Risteli J., Laitala-Leinonen T., et al. Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio. Bone 36 (2005) 159-172
33. Yano K., Tsuda E., Washida N., Kobayashi F., Goto M., Harada A., et al. Immunological characterization of circulating osteoprotegerin/osteoclastogenesis inhibitory factor: increased serum concentrations in postmenopausal women with osteoporosis. J. Bone Miner. Res. 14 (1999) 518-527
34. Ott S.M. Histomorphometric analysis of bone remodeling. In: Bilezikian J.P., Raisz L.G., and Rodan G.A. (Eds). Principles of bone biology (2002), Academic Press, San Diego, CA 303-319
35. Bekker P.J., Holloway D., Nakanishi A., Arrighi M., Leese P.T., and Dunstan C.R. The effect of a single dose of osteoprotegerin in postmenopausal women. J. Bone Miner. Res. 16 (2001) 348-360
36. Morony S., Capparelli C., Lee R., Shimamoto G., Boone T., Lacey D.L., et al. A chimeric form of osteoprotegerin inhibits hypercalcemia and bone resorption induced by IL-1beta, TNF-alpha, PTH, PTHrP, and 1, 25(OH)2D3. J. Bone Miner. Res. 14 (1999) 1478-1485
37. George M., Stein B., Muller O., Weis-Klemm M., Pap T., Parak W.J., et al. Metabolic activation stimulates acid secretion and expression of matrix degrading proteases in human osteoblasts. Ann. Rheum. Dis. 63 (2004) 67-70
38. Frassetto L.A., Morris Jr. R.C., and Sebastian A. Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline. Am. J. Physiol. 271 (1996) F1114-F1122
39. Sebastian A., Harris S.T., Ottaway J.H., Todd K.M., and Morris Jr. R.C. Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N. Engl. J. Med. 330 (1994) 1776-1781